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Threatened miscarriage

MedGen UID:
47
Concept ID:
C0000821
Pathologic Function
Synonyms: Abortion, Threatened; Miscarriage, Threatened; Threatened Abortion; Threatened Abortions; Threatened Miscarriage; Threatened Miscarriages
SNOMED CT: Threatened abortion (antepartum) (54048003); Threatened miscarriage (54048003); Threatened abortion (54048003)

Definition

Vaginal bleeding preceding the 20th week of gestation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThreatened miscarriage

Professional guidelines

PubMed

Duncan WC
Reprod Fertil 2022 Apr 1;3(2):C4-C6. Epub 2022 Apr 7 doi: 10.1530/RAF-21-0122. PMID: 35514538Free PMC Article
Schindler AE
Horm Mol Biol Clin Investig 2016 Aug 1;27(2):49-53. doi: 10.1515/hmbci-2016-0028. PMID: 27662647
Sotiriadis A, Papatheodorou S, Makrydimas G
BMJ 2004 Jul 17;329(7458):152-5. doi: 10.1136/bmj.329.7458.152. PMID: 15258071Free PMC Article

Recent clinical studies

Etiology

McLindon LA, James G, Beckmann MM, Bertolone J, Mahomed K, Vane M, Baker T, Gleed M, Grey S, Tettamanzi L, Mol BWJ, Li W
Hum Reprod 2023 Apr 3;38(4):560-568. doi: 10.1093/humrep/dead029. PMID: 36806843Free PMC Article
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Coomarasamy A, Harb HM, Devall AJ, Cheed V, Roberts TE, Goranitis I, Ogwulu CB, Williams HM, Gallos ID, Eapen A, Daniels JP, Ahmed A, Bender-Atik R, Bhatia K, Bottomley C, Brewin J, Choudhary M, Crosfill F, Deb S, Duncan WC, Ewer A, Hinshaw K, Holland T, Izzat F, Johns J, Lumsden MA, Manda P, Norman JE, Nunes N, Overton CE, Kriedt K, Quenby S, Rao S, Ross J, Shahid A, Underwood M, Vaithilingham N, Watkins L, Wykes C, Horne AW, Jurkovic D, Middleton LJ
Health Technol Assess 2020 Jun;24(33):1-70. doi: 10.3310/hta24330. PMID: 32609084Free PMC Article
Coomarasamy A, Devall AJ, Brosens JJ, Quenby S, Stephenson MD, Sierra S, Christiansen OB, Small R, Brewin J, Roberts TE, Dhillon-Smith R, Harb H, Noordali H, Papadopoulou A, Eapen A, Prior M, Di Renzo GC, Hinshaw K, Mol BW, Lumsden MA, Khalaf Y, Shennan A, Goddijn M, van Wely M, Al-Memar M, Bennett P, Bourne T, Rai R, Regan L, Gallos ID
Am J Obstet Gynecol 2020 Aug;223(2):167-176. Epub 2020 Jan 31 doi: 10.1016/j.ajog.2019.12.006. PMID: 32008730Free PMC Article
Mirza FG, Patki A, Pexman-Fieth C
Gynecol Endocrinol 2016;32(2):97-106. Epub 2016 Jan 22 doi: 10.3109/09513590.2015.1121982. PMID: 26800266

Diagnosis

Carp HJA
Horm Mol Biol Clin Investig 2020 May 22;42(2):143-148. doi: 10.1515/hmbci-2019-0067. PMID: 32432564
Pontius E, Vieth JT
Emerg Med Clin North Am 2019 May;37(2):219-237. doi: 10.1016/j.emc.2019.01.004. PMID: 30940368
Lee HJ, Norwitz E, Lee B
BMC Pregnancy Childbirth 2018 Aug 6;18(1):318. doi: 10.1186/s12884-018-1955-2. PMID: 30081861Free PMC Article
Breeze C
Aust Fam Physician 2016 May;45(5):283-6. PMID: 27166462
Sotiriadis A, Papatheodorou S, Makrydimas G
BMJ 2004 Jul 17;329(7458):152-5. doi: 10.1136/bmj.329.7458.152. PMID: 15258071Free PMC Article

Therapy

Piccinni MP, Raghupathy R, Saito S, Szekeres-Bartho J
Front Immunol 2021;12:717808. Epub 2021 Jul 28 doi: 10.3389/fimmu.2021.717808. PMID: 34394125Free PMC Article
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Devall AJ, Coomarasamy A
Best Pract Res Clin Obstet Gynaecol 2020 Nov;69:30-39. Epub 2020 Sep 8 doi: 10.1016/j.bpobgyn.2020.09.002. PMID: 32978069
Coomarasamy A, Devall AJ, Brosens JJ, Quenby S, Stephenson MD, Sierra S, Christiansen OB, Small R, Brewin J, Roberts TE, Dhillon-Smith R, Harb H, Noordali H, Papadopoulou A, Eapen A, Prior M, Di Renzo GC, Hinshaw K, Mol BW, Lumsden MA, Khalaf Y, Shennan A, Goddijn M, van Wely M, Al-Memar M, Bennett P, Bourne T, Rai R, Regan L, Gallos ID
Am J Obstet Gynecol 2020 Aug;223(2):167-176. Epub 2020 Jan 31 doi: 10.1016/j.ajog.2019.12.006. PMID: 32008730Free PMC Article
Mirza FG, Patki A, Pexman-Fieth C
Gynecol Endocrinol 2016;32(2):97-106. Epub 2016 Jan 22 doi: 10.3109/09513590.2015.1121982. PMID: 26800266

Prognosis

Tanimura K, Uchida A, Imafuku H, Tairaku S, Fujioka K, Morioka I, Yamada H
Int J Mol Sci 2021 Dec 15;22(24) doi: 10.3390/ijms222413487. PMID: 34948284Free PMC Article
Herevych NV, Nochvina OA, Nikitina IM
Wiad Lek 2021;74(1):28-34. PMID: 33851582
Petriglia G, Palaia I, Musella A, Marchetti C, Antonilli M, Brunelli R, Ostuni R, Benedetti Panici P
Minerva Ginecol 2015 Dec;67(6):491-7. Epub 2015 Feb 5 PMID: 25668506
Carp H
Gynecol Endocrinol 2012 Dec;28(12):983-90. Epub 2012 Jul 16 doi: 10.3109/09513590.2012.702875. PMID: 22794306Free PMC Article
Saraswat L, Bhattacharya S, Maheshwari A, Bhattacharya S
BJOG 2010 Feb;117(3):245-57. Epub 2009 Nov 26 doi: 10.1111/j.1471-0528.2009.02427.x. PMID: 19943827

Clinical prediction guides

Zhao Y, Miao C, Wang R, Chen Y, Ren N, Ma J, Gao T, Zhang Q
J Ethnopharmacol 2024 Apr 24;324:117796. Epub 2024 Jan 19 doi: 10.1016/j.jep.2024.117796. PMID: 38246482
Coomarasamy A, Harb HM, Devall AJ, Cheed V, Roberts TE, Goranitis I, Ogwulu CB, Williams HM, Gallos ID, Eapen A, Daniels JP, Ahmed A, Bender-Atik R, Bhatia K, Bottomley C, Brewin J, Choudhary M, Crosfill F, Deb S, Duncan WC, Ewer A, Hinshaw K, Holland T, Izzat F, Johns J, Lumsden MA, Manda P, Norman JE, Nunes N, Overton CE, Kriedt K, Quenby S, Rao S, Ross J, Shahid A, Underwood M, Vaithilingham N, Watkins L, Wykes C, Horne AW, Jurkovic D, Middleton LJ
Health Technol Assess 2020 Jun;24(33):1-70. doi: 10.3310/hta24330. PMID: 32609084Free PMC Article
Coomarasamy A, Devall AJ, Brosens JJ, Quenby S, Stephenson MD, Sierra S, Christiansen OB, Small R, Brewin J, Roberts TE, Dhillon-Smith R, Harb H, Noordali H, Papadopoulou A, Eapen A, Prior M, Di Renzo GC, Hinshaw K, Mol BW, Lumsden MA, Khalaf Y, Shennan A, Goddijn M, van Wely M, Al-Memar M, Bennett P, Bourne T, Rai R, Regan L, Gallos ID
Am J Obstet Gynecol 2020 Aug;223(2):167-176. Epub 2020 Jan 31 doi: 10.1016/j.ajog.2019.12.006. PMID: 32008730Free PMC Article
Pillai RN, Konje JC, Richardson M, Tincello DG, Potdar N
Eur J Obstet Gynecol Reprod Biol 2018 Jan;220:122-131. Epub 2017 Nov 4 doi: 10.1016/j.ejogrb.2017.10.024. PMID: 29207325
Petriglia G, Palaia I, Musella A, Marchetti C, Antonilli M, Brunelli R, Ostuni R, Benedetti Panici P
Minerva Ginecol 2015 Dec;67(6):491-7. Epub 2015 Feb 5 PMID: 25668506

Recent systematic reviews

Zhao Y, D'Souza R, Gao Y, Hao Q, Kallas-Silva L, Steen JP, Guyatt G
Acta Obstet Gynecol Scand 2024 Sep;103(9):1689-1701. Epub 2024 Mar 13 doi: 10.1111/aogs.14829. PMID: 38481031Free PMC Article
Devall AJ, Papadopoulou A, Podesek M, Haas DM, Price MJ, Coomarasamy A, Gallos ID
Cochrane Database Syst Rev 2021 Apr 19;4(4):CD013792. doi: 10.1002/14651858.CD013792.pub2. PMID: 33872382Free PMC Article
Carp H
Gynecol Endocrinol 2012 Dec;28(12):983-90. Epub 2012 Jul 16 doi: 10.3109/09513590.2012.702875. PMID: 22794306Free PMC Article
Wahabi HA, Fayed AA, Esmaeil SA, Al Zeidan RA
Cochrane Database Syst Rev 2011 Dec 7;(12):CD005943. doi: 10.1002/14651858.CD005943.pub4. PMID: 22161393
Wahabi HA, Abed Althagafi NF, Elawad M, Al Zeidan RA
Cochrane Database Syst Rev 2011 Mar 16;(3):CD005943. doi: 10.1002/14651858.CD005943.pub3. PMID: 21412891

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