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Meconium plug

MedGen UID:
472618
•Concept ID:
C0270246
•
Disease or Syndrome
Synonyms: Meconium Plug Syndrome; Meconium plug syndrome
SNOMED CT: Meconium plug (206528005); Meconium plug syndrome (206528005)

Definition

A transient colonic dysfunction in the newborn characterized by the delayed passage of meconium and associated intestinal dilatation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeconium plug

Professional guidelines

PubMed

Diagnostic decision-making tool for imaging term neonatal bowel obstruction.
Tsitsiou Y, Calle-Toro JS, Zouvani A, Andronikou S
Clin Radiol 2021 Mar;76(3):163-171. Epub 2020 Oct 20 doi: 10.1016/j.crad.2020.09.016. PMID: 33097229
"Pulling the plug"--management of meconium plug syndrome in neonates.
Cuenca AG, Ali AS, Kays DW, Islam S
J Surg Res 2012 Jun 15;175(2):e43-6. Epub 2012 Mar 10 doi: 10.1016/j.jss.2012.01.029. PMID: 22459290
Meconium obstruction in extremely low-birth-weight neonates: guidelines for diagnosis and management.
Emil S, Nguyen T, Sills J, Padilla G
J Pediatr Surg 2004 May;39(5):731-7. doi: 10.1016/j.jpedsurg.2004.01.027. PMID: 15137008

Recent clinical studies

Etiology

Gastrointestinal Emergency in Neonates and Infants: A Pictorial Essay.
Choi G, Je BK, Kim YJ
Korean J Radiol 2022 Jan;23(1):124-138. doi: 10.3348/kjr.2021.0111. PMID: 34983099Free PMC Article
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
"Pulling the plug"--management of meconium plug syndrome in neonates.
Cuenca AG, Ali AS, Kays DW, Islam S
J Surg Res 2012 Jun 15;175(2):e43-6. Epub 2012 Mar 10 doi: 10.1016/j.jss.2012.01.029. PMID: 22459290
Meconium plug obstruction.
Burge D, Drewett M
Pediatr Surg Int 2004 Feb;20(2):108-10. Epub 2004 Feb 4 doi: 10.1007/s00383-003-1098-y. PMID: 14760494
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Diagnosis

Gastrointestinal Emergency in Neonates and Infants: A Pictorial Essay.
Choi G, Je BK, Kim YJ
Korean J Radiol 2022 Jan;23(1):124-138. doi: 10.3348/kjr.2021.0111. PMID: 34983099Free PMC Article
Diagnostic decision-making tool for imaging term neonatal bowel obstruction.
Tsitsiou Y, Calle-Toro JS, Zouvani A, Andronikou S
Clin Radiol 2021 Mar;76(3):163-171. Epub 2020 Oct 20 doi: 10.1016/j.crad.2020.09.016. PMID: 33097229
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
"Pulling the plug"--management of meconium plug syndrome in neonates.
Cuenca AG, Ali AS, Kays DW, Islam S
J Surg Res 2012 Jun 15;175(2):e43-6. Epub 2012 Mar 10 doi: 10.1016/j.jss.2012.01.029. PMID: 22459290
Meconium plug obstruction.
Burge D, Drewett M
Pediatr Surg Int 2004 Feb;20(2):108-10. Epub 2004 Feb 4 doi: 10.1007/s00383-003-1098-y. PMID: 14760494

Therapy

Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
Ultrasound-guided contrast enema for meconium obstruction in very low birth weight infants: Factors that affect treatment success.
Cho HH, Cheon JE, Choi YH, Lee SM, Kim WS, Kim IO, Shin SM, Kim EK, Kim HS, Choi JH, You SK
Eur J Radiol 2015 Oct;84(10):2024-31. Epub 2015 Jun 7 doi: 10.1016/j.ejrad.2015.06.006. PMID: 26159485
Pneumoperitoneum in the newborn infant.
Steves M, Ricketts RR
Am Surg 1987 Apr;53(4):226-30. PMID: 3579030
Early diagnosis and intrauterine therapy of meconium plug syndrome in the fetus: risks and benefits.
Samuel N, Dicker D, Landman J, Feldberg D, Goldman JA
J Ultrasound Med 1986 Aug;5(8):425-8. doi: 10.7863/jum.1986.5.8.425. PMID: 3528519
Neonatal hypermagnesemia and the meconium-plug syndrome.
Sokal MM, Koenigsberger MR, Rose JS, Berdon WE, Santulli TV
N Engl J Med 1972 Apr 13;286(15):823-5. doi: 10.1056/NEJM197204132861507. PMID: 5011790

Prognosis

"Pulling the plug"--management of meconium plug syndrome in neonates.
Cuenca AG, Ali AS, Kays DW, Islam S
J Surg Res 2012 Jun 15;175(2):e43-6. Epub 2012 Mar 10 doi: 10.1016/j.jss.2012.01.029. PMID: 22459290
Meconium plug obstruction.
Burge D, Drewett M
Pediatr Surg Int 2004 Feb;20(2):108-10. Epub 2004 Feb 4 doi: 10.1007/s00383-003-1098-y. PMID: 14760494
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270
Plain film diagnosis in meconium plug syndrome, meconium ileus and neonatal Hirschsprung's disease. A scoring system.
Hussain SM, Meradji M, Robben SG, Hop WC
Pediatr Radiol 1991;21(8):556-9. doi: 10.1007/BF02012596. PMID: 1815174
THE MECONIUM-PLUG SYNDROME AND HIRSCHSPRUNG'S DISEASE.
GILLIS DA, GRANTMYRE EB
Can Med Assoc J 1965 Jan 30;92(5):225-7. PMID: 14246296Free PMC Article

Clinical prediction guides

Should we look for Hirschsprung disease in all children with meconium plug syndrome?
Buonpane C, Lautz TB, Hu YY
J Pediatr Surg 2019 Jun;54(6):1164-1167. Epub 2019 Mar 1 doi: 10.1016/j.jpedsurg.2019.02.036. PMID: 30879740
Ultrasound-guided contrast enema for meconium obstruction in very low birth weight infants: Factors that affect treatment success.
Cho HH, Cheon JE, Choi YH, Lee SM, Kim WS, Kim IO, Shin SM, Kim EK, Kim HS, Choi JH, You SK
Eur J Radiol 2015 Oct;84(10):2024-31. Epub 2015 Jun 7 doi: 10.1016/j.ejrad.2015.06.006. PMID: 26159485
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270
Plain film diagnosis in meconium plug syndrome, meconium ileus and neonatal Hirschsprung's disease. A scoring system.
Hussain SM, Meradji M, Robben SG, Hop WC
Pediatr Radiol 1991;21(8):556-9. doi: 10.1007/BF02012596. PMID: 1815174
Hirschsprung disease: accuracy of the barium enema examination.
Rosenfield NS, Ablow RC, Markowitz RI, DiPietro M, Seashore JH, Touloukian RJ, Cicchetti DV
Radiology 1984 Feb;150(2):393-400. doi: 10.1148/radiology.150.2.6691093. PMID: 6691093

Recent systematic reviews

Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article

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