U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Meconium plug

MedGen UID:
472618
•Concept ID:
C0270246
•
Disease or Syndrome
Synonyms: Meconium Plug Syndrome; Meconium plug syndrome
SNOMED CT: Meconium plug (206528005); Meconium plug syndrome (206528005)

Definition

A transient colonic dysfunction in the newborn characterized by the delayed passage of meconium and associated intestinal dilatation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeconium plug

Professional guidelines

PubMed

Diagnostic decision-making tool for imaging term neonatal bowel obstruction.
Tsitsiou Y, Calle-Toro JS, Zouvani A, Andronikou S
Clin Radiol 2021 Mar;76(3):163-171. Epub 2020 Oct 20 doi: 10.1016/j.crad.2020.09.016. PMID: 33097229
"Pulling the plug"--management of meconium plug syndrome in neonates.
Cuenca AG, Ali AS, Kays DW, Islam S
J Surg Res 2012 Jun 15;175(2):e43-6. Epub 2012 Mar 10 doi: 10.1016/j.jss.2012.01.029. PMID: 22459290
Meconium obstruction in extremely low-birth-weight neonates: guidelines for diagnosis and management.
Emil S, Nguyen T, Sills J, Padilla G
J Pediatr Surg 2004 May;39(5):731-7. doi: 10.1016/j.jpedsurg.2004.01.027. PMID: 15137008

Recent clinical studies

Etiology

Gastrointestinal Emergency in Neonates and Infants: A Pictorial Essay.
Choi G, Je BK, Kim YJ
Korean J Radiol 2022 Jan;23(1):124-138. doi: 10.3348/kjr.2021.0111. PMID: 34983099Free PMC Article
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
"Pulling the plug"--management of meconium plug syndrome in neonates.
Cuenca AG, Ali AS, Kays DW, Islam S
J Surg Res 2012 Jun 15;175(2):e43-6. Epub 2012 Mar 10 doi: 10.1016/j.jss.2012.01.029. PMID: 22459290
Meconium plug obstruction.
Burge D, Drewett M
Pediatr Surg Int 2004 Feb;20(2):108-10. Epub 2004 Feb 4 doi: 10.1007/s00383-003-1098-y. PMID: 14760494
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Diagnosis

Gastrointestinal Emergency in Neonates and Infants: A Pictorial Essay.
Choi G, Je BK, Kim YJ
Korean J Radiol 2022 Jan;23(1):124-138. doi: 10.3348/kjr.2021.0111. PMID: 34983099Free PMC Article
Diagnostic decision-making tool for imaging term neonatal bowel obstruction.
Tsitsiou Y, Calle-Toro JS, Zouvani A, Andronikou S
Clin Radiol 2021 Mar;76(3):163-171. Epub 2020 Oct 20 doi: 10.1016/j.crad.2020.09.016. PMID: 33097229
Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
Meconium plug obstruction.
Burge D, Drewett M
Pediatr Surg Int 2004 Feb;20(2):108-10. Epub 2004 Feb 4 doi: 10.1007/s00383-003-1098-y. PMID: 14760494
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270

Therapy

Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article
Ultrasound-guided contrast enema for meconium obstruction in very low birth weight infants: Factors that affect treatment success.
Cho HH, Cheon JE, Choi YH, Lee SM, Kim WS, Kim IO, Shin SM, Kim EK, Kim HS, Choi JH, You SK
Eur J Radiol 2015 Oct;84(10):2024-31. Epub 2015 Jun 7 doi: 10.1016/j.ejrad.2015.06.006. PMID: 26159485
Pneumoperitoneum in the newborn infant.
Steves M, Ricketts RR
Am Surg 1987 Apr;53(4):226-30. PMID: 3579030
Early diagnosis and intrauterine therapy of meconium plug syndrome in the fetus: risks and benefits.
Samuel N, Dicker D, Landman J, Feldberg D, Goldman JA
J Ultrasound Med 1986 Aug;5(8):425-8. doi: 10.7863/jum.1986.5.8.425. PMID: 3528519
Neonatal hypermagnesemia and the meconium-plug syndrome.
Sokal MM, Koenigsberger MR, Rose JS, Berdon WE, Santulli TV
N Engl J Med 1972 Apr 13;286(15):823-5. doi: 10.1056/NEJM197204132861507. PMID: 5011790

Prognosis

"Pulling the plug"--management of meconium plug syndrome in neonates.
Cuenca AG, Ali AS, Kays DW, Islam S
J Surg Res 2012 Jun 15;175(2):e43-6. Epub 2012 Mar 10 doi: 10.1016/j.jss.2012.01.029. PMID: 22459290
Meconium plug obstruction.
Burge D, Drewett M
Pediatr Surg Int 2004 Feb;20(2):108-10. Epub 2004 Feb 4 doi: 10.1007/s00383-003-1098-y. PMID: 14760494
'Spontaneous' neonatal gastric perforation: is it really spontaneous?
Leone RJ Jr, Krasna IH
J Pediatr Surg 2000 Jul;35(7):1066-9. doi: 10.1053/jpsu.2000.7773. PMID: 10917298
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270
THE MECONIUM-PLUG SYNDROME AND HIRSCHSPRUNG'S DISEASE.
GILLIS DA, GRANTMYRE EB
Can Med Assoc J 1965 Jan 30;92(5):225-7. PMID: 14246296Free PMC Article

Clinical prediction guides

Should we look for Hirschsprung disease in all children with meconium plug syndrome?
Buonpane C, Lautz TB, Hu YY
J Pediatr Surg 2019 Jun;54(6):1164-1167. Epub 2019 Mar 1 doi: 10.1016/j.jpedsurg.2019.02.036. PMID: 30879740
Ultrasound-guided contrast enema for meconium obstruction in very low birth weight infants: Factors that affect treatment success.
Cho HH, Cheon JE, Choi YH, Lee SM, Kim WS, Kim IO, Shin SM, Kim EK, Kim HS, Choi JH, You SK
Eur J Radiol 2015 Oct;84(10):2024-31. Epub 2015 Jun 7 doi: 10.1016/j.ejrad.2015.06.006. PMID: 26159485
Intestinal neuronal dysplasia.
Schofield DE, Yunis EJ
J Pediatr Gastroenterol Nutr 1991 Feb;12(2):182-9. doi: 10.1097/00005176-199102000-00008. PMID: 2051270
Plain film diagnosis in meconium plug syndrome, meconium ileus and neonatal Hirschsprung's disease. A scoring system.
Hussain SM, Meradji M, Robben SG, Hop WC
Pediatr Radiol 1991;21(8):556-9. doi: 10.1007/BF02012596. PMID: 1815174
Hirschsprung disease: accuracy of the barium enema examination.
Rosenfield NS, Ablow RC, Markowitz RI, DiPietro M, Seashore JH, Touloukian RJ, Cicchetti DV
Radiology 1984 Feb;150(2):393-400. doi: 10.1148/radiology.150.2.6691093. PMID: 6691093

Recent systematic reviews

Probiotics to prevent infantile colic.
Ong TG, Gordon M, Banks SS, Thomas MR, Akobeng AK
Cochrane Database Syst Rev 2019 Mar 13;3(3):CD012473. doi: 10.1002/14651858.CD012473.pub2. PMID: 30865287Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...