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Anemia of prematurity

MedGen UID:
472907
•Concept ID:
C0158996
•
Disease or Syndrome
Synonyms: Anemia of Prematurity; anemia of prematurity; AOP
SNOMED CT: Anemia of prematurity (47100003)
 
Monarch Initiative: MONDO:0001239

Definition

A blood disorder characterized by low hemoglobin levels in premature neonates that usually spontaneously resolves within 3-6 months post birth. A combination of factors including the transition from the liver to the bone marrow for erythropoiesis in a neonate, blood loss experienced during delivery, the shortened life span of fetal blood cells, and an acclimation to a relatively hyperoxic environment outside the womb can predispose a neonate to this condition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnemia of prematurity

Professional guidelines

PubMed

Reticulocyte hemoglobin content changes after treatment of anemia of prematurity.
Nii M, Okamoto T, Sugiyama T, Aoyama A, Nagaya K
Pediatr Int 2022 Jan;64(1):e15330. doi: 10.1111/ped.15330. PMID: 36321339
Current controversies in the management of the anemia of prematurity.
Bishara N, Ohls RK
Semin Perinatol 2009 Feb;33(1):29-34. doi: 10.1053/j.semperi.2008.10.006. PMID: 19167579
Iron status and the treatment of the anemia of prematurity.
Kling PJ, Winzerling JJ
Clin Perinatol 2002 Jun;29(2):283-94. doi: 10.1016/s0095-5108(02)00002-7. PMID: 12168242

Recent clinical studies

Etiology

Effect of Early Erythropoietin on Retinopathy of Prematurity: A Stratified Meta-Analysis.
Fischer HS, Reibel NJ, Bührer C, Dame C
Neonatology 2023;120(5):566-576. Epub 2023 Jun 27 doi: 10.1159/000530126. PMID: 37369177
Reticulocyte hemoglobin content changes after treatment of anemia of prematurity.
Nii M, Okamoto T, Sugiyama T, Aoyama A, Nagaya K
Pediatr Int 2022 Jan;64(1):e15330. doi: 10.1111/ped.15330. PMID: 36321339
Anemia of Prematurity and Oral Feeding Milestones in Premature Infants.
Viswanathan S, Jadcherla S
Am J Perinatol 2021 May;38(6):553-559. Epub 2019 Nov 27 doi: 10.1055/s-0039-1700488. PMID: 31777047
Anemia of prematurity.
Salsbury DC
Neonatal Netw 2001 Aug;20(5):13-20. doi: 10.1891/0730-0832.20.5.13. PMID: 12144218
Recombinant erythropoietin.
Christensen RD
Pediatr Rev 1991 Feb;12(8):244-8. doi: 10.1542/pir.12-8-244. PMID: 2006127

Diagnosis

Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
Neonatal anemia.
Aher S, Malwatkar K, Kadam S
Semin Fetal Neonatal Med 2008 Aug;13(4):239-47. Epub 2008 Apr 14 doi: 10.1016/j.siny.2008.02.009. PMID: 18411074
Anemia of prematurity.
Salsbury DC
Neonatal Netw 2001 Aug;20(5):13-20. doi: 10.1891/0730-0832.20.5.13. PMID: 12144218
Erythropoietin.
Erslev AJ
Leuk Res 1990;14(8):683-8. doi: 10.1016/0145-2126(90)90094-p. PMID: 2201820
Anemia of prematurity.
Stockman JA 3rd
Clin Perinatol 1977 Sep;4(2):239-57. PMID: 332429

Therapy

Neonatal Anemia.
German KR, Juul SE
Curr Pediatr Rev 2023;19(4):388-394. doi: 10.2174/1573396319666221121140627. PMID: 36411551
Necrotizing enterocolitis and the role of anemia of prematurity.
Singh R, Shah BL, Frantz ID 3rd
Semin Perinatol 2012 Aug;36(4):277-82. doi: 10.1053/j.semperi.2012.04.008. PMID: 22818548
Neonatal anemia.
Aher S, Malwatkar K, Kadam S
Semin Fetal Neonatal Med 2008 Aug;13(4):239-47. Epub 2008 Apr 14 doi: 10.1016/j.siny.2008.02.009. PMID: 18411074
Anemia of prematurity.
Salsbury DC
Neonatal Netw 2001 Aug;20(5):13-20. doi: 10.1891/0730-0832.20.5.13. PMID: 12144218
Erythropoietin.
Erslev AJ
Leuk Res 1990;14(8):683-8. doi: 10.1016/0145-2126(90)90094-p. PMID: 2201820

Prognosis

Anemia of Prematurity and Oral Feeding Milestones in Premature Infants.
Viswanathan S, Jadcherla S
Am J Perinatol 2021 May;38(6):553-559. Epub 2019 Nov 27 doi: 10.1055/s-0039-1700488. PMID: 31777047
Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates.
Fujita H, Teratani M, Hazama Y, Nakahara M, Asaka H, Nishimura S
Transfusion 2018 Oct;58(10):2383-2387. Epub 2018 Sep 4 doi: 10.1111/trf.14897. PMID: 30178874
Effects of transfusion in anemia of prematurity.
Schwarz KB, Dear PR, Gill AB, Newell SJ, Richards M
Pediatr Hematol Oncol 2005 Oct-Nov;22(7):551-9. doi: 10.1080/08880010500198418. PMID: 16166047
Use and safety of elevated dosages of vitamin E in infants and children.
Mino M
Int J Vitam Nutr Res Suppl 1989;30:69-80. PMID: 2507708
Anemia of prematurity. Current concepts in the issue of when to transfuse.
Stockman JA 3rd
Pediatr Clin North Am 1986 Feb;33(1):111-28. doi: 10.1016/s0031-3955(16)34972-0. PMID: 3513096

Clinical prediction guides

Anemia of Prematurity and Oral Feeding Milestones in Premature Infants.
Viswanathan S, Jadcherla S
Am J Perinatol 2021 May;38(6):553-559. Epub 2019 Nov 27 doi: 10.1055/s-0039-1700488. PMID: 31777047
Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Erythropoietin Alone, and Erythropoietin Combined with Hypothermia: History, Current Status, and Future Research.
Oorschot DE, Sizemore RJ, Amer AR
Int J Mol Sci 2020 Feb 21;21(4) doi: 10.3390/ijms21041487. PMID: 32098276Free PMC Article
The role of erythropoietin in the anemia of prematurity.
Doyle JJ
Semin Perinatol 1997 Feb;21(1):20-7. doi: 10.1016/s0146-0005(97)80016-x. PMID: 9190030
Use of recombinant erythropoietin in treatment of the anemia of prematurity.
Halpérin DS
Am J Pediatr Hematol Oncol 1991 Fall;13(3):351-63. doi: 10.1097/00043426-199123000-00020. PMID: 1793163
Anemia of prematurity. Current concepts in the issue of when to transfuse.
Stockman JA 3rd
Pediatr Clin North Am 1986 Feb;33(1):111-28. doi: 10.1016/s0031-3955(16)34972-0. PMID: 3513096

Recent systematic reviews

Clinical Outcomes Related to the Gastrointestinal Trophic Effects of Erythropoietin in Preterm Neonates: A Systematic Review and Meta-Analysis.
Ananthan A, Balasubramanian H, Rao S, Patole S
Adv Nutr 2018 May 1;9(3):238-246. doi: 10.1093/advances/nmy005. PMID: 29767696Free PMC Article

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