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Increased body mass index

MedGen UID:
472957
•Concept ID:
C0231254
•
Finding
Synonym: Increased BMI
SNOMED CT: Body mass index above normal parameters (48499001); Increased body mass index (48499001)
 
HPO: HP:0031418

Definition

Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased body mass index

Conditions with this feature

X-linked intellectual disability-short stature-overweight syndrome
MedGen UID:
901885
•Concept ID:
C0796218
•
Disease or Syndrome
X-linked intellectual developmental disorder-12 (XLID12) is characterized by borderline to severe intellectual disability with variable neurologic features, short stature, and elevated body mass index (BMI) (Kumar et al., 2015).
See: Condition Record
Congenital nongoitrous hypothryoidism 6
MedGen UID:
482447
•Concept ID:
C3280817
•
Disease or Syndrome
Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the THRA gene.
See: Condition Record
Congenital nongoitrous hypothryoidism 6
X-linked intellectual disability-short stature-overweight syndrome

Professional guidelines

PubMed

Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037
The Evaluation and Management of Suspicious Gastric Lesions Following Bariatric Surgery.
Gomez G
Surg Clin North Am 2017 Apr;97(2):467-474. doi: 10.1016/j.suc.2016.12.003. PMID: 28325198
ASPS clinical practice guideline summary on reduction mammaplasty.
Kalliainen LK; ASPS Health Policy Committee
Plast Reconstr Surg 2012 Oct;130(4):785-789. doi: 10.1097/PRS.0b013e318262f0c0. PMID: 23018692

Recent clinical studies

Etiology

Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Plantar Fasciitis.
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review.
Sommer A, Twig G
Curr Diab Rep 2018 Aug 30;18(10):91. doi: 10.1007/s11892-018-1062-9. PMID: 30167798
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Diagnosis

Sarcopenic obesity is associated with cognitive impairment in community-dwelling older adults: The Bunkyo Health Study.
Someya Y, Tamura Y, Kaga H, Sugimoto D, Kadowaki S, Suzuki R, Aoki S, Hattori N, Motoi Y, Shimada K, Daida H, Ishijima M, Kaneko K, Nojiri S, Kawamori R, Watada H
Clin Nutr 2022 May;41(5):1046-1051. Epub 2022 Mar 16 doi: 10.1016/j.clnu.2022.03.017. PMID: 35390728
Epidemiology of meningiomas.
Walsh KM
Handb Clin Neurol 2020;169:3-15. doi: 10.1016/B978-0-12-804280-9.00001-9. PMID: 32553297
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Plantar Fasciitis.
Trojian T, Tucker AK
Am Fam Physician 2019 Jun 15;99(12):744-750. PMID: 31194492
Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037

Therapy

Esophageal hiatal hernia: risk, diagnosis and management.
Yu HX, Han CS, Xue JR, Han ZF, Xin H
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):319-329. Epub 2018 Feb 22 doi: 10.1080/17474124.2018.1441711. PMID: 29451037
The role of increased body mass index in outcomes of sepsis: a systematic review and meta-analysis.
Wang S, Liu X, Chen Q, Liu C, Huang C, Fang X
BMC Anesthesiol 2017 Aug 31;17(1):118. doi: 10.1186/s12871-017-0405-4. PMID: 28859605Free PMC Article
Acne: risk indicator for increased body mass index and insulin resistance.
Melnik BC, John SM, Plewig G
Acta Derm Venereol 2013 Nov;93(6):644-9. doi: 10.2340/00015555-1677. PMID: 23975508
Chemistry behind Vegetarianism.
Li D
J Agric Food Chem 2011 Feb 9;59(3):777-84. Epub 2011 Jan 4 doi: 10.1021/jf103846u. PMID: 21204526
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Prognosis

Obesity, metabolic syndrome, and cancer: pathophysiological and therapeutic associations.
Mili N, Paschou SA, Goulis DG, Dimopoulos MA, Lambrinoudaki I, Psaltopoulou T
Endocrine 2021 Dec;74(3):478-497. Epub 2021 Oct 8 doi: 10.1007/s12020-021-02884-x. PMID: 34625915
Epidemiology of meningiomas.
Walsh KM
Handb Clin Neurol 2020;169:3-15. doi: 10.1016/B978-0-12-804280-9.00001-9. PMID: 32553297
Obesity-associated Breast Cancer: Analysis of risk factors.
Engin A
Adv Exp Med Biol 2017;960:571-606. doi: 10.1007/978-3-319-48382-5_25. PMID: 28585217
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article
Obesity and the risk of heart failure.
Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS
N Engl J Med 2002 Aug 1;347(5):305-13. doi: 10.1056/NEJMoa020245. PMID: 12151467

Clinical prediction guides

Obesity, metabolic syndrome, and primary hypertension.
Litwin M, Kułaga Z
Pediatr Nephrol 2021 Apr;36(4):825-837. Epub 2020 May 9 doi: 10.1007/s00467-020-04579-3. PMID: 32388582Free PMC Article
Diabetes in HFE Hemochromatosis.
Barton JC, Acton RT
J Diabetes Res 2017;2017:9826930. Epub 2017 Feb 26 doi: 10.1155/2017/9826930. PMID: 28331855Free PMC Article
Body mass index and risk of surgical site infection following spine surgery: a meta-analysis.
Abdallah DY, Jadaan MM, McCabe JP
Eur Spine J 2013 Dec;22(12):2800-9. Epub 2013 Jul 5 doi: 10.1007/s00586-013-2890-6. PMID: 23828507Free PMC Article
Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis.
Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y, Zhao Y, Wang C
Joint Bone Spine 2012 May;79(3):291-7. Epub 2011 Jul 30 doi: 10.1016/j.jbspin.2011.05.015. PMID: 21803633
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index.
Taheri S, Lin L, Austin D, Young T, Mignot E
PLoS Med 2004 Dec;1(3):e62. Epub 2004 Dec 7 doi: 10.1371/journal.pmed.0010062. PMID: 15602591Free PMC Article

Recent systematic reviews

Obesity and anxiety symptoms: a systematic review and meta-analysis.
Amiri S, Behnezhad S
Neuropsychiatr 2019 Jun;33(2):72-89. Epub 2019 Feb 18 doi: 10.1007/s40211-019-0302-9. PMID: 30778841
The Impact of Childhood and Adolescent Obesity on Cardiovascular Risk in Adulthood: a Systematic Review.
Sommer A, Twig G
Curr Diab Rep 2018 Aug 30;18(10):91. doi: 10.1007/s11892-018-1062-9. PMID: 30167798
The role of increased body mass index in outcomes of sepsis: a systematic review and meta-analysis.
Wang S, Liu X, Chen Q, Liu C, Huang C, Fang X
BMC Anesthesiol 2017 Aug 31;17(1):118. doi: 10.1186/s12871-017-0405-4. PMID: 28859605Free PMC Article
Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis.
Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y, Zhao Y, Wang C
Joint Bone Spine 2012 May;79(3):291-7. Epub 2011 Jul 30 doi: 10.1016/j.jbspin.2011.05.015. PMID: 21803633
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

Supplemental Content

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    Clinical resources

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