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Renal vein thrombosis

MedGen UID:
472971
•Concept ID:
C0238457
•
Pathologic Function
Synonyms: Renal Vein Thrombosis; RVT - Renal vein thrombosis; Thrombosis of renal vein
SNOMED CT: RVT - Renal vein thrombosis (15842009); Thrombosis of renal vein (15842009); Renal vein thrombosis (15842009)
 
HPO: HP:0034239

Definition

The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal vein thrombosis

Professional guidelines

PubMed

Wunderlich Syndrome: Comprehensive Review of Diagnosis and Management.
Shah JN, Gandhi D, Prasad SR, Sandhu PK, Banker H, Molina R, Khan S, Garg T, Katabathina VS
Radiographics 2023 Jun;43(6):e220172. doi: 10.1148/rg.220172. PMID: 37227946
Treatment of venous thromboembolism in pediatric patients.
Witmer C, Raffini L
Blood 2020 Jan 30;135(5):335-343. doi: 10.1182/blood.2019001847. PMID: 31917400
Management of thrombosis in children and neonates: practical use of anticoagulants in children.
Monagle P, Newall F
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):399-404. doi: 10.1182/asheducation-2018.1.399. PMID: 30504338Free PMC Article

Recent clinical studies

Etiology

Intra-abdominal Complications After Pediatric Kidney Transplantation: Incidence and Risk Factors.
Taher A, Zhu B, Ma S, Shun A, Durkan AM
Transplantation 2019 Jun;103(6):1234-1239. doi: 10.1097/TP.0000000000002420. PMID: 30113998
Transplant Renal Vein Thrombosis.
El Zorkany K, Bridson JM, Sharma A, Halawa A
Exp Clin Transplant 2017 Apr;15(2):123-129. doi: 10.6002/ect.2016.0060. PMID: 28338457
Hypercoagulability and nephrotic syndrome.
Gigante A, Barbano B, Sardo L, Martina P, Gasperini ML, Labbadia R, Liberatori M, Amoroso A, Cianci R
Curr Vasc Pharmacol 2014 May;12(3):512-7. doi: 10.2174/157016111203140518172048. PMID: 22724465
Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathy.
Tektonidou MG
Clin Rev Allergy Immunol 2009 Jun;36(2-3):131-40. doi: 10.1007/s12016-008-8112-z. PMID: 19048414
Acute renal failure in the newborn.
Andreoli SP
Semin Perinatol 2004 Apr;28(2):112-23. doi: 10.1053/j.semperi.2003.11.003. PMID: 15200250

Diagnosis

Venous thrombosis in unusual sites: A practical review for the hematologist.
Shatzel JJ, O'Donnell M, Olson SR, Kearney MR, Daughety MM, Hum J, Nguyen KP, DeLoughery TG
Eur J Haematol 2019 Jan;102(1):53-62. Epub 2018 Oct 29 doi: 10.1111/ejh.13177. PMID: 30267448
Intra-abdominal Complications After Pediatric Kidney Transplantation: Incidence and Risk Factors.
Taher A, Zhu B, Ma S, Shun A, Durkan AM
Transplantation 2019 Jun;103(6):1234-1239. doi: 10.1097/TP.0000000000002420. PMID: 30113998
Management of thrombosis in children and neonates: practical use of anticoagulants in children.
Monagle P, Newall F
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):399-404. doi: 10.1182/asheducation-2018.1.399. PMID: 30504338Free PMC Article
Transplant Renal Vein Thrombosis.
El Zorkany K, Bridson JM, Sharma A, Halawa A
Exp Clin Transplant 2017 Apr;15(2):123-129. doi: 10.6002/ect.2016.0060. PMID: 28338457
CT evaluation of renovascular disease.
Kawashima A, Sandler CM, Ernst RD, Tamm EP, Goldman SM, Fishman EK
Radiographics 2000 Sep-Oct;20(5):1321-40. doi: 10.1148/radiographics.20.5.g00se141321. PMID: 10992021

Therapy

Treatment of venous thromboembolism in pediatric patients.
Witmer C, Raffini L
Blood 2020 Jan 30;135(5):335-343. doi: 10.1182/blood.2019001847. PMID: 31917400
Management of thrombosis in children and neonates: practical use of anticoagulants in children.
Monagle P, Newall F
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):399-404. doi: 10.1182/asheducation-2018.1.399. PMID: 30504338Free PMC Article
Transplant Renal Vein Thrombosis.
El Zorkany K, Bridson JM, Sharma A, Halawa A
Exp Clin Transplant 2017 Apr;15(2):123-129. doi: 10.6002/ect.2016.0060. PMID: 28338457
Hypercoagulability and nephrotic syndrome.
Gigante A, Barbano B, Sardo L, Martina P, Gasperini ML, Labbadia R, Liberatori M, Amoroso A, Cianci R
Curr Vasc Pharmacol 2014 May;12(3):512-7. doi: 10.2174/157016111203140518172048. PMID: 22724465
Congestive renal failure: the pathophysiology and treatment of renal venous hypertension.
Ross EA
J Card Fail 2012 Dec;18(12):930-8. Epub 2012 Oct 27 doi: 10.1016/j.cardfail.2012.10.010. PMID: 23207082

Prognosis

Intra-abdominal Complications After Pediatric Kidney Transplantation: Incidence and Risk Factors.
Taher A, Zhu B, Ma S, Shun A, Durkan AM
Transplantation 2019 Jun;103(6):1234-1239. doi: 10.1097/TP.0000000000002420. PMID: 30113998
Transplant Renal Vein Thrombosis.
El Zorkany K, Bridson JM, Sharma A, Halawa A
Exp Clin Transplant 2017 Apr;15(2):123-129. doi: 10.6002/ect.2016.0060. PMID: 28338457
Hypercoagulability and nephrotic syndrome.
Gigante A, Barbano B, Sardo L, Martina P, Gasperini ML, Labbadia R, Liberatori M, Amoroso A, Cianci R
Curr Vasc Pharmacol 2014 May;12(3):512-7. doi: 10.2174/157016111203140518172048. PMID: 22724465
Acute renal failure in the newborn.
Andreoli SP
Semin Perinatol 2004 Apr;28(2):112-23. doi: 10.1053/j.semperi.2003.11.003. PMID: 15200250
Laparoscopic-assisted renal autotransplantation.
Bluebond-Langner R, Rha KH, Pinto PA, Varkarakis J, Douyon E, Komotar RJ, Jarrett TW, Kavoussi LR, Molmenti EP
Urology 2004 May;63(5):853-6. doi: 10.1016/j.urology.2003.12.019. PMID: 15134964

Clinical prediction guides

Renal involvement in antiphospholipid syndrome.
de Azevedo FVA, Maia DG, de Carvalho JF, Rodrigues CEM
Rheumatol Int 2018 Oct;38(10):1777-1789. Epub 2018 May 5 doi: 10.1007/s00296-018-4040-2. PMID: 29730854
Transplant Renal Vein Thrombosis.
El Zorkany K, Bridson JM, Sharma A, Halawa A
Exp Clin Transplant 2017 Apr;15(2):123-129. doi: 10.6002/ect.2016.0060. PMID: 28338457
Hypercoagulability and nephrotic syndrome.
Gigante A, Barbano B, Sardo L, Martina P, Gasperini ML, Labbadia R, Liberatori M, Amoroso A, Cianci R
Curr Vasc Pharmacol 2014 May;12(3):512-7. doi: 10.2174/157016111203140518172048. PMID: 22724465
Laparoscopic-assisted renal autotransplantation.
Bluebond-Langner R, Rha KH, Pinto PA, Varkarakis J, Douyon E, Komotar RJ, Jarrett TW, Kavoussi LR, Molmenti EP
Urology 2004 May;63(5):853-6. doi: 10.1016/j.urology.2003.12.019. PMID: 15134964
Extrarenal complications of the nephrotic syndrome.
Harris RC, Ismail N
Am J Kidney Dis 1994 Apr;23(4):477-97. doi: 10.1016/s0272-6386(12)80369-6. PMID: 8154483

Recent systematic reviews

Low-molecular-weight heparins in pregnancy.
Ensom MH, Stephenson MD
Pharmacotherapy 1999 Sep;19(9):1013-25. doi: 10.1592/phco.19.13.1013.31588. PMID: 10610007

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