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Persistent cloaca

MedGen UID:
472998
Concept ID:
C0266225
Congenital Abnormality; Embryonic Structure
Synonyms: Anal and urogenital canal fusion; Anal fusion; Cloacogenic bladder; Persistent Cloaca
SNOMED CT: Persistent cloaca (74829002); Anal fusion (74829002); Anal and urogenital canal fusion (74829002)
 
HPO: HP:0012621

Definition

Developmental anomaly in which the vagina, bladder, and rectum fuse resulting in a common channel. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPersistent cloaca

Conditions with this feature

Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome
MedGen UID:
816673
Concept ID:
C3810343
Disease or Syndrome
Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome is a rare, genetic, neural tube defect malformation syndrome characterized by sacral agenesis and abnormal vertebral body ossification with normal vertebral arches associated with notochord canal persistence on ultrasonography. Additional findings include bilateral clubfoot, oligohydramnios, single umbilical artery and, in some, increased nuchal translucency.

Professional guidelines

PubMed

Yamamichi T, Sakai T, Yoshida M, Takayama K, Uga N, Umeda S, Maekawa S, Usui N
Pediatr Surg Int 2022 Nov;38(11):1577-1583. Epub 2022 Sep 2 doi: 10.1007/s00383-022-05204-0. PMID: 36053329
Peiro JL, Scorletti F, Sbragia L
Semin Pediatr Surg 2016 Apr;25(2):71-5. Epub 2015 Nov 10 doi: 10.1053/j.sempedsurg.2015.11.004. PMID: 26969229
Livingston JC, Elicevik M, Breech L, Crombleholme TM, Peña A, Levitt MA
J Ultrasound Med 2012 Mar;31(3):403-7. doi: 10.7863/jum.2012.31.3.403. PMID: 22368130

Recent clinical studies

Etiology

Yamamichi T, Sakai T, Yoshida M, Takayama K, Uga N, Umeda S, Maekawa S, Usui N
Pediatr Surg Int 2022 Nov;38(11):1577-1583. Epub 2022 Sep 2 doi: 10.1007/s00383-022-05204-0. PMID: 36053329
Pathak M, Saxena AK
J Pediatr Urol 2022 Apr;18(2):142-149. Epub 2022 Jan 19 doi: 10.1016/j.jpurol.2021.12.014. PMID: 35101384
Divya G, Kundal VK, Debnath PR, Addagatla R, Garbhapu AK, Sen A, Saha AK, Meena AK, Shah S, Syal S, Khanna C, Dotikalkar R, Gautam V
Pediatr Surg Int 2021 Apr;37(4):451-456. Epub 2021 Jan 15 doi: 10.1007/s00383-020-04843-5. PMID: 33449157
Caldwell BT, Wilcox DT
Semin Pediatr Surg 2016 Apr;25(2):108-11. Epub 2015 Nov 10 doi: 10.1053/j.sempedsurg.2015.11.010. PMID: 26969235
VanderBrink BA, Reddy PP
Semin Pediatr Surg 2016 Apr;25(2):82-9. Epub 2015 Nov 10 doi: 10.1053/j.sempedsurg.2015.11.005. PMID: 26969231

Diagnosis

Yamamichi T, Sakai T, Yoshida M, Takayama K, Uga N, Umeda S, Maekawa S, Usui N
Pediatr Surg Int 2022 Nov;38(11):1577-1583. Epub 2022 Sep 2 doi: 10.1007/s00383-022-05204-0. PMID: 36053329
Kawamura T, Kamo A, Nishiguchi T
Am J Case Rep 2020 May 8;21:e921576. doi: 10.12659/AJCR.921576. PMID: 32381998Free PMC Article
Peiro JL, Scorletti F, Sbragia L
Semin Pediatr Surg 2016 Apr;25(2):71-5. Epub 2015 Nov 10 doi: 10.1053/j.sempedsurg.2015.11.004. PMID: 26969229
Arlen AM, Smith EA
Clin Perinatol 2014 Sep;41(3):695-707. Epub 2014 Jul 18 doi: 10.1016/j.clp.2014.05.015. PMID: 25155736
Warne SA, Hiorns MP, Curry J, Mushtaq I
Arch Dis Child 2011 Nov;96(11):1072-6. Epub 2011 Jan 23 doi: 10.1136/adc.2009.175034. PMID: 21262748

Therapy

Okada S, Miyazono A, Inaba Y, Eura R, Itesako T, Kawano Y, Okamoto Y
CEN Case Rep 2022 Aug;11(3):363-365. Epub 2022 Jan 31 doi: 10.1007/s13730-022-00686-2. PMID: 35099756Free PMC Article
Wang C, Li L, Diao M, Liu S, Zhang J, Chen Z, Li X, Cheng W
J Laparoendosc Adv Surg Tech A 2016 Apr;26(4):328-33. Epub 2016 Jan 28 doi: 10.1089/lap.2015.0296. PMID: 27096816
Zalimas A, Posiunas G, Strupas S, Raugalas R, Raistenskis J, Verkauskas G
BMC Pediatr 2015 Oct 8;15:150. doi: 10.1186/s12887-015-0469-6. PMID: 26450698Free PMC Article
Gabarain G, Garcia-Naveiro R, Ponsky TA, Boulanger SC, Parry RL
J Pediatr Surg 2012 Jan;47(1):e19-22. doi: 10.1016/j.jpedsurg.2011.09.060. PMID: 22244431
Peña A, Grasshoff S, Levitt M
J Pediatr Surg 2007 Feb;42(2):318-25. doi: 10.1016/j.jpedsurg.2006.10.034. PMID: 17270542

Prognosis

Wang Z, Wu H, Wang Y, Lu L, He Q, Li Y, Zhang S, Xie X, Yan B, Yu J, Zhong W
Clin Radiol 2019 Jun;74(6):488.e9-488.e15. Epub 2019 Mar 21 doi: 10.1016/j.crad.2019.01.023. PMID: 30905379
Takii M, Suehiro T, Shima A, Yotsueda H, Hisano S, Katafuchi R
BMC Nephrol 2017 Sep 6;18(1):288. doi: 10.1186/s12882-017-0704-5. PMID: 28877681Free PMC Article
Kubota M
Pediatr Surg Int 2017 Apr;33(4):505-512. Epub 2017 Jan 5 doi: 10.1007/s00383-016-4053-4. PMID: 28058485Free PMC Article
Warne SA, Hiorns MP, Curry J, Mushtaq I
Arch Dis Child 2011 Nov;96(11):1072-6. Epub 2011 Jan 23 doi: 10.1136/adc.2009.175034. PMID: 21262748
Bargaje A, Yerger JF, Khouzami A, Jones C
Ann Diagn Pathol 2008 Feb;12(1):62-6. Epub 2007 Jul 24 doi: 10.1016/j.anndiagpath.2006.08.003. PMID: 18164419

Clinical prediction guides

Yamamichi T, Sakai T, Yoshida M, Takayama K, Uga N, Umeda S, Maekawa S, Usui N
Pediatr Surg Int 2022 Nov;38(11):1577-1583. Epub 2022 Sep 2 doi: 10.1007/s00383-022-05204-0. PMID: 36053329
Pathak M, Saxena AK
J Pediatr Urol 2022 Apr;18(2):142-149. Epub 2022 Jan 19 doi: 10.1016/j.jpurol.2021.12.014. PMID: 35101384
Divya G, Kundal VK, Debnath PR, Addagatla R, Garbhapu AK, Sen A, Saha AK, Meena AK, Shah S, Syal S, Khanna C, Dotikalkar R, Gautam V
Pediatr Surg Int 2021 Apr;37(4):451-456. Epub 2021 Jan 15 doi: 10.1007/s00383-020-04843-5. PMID: 33449157
Kawamura T, Kamo A, Nishiguchi T
Am J Case Rep 2020 May 8;21:e921576. doi: 10.12659/AJCR.921576. PMID: 32381998Free PMC Article
Wang C, Li L, Cheng W, Liu S, Diao M, Li X, Qiao G, Zhang Z, Chen Z
J Pediatr Surg 2015 Jul;50(7):1236-40. Epub 2015 May 10 doi: 10.1016/j.jpedsurg.2015.04.016. PMID: 25981991

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