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Pseudoepitheliomatous hyperplasia

MedGen UID:: 473049
•Concept ID:: C0333988
•: Pathologic Function

Synonyms:	Pseudocarcinomatous hyperplasia; Pseudoepitheliomatous Hyperplasia
SNOMED CT:	Pseudoepitheliomatous hyperplasia (112669001); Pseudocarcinomatous hyperplasia (112669001); Pseudoepitheliomatous hyperplasia (254665009)

Definition

A benign lesion characterized by epidermal and adnexal epithelial hyperplasia. It is caused by chronic inflammation and infection. It may be associated with cutaneous neoplasms as well. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPseudoepitheliomatous hyperplasia

Pathological process
- Disease
  - Non-Neoplastic Disorder
    - Non-Neoplastic Disorder by Special Category
      - Hyperplasia
        Epithelial hyperplasia of skin
        Pseudoepitheliomatous hyperplasia

Professional guidelines

PubMed

Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.

Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216

Tattoo-associated skin reaction: the importance of an early diagnosis and proper treatment.

Bassi A, Campolmi P, Cannarozzo G, Conti R, Bruscino N, Gola M, Ermini S, Massi D, Moretti S
Biomed Res Int 2014;2014:354608. Epub 2014 Jul 23 doi: 10.1155/2014/354608. PMID: 25147796 Free PMC Article

Rhabdomyoma of the head and neck: morphology and differential diagnosis.

Hansen T, Katenkamp D
Virchows Arch 2005 Nov;447(5):849-54. Epub 2005 Aug 18 doi: 10.1007/s00428-005-0038-8. PMID: 16133368

See all (5)

Recent clinical studies

Etiology

Expression of Ki-67 and Βeta-Catenin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma in Oral Mucosal Biopsies : An Immunohistochemical Study.

Ahmad B, Asif M, Ali A, Jamal S, Khan MZ, Khadim MT
Asian Pac J Cancer Prev 2020 Jan 1;21(1):157-161. doi: 10.31557/APJCP.2020.21.1.157. PMID: 31983178 Free PMC Article

Mucocele of the hard palate in children.

Abdel-Aziz M, Khalifa B, Nassar A, Kamel A, Naguib N, El-Tahan AR
Int J Pediatr Otorhinolaryngol 2016 Jun;85:46-9. Epub 2016 Mar 18 doi: 10.1016/j.ijporl.2016.03.007. PMID: 27240495

Squamous epithelial changes of the larynx: diagnosis and therapy.

Ferlito A, Devaney KO, Woolgar JA, Slootweg PJ, Paleri V, Takes RP, Strojan P, Bradley PJ, Rinaldo A
Head Neck 2012 Dec;34(12):1810-6. Epub 2011 Oct 3 doi: 10.1002/hed.21862. PMID: 21971762

Pseudoepitheliomatous hyperplasia in cutaneous T-cell lymphoma. A clinical, histopathological and immunohistochemical study with particular interest in epithelial growth factor expression. The French Study Group on Cutaneous Lymphoma.

Courville P, Wechsler J, Thomine E, Vergier B, Fonck Y, Souteyrand P, Beylot-Barry M, Bagot M, Joly P
Br J Dermatol 1999 Mar;140(3):421-6. doi: 10.1046/j.1365-2133.1999.02703.x. PMID: 10233260

Forestomach carcinogens: pathology and relevance to man.

Wester PW, Kroes R
Toxicol Pathol 1988;16(2):165-71. doi: 10.1177/019262338801600209. PMID: 3055226

See all (62)

Diagnosis

Chondrodermatitis nodularis nasi.

Kasitinon SY, Vandergriff T
J Cutan Pathol 2020 Nov;47(11):1046-1049. Epub 2020 Sep 13 doi: 10.1111/cup.13786. PMID: 32578245

Tongue Lumps and Bumps: Histopathological Dilemmas and Clues for Diagnosis.

Allon I, Vered M, Kaplan I
Head Neck Pathol 2019 Mar;13(1):114-124. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01005-5. PMID: 30693454 Free PMC Article

Mucocutaneous pseudoepitheliomatous hyperplasia: a review.

El-Khoury J, Kibbi AG, Abbas O
Am J Dermatopathol 2012 Apr;34(2):165-75. doi: 10.1097/DAD.0b013e31821816ab. PMID: 21993336

Pseudoepitheliomatous hyperplasia: a review.

Zayour M, Lazova R
Am J Dermatopathol 2011 Apr;33(2):112-22; quiz 123-6. doi: 10.1097/DAD.0b013e3181fcfb47. PMID: 21399447

Laryngeal tuberculosis.

Yencha MW, Linfesty R, Blackmon A
Am J Otolaryngol 2000 Mar-Apr;21(2):122-6. doi: 10.1016/s0196-0709(00)85010-3. PMID: 10758999

See all (207)

Therapy

Chondrodermatitis nodularis nasi.

Kasitinon SY, Vandergriff T
J Cutan Pathol 2020 Nov;47(11):1046-1049. Epub 2020 Sep 13 doi: 10.1111/cup.13786. PMID: 32578245

Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw.

Zustin J, Reske D, Zrnc TA, Heiland M, Scheuer HA, Assaf AT, Friedrich RE
In Vivo 2014 Jan-Feb;28(1):125-31. PMID: 24425847

Pseudoepitheliomatous hyperplasia treated by photodynamic therapy with variable irradiation dose and concentration of photosensitizer.

Li Q, Jiao B, Long HA
Photomed Laser Surg 2011 Feb;29(2):127-30. Epub 2010 Oct 22 doi: 10.1089/pho.2009.2704. PMID: 20969441 Free PMC Article

Blastomycosis-like pyoderma.

Sawalka SS, Phiske MM, Jerajani HR
Indian J Dermatol Venereol Leprol 2007 Mar-Apr;73(2):117-9. doi: 10.4103/0378-6323.31900. PMID: 17456921

Laryngeal tuberculosis.

Yencha MW, Linfesty R, Blackmon A
Am J Otolaryngol 2000 Mar-Apr;21(2):122-6. doi: 10.1016/s0196-0709(00)85010-3. PMID: 10758999

See all (66)

Prognosis

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.

Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159

Expression of Ki-67 and Βeta-Catenin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma in Oral Mucosal Biopsies : An Immunohistochemical Study.

Ahmad B, Asif M, Ali A, Jamal S, Khan MZ, Khadim MT
Asian Pac J Cancer Prev 2020 Jan 1;21(1):157-161. doi: 10.31557/APJCP.2020.21.1.157. PMID: 31983178 Free PMC Article

Differentiating cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia by multiplex qRT-PCR.

Su A, Ra S, Li X, Zhou J, Binder S
Mod Pathol 2013 Nov;26(11):1433-7. Epub 2013 May 24 doi: 10.1038/modpathol.2013.82. PMID: 23702732

Squamous epithelial changes of the larynx: diagnosis and therapy.

Ferlito A, Devaney KO, Woolgar JA, Slootweg PJ, Paleri V, Takes RP, Strojan P, Bradley PJ, Rinaldo A
Head Neck 2012 Dec;34(12):1810-6. Epub 2011 Oct 3 doi: 10.1002/hed.21862. PMID: 21971762

Mandibular pseudocarcinomatous hyperplasia.

Warter A, Walter P, Meyer C, Barrière P, Galatir L, Wilk A
Histopathology 2000 Aug;37(2):115-7. doi: 10.1046/j.1365-2559.2000.00949.x. PMID: 10931233

See all (45)

Clinical prediction guides

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.

Localized juvenile spongiotic gingival hyperplasia: Microscopic variations and proposed change to nomenclature.

Theofilou VI, Pettas E, Georgaki M, Daskalopoulos A, Nikitakis NG
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Mar;131(3):329-338. Epub 2020 Nov 5 doi: 10.1016/j.oooo.2020.10.024. PMID: 33309266

Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw.

Zustin J, Reske D, Zrnc TA, Heiland M, Scheuer HA, Assaf AT, Friedrich RE
In Vivo 2014 Jan-Feb;28(1):125-31. PMID: 24425847

Differentiating cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia by multiplex qRT-PCR.

Su A, Ra S, Li X, Zhou J, Binder S
Mod Pathol 2013 Nov;26(11):1433-7. Epub 2013 May 24 doi: 10.1038/modpathol.2013.82. PMID: 23702732

Histopathology of chromoblastomycosis.

Uribe F, Zuluaga AI, Leon W, Restrepo A
Mycopathologia 1989 Jan;105(1):1-6. doi: 10.1007/BF00443822. PMID: 2739689

See all (53)

Recent systematic reviews

Oral granular cell tumour: A multicentric study of 56 cases and a systematic review.

Lafuente Ibáñez de Mendoza I, López Ortega K, Trierveiler M, Oliveira Alves MG, Dias Almeida J, Gándara Vila P, Aguirre Urízar JM, Pérez Sayans M
Oral Dis 2020 Apr;26(3):573-589. Epub 2020 Jan 28 doi: 10.1111/odi.13273. PMID: 31898368

See all (1)

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