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Pseudoepitheliomatous hyperplasia

MedGen UID:
473049
•Concept ID:
C0333988
•
Pathologic Function
Synonyms: Pseudocarcinomatous hyperplasia; Pseudoepitheliomatous Hyperplasia
SNOMED CT: Pseudoepitheliomatous hyperplasia (112669001); Pseudocarcinomatous hyperplasia (112669001); Pseudoepitheliomatous hyperplasia (254665009)

Definition

A benign lesion characterized by epidermal and adnexal epithelial hyperplasia. It is caused by chronic inflammation and infection. It may be associated with cutaneous neoplasms as well. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudoepitheliomatous hyperplasia

Professional guidelines

PubMed

Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
Tattoo-associated skin reaction: the importance of an early diagnosis and proper treatment.
Bassi A, Campolmi P, Cannarozzo G, Conti R, Bruscino N, Gola M, Ermini S, Massi D, Moretti S
Biomed Res Int 2014;2014:354608. Epub 2014 Jul 23 doi: 10.1155/2014/354608. PMID: 25147796Free PMC Article
Rhabdomyoma of the head and neck: morphology and differential diagnosis.
Hansen T, Katenkamp D
Virchows Arch 2005 Nov;447(5):849-54. Epub 2005 Aug 18 doi: 10.1007/s00428-005-0038-8. PMID: 16133368

Recent clinical studies

Etiology

Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
Expression of Ki-67 and Βeta-Catenin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma in Oral Mucosal Biopsies : An Immunohistochemical Study.
Ahmad B, Asif M, Ali A, Jamal S, Khan MZ, Khadim MT
Asian Pac J Cancer Prev 2020 Jan 1;21(1):157-161. doi: 10.31557/APJCP.2020.21.1.157. PMID: 31983178Free PMC Article
Mucocele of the hard palate in children.
Abdel-Aziz M, Khalifa B, Nassar A, Kamel A, Naguib N, El-Tahan AR
Int J Pediatr Otorhinolaryngol 2016 Jun;85:46-9. Epub 2016 Mar 18 doi: 10.1016/j.ijporl.2016.03.007. PMID: 27240495
Squamous epithelial changes of the larynx: diagnosis and therapy.
Ferlito A, Devaney KO, Woolgar JA, Slootweg PJ, Paleri V, Takes RP, Strojan P, Bradley PJ, Rinaldo A
Head Neck 2012 Dec;34(12):1810-6. Epub 2011 Oct 3 doi: 10.1002/hed.21862. PMID: 21971762
Superficial skin ulcers.
Samaila MO, Rafindadi AH, Adewuyi SA, Oluwole OP
Saudi Med J 2007 Jan;28(1):46-8. PMID: 17206288

Diagnosis

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Chondrodermatitis nodularis nasi.
Kasitinon SY, Vandergriff T
J Cutan Pathol 2020 Nov;47(11):1046-1049. Epub 2020 Sep 13 doi: 10.1111/cup.13786. PMID: 32578245
Tongue Lumps and Bumps: Histopathological Dilemmas and Clues for Diagnosis.
Allon I, Vered M, Kaplan I
Head Neck Pathol 2019 Mar;13(1):114-124. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01005-5. PMID: 30693454Free PMC Article
Mucocutaneous pseudoepitheliomatous hyperplasia: a review.
El-Khoury J, Kibbi AG, Abbas O
Am J Dermatopathol 2012 Apr;34(2):165-75. doi: 10.1097/DAD.0b013e31821816ab. PMID: 21993336
Pseudoepitheliomatous hyperplasia: a review.
Zayour M, Lazova R
Am J Dermatopathol 2011 Apr;33(2):112-22; quiz 123-6. doi: 10.1097/DAD.0b013e3181fcfb47. PMID: 21399447

Therapy

Chondrodermatitis nodularis nasi.
Kasitinon SY, Vandergriff T
J Cutan Pathol 2020 Nov;47(11):1046-1049. Epub 2020 Sep 13 doi: 10.1111/cup.13786. PMID: 32578245
Pseudoepitheliomatous hyperplasia arising from purple tattoo pigment.
Kheradmand S, Perry BM, Bohlke A
Cutis 2020 Apr;105(4):E22-E24. PMID: 32463858
Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature.
Wipf A, Wipf H, Miller D
J Cutan Pathol 2019 Jul;46(7):520-527. Epub 2019 Apr 17 doi: 10.1111/cup.13436. PMID: 30734344
Blastomycosis-like pyoderma.
Sawalka SS, Phiske MM, Jerajani HR
Indian J Dermatol Venereol Leprol 2007 Mar-Apr;73(2):117-9. doi: 10.4103/0378-6323.31900. PMID: 17456921
Laryngeal tuberculosis.
Yencha MW, Linfesty R, Blackmon A
Am J Otolaryngol 2000 Mar-Apr;21(2):122-6. doi: 10.1016/s0196-0709(00)85010-3. PMID: 10758999

Prognosis

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Expression of Ki-67 and Βeta-Catenin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma in Oral Mucosal Biopsies : An Immunohistochemical Study.
Ahmad B, Asif M, Ali A, Jamal S, Khan MZ, Khadim MT
Asian Pac J Cancer Prev 2020 Jan 1;21(1):157-161. doi: 10.31557/APJCP.2020.21.1.157. PMID: 31983178Free PMC Article
Differentiating cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia by multiplex qRT-PCR.
Su A, Ra S, Li X, Zhou J, Binder S
Mod Pathol 2013 Nov;26(11):1433-7. Epub 2013 May 24 doi: 10.1038/modpathol.2013.82. PMID: 23702732
Squamous epithelial changes of the larynx: diagnosis and therapy.
Ferlito A, Devaney KO, Woolgar JA, Slootweg PJ, Paleri V, Takes RP, Strojan P, Bradley PJ, Rinaldo A
Head Neck 2012 Dec;34(12):1810-6. Epub 2011 Oct 3 doi: 10.1002/hed.21862. PMID: 21971762
Verrucous carcinoma of the skin and mucosa.
Schwartz RA
J Am Acad Dermatol 1995 Jan;32(1):1-21; quiz 22-4. doi: 10.1016/0190-9622(95)90177-9. PMID: 7822496

Clinical prediction guides

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Localized juvenile spongiotic gingival hyperplasia: Microscopic variations and proposed change to nomenclature.
Theofilou VI, Pettas E, Georgaki M, Daskalopoulos A, Nikitakis NG
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Mar;131(3):329-338. Epub 2020 Nov 5 doi: 10.1016/j.oooo.2020.10.024. PMID: 33309266
Differentiating cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia by multiplex qRT-PCR.
Su A, Ra S, Li X, Zhou J, Binder S
Mod Pathol 2013 Nov;26(11):1433-7. Epub 2013 May 24 doi: 10.1038/modpathol.2013.82. PMID: 23702732
p53 expression in pseudoepitheliomatous hyperplasia, keratoacanthoma, and squamous cell carcinoma of skin.
Lee YS, Teh M
Cancer 1994 May 1;73(9):2317-23. doi: 10.1002/1097-0142(19940501)73:9<2317::aid-cncr2820730913>3.0.co;2-0. PMID: 8168036
Histopathology of chromoblastomycosis.
Uribe F, Zuluaga AI, Leon W, Restrepo A
Mycopathologia 1989 Jan;105(1):1-6. doi: 10.1007/BF00443822. PMID: 2739689

Recent systematic reviews

Granular Cell Tumors of the Larynx: A Systematic Review.
Luke AS, Mairson TM, Husain IA, Kaplan SE
Laryngoscope 2024 Apr;134(4):1523-1530. Epub 2023 Oct 2 doi: 10.1002/lary.31071. PMID: 37782552
Oral granular cell tumour: A multicentric study of 56 cases and a systematic review.
Lafuente Ibáñez de Mendoza I, López Ortega K, Trierveiler M, Oliveira Alves MG, Dias Almeida J, Gándara Vila P, Aguirre Urízar JM, Pérez Sayans M
Oral Dis 2020 Apr;26(3):573-589. Epub 2020 Jan 28 doi: 10.1111/odi.13273. PMID: 31898368

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