U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tympanosclerosis

MedGen UID:
473094
Concept ID:
C0395887
Disease or Syndrome
Synonyms: Calcification, Tympanic; Tympanic Calcification; Tympanoscleroses
SNOMED CT: TS - Tympanosclerosis (23606001); Tympanosclerosis (23606001)
 
HPO: HP:0020123
Monarch Initiative: MONDO:0001443

Definition

A stiffening of the tympanic membrane due to calcification, typically presents as white plaque-like lesions, involving discrete regions of the tympanic membrane and/or middle ear. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTympanosclerosis

Conditions with this feature

Polyglandular autoimmune syndrome, type 1
MedGen UID:
39125
Concept ID:
C0085859
Disease or Syndrome
Autoimmune polyglandular syndrome type I (APS1) is characterized by the presence of 2 of 3 major clinical symptoms: Addison disease, and/or hypoparathyroidism, and/or chronic mucocutaneous candidiasis (Neufeld et al., 1981). However, variable APS1 phenotypes have been observed, even among sibs. In addition, some patients may exhibit apparent isolated hypoparathyroidism, an early manifestation of APS1 with peak incidence at around age 5 years; over long-term follow-up, the development of additional features of APS1 may be observed (Cranston et al., 2022).

Professional guidelines

PubMed

Kazikdas KC, Onal K, Boyraz I, Karabulut E
Eur Arch Otorhinolaryngol 2007 Sep;264(9):985-9. Epub 2007 Mar 31 doi: 10.1007/s00405-007-0291-3. PMID: 17401572
Uneri C, Bağlam T, Yazici M
Int J Pediatr Otorhinolaryngol 2006 Jun;70(6):1045-8. Epub 2005 Dec 20 doi: 10.1016/j.ijporl.2005.10.019. PMID: 16368152
Barfoed C, Rosborg J
Arch Otolaryngol 1980 Sep;106(9):553-6. doi: 10.1001/archotol.1980.00790330033010. PMID: 7190819

Recent clinical studies

Etiology

Gutierrez JA 3rd, Cabrera CI, Stout A, Mowry SE
Ann Otol Rhinol Laryngol 2023 Nov;132(11):1453-1466. Epub 2023 Mar 23 doi: 10.1177/00034894231159000. PMID: 36951041
Tihanyi A, Speck I, Wolff K, Arnold P, Aschendorff A, Arndt S
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4353-4362. Epub 2022 Jan 24 doi: 10.1007/s00405-021-07190-w. PMID: 35072768Free PMC Article
Gonçalves AI, Rato C, Duarte D, de Vilhena D
Int J Pediatr Otorhinolaryngol 2021 Nov;150:110899. Epub 2021 Aug 23 doi: 10.1016/j.ijporl.2021.110899. PMID: 34450544
Bedri EH, Teferi N, Redleaf M
Otol Neurotol 2018 Feb;39(2):184-188. doi: 10.1097/MAO.0000000000001639. PMID: 29210944
Colletti V
Audiology 1977 Jul-Aug;16(4):278-87. doi: 10.3109/00206097709071839. PMID: 883908

Diagnosis

Page JC, Gau VL, Allsopp T, King D, Jervis-Bardy J, Dornhoffer JL
Otol Neurotol 2019 Sep;40(8):1054-1058. doi: 10.1097/MAO.0000000000002331. PMID: 31356485
Kakehata S
Otolaryngol Clin North Am 2013 Apr;46(2):227-32. doi: 10.1016/j.otc.2012.10.006. PMID: 23566908
Kösling S, Omenzetter M, Bartel-Friedrich S
Eur J Radiol 2009 Feb;69(2):269-79. Epub 2007 Dec 3 doi: 10.1016/j.ejrad.2007.10.019. PMID: 18054456
Wielinga EW, Kerr AG
Clin Otolaryngol Allied Sci 1993 Oct;18(5):341-9. doi: 10.1111/j.1365-2273.1993.tb00590.x. PMID: 8877197
Colletti V
Audiology 1977 Jul-Aug;16(4):278-87. doi: 10.3109/00206097709071839. PMID: 883908

Therapy

MacKeith S, Mulvaney CA, Galbraith K, Webster KE, Connolly R, Paing A, Marom T, Daniel M, Venekamp RP, Rovers MM, Schilder AG
Cochrane Database Syst Rev 2023 Nov 15;11(11):CD015215. doi: 10.1002/14651858.CD015215.pub2. PMID: 37965944Free PMC Article
Bedri EH, Teferi N, Redleaf M
Otol Neurotol 2018 Feb;39(2):184-188. doi: 10.1097/MAO.0000000000001639. PMID: 29210944
van Sonsbeek S, Pullens B, van Benthem PP
Cochrane Database Syst Rev 2015 Mar 10;2015(3):CD008419. doi: 10.1002/14651858.CD008419.pub2. PMID: 25756795Free PMC Article
Wallace IF, Berkman ND, Lohr KN, Harrison MF, Kimple AJ, Steiner MJ
Pediatrics 2014 Feb;133(2):296-311. Epub 2014 Jan 6 doi: 10.1542/peds.2013-3228. PMID: 24394689
Williamson I
BMJ Clin Evid 2011 Jan 12;2011 PMID: 21477396Free PMC Article

Prognosis

Gutierrez JA 3rd, Cabrera CI, Stout A, Mowry SE
Ann Otol Rhinol Laryngol 2023 Nov;132(11):1453-1466. Epub 2023 Mar 23 doi: 10.1177/00034894231159000. PMID: 36951041
Tihanyi A, Speck I, Wolff K, Arnold P, Aschendorff A, Arndt S
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4353-4362. Epub 2022 Jan 24 doi: 10.1007/s00405-021-07190-w. PMID: 35072768Free PMC Article
Gonçalves AI, Rato C, Duarte D, de Vilhena D
Int J Pediatr Otorhinolaryngol 2021 Nov;150:110899. Epub 2021 Aug 23 doi: 10.1016/j.ijporl.2021.110899. PMID: 34450544
Williamson I
BMJ Clin Evid 2007 Aug 1;2007 PMID: 19454116Free PMC Article
Asiri S, Hasham A, al Anazy F, Zakzouk S, Banjar A
J Laryngol Otol 1999 Dec;113(12):1076-80. doi: 10.1017/s0022215100157937. PMID: 10767919

Clinical prediction guides

Gutierrez JA 3rd, Cabrera CI, Stout A, Mowry SE
Ann Otol Rhinol Laryngol 2023 Nov;132(11):1453-1466. Epub 2023 Mar 23 doi: 10.1177/00034894231159000. PMID: 36951041
Tihanyi A, Speck I, Wolff K, Arnold P, Aschendorff A, Arndt S
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4353-4362. Epub 2022 Jan 24 doi: 10.1007/s00405-021-07190-w. PMID: 35072768Free PMC Article
Dong Z, Zhou M, Ye G, Ye J, Xiao M
Ear Nose Throat J 2022 May;101(4):NP169-NP177. Epub 2020 Sep 7 doi: 10.1177/0145561320951676. PMID: 32894702
Wright CG, Meyerhoff WL
Ann Otol Rhinol Laryngol Suppl 1994 May;163:24-6. doi: 10.1177/00034894941030s507. PMID: 8179265
Colletti V
Audiology 1977 Jul-Aug;16(4):278-87. doi: 10.3109/00206097709071839. PMID: 883908

Recent systematic reviews

MacKeith S, Mulvaney CA, Galbraith K, Webster KE, Connolly R, Paing A, Marom T, Daniel M, Venekamp RP, Rovers MM, Schilder AG
Cochrane Database Syst Rev 2023 Nov 15;11(11):CD015215. doi: 10.1002/14651858.CD015215.pub2. PMID: 37965944Free PMC Article
Gutierrez JA 3rd, Cabrera CI, Stout A, Mowry SE
Ann Otol Rhinol Laryngol 2023 Nov;132(11):1453-1466. Epub 2023 Mar 23 doi: 10.1177/00034894231159000. PMID: 36951041
Wallace IF, Berkman ND, Lohr KN, Harrison MF, Kimple AJ, Steiner MJ
Pediatrics 2014 Feb;133(2):296-311. Epub 2014 Jan 6 doi: 10.1542/peds.2013-3228. PMID: 24394689
Williamson I
BMJ Clin Evid 2011 Jan 12;2011 PMID: 21477396Free PMC Article
Williamson I
BMJ Clin Evid 2007 Aug 1;2007 PMID: 19454116Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...