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Drug-induced gingival hyperplasia

MedGen UID:
473100
•Concept ID:
C0399439
•
Disease or Syndrome
Synonyms: Drug Induced Gingival Hyperplasia; Hyperplasia of gingiva caused by drug
SNOMED CT: Drug-induced gingival hyperplasia (93434009); Hyperplasia of gingiva caused by drug (93434009)

Definition

Overgrowth of the gingival tissue caused by phenytoin, cyclosporine A, and calcium channel blockers. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDrug-induced gingival hyperplasia

Professional guidelines

PubMed

Using Evidence-Based Dentistry in the Clinical Management of Combined Periodontal Conditions.
Shaikh S, Dragan IF, Nevius A, Mehta N, Karimbux N
J Evid Based Dent Pract 2018 Dec;18(4):290-297. Epub 2018 Feb 13 doi: 10.1016/j.jebdp.2018.02.001. PMID: 30514443

Recent clinical studies

Etiology

Drug-induced gingival hyperplasia - experimental model.
Goriuc A, Foia LG, Minea B, Luchian AI, Surdu AE, Toma V, Costuleanu M, Mârţu I
Rom J Morphol Embryol 2017;58(4):1371-1376. PMID: 29556630
Dental implants in persons with severe epilepsy and multiple disabilities: a long-term retrospective study.
Cune MS, Strooker H, van der Reijden WA, de Putter C, Laine ML, Verhoeven JW
Int J Oral Maxillofac Implants 2009 May-Jun;24(3):534-40. PMID: 19587878
Do MMP-1 levels of gingival fibroblasts have a role in the gingival overgrowth of cyclosporine-treated patients?
Sonmez S, Cavdar C, Gunduz C, Nizam N, Biray C, Atila K, Camsari T
Transplant Proc 2008 Jan-Feb;40(1):181-3. doi: 10.1016/j.transproceed.2007.11.064. PMID: 18261580
Calcium antagonists and deep gingival pockets in the population-based SHIP study.
Meisel P, Schwahn C, John U, Kroemer HK, Kocher T
Br J Clin Pharmacol 2005 Nov;60(5):552-9. doi: 10.1111/j.1365-2125.2005.02485.x. PMID: 16236046Free PMC Article
Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia.
Iacopino AM, Doxey D, Cutler CW, Nares S, Stoever K, Fojt J, Gonzales A, Dill RE
J Periodontol 1997 Jan;68(1):73-83. doi: 10.1902/jop.1997.68.1.73. PMID: 9029455

Diagnosis

Amlodipine Induced Gum Hypertrophy: A Rare Case Report.
Reddy SC, Midha N, Chhabra V, Kumar D, Bohra GK
Curr Drug Saf 2022;17(3):281-283. doi: 10.2174/1574886316666211122125215. PMID: 34809550
Using Evidence-Based Dentistry in the Clinical Management of Combined Periodontal Conditions.
Shaikh S, Dragan IF, Nevius A, Mehta N, Karimbux N
J Evid Based Dent Pract 2018 Dec;18(4):290-297. Epub 2018 Feb 13 doi: 10.1016/j.jebdp.2018.02.001. PMID: 30514443
Drug-induced gingival hyperplasia and its management--a literature review.
Botha PJ
J Dent Assoc S Afr 1997 Nov;52(11):659-64. PMID: 9589004

Therapy

Drug-Induced Gingival Overgrowth: A Pilot Study on the Effect of Diphenylhydantoin and Gabapentin on Human Gingival Fibroblasts.
Lauritano D, Moreo G, Limongelli L, Tregambi E, Palmieri A, Carinci F
Int J Environ Res Public Health 2020 Nov 7;17(21) doi: 10.3390/ijerph17218229. PMID: 33171749Free PMC Article
Drug-induced gingival hyperplasia.
Prescrire Int 2011 Dec;20(122):293-4. PMID: 22216543
Amlodipine-induced gingival hyperplasia.
Lafzi A, Farahani RM, Shoja MA
Med Oral Patol Oral Cir Bucal 2006 Nov 1;11(6):E480-2. PMID: 17072250
Drug-induced gingival hyperplasia in transplant recipients.
Hood KA
Prog Transplant 2002 Mar;12(1):17-21; quiz 22-3. doi: 10.1177/152692480201200104. PMID: 11993065
Drug-induced gingival hyperplasia and its management--a literature review.
Botha PJ
J Dent Assoc S Afr 1997 Nov;52(11):659-64. PMID: 9589004

Prognosis

Do MMP-1 levels of gingival fibroblasts have a role in the gingival overgrowth of cyclosporine-treated patients?
Sonmez S, Cavdar C, Gunduz C, Nizam N, Biray C, Atila K, Camsari T
Transplant Proc 2008 Jan-Feb;40(1):181-3. doi: 10.1016/j.transproceed.2007.11.064. PMID: 18261580
Upper airway obstruction due to massive gingival hyperplasia. A case report and description of a new surgical treatment.
Bolger WE, West CB Jr, Parsons DS, Gates GA
Int J Pediatr Otorhinolaryngol 1990 Mar;19(1):63-72. doi: 10.1016/0165-5876(90)90196-x. PMID: 2341235

Clinical prediction guides

Calcium antagonists and deep gingival pockets in the population-based SHIP study.
Meisel P, Schwahn C, John U, Kroemer HK, Kocher T
Br J Clin Pharmacol 2005 Nov;60(5):552-9. doi: 10.1111/j.1365-2125.2005.02485.x. PMID: 16236046Free PMC Article
Expression of p53 protein and Ki-67 antigen in gingival hyperplasia induced by nifedipine and phenytoin.
Saito K, Mori S, Tanda N, Sakamoto S
J Periodontol 1999 Jun;70(6):581-6. doi: 10.1902/jop.1999.70.6.581. PMID: 10397512
Immunohistochemical localization of transforming growth factor beta, basic fibroblast growth factor and heparan sulphate glycosaminoglycan in gingival hyperplasia induced by nifedipine and phenytoin.
Saito K, Mori S, Iwakura M, Sakamoto S
J Periodontal Res 1996 Nov;31(8):545-55. doi: 10.1111/j.1600-0765.1996.tb00519.x. PMID: 8971653
Distribution of fibronectin in healthy, inflamed and drug-induced gingival hyperplasia.
Romanos GE, Schröter-Kermani C, Hinz N, Bernimoulin JP
J Oral Pathol Med 1992 Jul;21(6):256-60. doi: 10.1111/j.1600-0714.1992.tb01006.x. PMID: 1501157
Drug-induced gingival hyperplasia: phenytoin, cyclosporine, and nifedipine.
Butler RT, Kalkwarf KL, Kaldahl WB
J Am Dent Assoc 1987 Jan;114(1):56-60. doi: 10.14219/jada.archive.1987.0050. PMID: 3468168

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