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Double coronary vessel disease

MedGen UID:
473216
•Concept ID:
C0581375
•
Disease or Syndrome
Synonyms: Double vessel coronary artery disease; Two coronary vessel disease; Two Vessel Coronary Disease
SNOMED CT: Double vessel coronary artery disease (194843003); Double coronary vessel disease (194843003); Two coronary vessel disease (194843003)

Definition

There was greater than or equal to 50% stenosis (reduction in cross-sectional area) in two coronary arteries (or greater than or equal to 50% stenosis in the left main coronary artery). (ACC) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDouble coronary vessel disease

Professional guidelines

PubMed

Spontaneous coronary artery dissection in Spain: clinical and angiographic characteristics, management, and in-hospital events.
García-Guimaraes M, Bastante T, Macaya F, Roura G, Sanz R, Barahona Alvarado JC, Tizón H, Flores-Ríos X, Moreu J, Ojeda S, Nogales JM, Veiga G, Masotti M, Camacho-Freire SJ, Jiménez-Valero S, Jiménez-Kockar M, Lozano Í, González-Ferreiro R, Velázquez M, Avanzas P, Rivero F, Alfonso F
Rev Esp Cardiol (Engl Ed) 2021 Jan;74(1):15-23. Epub 2020 May 14 doi: 10.1016/j.rec.2020.04.002. PMID: 32418854
The Role of Angiogenesis in Coronary Artery Disease: A Double-Edged Sword: Intraplaque Angiogenesis in Physiopathology and Therapeutic Angiogenesis for Treatment.
Wu W, Li X, Zuo G, Pu J, Wu X, Chen S
Curr Pharm Des 2018;24(4):451-464. doi: 10.2174/1381612824666171227220815. PMID: 29283055
Large vessel coronary vasospasm: diagnosis, natural history and treatment.
Conti CR
Am J Cardiol 1985 Jan 25;55(3):41B-49B. doi: 10.1016/0002-9149(85)90612-5. PMID: 2857517

Recent clinical studies

Etiology

Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial.
Kedhi E, Berta B, Roleder T, Hermanides RS, Fabris E, IJsselmuiden AJJ, Kauer F, Alfonso F, von Birgelen C, Escaned J, Camaro C, Kennedy MW, Pereira B, Magro M, Nef H, Reith S, Al Nooryani A, Rivero F, Malinowski K, De Luca G, Garcia Garcia H, Granada JF, Wojakowski W
Eur Heart J 2021 Dec 1;42(45):4671-4679. doi: 10.1093/eurheartj/ehab433. PMID: 34345911
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction.
Broch K, Anstensrud AK, Woxholt S, Sharma K, Tøllefsen IM, Bendz B, Aakhus S, Ueland T, Amundsen BH, Damås JK, Berg ES, Bjørkelund E, Bendz C, Hopp E, Kleveland O, Stensæth KH, Opdahl A, Kløw NE, Seljeflot I, Andersen GØ, Wiseth R, Aukrust P, Gullestad L
J Am Coll Cardiol 2021 Apr 20;77(15):1845-1855. doi: 10.1016/j.jacc.2021.02.049. PMID: 33858620
Antiplatelet therapy in patients with myocardial infarction without obstructive coronary artery disease.
Bossard M, Gao P, Boden W, Steg G, Tanguay JF, Joyner C, Granger CB, Kastrati A, Faxon D, Budaj A, Pais P, Di Pasquale G, Valentin V, Flather M, Moccetti T, Yusuf S, Mehta SR
Heart 2021 Nov;107(21):1739-1747. Epub 2021 Jan 27 doi: 10.1136/heartjnl-2020-318045. PMID: 33504513
COVID-19: A double threat to takotsubo cardiomyopathy and spontaneous coronary artery dissection?
Shojaei F, Habibi Z, Goudarzi S, Firouzabadi FD, Montazerin SM, Najafi H, Kahe F, Momenzadeh K, Mir M, Khan F, Jamil U, Jamil A, Lee JJ, Chi G
Med Hypotheses 2021 Jan;146:110410. Epub 2020 Nov 22 doi: 10.1016/j.mehy.2020.110410. PMID: 33267999Free PMC Article
Contemporary management and outcomes in congenitally corrected transposition of the great arteries.
Kutty S, Danford DA, Diller GP, Tutarel O
Heart 2018 Jul;104(14):1148-1155. Epub 2018 Jan 11 doi: 10.1136/heartjnl-2016-311032. PMID: 29326110

Diagnosis

Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial.
Kedhi E, Berta B, Roleder T, Hermanides RS, Fabris E, IJsselmuiden AJJ, Kauer F, Alfonso F, von Birgelen C, Escaned J, Camaro C, Kennedy MW, Pereira B, Magro M, Nef H, Reith S, Al Nooryani A, Rivero F, Malinowski K, De Luca G, Garcia Garcia H, Granada JF, Wojakowski W
Eur Heart J 2021 Dec 1;42(45):4671-4679. doi: 10.1093/eurheartj/ehab433. PMID: 34345911
Antiplatelet therapy in patients with myocardial infarction without obstructive coronary artery disease.
Bossard M, Gao P, Boden W, Steg G, Tanguay JF, Joyner C, Granger CB, Kastrati A, Faxon D, Budaj A, Pais P, Di Pasquale G, Valentin V, Flather M, Moccetti T, Yusuf S, Mehta SR
Heart 2021 Nov;107(21):1739-1747. Epub 2021 Jan 27 doi: 10.1136/heartjnl-2020-318045. PMID: 33504513
Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).
Williams MC, Kwiecinski J, Doris M, McElhinney P, D'Souza MS, Cadet S, Adamson PD, Moss AJ, Alam S, Hunter A, Shah ASV, Mills NL, Pawade T, Wang C, Weir McCall J, Bonnici-Mallia M, Murrills C, Roditi G, van Beek EJR, Shaw LJ, Nicol ED, Berman DS, Slomka PJ, Newby DE, Dweck MR, Dey D
Circulation 2020 May 5;141(18):1452-1462. Epub 2020 Mar 16 doi: 10.1161/CIRCULATIONAHA.119.044720. PMID: 32174130Free PMC Article
Contemporary management and outcomes in congenitally corrected transposition of the great arteries.
Kutty S, Danford DA, Diller GP, Tutarel O
Heart 2018 Jul;104(14):1148-1155. Epub 2018 Jan 11 doi: 10.1136/heartjnl-2016-311032. PMID: 29326110
Coronary arteries.
Wielopolski PA, van Geuns RJ, de Feyter PJ, Oudkerk M
Eur Radiol 1998;8(6):873-85. doi: 10.1007/s003300050484. PMID: 9683689

Therapy

FFR-Guided PCI Optimization Directed by High-Definition IVUS Versus Standard of Care: The FFR REACT Trial.
Neleman T, van Zandvoort LJC, Tovar Forero MN, Masdjedi K, Ligthart JMR, Witberg KT, Groenland FTW, Cummins P, Lenzen MJ, Boersma E, Nuis RJ, den Dekker WK, Diletti R, Wilschut J, Zijlstra F, Van Mieghem NM, Daemen J
JACC Cardiovasc Interv 2022 Aug 22;15(16):1595-1607. doi: 10.1016/j.jcin.2022.06.018. PMID: 35981832
Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial.
Kedhi E, Berta B, Roleder T, Hermanides RS, Fabris E, IJsselmuiden AJJ, Kauer F, Alfonso F, von Birgelen C, Escaned J, Camaro C, Kennedy MW, Pereira B, Magro M, Nef H, Reith S, Al Nooryani A, Rivero F, Malinowski K, De Luca G, Garcia Garcia H, Granada JF, Wojakowski W
Eur Heart J 2021 Dec 1;42(45):4671-4679. doi: 10.1093/eurheartj/ehab433. PMID: 34345911
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction.
Broch K, Anstensrud AK, Woxholt S, Sharma K, Tøllefsen IM, Bendz B, Aakhus S, Ueland T, Amundsen BH, Damås JK, Berg ES, Bjørkelund E, Bendz C, Hopp E, Kleveland O, Stensæth KH, Opdahl A, Kløw NE, Seljeflot I, Andersen GØ, Wiseth R, Aukrust P, Gullestad L
J Am Coll Cardiol 2021 Apr 20;77(15):1845-1855. doi: 10.1016/j.jacc.2021.02.049. PMID: 33858620
Antiplatelet therapy in patients with myocardial infarction without obstructive coronary artery disease.
Bossard M, Gao P, Boden W, Steg G, Tanguay JF, Joyner C, Granger CB, Kastrati A, Faxon D, Budaj A, Pais P, Di Pasquale G, Valentin V, Flather M, Moccetti T, Yusuf S, Mehta SR
Heart 2021 Nov;107(21):1739-1747. Epub 2021 Jan 27 doi: 10.1136/heartjnl-2020-318045. PMID: 33504513
Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial.
Connolly SJ, Eikelboom JW, Bosch J, Dagenais G, Dyal L, Lanas F, Metsarinne K, O'Donnell M, Dans AL, Ha JW, Parkhomenko AN, Avezum AA, Lonn E, Lisheng L, Torp-Pedersen C, Widimsky P, Maggioni AP, Felix C, Keltai K, Hori M, Yusoff K, Guzik TJ, Bhatt DL, Branch KRH, Cook Bruns N, Berkowitz SD, Anand SS, Varigos JD, Fox KAA, Yusuf S; COMPASS investigators
Lancet 2018 Jan 20;391(10117):205-218. Epub 2017 Nov 10 doi: 10.1016/S0140-6736(17)32458-3. PMID: 29132879

Prognosis

Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial.
Kedhi E, Berta B, Roleder T, Hermanides RS, Fabris E, IJsselmuiden AJJ, Kauer F, Alfonso F, von Birgelen C, Escaned J, Camaro C, Kennedy MW, Pereira B, Magro M, Nef H, Reith S, Al Nooryani A, Rivero F, Malinowski K, De Luca G, Garcia Garcia H, Granada JF, Wojakowski W
Eur Heart J 2021 Dec 1;42(45):4671-4679. doi: 10.1093/eurheartj/ehab433. PMID: 34345911
Antiplatelet therapy in patients with myocardial infarction without obstructive coronary artery disease.
Bossard M, Gao P, Boden W, Steg G, Tanguay JF, Joyner C, Granger CB, Kastrati A, Faxon D, Budaj A, Pais P, Di Pasquale G, Valentin V, Flather M, Moccetti T, Yusuf S, Mehta SR
Heart 2021 Nov;107(21):1739-1747. Epub 2021 Jan 27 doi: 10.1136/heartjnl-2020-318045. PMID: 33504513
Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).
Williams MC, Kwiecinski J, Doris M, McElhinney P, D'Souza MS, Cadet S, Adamson PD, Moss AJ, Alam S, Hunter A, Shah ASV, Mills NL, Pawade T, Wang C, Weir McCall J, Bonnici-Mallia M, Murrills C, Roditi G, van Beek EJR, Shaw LJ, Nicol ED, Berman DS, Slomka PJ, Newby DE, Dweck MR, Dey D
Circulation 2020 May 5;141(18):1452-1462. Epub 2020 Mar 16 doi: 10.1161/CIRCULATIONAHA.119.044720. PMID: 32174130Free PMC Article
Short- and intermediate-term outcomes of hybrid coronary revascularization for double-vessel disease.
Patel NC, Hemli JM, Kim MC, Seetharam K, Pirelli L, Brinster DR, Scheinerman SJ, Singh VP
J Thorac Cardiovasc Surg 2018 Nov;156(5):1799-1807.e3. Epub 2018 Apr 30 doi: 10.1016/j.jtcvs.2018.04.078. PMID: 30119899
Coronary arteries.
Wielopolski PA, van Geuns RJ, de Feyter PJ, Oudkerk M
Eur Radiol 1998;8(6):873-85. doi: 10.1007/s003300050484. PMID: 9683689

Clinical prediction guides

Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial.
Kedhi E, Berta B, Roleder T, Hermanides RS, Fabris E, IJsselmuiden AJJ, Kauer F, Alfonso F, von Birgelen C, Escaned J, Camaro C, Kennedy MW, Pereira B, Magro M, Nef H, Reith S, Al Nooryani A, Rivero F, Malinowski K, De Luca G, Garcia Garcia H, Granada JF, Wojakowski W
Eur Heart J 2021 Dec 1;42(45):4671-4679. doi: 10.1093/eurheartj/ehab433. PMID: 34345911
Clinical Outcomes Following Coronary Bifurcation PCI Techniques: A Systematic Review and Network Meta-Analysis Comprising 5,711 Patients.
Di Gioia G, Sonck J, Ferenc M, Chen SL, Colaiori I, Gallinoro E, Mizukami T, Kodeboina M, Nagumo S, Franco D, Bartunek J, Vanderheyden M, Wyffels E, De Bruyne B, Lassen JF, Bennett J, Vassilev D, Serruys PW, Stankovic G, Louvard Y, Barbato E, Collet C
JACC Cardiovasc Interv 2020 Jun 22;13(12):1432-1444. doi: 10.1016/j.jcin.2020.03.054. PMID: 32553331
Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).
Williams MC, Kwiecinski J, Doris M, McElhinney P, D'Souza MS, Cadet S, Adamson PD, Moss AJ, Alam S, Hunter A, Shah ASV, Mills NL, Pawade T, Wang C, Weir McCall J, Bonnici-Mallia M, Murrills C, Roditi G, van Beek EJR, Shaw LJ, Nicol ED, Berman DS, Slomka PJ, Newby DE, Dweck MR, Dey D
Circulation 2020 May 5;141(18):1452-1462. Epub 2020 Mar 16 doi: 10.1161/CIRCULATIONAHA.119.044720. PMID: 32174130Free PMC Article
Hybrid Coronary Artery Revascularization: A Review and Current Evidence.
Kiaii B, Teefy P
Innovations (Phila) 2019 Oct;14(5):394-404. Epub 2019 Sep 10 doi: 10.1177/1556984519872998. PMID: 31500492
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
Coxib and traditional NSAID Trialists' (CNT) Collaboration, Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J, Baigent C
Lancet 2013 Aug 31;382(9894):769-79. Epub 2013 May 30 doi: 10.1016/S0140-6736(13)60900-9. PMID: 23726390Free PMC Article

Recent systematic reviews

Orthostatic hypertension and major adverse events: a systematic review and meta-analysis.
Pasdar Z, De Paola L, Carter B, Pana TA, Potter JF, Myint PK
Eur J Prev Cardiol 2023 Aug 1;30(10):1028-1038. doi: 10.1093/eurjpc/zwad158. PMID: 37202364
Tongxinluo capsule as supplementation and cardiovascular endpoint events in patients with coronary heart disease: A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials.
Lv J, Liu S, Guo S, Gao J, Song Q, Cui X
J Ethnopharmacol 2022 May 10;289:115033. Epub 2022 Jan 26 doi: 10.1016/j.jep.2022.115033. PMID: 35091010
Stenting techniques for coronary bifurcation disease: a systematic review and network meta-analysis demonstrates superiority of double-kissing crush in complex lesions.
Wang R, Ding Y, Yang J, Wang K, Gao W, Fang Z, Zhou Y, Ge H
Clin Res Cardiol 2022 Jul;111(7):761-775. Epub 2021 Dec 4 doi: 10.1007/s00392-021-01979-9. PMID: 34862569Free PMC Article
Clinical Outcomes Following Coronary Bifurcation PCI Techniques: A Systematic Review and Network Meta-Analysis Comprising 5,711 Patients.
Di Gioia G, Sonck J, Ferenc M, Chen SL, Colaiori I, Gallinoro E, Mizukami T, Kodeboina M, Nagumo S, Franco D, Bartunek J, Vanderheyden M, Wyffels E, De Bruyne B, Lassen JF, Bennett J, Vassilev D, Serruys PW, Stankovic G, Louvard Y, Barbato E, Collet C
JACC Cardiovasc Interv 2020 Jun 22;13(12):1432-1444. doi: 10.1016/j.jcin.2020.03.054. PMID: 32553331
Extracardiac findings on coronary CT angiography: a systematic review.
Karius P, Schuetz GM, Schlattmann P, Dewey M
J Cardiovasc Comput Tomogr 2014 May-Jun;8(3):174-82.e1-6. Epub 2014 Apr 13 doi: 10.1016/j.jcct.2014.04.002. PMID: 24939065

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