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Metastatic Malignant Neoplasm in the Stomach

MedGen UID:
473255
•Concept ID:
C0686068
•
Neoplastic Process
Synonyms: Cancer metastatic to stomach; Metastatic malignant neoplasm of stomach; Metastatic malignant neoplasm to stomach; Metastatic Malignant Neoplasm to the Stomach; Secondary malignant neoplasm of stomach
SNOMED CT: Secondary malignant neoplasm of stomach (94606003); Metastatic malignant neoplasm to stomach (94606003); Cancer metastatic to stomach (94606003); Metastatic malignant neoplasm of stomach (94606003)

Definition

A malignant neoplasm that has spread to the stomach from another organ or system, or from another primary gastric tumor. The primary gastric tumor is not in continuity with the metastatic lesion. Representative examples of metastatic malignant neoplasms to the stomach include breast, lung, and esophageal metastatic carcinomas and melanomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Stomach

Professional guidelines

PubMed

Gastric cancer treatment: recent progress and future perspectives.
Guan WL, He Y, Xu RH
J Hematol Oncol 2023 May 27;16(1):57. doi: 10.1186/s13045-023-01451-3. PMID: 37245017Free PMC Article
Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Fanta P, Farjah F, Gerdes H, Gibson MK, Hochwald S, Hofstetter WL, Ilson DH, Keswani RN, Kim S, Kleinberg LR, Klempner SJ, Lacy J, Ly QP, Matkowskyj KA, McNamara M, Mulcahy MF, Outlaw D, Park H, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian N, Pluchino LA
J Natl Compr Canc Netw 2022 Feb;20(2):167-192. doi: 10.6004/jnccn.2022.0008. PMID: 35130500
Current treatment and recent progress in gastric cancer.
Joshi SS, Badgwell BD
CA Cancer J Clin 2021 May;71(3):264-279. Epub 2021 Feb 16 doi: 10.3322/caac.21657. PMID: 33592120Free PMC Article

Recent clinical studies

Etiology

Current state of the art: immunotherapy in esophageal cancer and gastroesophageal junction cancer.
Li N, Sohal D
Cancer Immunol Immunother 2023 Dec;72(12):3939-3952. Epub 2023 Nov 23 doi: 10.1007/s00262-023-03566-5. PMID: 37995002
Safety and efficacy of apatinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma after the failure of two or more lines of chemotherapy (AHEAD): a prospective, single-arm, multicenter, phase IV study.
Li J, Qin S, Wen L, Wang J, Deng W, Guo W, Jia T, Jiang D, Zhang G, He Y, Ba Y, Zhong H, Wang L, Lin X, Yang J, Zhao J, Bai Y, Wu X, Gao F, Sun G, Wu Y, Ye F, Wang Q, Xie Z, Yi T, Huang Y, Yu G, Lu L, Yuan Y, Li W, Liu L, Sun Y, Sun Y, Yin L, Hou Z
BMC Med 2023 May 5;21(1):173. doi: 10.1186/s12916-023-02841-7. PMID: 37147645Free PMC Article
Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Gastritis: update on etiological features and histological practical approach.
Pennelli G, Grillo F, Galuppini F, Ingravallo G, Pilozzi E, Rugge M, Fiocca R, Fassan M, Mastracci L
Pathologica 2020 Sep;112(3):153-165. doi: 10.32074/1591-951X-163. PMID: 33179619Free PMC Article
Problems Associated with Deprescribing of Proton Pump Inhibitors.
Helgadottir H, Bjornsson ES
Int J Mol Sci 2019 Nov 2;20(21) doi: 10.3390/ijms20215469. PMID: 31684070Free PMC Article

Diagnosis

Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Gastritis: The clinico-pathological spectrum.
Rugge M, Savarino E, Sbaraglia M, Bricca L, Malfertheiner P
Dig Liver Dis 2021 Oct;53(10):1237-1246. Epub 2021 Mar 28 doi: 10.1016/j.dld.2021.03.007. PMID: 33785282
Gastritis: update on etiological features and histological practical approach.
Pennelli G, Grillo F, Galuppini F, Ingravallo G, Pilozzi E, Rugge M, Fiocca R, Fassan M, Mastracci L
Pathologica 2020 Sep;112(3):153-165. doi: 10.32074/1591-951X-163. PMID: 33179619Free PMC Article
The role of surgery in advanced disease for esophageal and junctional cancer.
Mönig S, van Hootegem S, Chevallay M, Wijnhoven BPL
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:91-96. Epub 2018 Nov 24 doi: 10.1016/j.bpg.2018.11.002. PMID: 30551863
Surveillance for Gastric Cancer.
Laks S, Meyers MO, Kim HJ
Surg Clin North Am 2017 Apr;97(2):317-331. Epub 2017 Feb 14 doi: 10.1016/j.suc.2016.11.007. PMID: 28325189

Therapy

HERIZON-GEA-01: Zanidatamab + chemo ± tislelizumab for 1L treatment of HER2-positive gastroesophageal adenocarcinoma.
Tabernero J, Shen L, Elimova E, Ku G, Liu T, Shitara K, Lin X, Boyken L, Li H, Grim J, Ajani J
Future Oncol 2022 Sep;18(29):3255-3266. Epub 2022 Aug 24 doi: 10.2217/fon-2022-0595. PMID: 36000541
MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer.
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer.
Janjigian YY, Kawazoe A, Yañez P, Li N, Lonardi S, Kolesnik O, Barajas O, Bai Y, Shen L, Tang Y, Wyrwicz LS, Xu J, Shitara K, Qin S, Van Cutsem E, Tabernero J, Li L, Shah S, Bhagia P, Chung HC
Nature 2021 Dec;600(7890):727-730. Epub 2021 Dec 15 doi: 10.1038/s41586-021-04161-3. PMID: 34912120Free PMC Article
KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma.
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article
Problems Associated with Deprescribing of Proton Pump Inhibitors.
Helgadottir H, Bjornsson ES
Int J Mol Sci 2019 Nov 2;20(21) doi: 10.3390/ijms20215469. PMID: 31684070Free PMC Article

Prognosis

Variations in the origin of the infrapyloric artery: A systematic review and meta-analysis.
Abelleyra Lastoria DA, Benny CK
Ann Anat 2023 Aug;249:152109. Epub 2023 May 18 doi: 10.1016/j.aanat.2023.152109. PMID: 37207852
Incidence and mortality trends in gastric cancer in the United States, 1992-2019.
Chen M, Chen K, Hou H, Li W, Wang X, Dao Q, Wang Z
Int J Cancer 2023 May 1;152(9):1827-1836. Epub 2023 Jan 3 doi: 10.1002/ijc.34415. PMID: 36562305
Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial.
Li WQ, Zhang JY, Ma JL, Li ZX, Zhang L, Zhang Y, Guo Y, Zhou T, Li JY, Shen L, Liu WD, Han ZX, Blot WJ, Gail MH, Pan KF, You WC
BMJ 2019 Sep 11;366:l5016. doi: 10.1136/bmj.l5016. PMID: 31511230Free PMC Article
Targeted therapies for advanced and metastatic adenocarcinoma of the gastroesophageal junction: is there something new?
Pasini F, Fraccon AP, Modena Y, Bencivenga M, Giacopuzzi S, La Russa F, Gusella M, de Manzoni G
Gastric Cancer 2017 Jan;20(1):31-42. Epub 2016 Aug 27 doi: 10.1007/s10120-016-0626-0. PMID: 27568322

Clinical prediction guides

First-line nivolumab plus chemotherapy vs chemotherapy in patients with advanced gastric, gastroesophageal junction and esophageal adenocarcinoma: CheckMate 649 Chinese subgroup analysis.
Liu T, Bai Y, Lin X, Li W, Wang J, Zhang X, Pan H, Bai C, Bai L, Cheng Y, Zhang J, Zhong H, Ba Y, Hu W, Xu R, Guo W, Qin S, Yang N, Lu J, Shitara K, Lei M, Li M, Bao N, Chen T, Shen L
Int J Cancer 2023 Feb 15;152(4):749-760. Epub 2022 Oct 31 doi: 10.1002/ijc.34296. PMID: 36121651Free PMC Article
Recent progress and current challenges of immunotherapy in advanced/metastatic esophagogastric adenocarcinoma.
Moehler M, Högner A, Wagner AD, Obermannova R, Alsina M, Thuss-Patience P, van Laarhoven H, Smyth E
Eur J Cancer 2022 Nov;176:13-29. Epub 2022 Sep 29 doi: 10.1016/j.ejca.2022.08.023. PMID: 36183651
Immunotherapy in Gastric Cancer.
Högner A, Moehler M
Curr Oncol 2022 Mar 2;29(3):1559-1574. doi: 10.3390/curroncol29030131. PMID: 35323331Free PMC Article
Gastritis: update on etiological features and histological practical approach.
Pennelli G, Grillo F, Galuppini F, Ingravallo G, Pilozzi E, Rugge M, Fiocca R, Fassan M, Mastracci L
Pathologica 2020 Sep;112(3):153-165. doi: 10.32074/1591-951X-163. PMID: 33179619Free PMC Article
Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis.
Ye G, Yang Q, Lei X, Zhu X, Li F, He J, Chen H, Ling R, Zhang H, Lin T, Liang Z, Liang Y, Huang H, Guo W, Deng H, Liu H, Hu Y, Yu J, Li G
Theranostics 2020;10(17):7545-7560. Epub 2020 Jun 12 doi: 10.7150/thno.46001. PMID: 32685004Free PMC Article

Recent systematic reviews

Efficacy and safety of nab-paclitaxel in metastatic gastric cancer: a meta-analysis.
Ahmad S, Lambuk L, Ahmed N, Mussa A, Tee V, Mohd Idris RA, Sahran NF, Chan YY, Hassan R, Lee YY, Mohamud R
Nanomedicine (Lond) 2023 Oct;18(24):1733-1744. Epub 2023 Nov 20 doi: 10.2217/nnm-2022-0300. PMID: 37982749
Tumour-derived exosomes in liver metastasis: A Pandora's box.
Li S, Qu Y, Liu L, Wang C, Yuan L, Bai H, Wang J
Cell Prolif 2023 Oct;56(10):e13452. Epub 2023 Mar 20 doi: 10.1111/cpr.13452. PMID: 36941028Free PMC Article
Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Risk Factors for Gastric Cancer: A Systematic Review.
Yusefi AR, Bagheri Lankarani K, Bastani P, Radinmanesh M, Kavosi Z
Asian Pac J Cancer Prev 2018 Mar 27;19(3):591-603. doi: 10.22034/APJCP.2018.19.3.591. PMID: 29579788Free PMC Article

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