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Therapy-Related Malignant Neoplasm

MedGen UID:: 473326
•Concept ID:: C0877578
•: Neoplastic Process

Synonyms:

Cancer, Therapy-Associated; Cancer, Therapy-Related; Cancer, Treatment-Associated; Cancer, Treatment-Related; Cancers, Therapy-Associated; Cancers, Therapy-Related; Cancers, Treatment-Associated; Cancers, Treatment-Related; Therapy Associated Cancer; Therapy Related Cancer; Therapy-Associated Cancer; Therapy-Associated Cancers; Therapy-Related Cancer; Therapy-Related Cancers; Treatment Associated Cancer; Treatment Related Cancer; Treatment-Associated Cancer; Treatment-Associated Cancers; Treatment-Related Cancer; Treatment-Related Cancers

Definition

The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTherapy-Related Malignant Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Therapy-Related Malignant Neoplasm
        Iatrogenic Kaposi sarcoma
        Kaposi Sarcoma Related to Immunosuppressive Treatment
        Transplant-Related Kaposi Sarcoma
        Methotrexate-Associated Lymphoma
        Methotrexate-Associated Diffuse Large B-Cell Lymphoma
        Methotrexate-Associated Follicular Lymphoma
        Methotrexate-Associated Hodgkin Lymphoma
        Methotrexate-Associated Peripheral T-Cell Lymphoma
        Radiation-Related Sarcoma
        Radiation-Related Angiosarcoma
        Skin Radiation-Related Angiosarcoma
        Radiation-Related Osteosarcoma
        Therapy related acute myeloid leukemia and myelodysplastic syndrome
        Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
        Alkylating Agent-Related Acute Myeloid Leukemia
        Alkylating Agent-Related Myelodysplastic Syndrome
        Acute myeloid leukemia and myelodysplastic syndromes related to radiation
        Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
        Therapy-Related Acute Myeloid Leukemia
        Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia
        Therapy-Related Myelodysplastic Syndrome
        Epipodophyllotoxin-Related Myelodysplastic Syndrome
        Therapy-Related Myelodysplastic/Myeloproliferative Neoplasm
        Therapy-Related Leukemia
        Chemotherapy-Related Leukemia
        Transplant-Related Malignant Neoplasm
        Transplant-Related Carcinoma
        Transplant-Related Bladder Urothelial Carcinoma
        Transplant-Related Hepatocellular Carcinoma
        Transplant-Related Lung Carcinoma
        Transplant-Related Renal Cell Carcinoma
        Transplant-Related Squamous Cell Carcinoma
        Transplant-Related Hematologic Malignancy
        EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder
        Monomorphic Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022.

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:256-284. Epub 2022 May 24 doi: 10.1016/j.ejca.2022.04.018. PMID: 35623961

Radiomics Improves Cancer Screening and Early Detection.

Gillies RJ, Schabath MB
Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2556-2567. Epub 2020 Sep 11 doi: 10.1158/1055-9965.EPI-20-0075. PMID: 32917666

Testicular Cancer: Diagnosis and Treatment.

Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

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Recent clinical studies

Etiology

TP53 and therapy-related myeloid neoplasms.

Chung J, Sallman DA, Padron E
Best Pract Res Clin Haematol 2019 Mar;32(1):98-103. Epub 2019 Feb 19 doi: 10.1016/j.beha.2019.02.009. PMID: 30927980

Clonal Hematopoiesis and therapy related MDS/AML.

Desai P, Roboz GJ
Best Pract Res Clin Haematol 2019 Mar;32(1):13-23. Epub 2019 Feb 15 doi: 10.1016/j.beha.2019.02.006. PMID: 30927970

Radiation-Induced Gliomas.

Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370

Therapy-related myeloid neoplasms.

Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389

Therapy-related myeloid neoplasms.

Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440

See all (21182)

Diagnosis

Moreno Berggren D, Garelius H, Willner Hjelm P, Nilsson L, Rasmussen B, Weibull CE, Lambe M, Lehmann S, Hellström-Lindberg E, Jädersten M, Ejerblad E
Leukemia 2023 May;37(5):1103-1112. Epub 2023 Mar 17 doi: 10.1038/s41375-023-01864-6. PMID: 36928008 Free PMC Article

Donor-Transmitted Melanoma: Is It Still Bothering Us?

Abdullayeva L
Curr Treat Options Oncol 2020 Apr 23;21(5):38. doi: 10.1007/s11864-020-00740-0. PMID: 32328846

Radiation-Induced Gliomas.

Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370

Therapy-related myeloid neoplasms.

Ganser A, Heuser M
Curr Opin Hematol 2017 Mar;24(2):152-158. doi: 10.1097/MOH.0000000000000316. PMID: 27930389

Therapy-Related Myeloid Neoplasms.

Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306

See all (18435)

Therapy

Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial.

Basch E, Schrag D, Henson S, Jansen J, Ginos B, Stover AM, Carr P, Spears PA, Jonsson M, Deal AM, Bennett AV, Thanarajasingam G, Rogak LJ, Reeve BB, Snyder C, Bruner D, Cella D, Kottschade LA, Perlmutter J, Geoghegan C, Samuel-Ryals CA, Given B, Mazza GL, Miller R, Strasser JF, Zylla DM, Weiss A, Blinder VS, Dueck AC
JAMA 2022 Jun 28;327(24):2413-2422. doi: 10.1001/jama.2022.9265. PMID: 35661856 Free PMC Article

Retreatment of Recurrent or Second Primary Head and Neck Cancer After Prior Radiation: Executive Summary of the American Radium Society Appropriate Use Criteria.

Ward MC, Koyfman SA, Bakst RL, Margalit DN, Beadle BM, Beitler JJ, Chang SS, Cooper JS, Galloway TJ, Ridge JA, Robbins JR, Sacco AG, Tsai CJ, Yom SS, Siddiqui F
Int J Radiat Oncol Biol Phys 2022 Jul 15;113(4):759-786. Epub 2022 Apr 8 doi: 10.1016/j.ijrobp.2022.03.034. PMID: 35398456

Tobacco Smoking and Risk of Second Primary Lung Cancer.

Aredo JV, Luo SJ, Gardner RM, Sanyal N, Choi E, Hickey TP, Riley TL, Huang WY, Kurian AW, Leung AN, Wilkens LR, Robbins HA, Riboli E, Kaaks R, Tjønneland A, Vermeulen RCH, Panico S, Le Marchand L, Amos CI, Hung RJ, Freedman ND, Johansson M, Cheng I, Wakelee HA, Han SS
J Thorac Oncol 2021 Jun;16(6):968-979. Epub 2021 Mar 17 doi: 10.1016/j.jtho.2021.02.024. PMID: 33722709 Free PMC Article

CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.

Lancet JE, Uy GL, Cortes JE, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Stone RM, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Hoering A, Banerjee K, Chiarella M, Louie AC, Medeiros BC
J Clin Oncol 2018 Sep 10;36(26):2684-2692. Epub 2018 Jul 19 doi: 10.1200/JCO.2017.77.6112. PMID: 30024784 Free PMC Article

Radiation-Induced Gliomas.

Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370

See all (15331)

Prognosis

Subsequent neoplasms in childhood cancer survivors.

Zichová A, Eckschlager T, Ganevová M, Malinová B, Lukš A, Kruseová J
Cancer Epidemiol 2020 Oct;68:101779. Epub 2020 Jul 15 doi: 10.1016/j.canep.2020.101779. PMID: 32682319

Secondary Tumors After Urinary Diversion.

Li R, Baack Kukreja JE, Kamat AM
Urol Clin North Am 2018 Feb;45(1):91-99. doi: 10.1016/j.ucl.2017.09.010. PMID: 29169454

Risk of second cancer following radiotherapy.

Toma-Dasu I, Wojcik A, Kjellsson Lindblom E
Phys Med 2017 Oct;42:211-212. Epub 2017 Nov 9 doi: 10.1016/j.ejmp.2017.10.004. PMID: 29129741

Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.

Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N
N Engl J Med 2002 Oct 17;347(16):1233-41. doi: 10.1056/NEJMoa022152. PMID: 12393820

Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer.

Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E
N Engl J Med 2002 Oct 17;347(16):1227-32. doi: 10.1056/NEJMoa020989. PMID: 12393819

See all (18018)

Clinical prediction guides

Polygenic Risk and Chemotherapy-Related Subsequent Malignancies in Childhood Cancer Survivors: A Childhood Cancer Survivor Study and St Jude Lifetime Cohort Study Report.

Im C, Sharafeldin N, Yuan Y, Wang Z, Sapkota Y, Lu Z, Spector LG, Howell RM, Arnold MA, Hudson MM, Ness KK, Robison LL, Bhatia S, Armstrong GT, Neglia JP, Yasui Y, Turcotte LM
J Clin Oncol 2023 Sep 20;41(27):4381-4393. Epub 2023 Jul 17 doi: 10.1200/JCO.23.00428. PMID: 37459583 Free PMC Article

Role of Germline Predisposition to Therapy-Related Myeloid Neoplasms.

Baranwal A, Hahn CN, Shah MV, Hiwase DK
Curr Hematol Malig Rep 2022 Dec;17(6):254-265. Epub 2022 Aug 20 doi: 10.1007/s11899-022-00676-2. PMID: 35986863

Whole-body MRI in paediatric oncology.

Nievelstein RA, Littooij AS
Radiol Med 2016 May;121(5):442-53. Epub 2015 Dec 2 doi: 10.1007/s11547-015-0600-7. PMID: 26631075 Free PMC Article

Therapy-related myeloid neoplasms.

Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440

Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422 Free PMC Article

See all (11800)

Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.

Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314 Free PMC Article

MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.

Madariaga A, Lau J, Ghoshal A, Dzierżanowski T, Larkin P, Sobocki J, Dickman A, Furness K, Fazelzad R, Crawford GB, Lheureux S
Support Care Cancer 2022 Jun;30(6):4711-4728. Epub 2022 Mar 10 doi: 10.1007/s00520-022-06889-8. PMID: 35274188 Free PMC Article

The management of menopause in women with a history of endometriosis: a systematic review.

Gemmell LC, Webster KE, Kirtley S, Vincent K, Zondervan KT, Becker CM
Hum Reprod Update 2017 Jul 1;23(4):481-500. doi: 10.1093/humupd/dmx011. PMID: 28498913 Free PMC Article

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.

Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
J Clin Oncol 2016 Feb 20;34(6):611-35. Epub 2015 Dec 7 doi: 10.1200/JCO.2015.64.3809. PMID: 26644543

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.

Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA
CA Cancer J Clin 2016 Jan-Feb;66(1):43-73. Epub 2015 Dec 7 doi: 10.3322/caac.21319. PMID: 26641959

See all (729)

MedGen

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Therapy-Related Malignant Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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