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Benign Gastrointestinal Stromal Tumor

MedGen UID:
473367
•Concept ID:
C1266136
•
Neoplastic Process
Synonyms: Gastrointestinal stromal tumor, benign; GIST, benign
SNOMED CT: GIST, benign (128754004); Gastrointestinal stromal tumor, benign (128754004)

Definition

A gastrointestinal stromal tumor that is characterized by a maximum diameter equal or less than 5 cm (gastric localization), or equal or less than 2 cm (intestinal localization) and no more than 5 mitotic figures per 50 high power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article

Recent clinical studies

Etiology

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
GIST: Correlation of risk classifications and outcome.
Kersting S, Janot-Matuschek MS, Schnitzler C, Chourio Barboza DE, Uhl W, Mittelkötter U
J Med Life 2022 Aug;15(8):932-943. doi: 10.25122/jml-2021-0110. PMID: 36188659Free PMC Article
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Von Hippel-Lindau and Hereditary Pheochromocytoma/Paraganglioma Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
Rednam SP, Erez A, Druker H, Janeway KA, Kamihara J, Kohlmann WK, Nathanson KL, States LJ, Tomlinson GE, Villani A, Voss SD, Schiffman JD, Wasserman JD
Clin Cancer Res 2017 Jun 15;23(12):e68-e75. doi: 10.1158/1078-0432.CCR-17-0547. PMID: 28620007
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056

Diagnosis

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Management of gastric polyps: an endoscopy-based approach.
Shaib YH, Rugge M, Graham DY, Genta RM
Clin Gastroenterol Hepatol 2013 Nov;11(11):1374-84. Epub 2013 Apr 10 doi: 10.1016/j.cgh.2013.03.019. PMID: 23583466Free PMC Article

Therapy

Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images.
Hirai K, Kuwahara T, Furukawa K, Kakushima N, Furune S, Yamamoto H, Marukawa T, Asai H, Matsui K, Sasaki Y, Sakai D, Yamada K, Nishikawa T, Hayashi D, Obayashi T, Komiyama T, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Kawashima H, Ishigami M, Fujishiro M
Gastric Cancer 2022 Mar;25(2):382-391. Epub 2021 Nov 16 doi: 10.1007/s10120-021-01261-x. PMID: 34783924
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Unusual gastric tumors and tumor-like lesions: Radiological with pathological correlation and literature review.
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Gastrointestinal stromal tumors.
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170

Prognosis

GIST: Correlation of risk classifications and outcome.
Kersting S, Janot-Matuschek MS, Schnitzler C, Chourio Barboza DE, Uhl W, Mittelkötter U
J Med Life 2022 Aug;15(8):932-943. doi: 10.25122/jml-2021-0110. PMID: 36188659Free PMC Article
Current clinical management of gastrointestinal stromal tumor.
Akahoshi K, Oya M, Koga T, Shiratsuchi Y
World J Gastroenterol 2018 Jul 14;24(26):2806-2817. doi: 10.3748/wjg.v24.i26.2806. PMID: 30018476Free PMC Article
Neurofibromatosis type 1 (NF1) and associated tumors.
Rosenbaum T, Wimmer K
Klin Padiatr 2014 Nov;226(6-7):309-15. Epub 2014 Jul 25 doi: 10.1055/s-0034-1382021. PMID: 25062113
Hereditary paragangliomas.
Raygada M, Pasini B, Stratakis CA
Adv Otorhinolaryngol 2011;70:99-106. Epub 2011 Feb 24 doi: 10.1159/000322484. PMID: 21358191Free PMC Article
Gastrointestinal stromal tumors.
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170

Clinical prediction guides

GIST: Correlation of risk classifications and outcome.
Kersting S, Janot-Matuschek MS, Schnitzler C, Chourio Barboza DE, Uhl W, Mittelkötter U
J Med Life 2022 Aug;15(8):932-943. doi: 10.25122/jml-2021-0110. PMID: 36188659Free PMC Article
Unusual gastric tumors and tumor-like lesions: Radiological with pathological correlation and literature review.
Lin YM, Chiu NC, Li AF, Liu CA, Chou YH, Chiou YY
World J Gastroenterol 2017 Apr 14;23(14):2493-2504. doi: 10.3748/wjg.v23.i14.2493. PMID: 28465633Free PMC Article
PDGFRA-mutant syndrome.
Ricci R, Martini M, Cenci T, Carbone A, Lanza P, Biondi A, Rindi G, Cassano A, Larghi A, Persiani R, Larocca LM
Mod Pathol 2015 Jul;28(7):954-64. Epub 2015 May 15 doi: 10.1038/modpathol.2015.56. PMID: 25975287
Neurofibromatosis type 1 (NF1) and associated tumors.
Rosenbaum T, Wimmer K
Klin Padiatr 2014 Nov;226(6-7):309-15. Epub 2014 Jul 25 doi: 10.1055/s-0034-1382021. PMID: 25062113
Gastrointestinal stromal tumors: epidemiology, clinical picture, diagnosis, prognosis and treatment.
Cichoz-Lach H, Kasztelan-Szczerbińska B, Słomka M
Pol Arch Med Wewn 2008 Apr;118(4):216-21. PMID: 18575421

Recent systematic reviews

Diagnostic value of contrast-enhanced harmonic endoscopic ultrasonography in predicting the malignancy potential of submucosal tumors: a systematic review and meta-analysis.
Yang YT, Shen N, Ao F, Chen WQ
Surg Endosc 2020 Sep;34(9):3754-3765. Epub 2020 Apr 29 doi: 10.1007/s00464-020-07585-6. PMID: 32350667
Value of contrast-enhanced harmonic endoscopic ultrasonography in differentiating between gastrointestinal stromal tumors: A meta-analysis.
Tang JY, Tao KG, Zhang LY, Wu KM, Shi J, Zeng X, Lin Y
J Dig Dis 2019 Mar;20(3):127-134. doi: 10.1111/1751-2980.12710. PMID: 30714350
Pediatric plexiform fibromyxoma: A PRISMA-compliant systematic literature review.
Fukazawa M, Koga H, Hiroshige S, Matsumoto T, Nakazono Y, Yoshikawa Y
Medicine (Baltimore) 2019 Jan;98(3):e14186. doi: 10.1097/MD.0000000000014186. PMID: 30653169Free PMC Article
Molecular analyses in the diagnosis and prediction of prognosis in non-GIST soft tissue sarcomas: A systematic review and meta-analysis.
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714
A systematic review of transanal minimally invasive surgery (TAMIS) from 2010 to 2013.
Martin-Perez B, Andrade-Ribeiro GD, Hunter L, Atallah S
Tech Coloproctol 2014 Sep;18(9):775-88. Epub 2014 May 7 doi: 10.1007/s10151-014-1148-6. PMID: 24848524

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