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Retinopathy of prematurity stage 4

MedGen UID:
473429
Concept ID:
C1443384
Disease or Syndrome
Synonyms: Retinopathy of prematurity stage 4 - subtotal retinal detachment; Retinopathy of Prematurity Stage 4 Subtotal Retinal Detachment; ROP stage 4
SNOMED CT: Retinopathy of prematurity stage 4 - subtotal retinal detachment (408850009)
 
HPO: HP:0500053

Definition

Scar tissue that forms a continuous sheet coming up from the edge of the vascularized retina. This scar tissue can grow toward the vitreous base/posterior lens capsule resulting in traction, distortion, and even detachment. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity stage 4

Professional guidelines

PubMed

Hamichi SE, Saigal K, Anzaldo EF, Gold A, Berrocal AM, Murray TG
Ophthalmic Surg Lasers Imaging Retina 2022 Mar;53(3):159-163. Epub 2022 Mar 1 doi: 10.3928/23258160-20220211-01. PMID: 35272561
Chandra P, Kumawat D, Agarwal D, Chawla R
J Pediatr Ophthalmol Strabismus 2020 Jan 1;57(1):61-66. doi: 10.3928/01913913-20191030-01. PMID: 31972043

Recent clinical studies

Etiology

Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Venincasa VD, Bugg V, Dvorak J, Ding K, Bhatti F, Siatkowski RM
J Pediatr Ophthalmol Strabismus 2019 Mar 19;56(2):116-123. doi: 10.3928/01913913-20190205-01. PMID: 30889266
Jensen AK, Ying GS, Huang J, Quinn GE, Binenbaum G
J AAPOS 2018 Apr;22(2):119-123. Epub 2018 Mar 14 doi: 10.1016/j.jaapos.2017.11.009. PMID: 29548837Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Diagnosis

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A
Ophthalmology 2021 Oct;128(10):e51-e68. Epub 2021 Jul 8 doi: 10.1016/j.ophtha.2021.05.031. PMID: 34247850Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Rajeshuni N, Zubair T, Ludwig CA, Moshfeghi DM, Mruthyunjaya P
JAMA Ophthalmol 2020 Aug 1;138(8):876-884. doi: 10.1001/jamaophthalmol.2020.2254. PMID: 32614376Free PMC Article
Venincasa VD, Bugg V, Dvorak J, Ding K, Bhatti F, Siatkowski RM
J Pediatr Ophthalmol Strabismus 2019 Mar 19;56(2):116-123. doi: 10.3928/01913913-20190205-01. PMID: 30889266

Therapy

Schmitz T, Doret-Dion M, Sentilhes L, Parant O, Claris O, Renesme L, Abbal J, Girault A, Torchin H, Houllier M, Le Saché N, Vivanti AJ, De Luca D, Winer N, Flamant C, Thuillier C, Boileau P, Blanc J, Brevaut V, Bouet PE, Gascoin G, Beucher G, Datin-Dorriere V, Bounan S, Bolot P, Poncelet C, Alberti C, Ursino M, Aupiais C, Baud O; BETADOSE trial study group; Groupe de Recherche en Obstétrique et Gynécologie
Lancet 2022 Aug 20;400(10352):592-604. doi: 10.1016/S0140-6736(22)01535-5. PMID: 35988568
Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Prognosis

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Cao Y, Jiang S, Sun J, Hei M, Wang L, Zhang H, Ma X, Wu H, Li X, Sun H, Zhou W, Shi Y, Wang Y, Gu X, Yang T, Lu Y, Du L, Chen C, Lee SK, Zhou W; Chinese Neonatal Network
JAMA Netw Open 2021 Aug 2;4(8):e2118904. doi: 10.1001/jamanetworkopen.2021.18904. PMID: 34338792Free PMC Article
Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Venincasa VD, Bugg V, Dvorak J, Ding K, Bhatti F, Siatkowski RM
J Pediatr Ophthalmol Strabismus 2019 Mar 19;56(2):116-123. doi: 10.3928/01913913-20190205-01. PMID: 30889266
Wu T, Zhang L, Tong Y, Qu Y, Xia B, Mu D
Invest Ophthalmol Vis Sci 2018 Feb 1;59(2):757-763. doi: 10.1167/iovs.17-23158. PMID: 29392321

Clinical prediction guides

Hou S, Yu Y, Wu Y, Cao Y, Zhang J, Liu Z, Guo C, Chen Y, Sun X, Li M, Gao Y, Zhao G, Niu S, Zhou Z, Wang Y, Yang Z, Huang L, Zhang C, Chen T, Zhao X, Li X, Zhang Y, Zhao P, Bi M, Zhao R
Indian J Pediatr 2022 Aug;89(8):785-792. Epub 2022 Mar 14 doi: 10.1007/s12098-021-04023-w. PMID: 35286565Free PMC Article
Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Kermorvant-Duchemin E, Le Meur G, Plaisant F, Marchand-Martin L, Flamant C, Porcher R, Lapillonne A, Chemtob S, Claris O, Ancel PY, Rozé JC
PLoS Med 2020 Dec;17(12):e1003477. Epub 2020 Dec 11 doi: 10.1371/journal.pmed.1003477. PMID: 33306685Free PMC Article
Larsen PP, Kipfmueller F, Holz FG, Reutter H, Müller A, Krohne TU
J Pediatr Surg 2020 Jul;55(7):1292-1295. Epub 2019 Aug 25 doi: 10.1016/j.jpedsurg.2019.07.021. PMID: 31575413
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871

Recent systematic reviews

Rath CP, Shivamallappa M, Muthusamy S, Rao SC, Patole S
Arch Dis Child Fetal Neonatal Ed 2022 May;107(3):269-280. Epub 2021 Jul 30 doi: 10.1136/archdischild-2020-321449. PMID: 34330757
Sankar MJ, Sankar J, Chandra P
Cochrane Database Syst Rev 2018 Jan 8;1(1):CD009734. doi: 10.1002/14651858.CD009734.pub3. PMID: 29308602Free PMC Article
Howlett A, Ohlsson A, Plakkal N
Cochrane Database Syst Rev 2015 Feb 4;(2):CD000366. doi: 10.1002/14651858.CD000366.pub3. PMID: 25927089
Howlett A, Ohlsson A, Plakkal N
Cochrane Database Syst Rev 2012 Mar 14;(3):CD000366. doi: 10.1002/14651858.CD000366.pub2. PMID: 22419275
Soll RF
Cochrane Database Syst Rev 2000;(2):CD001079. doi: 10.1002/14651858.CD001079. PMID: 10796410

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