U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Retinopathy of prematurity stage 4

MedGen UID:
473429
Concept ID:
C1443384
Disease or Syndrome
Synonyms: Retinopathy of prematurity stage 4 - subtotal retinal detachment; Retinopathy of Prematurity Stage 4 Subtotal Retinal Detachment; ROP stage 4
SNOMED CT: Retinopathy of prematurity stage 4 - subtotal retinal detachment (408850009)
 
HPO: HP:0500053

Definition

Scar tissue that forms a continuous sheet coming up from the edge of the vascularized retina. This scar tissue can grow toward the vitreous base/posterior lens capsule resulting in traction, distortion, and even detachment. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity stage 4

Professional guidelines

PubMed

Hamichi SE, Saigal K, Anzaldo EF, Gold A, Berrocal AM, Murray TG
Ophthalmic Surg Lasers Imaging Retina 2022 Mar;53(3):159-163. Epub 2022 Mar 1 doi: 10.3928/23258160-20220211-01. PMID: 35272561
Chandra P, Kumawat D, Agarwal D, Chawla R
J Pediatr Ophthalmol Strabismus 2020 Jan 1;57(1):61-66. doi: 10.3928/01913913-20191030-01. PMID: 31972043

Recent clinical studies

Etiology

Berrocal AM, Fan KC, Al-Khersan H, Negron CI, Murray T
Am J Ophthalmol 2022 Jan;233:189-215. Epub 2021 Jul 21 doi: 10.1016/j.ajo.2021.07.016. PMID: 34298009Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Diagnosis

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Paul Chan RV, Berrocal A, Binenbaum G, Blair M, Peter Campbell J, Capone A Jr, Chen Y, Dai S, Ells A, Fleck BW, Good WV, Elizabeth Hartnett M, Holmstrom G, Kusaka S, Kychenthal A, Lepore D, Lorenz B, Martinez-Castellanos MA, Özdek Ş, Ademola-Popoola D, Reynolds JD, Shah PK, Shapiro M, Stahl A, Toth C, Vinekar A, Visser L, Wallace DK, Wu WC, Zhao P, Zin A
Ophthalmology 2021 Oct;128(10):e51-e68. Epub 2021 Jul 8 doi: 10.1016/j.ophtha.2021.05.031. PMID: 34247850Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Patel SN, Singh R, Jonas KE, Ostmo S, Gupta MP, Campbell JP, Chiang MF, Chan RVP; Imaging and Informatics for Retinopathy of Prematurity Research Consortium
Ophthalmol Retina 2018 Jan;2(1):59-64. Epub 2017 Jun 9 doi: 10.1016/j.oret.2017.04.001. PMID: 31047304
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871

Therapy

Stahl A, Sukgen EA, Wu WC, Lepore D, Nakanishi H, Mazela J, Moshfeghi DM, Vitti R, Athanikar A, Chu K, Iveli P, Zhao F, Schmelter T, Leal S, Köfüncü E, Azuma N; FIREFLEYE Study Group
JAMA 2022 Jul 26;328(4):348-359. doi: 10.1001/jama.2022.10564. PMID: 35881122Free PMC Article
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Hellström A, Nilsson AK, Wackernagel D, Pivodic A, Vanpee M, Sjöbom U, Hellgren G, Hallberg B, Domellöf M, Klevebro S, Hellström W, Andersson M, Lund AM, Löfqvist C, Elfvin A, Sävman K, Hansen-Pupp I, Hård AL, Smith LEH, Ley D
JAMA Pediatr 2021 Apr 1;175(4):359-367. doi: 10.1001/jamapediatrics.2020.5653. PMID: 33523106Free PMC Article
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871
Mintz-Hittner HA, Kennedy KA, Chuang AZ; BEAT-ROP Cooperative Group
N Engl J Med 2011 Feb 17;364(7):603-15. doi: 10.1056/NEJMoa1007374. PMID: 21323540Free PMC Article

Prognosis

Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Cao Y, Jiang S, Sun J, Hei M, Wang L, Zhang H, Ma X, Wu H, Li X, Sun H, Zhou W, Shi Y, Wang Y, Gu X, Yang T, Lu Y, Du L, Chen C, Lee SK, Zhou W; Chinese Neonatal Network
JAMA Netw Open 2021 Aug 2;4(8):e2118904. doi: 10.1001/jamanetworkopen.2021.18904. PMID: 34338792Free PMC Article
Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D'Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L'Hélias L, Marchand-Martin L, Kaminski M
JAMA Pediatr 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351. PMID: 25621457
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871

Clinical prediction guides

Narnaware SH, Bawankule PK
Lasers Med Sci 2021 Jul;36(5):989-993. Epub 2020 Sep 3 doi: 10.1007/s10103-020-03130-y. PMID: 32880773
Hartnett ME, Toth CA
Ophthalmic Surg Lasers Imaging Retina 2019 Apr 1;50(4):228-234. doi: 10.3928/23258160-20190401-05. PMID: 30998244
Cayabyab R, Ramanathan R
Neonatology 2016;109(4):369-76. Epub 2016 Jun 3 doi: 10.1159/000444901. PMID: 27251645
Fang JL, Sorita A, Carey WA, Colby CE, Murad MH, Alahdab F
Pediatrics 2016 Apr;137(4) Epub 2016 Mar 9 doi: 10.1542/peds.2015-3387. PMID: 26962240
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871

Recent systematic reviews

Huang J, Tang Y, Zhu T, Li Y, Chun H, Qu Y, Mu D
Medicine (Baltimore) 2019 Oct;98(42):e17512. doi: 10.1097/MD.0000000000017512. PMID: 31626109Free PMC Article
Wang X, Tang K, Chen L, Cheng S, Xu H
BMJ Open 2019 May 24;9(5):e025440. doi: 10.1136/bmjopen-2018-025440. PMID: 31129577Free PMC Article
Azami M, Jaafari Z, Rahmati S, Farahani AD, Badfar G
BMC Ophthalmol 2018 Apr 2;18(1):83. doi: 10.1186/s12886-018-0732-3. PMID: 29606108Free PMC Article
Kaempfen S, Neumann RP, Jost K, Schulzke SM
Cochrane Database Syst Rev 2018 Mar 2;3(3):CD011893. doi: 10.1002/14651858.CD011893.pub2. PMID: 29499081Free PMC Article
Zhu T, Zhang L, Zhao F, Qu Y, Mu D
PLoS One 2017;12(4):e0175374. Epub 2017 Apr 7 doi: 10.1371/journal.pone.0175374. PMID: 28388642Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...