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Liver Undifferentiated Carcinoma

MedGen UID:
473524
Concept ID:
C2064401
Neoplastic Process
Synonyms: Undifferentiated Liver Carcinoma; Undifferentiated Primary Liver Carcinoma

Definition

A rare carcinoma that arises from the liver. The diagnosis is made by immunohistochemical studies. Morphologic studies alone cannot establish the diagnosis of carcinoma or further subclassify the malignant tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Undifferentiated Carcinoma

Professional guidelines

PubMed

Wilkins T, Sams R, Carpenter M
Am Fam Physician 2019 Mar 1;99(5):314-323. PMID: 30811163
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jul;69(1):182-236. Epub 2018 Apr 5 doi: 10.1016/j.jhep.2018.03.019. PMID: 29628281
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2017 Aug;67(2):370-398. Epub 2017 Apr 18 doi: 10.1016/j.jhep.2017.03.021. PMID: 28427875

Recent clinical studies

Etiology

Cheishvili D, Wong C, Karim MM, Kibria MG, Jahan N, Das PC, Yousuf MAK, Islam MA, Das DC, Noor-E-Alam SM, Szyf M, Alam S, Khan WA, Al Mahtab M
Nat Commun 2023 Jun 7;14(1):3306. doi: 10.1038/s41467-023-39055-7. PMID: 37286539Free PMC Article
Guedj N
Curr Oncol 2022 Dec 26;30(1):370-380. doi: 10.3390/curroncol30010030. PMID: 36661679Free PMC Article
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931Free PMC Article

Diagnosis

Cheishvili D, Wong C, Karim MM, Kibria MG, Jahan N, Das PC, Yousuf MAK, Islam MA, Das DC, Noor-E-Alam SM, Szyf M, Alam S, Khan WA, Al Mahtab M
Nat Commun 2023 Jun 7;14(1):3306. doi: 10.1038/s41467-023-39055-7. PMID: 37286539Free PMC Article
Giraud J, Chalopin D, Blanc JF, Saleh M
Front Immunol 2021;12:655697. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.655697. PMID: 33815418Free PMC Article
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Ayuso C, Rimola J, Vilana R, Burrel M, Darnell A, García-Criado Á, Bianchi L, Belmonte E, Caparroz C, Barrufet M, Bruix J, Brú C
Eur J Radiol 2018 Apr;101:72-81. Epub 2018 Jan 31 doi: 10.1016/j.ejrad.2018.01.025. PMID: 29571804
Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931Free PMC Article

Therapy

Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Hack SP, Spahn J, Chen M, Cheng AL, Kaseb A, Kudo M, Lee HC, Yopp A, Chow P, Qin S
Future Oncol 2020 May;16(15):975-989. Epub 2020 Apr 30 doi: 10.2217/fon-2020-0162. PMID: 32352320
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190

Prognosis

Mocan L
Eur Rev Med Pharmacol Sci 2021 Jul;25(13):4470-4477. doi: 10.26355/eurrev_202107_26238. PMID: 34286489
Varol Fİ
J Gastrointest Cancer 2020 Dec;51(4):1169-1175. doi: 10.1007/s12029-020-00494-w. PMID: 32856229
Saillard C, Schmauch B, Laifa O, Moarii M, Toldo S, Zaslavskiy M, Pronier E, Laurent A, Amaddeo G, Regnault H, Sommacale D, Ziol M, Pawlotsky JM, Mulé S, Luciani A, Wainrib G, Clozel T, Courtiol P, Calderaro J
Hepatology 2020 Dec;72(6):2000-2013. doi: 10.1002/hep.31207. PMID: 32108950
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Gao Z, Wu S, Yang Y, Sun M, Tian X, Jin X
Invest New Drugs 2023 Oct;41(5):719-726. Epub 2023 Aug 17 doi: 10.1007/s10637-023-01391-2. PMID: 37589864
Bianco C, Jamialahmadi O, Pelusi S, Baselli G, Dongiovanni P, Zanoni I, Santoro L, Maier S, Liguori A, Meroni M, Borroni V, D'Ambrosio R, Spagnuolo R, Alisi A, Federico A, Bugianesi E, Petta S, Miele L, Vespasiani-Gentilucci U, Anstee QM, Stickel F, Hampe J, Fischer J, Berg T, Fracanzani AL, Soardo G, Reeves H, Prati D, Romeo S, Valenti L
J Hepatol 2021 Apr;74(4):775-782. Epub 2020 Nov 25 doi: 10.1016/j.jhep.2020.11.024. PMID: 33248170Free PMC Article
Rhee H, Cho ES, Nahm JH, Jang M, Chung YE, Baek SE, Lee S, Kim MJ, Park MS, Han DH, Choi JY, Park YN
J Hepatol 2021 Jan;74(1):109-121. Epub 2020 Aug 18 doi: 10.1016/j.jhep.2020.08.013. PMID: 32818570
Sherman M
Semin Liver Dis 2017 Nov;37(4):287-295. Epub 2017 Dec 22 doi: 10.1055/s-0037-1607452. PMID: 29272891
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Singal AG, Zhang E, Narasimman M, Rich NE, Waljee AK, Hoshida Y, Yang JD, Reig M, Cabibbo G, Nahon P, Parikh ND, Marrero JA
J Hepatol 2022 Jul;77(1):128-139. Epub 2022 Feb 6 doi: 10.1016/j.jhep.2022.01.023. PMID: 35139400Free PMC Article
Harding-Theobald E, Louissaint J, Maraj B, Cuaresma E, Townsend W, Mendiratta-Lala M, Singal AG, Su GL, Lok AS, Parikh ND
Aliment Pharmacol Ther 2021 Oct;54(7):890-901. Epub 2021 Aug 12 doi: 10.1111/apt.16563. PMID: 34390014Free PMC Article
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
Parikh ND, Waljee AK, Singal AG
Liver Transpl 2015 Sep;21(9):1142-52. doi: 10.1002/lt.24169. PMID: 25981135

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