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Liver Undifferentiated Carcinoma

MedGen UID:
473524
Concept ID:
C2064401
Neoplastic Process
Synonyms: Undifferentiated Liver Carcinoma; Undifferentiated Primary Liver Carcinoma

Definition

A rare carcinoma that arises from the liver. The diagnosis is made by immunohistochemical studies. Morphologic studies alone cannot establish the diagnosis of carcinoma or further subclassify the malignant tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Undifferentiated Carcinoma

Professional guidelines

PubMed

European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jul;69(1):182-236. Epub 2018 Apr 5 doi: 10.1016/j.jhep.2018.03.019. PMID: 29628281
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2017 Aug;67(2):370-398. Epub 2017 Apr 18 doi: 10.1016/j.jhep.2017.03.021. PMID: 28427875
Hartke J, Johnson M, Ghabril M
Semin Diagn Pathol 2017 Mar;34(2):153-159. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.011. PMID: 28108047

Recent clinical studies

Etiology

Guedj N
Curr Oncol 2022 Dec 26;30(1):370-380. doi: 10.3390/curroncol30010030. PMID: 36661679Free PMC Article
Ballestri S, Tana C, Di Girolamo M, Fontana MC, Capitelli M, Lonardo A, Cioni G
Curr Pharm Des 2020;26(32):3915-3927. doi: 10.2174/1381612826666200417142444. PMID: 32303161
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931Free PMC Article

Diagnosis

Giraud J, Chalopin D, Blanc JF, Saleh M
Front Immunol 2021;12:655697. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.655697. PMID: 33815418Free PMC Article
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Akkoç Y, Gözüaçık D
Turk J Gastroenterol 2018 May;29(3):270-282. doi: 10.5152/tjg.2018.150318. PMID: 29755011Free PMC Article
Ayuso C, Rimola J, Vilana R, Burrel M, Darnell A, García-Criado Á, Bianchi L, Belmonte E, Caparroz C, Barrufet M, Bruix J, Brú C
Eur J Radiol 2018 Apr;101:72-81. Epub 2018 Jan 31 doi: 10.1016/j.ejrad.2018.01.025. PMID: 29571804
Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931Free PMC Article

Therapy

Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Hack SP, Spahn J, Chen M, Cheng AL, Kaseb A, Kudo M, Lee HC, Yopp A, Chow P, Qin S
Future Oncol 2020 May;16(15):975-989. Epub 2020 Apr 30 doi: 10.2217/fon-2020-0162. PMID: 32352320
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn RS, Abecassis MM, Roberts LR, Heimbach JK
Hepatology 2018 Aug;68(2):723-750. doi: 10.1002/hep.29913. PMID: 29624699

Prognosis

Varol Fİ
J Gastrointest Cancer 2020 Dec;51(4):1169-1175. doi: 10.1007/s12029-020-00494-w. PMID: 32856229
Saillard C, Schmauch B, Laifa O, Moarii M, Toldo S, Zaslavskiy M, Pronier E, Laurent A, Amaddeo G, Regnault H, Sommacale D, Ziol M, Pawlotsky JM, Mulé S, Luciani A, Wainrib G, Clozel T, Courtiol P, Calderaro J
Hepatology 2020 Dec;72(6):2000-2013. doi: 10.1002/hep.31207. PMID: 32108950
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
Labgaa I, Stueck A, Ward SC
Am J Pathol 2017 Jul;187(7):1438-1444. Epub 2017 May 10 doi: 10.1016/j.ajpath.2017.02.022. PMID: 28500863
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Bianco C, Jamialahmadi O, Pelusi S, Baselli G, Dongiovanni P, Zanoni I, Santoro L, Maier S, Liguori A, Meroni M, Borroni V, D'Ambrosio R, Spagnuolo R, Alisi A, Federico A, Bugianesi E, Petta S, Miele L, Vespasiani-Gentilucci U, Anstee QM, Stickel F, Hampe J, Fischer J, Berg T, Fracanzani AL, Soardo G, Reeves H, Prati D, Romeo S, Valenti L
J Hepatol 2021 Apr;74(4):775-782. Epub 2020 Nov 25 doi: 10.1016/j.jhep.2020.11.024. PMID: 33248170Free PMC Article
Alenezi AO, Krishna S, Mendiratta-Lala M, Kielar AZ
Semin Ultrasound CT MR 2020 Apr;41(2):122-138. Epub 2019 Dec 14 doi: 10.1053/j.sult.2019.12.002. PMID: 32446427
Nascimbeni F, Ballestri S, Machado MV, Mantovani A, Cortez-Pinto H, Targher G, Lonardo A
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):351-367. Epub 2017 Dec 26 doi: 10.1080/17474124.2018.1415756. PMID: 29224471
Burt AD, Lackner C, Tiniakos DG
Semin Liver Dis 2015 Aug;35(3):207-20. Epub 2015 Sep 17 doi: 10.1055/s-0035-1562942. PMID: 26378639
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

El Hajra I, Sanduzzi-Zamparelli M, Sapena V, Muñoz-Martínez S, Mauro E, Llarch N, Iserte G, Forner A, Rios J, Bruix J, Reig M
Hepatology 2023 Apr 1;77(4):1139-1149. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000030. PMID: 36632997
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Singal AG, Zhang E, Narasimman M, Rich NE, Waljee AK, Hoshida Y, Yang JD, Reig M, Cabibbo G, Nahon P, Parikh ND, Marrero JA
J Hepatol 2022 Jul;77(1):128-139. Epub 2022 Feb 6 doi: 10.1016/j.jhep.2022.01.023. PMID: 35139400Free PMC Article
Harding-Theobald E, Louissaint J, Maraj B, Cuaresma E, Townsend W, Mendiratta-Lala M, Singal AG, Su GL, Lok AS, Parikh ND
Aliment Pharmacol Ther 2021 Oct;54(7):890-901. Epub 2021 Aug 12 doi: 10.1111/apt.16563. PMID: 34390014Free PMC Article
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898

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