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Liver Undifferentiated Carcinoma

MedGen UID:
473524
•Concept ID:
C2064401
•
Neoplastic Process
Synonyms: Undifferentiated Liver Carcinoma; Undifferentiated Primary Liver Carcinoma

Definition

A rare carcinoma that arises from the liver. The diagnosis is made by immunohistochemical studies. Morphologic studies alone cannot establish the diagnosis of carcinoma or further subclassify the malignant tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Undifferentiated Carcinoma

Professional guidelines

PubMed

Hepatitis B: Screening, Prevention, Diagnosis, and Treatment.
Wilkins T, Sams R, Carpenter M
Am Fam Physician 2019 Mar 1;99(5):314-323. PMID: 30811163
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2018 Jul;69(1):182-236. Epub 2018 Apr 5 doi: 10.1016/j.jhep.2018.03.019. PMID: 29628281
The diagnosis and treatment of hepatocellular carcinoma.
Hartke J, Johnson M, Ghabril M
Semin Diagn Pathol 2017 Mar;34(2):153-159. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.011. PMID: 28108047

Recent clinical studies

Etiology

Pathology of Cholangiocarcinomas.
Guedj N
Curr Oncol 2022 Dec 26;30(1):370-380. doi: 10.3390/curroncol30010030. PMID: 36661679Free PMC Article
Sex Hormone-Dependent Physiology and Diseases of Liver.
Kur P, Kolasa-Wołosiuk A, Misiakiewicz-Has K, Wiszniewska B
Int J Environ Res Public Health 2020 Apr 11;17(8) doi: 10.3390/ijerph17082620. PMID: 32290381Free PMC Article
Hepatocellular Carcinoma.
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Pediatric hepatocellular carcinoma.
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
Liver cirrhosis.
Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931Free PMC Article

Diagnosis

Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies.
Giraud J, Chalopin D, Blanc JF, Saleh M
Front Immunol 2021;12:655697. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.655697. PMID: 33815418Free PMC Article
Hepatocellular Carcinoma.
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Diagnosis and staging of hepatocellular carcinoma (HCC): current guidelines.
Ayuso C, Rimola J, Vilana R, Burrel M, Darnell A, García-Criado Á, Bianchi L, Belmonte E, Caparroz C, Barrufet M, Bruix J, Brú C
Eur J Radiol 2018 Apr;101:72-81. Epub 2018 Jan 31 doi: 10.1016/j.ejrad.2018.01.025. PMID: 29571804
Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches.
Borrelli A, Bonelli P, Tuccillo FM, Goldfine ID, Evans JL, Buonaguro FM, Mancini A
Redox Biol 2018 May;15:467-479. Epub 2018 Feb 3 doi: 10.1016/j.redox.2018.01.009. PMID: 29413959Free PMC Article
Liver cirrhosis.
Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931Free PMC Article

Therapy

Liver Transplantation for Intrahepatic Cholangiocarcinoma: Ready for Prime Time?
Sapisochin G, Ivanics T, Heimbach J
Hepatology 2022 Feb;75(2):455-472. Epub 2022 Jan 6 doi: 10.1002/hep.32258. PMID: 34859465
Strategies to Improve the Antitumor Effect of Immunotherapy for Hepatocellular Carcinoma.
Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.
Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550Free PMC Article
Hepatocellular Carcinoma.
Villanueva A
N Engl J Med 2019 Apr 11;380(15):1450-1462. doi: 10.1056/NEJMra1713263. PMID: 30970190
Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases.
Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn RS, Abecassis MM, Roberts LR, Heimbach JK
Hepatology 2018 Aug;68(2):723-750. doi: 10.1002/hep.29913. PMID: 29624699

Prognosis

Pediatric Hepatocellular Carcinoma.
Varol Fİ
J Gastrointest Cancer 2020 Dec;51(4):1169-1175. doi: 10.1007/s12029-020-00494-w. PMID: 32856229
Predicting Survival After Hepatocellular Carcinoma Resection Using Deep Learning on Histological Slides.
Saillard C, Schmauch B, Laifa O, Moarii M, Toldo S, Zaslavskiy M, Pronier E, Laurent A, Amaddeo G, Regnault H, Sommacale D, Ziol M, Pawlotsky JM, Mulé S, Luciani A, Wainrib G, Clozel T, Courtiol P, Calderaro J
Hepatology 2020 Dec;72(6):2000-2013. doi: 10.1002/hep.31207. PMID: 32108950
Pediatric hepatocellular carcinoma.
Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403Free PMC Article
Lymphoepithelioma-Like Carcinoma in Liver.
Labgaa I, Stueck A, Ward SC
Am J Pathol 2017 Jul;187(7):1438-1444. Epub 2017 May 10 doi: 10.1016/j.ajpath.2017.02.022. PMID: 28500863
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.
Bianco C, Jamialahmadi O, Pelusi S, Baselli G, Dongiovanni P, Zanoni I, Santoro L, Maier S, Liguori A, Meroni M, Borroni V, D'Ambrosio R, Spagnuolo R, Alisi A, Federico A, Bugianesi E, Petta S, Miele L, Vespasiani-Gentilucci U, Anstee QM, Stickel F, Hampe J, Fischer J, Berg T, Fracanzani AL, Soardo G, Reeves H, Prati D, Romeo S, Valenti L
J Hepatol 2021 Apr;74(4):775-782. Epub 2020 Nov 25 doi: 10.1016/j.jhep.2020.11.024. PMID: 33248170Free PMC Article
Imaging and Management of Liver Cancer.
Alenezi AO, Krishna S, Mendiratta-Lala M, Kielar AZ
Semin Ultrasound CT MR 2020 Apr;41(2):122-138. Epub 2019 Dec 14 doi: 10.1053/j.sult.2019.12.002. PMID: 32446427
Role of liver and spleen stiffness in predicting the recurrence of hepatocellular carcinoma after resection.
Marasco G, Colecchia A, Colli A, Ravaioli F, Casazza G, Bacchi Reggiani ML, Cucchetti A, Cescon M, Festi D
J Hepatol 2019 Mar;70(3):440-448. Epub 2018 Oct 31 doi: 10.1016/j.jhep.2018.10.022. PMID: 30389551
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article
Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy.
Wang Y, Li J, Xia Y, Gong R, Wang K, Yan Z, Wan X, Liu G, Wu D, Shi L, Lau W, Wu M, Shen F
J Clin Oncol 2013 Mar 20;31(9):1188-95. Epub 2013 Jan 28 doi: 10.1200/JCO.2012.41.5984. PMID: 23358969

Recent systematic reviews

Outcome of patients with HCC and liver dysfunction under immunotherapy: a systematic review and meta-analysis.
El Hajra I, Sanduzzi-Zamparelli M, Sapena V, Muñoz-Martínez S, Mauro E, Llarch N, Iserte G, Forner A, Rios J, Bruix J, Reig M
Hepatology 2023 Apr 1;77(4):1139-1149. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000030. PMID: 36632997
Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis.
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis: A meta-analysis.
Singal AG, Zhang E, Narasimman M, Rich NE, Waljee AK, Hoshida Y, Yang JD, Reig M, Cabibbo G, Nahon P, Parikh ND, Marrero JA
J Hepatol 2022 Jul;77(1):128-139. Epub 2022 Feb 6 doi: 10.1016/j.jhep.2022.01.023. PMID: 35139400Free PMC Article
Systematic review: radiomics for the diagnosis and prognosis of hepatocellular carcinoma.
Harding-Theobald E, Louissaint J, Maraj B, Cuaresma E, Townsend W, Mendiratta-Lala M, Singal AG, Su GL, Lok AS, Parikh ND
Aliment Pharmacol Ther 2021 Oct;54(7):890-901. Epub 2021 Aug 12 doi: 10.1111/apt.16563. PMID: 34390014Free PMC Article
Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systematic Review and Meta-analysis.
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898

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