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Biliary cystadenocarcinoma

MedGen UID:
473526
•Concept ID:
C2064409
•
Neoplastic Process
Synonyms: biliary cystadenocarcinoma; Intrahepatic Bile Duct Cystadenocarcinoma; Intrahepatic bile duct cystadenocarcinoma; intrahepatic bile duct cystadenocarcinoma; Intrahepatic Bile Duct MCN with an Associated Invasive Carcinoma; Intrahepatic Bile Duct Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018535
Orphanet: ORPHA424982

Definition

A mucinous cystic neoplasm that arises from the intrahepatic bile ducts and it is associated with an invasive carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBiliary cystadenocarcinoma

Professional guidelines

PubMed

Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Effective treatment of biliary cystadenoma.
Thomas KT, Welch D, Trueblood A, Sulur P, Wise P, Gorden DL, Chari RS, Wright JK Jr, Washington K, Pinson CW
Ann Surg 2005 May;241(5):769-73; discussion 773-5. doi: 10.1097/01.sla.0000161982.57360.1b. PMID: 15849512Free PMC Article
Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnoses.
Lee WJ, Lim HK, Jang KM, Kim SH, Lee SJ, Lim JH, Choo IW
Radiographics 2001 Oct;21 Spec No:S97-S116. doi: 10.1148/radiographics.21.suppl_1.g01oc12s97. PMID: 11598251

Recent clinical studies

Etiology

Diagnostic and Therapeutic Challenges of Intrahepatic Biliary Cystadenoma and Cystadenocarcinoma: A Report of 10 Cases and Review of the Literature.
Fragulidis GP, Vezakis AI, Konstantinidis CG, Chondrogiannis KK, Primetis ES, Kondi-Pafiti A, Polydorou AA
Int Surg 2015 Jul;100(7-8):1212-9. doi: 10.9738/INTSURG-D-15-00025.1. PMID: 26595495
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Surgical management of biliary cystadenoma and cystadenocarcinoma of the liver.
Chen YW, Li CH, Liu Z, Dong JH, Zhang WZ, Jiang K
Genet Mol Res 2014 Aug 25;13(3):6383-90. doi: 10.4238/2014.August.25.1. PMID: 25158256
Intrahepatic biliary cystadenoma and cystadenocarcinoma: an experience of 30 cases.
Wang C, Miao R, Liu H, Du X, Liu L, Lu X, Zhao H
Dig Liver Dis 2012 May;44(5):426-31. Epub 2011 Dec 9 doi: 10.1016/j.dld.2011.11.007. PMID: 22169273
Computed tomography of biliary cystadenoma and biliary cystadenocarcinoma.
Pojchamarnwiputh S, Na Chiangmai W, Chotirosniramit A, Lertprasertsuke N
Singapore Med J 2008 May;49(5):392-6. PMID: 18465049

Diagnosis

Management of Mucinous Cystic Neoplasms of the Liver.
Aziz H, Hamad A, Afyouni S, Kamel IR, Pawlik TM
J Gastrointest Surg 2023 Sep;27(9):1963-1970. Epub 2023 May 23 doi: 10.1007/s11605-023-05709-6. PMID: 37221388
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma.
Soares KC, Arnaoutakis DJ, Kamel I, Anders R, Adams RB, Bauer TW, Pawlik TM
J Am Coll Surg 2014 Jan;218(1):119-28. Epub 2013 Sep 14 doi: 10.1016/j.jamcollsurg.2013.08.014. PMID: 24045144Free PMC Article
Intrahepatic biliary cystadenoma and cystadenocarcinoma: an experience of 30 cases.
Wang C, Miao R, Liu H, Du X, Liu L, Lu X, Zhao H
Dig Liver Dis 2012 May;44(5):426-31. Epub 2011 Dec 9 doi: 10.1016/j.dld.2011.11.007. PMID: 22169273
Biliary papillary neoplasm of the liver.
Nakanuma Y, Sasaki M, Ishikawa A, Tsui W, Chen TC, Huang SF
Histol Histopathol 2002;17(3):851-61. doi: 10.14670/HH-17.851. PMID: 12168796

Therapy

Contrast enhanced ultrasound features of hepatic cystadenoma and hepatic cystadenocarcinoma.
Dong Y, Wang WP, Mao F, Fan M, Ignee A, Serra C, Sparchez Z, Sporea I, Braden B, Dietrich CF
Scand J Gastroenterol 2017 Mar;52(3):365-372. Epub 2016 Nov 25 doi: 10.1080/00365521.2016.1259652. PMID: 27887203
Endoscopic ultrasonography-guided drainage of infected intracystic papillary adenocarcinoma of the liver.
Kodama R, Saegusa H, Ushimaru H, Ikeno T, Makino M, Kawaguchi K
Clin J Gastroenterol 2015 Oct;8(5):335-9. Epub 2015 Sep 28 doi: 10.1007/s12328-015-0607-6. PMID: 26412329
A case of biliary cystadenocarcinoma with malignant seeding of the tract after percutaneous catheter drainage.
Yuefeng M, Weili F, Jing L, Wenxiang T, Tianqing L, Liming W
Turk J Gastroenterol 2012;23(6):795-8. doi: 10.4318/tjg.2012.0644. PMID: 23864459
Biliary cystadenocarcinoma with mesenchymal stroma.
Gómez-Martín C, Rodríguez A, Malón D, Cortés-Funes H
Clin Transl Oncol 2010 Mar;12(3):234-7. doi: 10.1007/s12094-010-0495-7. PMID: 20231130
Hepatic arterial infusion chemotherapy of cisplatin for biliary cystadenocarcinoma.
Hanazaki K, Yoshizawa K, Mori H
Hepatogastroenterology 1999 Jan-Feb;46(25):462-4. PMID: 10228843

Prognosis

Management of Mucinous Cystic Neoplasms of the Liver.
Aziz H, Hamad A, Afyouni S, Kamel IR, Pawlik TM
J Gastrointest Surg 2023 Sep;27(9):1963-1970. Epub 2023 May 23 doi: 10.1007/s11605-023-05709-6. PMID: 37221388
Clinicopathological characteristics and prognostic factors of intrahepatic biliary cystadenocarcinoma.
Xu MY, Shi XJ, Wan T, Liang YR, Wang HG, Zhang WZ, He L, Chen MY, Lyu SC, Zhang WW, Li HX
Chin Med J (Engl) 2015 May 5;128(9):1177-83. doi: 10.4103/0366-6999.156108. PMID: 25947400Free PMC Article
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Cystic neoplasms of the liver: biliary cystadenoma and cystadenocarcinoma.
Soares KC, Arnaoutakis DJ, Kamel I, Anders R, Adams RB, Bauer TW, Pawlik TM
J Am Coll Surg 2014 Jan;218(1):119-28. Epub 2013 Sep 14 doi: 10.1016/j.jamcollsurg.2013.08.014. PMID: 24045144Free PMC Article
Biliary cystadenoma and cystadenocarcinoma: report of 14 cases and review of the literature.
Ishak KG, Willis GW, Cummins SD, Bullock AA
Cancer 1977 Jan;39(1):322-38. doi: 10.1002/1097-0142(197701)39:1<322::aid-cncr2820390149>3.0.co;2-p. PMID: 318915

Clinical prediction guides

Clinicopathological features and management of biliary cystic tumors of the liver: a single-center experience.
El-Magd EA, El-Shobari M, Abdelsalam RA, Abbas A, Elmahdy Y, Hamed H
Langenbecks Arch Surg 2023 Jul 11;408(1):273. doi: 10.1007/s00423-023-02994-2. PMID: 37430153Free PMC Article
CT and MRI features differentiating mucinous cystic neoplasms of the liver from pathologically simple cysts.
Anderson MA, Dhami RS, Fadzen CM, Molina G, Taylor MS, Deshpande V, Qadan M, Catalano OA, Ferrone CR, Mojtahed A
Clin Imaging 2021 Aug;76:46-52. Epub 2021 Feb 3 doi: 10.1016/j.clinimag.2021.01.036. PMID: 33549919
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT, Dong JH
World J Gastroenterol 2014 Sep 21;20(35):12595-601. doi: 10.3748/wjg.v20.i35.12595. PMID: 25253963Free PMC Article
Intrahepatic biliary cystadenoma and cystadenocarcinoma: an experience of 30 cases.
Wang C, Miao R, Liu H, Du X, Liu L, Lu X, Zhao H
Dig Liver Dis 2012 May;44(5):426-31. Epub 2011 Dec 9 doi: 10.1016/j.dld.2011.11.007. PMID: 22169273
Diagnostic implications of albumin messenger RNA detection and cytokeratin pattern in benign hepatic lesions and biliary cystadenocarcinoma.
D'Errico A, Deleonardi G, Fiorentino M, Scoazec JY, Grigioni WF
Diagn Mol Pathol 1998 Dec;7(6):289-94. doi: 10.1097/00019606-199812000-00001. PMID: 10207666

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