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Extrahepatic Bile Duct Adenocarcinoma, Intestinal Type

MedGen UID:
473529
•Concept ID:
C2064429
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of neoplastic tubular glands lined by columnar cells or neoplastic glands lined by goblet cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic Bile Duct Adenocarcinoma, Intestinal Type

Professional guidelines

PubMed

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Surgical Treatment of Ampullary Adenocarcinoma - Single Center Experience and a Review of Literature.
Kunovský L, Kala Z, Procházka V, Potrusil M, Dastych M, Novotný I, Andrasina T, Pavlovský Z, Eid M, Moravcik P
Klin Onkol 2017 Winter;31(1):46-52. doi: 10.14735/amko201846. PMID: 29488778
Biliary tract malignancies: a population-based study on incidence, prognosis and management of patients.
Juliusson G, Jonasson JG, Jonsdottir SB, Garcia HG, Olafsdottir E, Möller PH, Björnsson ES
Scand J Gastroenterol 2016 Dec;51(12):1520-1525. Epub 2016 Aug 24 doi: 10.1080/00365521.2016.1218538. PMID: 27553174

Recent clinical studies

Etiology

Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater.
da Silveira Santos JPL, Machado CJ, Junior EP, Rodrigues JBSR, Vidigal PT, Resende V
J Gastrointest Surg 2018 Jul;22(7):1171-1178. Epub 2018 May 7 doi: 10.1007/s11605-018-3797-7. PMID: 29736668
Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies?
Westgaard A, Pomianowska E, Clausen OP, Gladhaug IP
Ann Surg Oncol 2013 Feb;20(2):430-9. Epub 2012 Sep 7 doi: 10.1245/s10434-012-2603-0. PMID: 22956064
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer
JAMA 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352. PMID: 22782416
Ampullary cancer.
Heinrich S, Clavien PA
Curr Opin Gastroenterol 2010 May;26(3):280-5. doi: 10.1097/MOG.0b013e3283378eb0. PMID: 20168227

Diagnosis

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Diagnostic strategy with a solid pancreatic mass.
Guarneri G, Gasparini G, Crippa S, Andreasi V, Falconi M
Presse Med 2019 Mar;48(3 Pt 2):e125-e145. Epub 2019 Mar 14 doi: 10.1016/j.lpm.2019.02.026. PMID: 30878333
Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater.
da Silveira Santos JPL, Machado CJ, Junior EP, Rodrigues JBSR, Vidigal PT, Resende V
J Gastrointest Surg 2018 Jul;22(7):1171-1178. Epub 2018 May 7 doi: 10.1007/s11605-018-3797-7. PMID: 29736668
Neuroendocrine carcinoma of the extrahepatic bile duct: case report and literature review.
Sasatomi E, Nalesnik MA, Marsh JW
World J Gastroenterol 2013 Jul 28;19(28):4616-23. doi: 10.3748/wjg.v19.i28.4616. PMID: 23901240Free PMC Article
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428

Therapy

Menopausal hormone therapy and risk of biliary tract cancers.
Jackson SS, Pfeiffer RM, Gabbi C, Anderson L, Gadalla SM, Koshiol J
Hepatology 2022 Feb;75(2):309-321. doi: 10.1002/hep.32198. PMID: 34766362Free PMC Article
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Adenocarcinoma of the ampulla of Vater: what treatment options are available?
Senatore FJ, Ynson ML, Dasanu CA
J Oncol Pharm Pract 2015 Oct;21(5):364-9. Epub 2014 Jun 5 doi: 10.1177/1078155214538086. PMID: 24906539
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer
JAMA 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352. PMID: 22782416
Ampullary cancer.
Heinrich S, Clavien PA
Curr Opin Gastroenterol 2010 May;26(3):280-5. doi: 10.1097/MOG.0b013e3283378eb0. PMID: 20168227

Prognosis

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Ampullary cancer--a separate clinical entity?
Perysinakis I, Margaris I, Kouraklis G
Histopathology 2014 May;64(6):759-68. Epub 2014 Jan 24 doi: 10.1111/his.12324. PMID: 24456259
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer
JAMA 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352. PMID: 22782416
Ampullary cancer.
Heinrich S, Clavien PA
Curr Opin Gastroenterol 2010 May;26(3):280-5. doi: 10.1097/MOG.0b013e3283378eb0. PMID: 20168227
Periampullary carcinomas.
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

Clinical prediction guides

Hepatoid carcinoma and related entities of the extrahepatic bile duct: A clinicopathological study of four cases.
Okura K, Esaki M, Nara S, Ban D, Takamoto T, Shimada K, Hiraoka N
Pathol Int 2022 Jun;72(6):332-342. Epub 2022 Apr 26 doi: 10.1111/pin.13226. PMID: 35472251
Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater.
da Silveira Santos JPL, Machado CJ, Junior EP, Rodrigues JBSR, Vidigal PT, Resende V
J Gastrointest Surg 2018 Jul;22(7):1171-1178. Epub 2018 May 7 doi: 10.1007/s11605-018-3797-7. PMID: 29736668
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer
JAMA 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352. PMID: 22782416
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286
Periampullary carcinomas.
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

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