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May-Thurner syndrome

MedGen UID:
473753
•Concept ID:
C3165062
•
Disease or Syndrome
Synonyms: Cockett Syndrome; Compression Syndrome, Iliocaval; Compression Syndromes, Iliocaval; Iliac Vein Compression Syndrome; Iliocaval Compression Syndrome; Iliocaval Compression Syndromes; May Thurner Syndrome; May-Thurner Syndrome; Syndrome, Cockett; Syndrome, Iliocaval Compression; Syndrome, May-Thurner; Syndromes, Iliocaval Compression
SNOMED CT: Iliac vein compression syndrome (448804008); May-Thurner syndrome (448804008)
 
Monarch Initiative: MONDO:0043361

Definition

A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMay-Thurner syndrome

Professional guidelines

PubMed

Contemporary treatment of May-Thurner Syndrome.
Fereydooni A, Stern JR
J Cardiovasc Surg (Torino) 2021 Oct;62(5):447-455. Epub 2021 Apr 19 doi: 10.23736/S0021-9509.21.11889-0. PMID: 33870678
Guidance for the treatment of deep vein thrombosis and pulmonary embolism.
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article
May-Thurner syndrome: diagnosis and management.
Brazeau NF, Harvey HB, Pinto EG, Deipolyi A, Hesketh RL, Oklu R
Vasa 2013 Mar;42(2):96-105. doi: 10.1024/0301-1526/a000252. PMID: 23485836

Recent clinical studies

Etiology

The Symptoms-Varices-Pathophysiology classification of pelvic venous disorders: A report of the American Vein & Lymphatic Society International Working Group on Pelvic Venous Disorders.
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism.
Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, Hutten BA, Jaff MR, Manja V, Schulman S, Thurston C, Vedantham S, Verhamme P, Witt DM, D Florez I, Izcovich A, Nieuwlaat R, Ross S, J Schünemann H, Wiercioch W, Zhang Y, Zhang Y
Blood Adv 2020 Oct 13;4(19):4693-4738. doi: 10.1182/bloodadvances.2020001830. PMID: 33007077Free PMC Article
May-Thurner syndrome.
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
May-Thurner Syndrome.
Sedhai YR, Golamari R, Salei A, Alukal J, Basnyat S, Pathak S, Timalsina S, Zia S, Malhan S, Bhatacharya PT
Am J Med Sci 2018 May;355(5):510-514. Epub 2017 Sep 28 doi: 10.1016/j.amjms.2017.09.011. PMID: 29753382
Guidance for the treatment of deep vein thrombosis and pulmonary embolism.
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Diagnosis

Contemporary treatment of May-Thurner Syndrome.
Fereydooni A, Stern JR
J Cardiovasc Surg (Torino) 2021 Oct;62(5):447-455. Epub 2021 Apr 19 doi: 10.23736/S0021-9509.21.11889-0. PMID: 33870678
The Symptoms-Varices-Pathophysiology classification of pelvic venous disorders: A report of the American Vein & Lymphatic Society International Working Group on Pelvic Venous Disorders.
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Iliac vein compression: epidemiology, diagnosis and treatment.
Radaideh Q, Patel NM, Shammas NW
Vasc Health Risk Manag 2019;15:115-122. Epub 2019 May 9 doi: 10.2147/VHRM.S203349. PMID: 31190849Free PMC Article
May-Thurner syndrome.
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
Guidance for the treatment of deep vein thrombosis and pulmonary embolism.
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Therapy

Contemporary treatment of May-Thurner Syndrome.
Fereydooni A, Stern JR
J Cardiovasc Surg (Torino) 2021 Oct;62(5):447-455. Epub 2021 Apr 19 doi: 10.23736/S0021-9509.21.11889-0. PMID: 33870678
Endovascular and medical therapy of May-Thurner syndrome: Case series and scoping literature review.
Montes MC, Carbonell JP, Gómez-Mesa JE
J Med Vasc 2021 Apr;46(2):80-89. Epub 2021 Mar 5 doi: 10.1016/j.jdmv.2021.02.004. PMID: 33752850
Intervention for Iliofemoral Deep Vein Thrombosis and May-Thurner Syndrome.
Salahuddin T, Armstrong EJ
Interv Cardiol Clin 2020 Apr;9(2):243-254. Epub 2020 Jan 30 doi: 10.1016/j.iccl.2019.11.003. PMID: 32147124
Iliac vein compression: epidemiology, diagnosis and treatment.
Radaideh Q, Patel NM, Shammas NW
Vasc Health Risk Manag 2019;15:115-122. Epub 2019 May 9 doi: 10.2147/VHRM.S203349. PMID: 31190849Free PMC Article
Guidance for the treatment of deep vein thrombosis and pulmonary embolism.
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Prognosis

The Symptoms-Varices-Pathophysiology classification of pelvic venous disorders: A report of the American Vein & Lymphatic Society International Working Group on Pelvic Venous Disorders.
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Iliac vein compression: epidemiology, diagnosis and treatment.
Radaideh Q, Patel NM, Shammas NW
Vasc Health Risk Manag 2019;15:115-122. Epub 2019 May 9 doi: 10.2147/VHRM.S203349. PMID: 31190849Free PMC Article
May-Thurner syndrome.
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
Right-sided Cockett's syndrome.
Du Pont B, Verbist J, Van den Eynde W, Peeters P
Acta Chir Belg 2016 Apr;116(2):114-8. Epub 2016 Apr 21 doi: 10.1080/00015458.2016.1139834. PMID: 27385298
Guidance for the treatment of deep vein thrombosis and pulmonary embolism.
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Clinical prediction guides

The Symptoms-Varices-Pathophysiology classification of pelvic venous disorders: A report of the American Vein & Lymphatic Society International Working Group on Pelvic Venous Disorders.
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Iliac vein compression: epidemiology, diagnosis and treatment.
Radaideh Q, Patel NM, Shammas NW
Vasc Health Risk Manag 2019;15:115-122. Epub 2019 May 9 doi: 10.2147/VHRM.S203349. PMID: 31190849Free PMC Article
May-Thurner syndrome.
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
May-Thurner Syndrome.
Sedhai YR, Golamari R, Salei A, Alukal J, Basnyat S, Pathak S, Timalsina S, Zia S, Malhan S, Bhatacharya PT
Am J Med Sci 2018 May;355(5):510-514. Epub 2017 Sep 28 doi: 10.1016/j.amjms.2017.09.011. PMID: 29753382
Guidance for the treatment of deep vein thrombosis and pulmonary embolism.
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Recent systematic reviews

Spontaneous Iliac Vein Ruptures: A Systematic Review.
Kooiman AL, Bakas JM, van Fessem JMK, Boellaard WPA, Cornelissen SAP, van Rijn MJE
Vasc Endovascular Surg 2023 Aug;57(6):617-625. Epub 2023 Mar 13 doi: 10.1177/15385744231163707. PMID: 36913198Free PMC Article
Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis.
Avila L, Cullinan N, White M, Gaballah M, Cahill AM, Warad D, Rodriguez V, Tarango C, Hoppmann A, Nelson S, Kuhn T, Biss T, Weiss A, Temple M, Amaral JG, Amiri N, Xavier AC, Renzi S, Brandão LR
J Thromb Haemost 2021 May;19(5):1283-1293. Epub 2021 Apr 1 doi: 10.1111/jth.15284. PMID: 33651481Free PMC Article
Association between deep vein thrombosis and stent patency in symptomatic iliac vein compression syndrome: Systematic review and meta-analysis.
Rodrigues LDS, Bertanha M, El Dib R, Moura R
J Vasc Surg Venous Lymphat Disord 2021 Jan;9(1):275-284. Epub 2020 Aug 20 doi: 10.1016/j.jvsv.2020.08.022. PMID: 32827731
A review into the management of May-Thurner syndrome in adolescents.
Hansrani V, Moughal S, Elmetwally A, Al-Khaffaf H
J Vasc Surg Venous Lymphat Disord 2020 Nov;8(6):1104-1110. Epub 2020 May 28 doi: 10.1016/j.jvsv.2020.05.006. PMID: 32474151
Systematic review of May-Thurner syndrome with emphasis on gender differences.
Kaltenmeier CT, Erben Y, Indes J, Lee A, Dardik A, Sarac T, Ochoa Chaar CI
J Vasc Surg Venous Lymphat Disord 2018 May;6(3):399-407.e4. Epub 2017 Dec 28 doi: 10.1016/j.jvsv.2017.11.006. PMID: 29290600

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