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May-Thurner syndrome

MedGen UID:
473753
Concept ID:
C3165062
Disease or Syndrome
Synonyms: Cockett Syndrome; Compression Syndrome, Iliocaval; Compression Syndromes, Iliocaval; Iliac Vein Compression Syndrome; Iliocaval Compression Syndrome; Iliocaval Compression Syndromes; May Thurner Syndrome; May-Thurner Syndrome; Syndrome, Cockett; Syndrome, Iliocaval Compression; Syndrome, May-Thurner; Syndromes, Iliocaval Compression
SNOMED CT: Iliac vein compression syndrome (448804008); May-Thurner syndrome (448804008)
 
Monarch Initiative: MONDO:0043361

Definition

A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMay-Thurner syndrome

Professional guidelines

PubMed

Fereydooni A, Stern JR
J Cardiovasc Surg (Torino) 2021 Oct;62(5):447-455. Epub 2021 Apr 19 doi: 10.23736/S0021-9509.21.11889-0. PMID: 33870678
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article
Brazeau NF, Harvey HB, Pinto EG, Deipolyi A, Hesketh RL, Oklu R
Vasa 2013 Mar;42(2):96-105. doi: 10.1024/0301-1526/a000252. PMID: 23485836

Recent clinical studies

Etiology

Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, Hutten BA, Jaff MR, Manja V, Schulman S, Thurston C, Vedantham S, Verhamme P, Witt DM, D Florez I, Izcovich A, Nieuwlaat R, Ross S, J Schünemann H, Wiercioch W, Zhang Y, Zhang Y
Blood Adv 2020 Oct 13;4(19):4693-4738. doi: 10.1182/bloodadvances.2020001830. PMID: 33007077Free PMC Article
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
Sedhai YR, Golamari R, Salei A, Alukal J, Basnyat S, Pathak S, Timalsina S, Zia S, Malhan S, Bhatacharya PT
Am J Med Sci 2018 May;355(5):510-514. Epub 2017 Sep 28 doi: 10.1016/j.amjms.2017.09.011. PMID: 29753382
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Diagnosis

Fereydooni A, Stern JR
J Cardiovasc Surg (Torino) 2021 Oct;62(5):447-455. Epub 2021 Apr 19 doi: 10.23736/S0021-9509.21.11889-0. PMID: 33870678
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
Peleg R, Treister-Goltzman Y
Isr Med Assoc J 2016 Dec;18(12):767. PMID: 28457084
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Therapy

Liu Q, Liu F, Lü P, Wu HX, Ye P, You Y, Yao Z
Curr Med Sci 2021 Dec;41(6):1178-1186. Epub 2021 Dec 17 doi: 10.1007/s11596-021-2481-4. PMID: 34918176
Fereydooni A, Stern JR
J Cardiovasc Surg (Torino) 2021 Oct;62(5):447-455. Epub 2021 Apr 19 doi: 10.23736/S0021-9509.21.11889-0. PMID: 33870678
Montes MC, Carbonell JP, Gómez-Mesa JE
J Med Vasc 2021 Apr;46(2):80-89. Epub 2021 Mar 5 doi: 10.1016/j.jdmv.2021.02.004. PMID: 33752850
Salahuddin T, Armstrong EJ
Interv Cardiol Clin 2020 Apr;9(2):243-254. Epub 2020 Jan 30 doi: 10.1016/j.iccl.2019.11.003. PMID: 32147124
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article

Prognosis

Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
Du Pont B, Verbist J, Van den Eynde W, Peeters P
Acta Chir Belg 2016 Apr;116(2):114-8. Epub 2016 Apr 21 doi: 10.1080/00015458.2016.1139834. PMID: 27385298
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article
Brazeau NF, Harvey HB, Pinto EG, Deipolyi A, Hesketh RL, Oklu R
Vasa 2013 Mar;42(2):96-105. doi: 10.1024/0301-1526/a000252. PMID: 23485836

Clinical prediction guides

Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Liddell RP, Evans NS
Vasc Med 2018 Oct;23(5):493-496. doi: 10.1177/1358863X18794276. PMID: 30187833
Sedhai YR, Golamari R, Salei A, Alukal J, Basnyat S, Pathak S, Timalsina S, Zia S, Malhan S, Bhatacharya PT
Am J Med Sci 2018 May;355(5):510-514. Epub 2017 Sep 28 doi: 10.1016/j.amjms.2017.09.011. PMID: 29753382
Streiff MB, Agnelli G, Connors JM, Crowther M, Eichinger S, Lopes R, McBane RD, Moll S, Ansell J
J Thromb Thrombolysis 2016 Jan;41(1):32-67. doi: 10.1007/s11239-015-1317-0. PMID: 26780738Free PMC Article
Brazeau NF, Harvey HB, Pinto EG, Deipolyi A, Hesketh RL, Oklu R
Vasa 2013 Mar;42(2):96-105. doi: 10.1024/0301-1526/a000252. PMID: 23485836

Recent systematic reviews

Kooiman AL, Bakas JM, van Fessem JMK, Boellaard WPA, Cornelissen SAP, van Rijn MJE
Vasc Endovascular Surg 2023 Aug;57(6):617-625. Epub 2023 Mar 13 doi: 10.1177/15385744231163707. PMID: 36913198Free PMC Article
Avila L, Cullinan N, White M, Gaballah M, Cahill AM, Warad D, Rodriguez V, Tarango C, Hoppmann A, Nelson S, Kuhn T, Biss T, Weiss A, Temple M, Amaral JG, Amiri N, Xavier AC, Renzi S, Brandão LR
J Thromb Haemost 2021 May;19(5):1283-1293. Epub 2021 Apr 1 doi: 10.1111/jth.15284. PMID: 33651481Free PMC Article
Rodrigues LDS, Bertanha M, El Dib R, Moura R
J Vasc Surg Venous Lymphat Disord 2021 Jan;9(1):275-284. Epub 2020 Aug 20 doi: 10.1016/j.jvsv.2020.08.022. PMID: 32827731
Hansrani V, Moughal S, Elmetwally A, Al-Khaffaf H
J Vasc Surg Venous Lymphat Disord 2020 Nov;8(6):1104-1110. Epub 2020 May 28 doi: 10.1016/j.jvsv.2020.05.006. PMID: 32474151
Kaltenmeier CT, Erben Y, Indes J, Lee A, Dardik A, Sarac T, Ochoa Chaar CI
J Vasc Surg Venous Lymphat Disord 2018 May;6(3):399-407.e4. Epub 2017 Dec 28 doi: 10.1016/j.jvsv.2017.11.006. PMID: 29290600

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