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Secondary malignant neoplasm

MedGen UID:
473807
Concept ID:
C3266877
Neoplastic Process
Synonyms: Secondary Cancer; secondary cancer; Secondary Malignancy; secondary malignancy; Secondary Malignant Neoplasm; secondary malignant neoplasm
 
Monarch Initiative: MONDO:0024881

Definition

A malignant neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary malignant neoplasm

Professional guidelines

PubMed

Hong KT, Lee DH, Kim BK, An HY, Choi JY, Phi JH, Cheon JE, Kang HJ, Kim SK, Kim JY, Park SH, Kim IH, Shin HY
BMC Cancer 2020 Oct 9;20(1):979. doi: 10.1186/s12885-020-07484-y. PMID: 33036578Free PMC Article
Goldfarb M, Freyer DR
Cancer 2014 Apr 15;120(8):1155-61. Epub 2014 Feb 24 doi: 10.1002/cncr.28463. PMID: 24615715
Lang K, Sussman M, Friedman M, Su J, Kan HJ, Mauro D, Tafesse E, Menzin J
Arch Otolaryngol Head Neck Surg 2009 Jun;135(6):582-8. doi: 10.1001/archoto.2009.46. PMID: 19528407

Recent clinical studies

Etiology

Paulino AC, Ludmir EB, Grosshans DR, Su JM, McGovern SL, Okcu MF, McAleer MF, Baxter PA, Mahajan A, Chintagumpala MM
Cancer 2021 Oct 15;127(20):3865-3871. Epub 2021 Jul 13 doi: 10.1002/cncr.33783. PMID: 34254296
Wijnen M, van den Heuvel-Eibrink MM, Medici M, Peeters RP, van der Lely AJ, Neggers SJ
Endocr Relat Cancer 2016 Jun;23(6):R299-321. Epub 2016 May 26 doi: 10.1530/ERC-16-0113. PMID: 27229933
Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE
Cancer 2014 Dec 15;120(24):3987-93. Epub 2014 Aug 12 doi: 10.1002/cncr.28936. PMID: 25116228
Goldfarb M, Freyer DR
Cancer 2014 Apr 15;120(8):1155-61. Epub 2014 Feb 24 doi: 10.1002/cncr.28463. PMID: 24615715
Fontenot JD, Lee AK, Newhauser WD
Int J Radiat Oncol Biol Phys 2009 Jun 1;74(2):616-22. doi: 10.1016/j.ijrobp.2009.01.001. PMID: 19427561Free PMC Article

Diagnosis

van Boemmel-Wegmann S, Brown JD, Diaby V, Huo J, Silver N, Park H
JCO Oncol Pract 2022 Jan;18(1):e163-e174. Epub 2021 Jul 6 doi: 10.1200/OP.21.00140. PMID: 34228489
Chao C, Bhatia S, Xu L, Cannavale KL, Wong FL, Huang PS, Cooper R, Armenian SH
JAMA Netw Open 2019 Jun 5;2(6):e195536. doi: 10.1001/jamanetworkopen.2019.5536. PMID: 31173129Free PMC Article
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE
Cancer 2014 Dec 15;120(24):3987-93. Epub 2014 Aug 12 doi: 10.1002/cncr.28936. PMID: 25116228
Harbron RW, Feltbower RG, Glaser A, Lilley J, Pearce MS
Pediatr Hematol Oncol 2014 Apr;31(3):259-67. Epub 2013 Oct 2 doi: 10.3109/08880018.2013.838723. PMID: 24087931

Therapy

Paulino AC, Ludmir EB, Grosshans DR, Su JM, McGovern SL, Okcu MF, McAleer MF, Baxter PA, Mahajan A, Chintagumpala MM
Cancer 2021 Oct 15;127(20):3865-3871. Epub 2021 Jul 13 doi: 10.1002/cncr.33783. PMID: 34254296
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Harbron RW, Feltbower RG, Glaser A, Lilley J, Pearce MS
Pediatr Hematol Oncol 2014 Apr;31(3):259-67. Epub 2013 Oct 2 doi: 10.3109/08880018.2013.838723. PMID: 24087931
Stanulla M, Schaeffeler E, Möricke A, Coulthard SA, Cario G, Schrauder A, Kaatsch P, Dördelmann M, Welte K, Zimmermann M, Reiter A, Eichelbaum M, Riehm H, Schrappe M, Schwab M
Blood 2009 Aug 13;114(7):1314-8. Epub 2009 Jun 17 doi: 10.1182/blood-2008-12-193250. PMID: 19535798
Fontenot JD, Lee AK, Newhauser WD
Int J Radiat Oncol Biol Phys 2009 Jun 1;74(2):616-22. doi: 10.1016/j.ijrobp.2009.01.001. PMID: 19427561Free PMC Article

Prognosis

Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Lee JS, DuBois SG, Boscardin WJ, Wustrack RL, Goldsby RE
Cancer 2014 Dec 15;120(24):3987-93. Epub 2014 Aug 12 doi: 10.1002/cncr.28936. PMID: 25116228
Harbron RW, Feltbower RG, Glaser A, Lilley J, Pearce MS
Pediatr Hematol Oncol 2014 Apr;31(3):259-67. Epub 2013 Oct 2 doi: 10.3109/08880018.2013.838723. PMID: 24087931
Stanulla M, Schaeffeler E, Möricke A, Coulthard SA, Cario G, Schrauder A, Kaatsch P, Dördelmann M, Welte K, Zimmermann M, Reiter A, Eichelbaum M, Riehm H, Schrappe M, Schwab M
Blood 2009 Aug 13;114(7):1314-8. Epub 2009 Jun 17 doi: 10.1182/blood-2008-12-193250. PMID: 19535798
Kiriu H, Yokozaki H, Yasui W, Ito K, Tahara E
Jpn J Clin Oncol 1998 Dec;28(12):733-9. doi: 10.1093/jjco/28.12.733. PMID: 9879290

Clinical prediction guides

van Boemmel-Wegmann S, Brown JD, Diaby V, Huo J, Silver N, Park H
JCO Oncol Pract 2022 Jan;18(1):e163-e174. Epub 2021 Jul 6 doi: 10.1200/OP.21.00140. PMID: 34228489
Mittal A, Bhethanabhotla S, Ganguly S, Vishnubhatla S, Khadgawat R, Patel C, Mohan A, Biswas A, Bakhshi S
Pediatr Blood Cancer 2021 Nov;68(11):e29293. Epub 2021 Aug 25 doi: 10.1002/pbc.29293. PMID: 34431211
Wijnen M, van den Heuvel-Eibrink MM, Medici M, Peeters RP, van der Lely AJ, Neggers SJ
Endocr Relat Cancer 2016 Jun;23(6):R299-321. Epub 2016 May 26 doi: 10.1530/ERC-16-0113. PMID: 27229933
Harbron RW, Feltbower RG, Glaser A, Lilley J, Pearce MS
Pediatr Hematol Oncol 2014 Apr;31(3):259-67. Epub 2013 Oct 2 doi: 10.3109/08880018.2013.838723. PMID: 24087931
Kiriu H, Yokozaki H, Yasui W, Ito K, Tahara E
Jpn J Clin Oncol 1998 Dec;28(12):733-9. doi: 10.1093/jjco/28.12.733. PMID: 9879290

Recent systematic reviews

Ding SX, Chen T, Wang T, Liu CY, Lu WL, Fu R
Acta Haematol 2018;140(3):141-145. Epub 2018 Sep 25 doi: 10.1159/000491816. PMID: 30253387
Franklin J, Eichenauer DA, Becker I, Monsef I, Engert A
Cochrane Database Syst Rev 2017 Sep 13;9(9):CD008814. doi: 10.1002/14651858.CD008814.pub2. PMID: 28901021Free PMC Article
Wijnen M, van den Heuvel-Eibrink MM, Medici M, Peeters RP, van der Lely AJ, Neggers SJ
Endocr Relat Cancer 2016 Jun;23(6):R299-321. Epub 2016 May 26 doi: 10.1530/ERC-16-0113. PMID: 27229933

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