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Gastric neuroendocrine tumor, well differentiated, low or intermediate grade

MedGen UID:
474032
Concept ID:
C3272399
Neoplastic Process
Synonyms: Gastric NET; gastric NET; gastric NET G1/2; Gastric Neuroendocrine Tumor; gastric neuroendocrine tumor; gastric neuroendocrine tumor, well differentiated, low or intermediate grade; gastric neuroendocrine tumour; Gastric Well Differentiated Endocrine Tumor; gastric well differentiated endocrine tumor; Gastric Well Differentiated Endocrine Tumor/Carcinoma; gastric well differentiated endocrine tumor/carcinoma; gastric well differentiated endocrine tumour; GNET; well-differentiated neuroendocrine tumors of the stomach; well-differentiated neuroendocrine tumours of the stomach
 
Monarch Initiative: MONDO:0015062

Definition

A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the stomach. [from NCI]

Professional guidelines

PubMed

Stahl A
Dtsch Arztebl Int 2020 Jul 20;117(29-30):513-520. doi: 10.3238/arztebl.2020.0513. PMID: 33087239Free PMC Article
Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB
Endocr Pract 2020 May;26(Suppl 1):1-46. doi: 10.4158/GL-2020-0524SUPPL. PMID: 32427503
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R; Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines
Endocr Pract 2016 Jul;22 Suppl 3:1-203. Epub 2016 May 24 doi: 10.4158/EP161365.GL. PMID: 27219496

Recent clinical studies

Etiology

Wang Y, Acs B, Robertson S, Liu B, Solorzano L, Wählby C, Hartman J, Rantalainen M
Ann Oncol 2022 Jan;33(1):89-98. Epub 2021 Sep 29 doi: 10.1016/j.annonc.2021.09.007. PMID: 34756513
Cusimano MC, Vicus D, Pulman K, Maganti M, Bernardini MQ, Bouchard-Fortier G, Laframboise S, May T, Hogen LF, Covens AL, Gien LT, Kupets R, Rouzbahman M, Clarke BA, Mirkovic J, Cesari M, Turashvili G, Zia A, Ene GEV, Ferguson SE
JAMA Surg 2021 Feb 1;156(2):157-164. doi: 10.1001/jamasurg.2020.5060. PMID: 33175109Free PMC Article
Ahdoot M, Wilbur AR, Reese SE, Lebastchi AH, Mehralivand S, Gomella PT, Bloom J, Gurram S, Siddiqui M, Pinsky P, Parnes H, Linehan WM, Merino M, Choyke PL, Shih JH, Turkbey B, Wood BJ, Pinto PA
N Engl J Med 2020 Mar 5;382(10):917-928. doi: 10.1056/NEJMoa1910038. PMID: 32130814Free PMC Article
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790

Diagnosis

Cusimano MC, Vicus D, Pulman K, Maganti M, Bernardini MQ, Bouchard-Fortier G, Laframboise S, May T, Hogen LF, Covens AL, Gien LT, Kupets R, Rouzbahman M, Clarke BA, Mirkovic J, Cesari M, Turashvili G, Zia A, Ene GEV, Ferguson SE
JAMA Surg 2021 Feb 1;156(2):157-164. doi: 10.1001/jamasurg.2020.5060. PMID: 33175109Free PMC Article
Ahdoot M, Wilbur AR, Reese SE, Lebastchi AH, Mehralivand S, Gomella PT, Bloom J, Gurram S, Siddiqui M, Pinsky P, Parnes H, Linehan WM, Merino M, Choyke PL, Shih JH, Turkbey B, Wood BJ, Pinto PA
N Engl J Med 2020 Mar 5;382(10):917-928. doi: 10.1056/NEJMoa1910038. PMID: 32130814Free PMC Article
Oronsky B, Ma PC, Morgensztern D, Carter CA
Neoplasia 2017 Dec;19(12):991-1002. Epub 2017 Nov 5 doi: 10.1016/j.neo.2017.09.002. PMID: 29091800Free PMC Article
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179
Fisher C
Adv Anat Pathol 2004 Jul;11(4):190-201. doi: 10.1097/01.pap.0000131773.16130.aa. PMID: 15220822

Therapy

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159
Barbui T, Tefferi A, Vannucchi AM, Passamonti F, Silver RT, Hoffman R, Verstovsek S, Mesa R, Kiladjian JJ, Hehlmann R, Reiter A, Cervantes F, Harrison C, Mc Mullin MF, Hasselbalch HC, Koschmieder S, Marchetti M, Bacigalupo A, Finazzi G, Kroeger N, Griesshammer M, Birgegard G, Barosi G
Leukemia 2018 May;32(5):1057-1069. Epub 2018 Feb 27 doi: 10.1038/s41375-018-0077-1. PMID: 29515238Free PMC Article
Garvey WT, Mechanick JI, Brett EM, Garber AJ, Hurley DL, Jastreboff AM, Nadolsky K, Pessah-Pollack R, Plodkowski R; Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines
Endocr Pract 2016 Jul;22 Suppl 3:1-203. Epub 2016 May 24 doi: 10.4158/EP161365.GL. PMID: 27219496
Yamato TP, Maher CG, Saragiotto BT, Hancock MJ, Ostelo RW, Cabral CM, Menezes Costa LC, Costa LO
Cochrane Database Syst Rev 2015 Jul 2;2015(7):CD010265. doi: 10.1002/14651858.CD010265.pub2. PMID: 26133923Free PMC Article
Gross A, Kay TM, Paquin JP, Blanchette S, Lalonde P, Christie T, Dupont G, Graham N, Burnie SJ, Gelley G, Goldsmith CH, Forget M, Hoving JL, Brønfort G, Santaguida PL; Cervical Overview Group
Cochrane Database Syst Rev 2015 Jan 28;1(1):CD004250. doi: 10.1002/14651858.CD004250.pub5. PMID: 25629215Free PMC Article

Prognosis

Cavalcoli F, Gallo C, Coltro LA, Rausa E, Cantù P, Invernizzi P, Massironi S
Medicina (Kaunas) 2023 Oct 1;59(10) doi: 10.3390/medicina59101757. PMID: 37893475Free PMC Article
Rogers L, Zhang P, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Brachman D, Jenrette JM, De Groot J, Bovi JA, Werner-Wasik M, Knisely JPS, Mehta MP
J Neurosurg 2018 Jul;129(1):35-47. Epub 2017 Oct 6 doi: 10.3171/2016.11.JNS161170. PMID: 28984517Free PMC Article
Hemmingsen B, Gimenez-Perez G, Mauricio D, Roqué I Figuls M, Metzendorf MI, Richter B
Cochrane Database Syst Rev 2017 Dec 4;12(12):CD003054. doi: 10.1002/14651858.CD003054.pub4. PMID: 29205264Free PMC Article
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article
International Non-Hodgkin's Lymphoma Prognostic Factors Project
N Engl J Med 1993 Sep 30;329(14):987-94. doi: 10.1056/NEJM199309303291402. PMID: 8141877

Clinical prediction guides

Cavalcoli F, Gallo C, Coltro LA, Rausa E, Cantù P, Invernizzi P, Massironi S
Medicina (Kaunas) 2023 Oct 1;59(10) doi: 10.3390/medicina59101757. PMID: 37893475Free PMC Article
Cusimano MC, Vicus D, Pulman K, Maganti M, Bernardini MQ, Bouchard-Fortier G, Laframboise S, May T, Hogen LF, Covens AL, Gien LT, Kupets R, Rouzbahman M, Clarke BA, Mirkovic J, Cesari M, Turashvili G, Zia A, Ene GEV, Ferguson SE
JAMA Surg 2021 Feb 1;156(2):157-164. doi: 10.1001/jamasurg.2020.5060. PMID: 33175109Free PMC Article
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew WP
J Clin Oncol 2011 Sep 1;29(25):3457-65. Epub 2011 Aug 1 doi: 10.1200/JCO.2011.34.7625. PMID: 21810685Free PMC Article

Recent systematic reviews

Shen Y, Shi Q, Nong K, Li S, Yue J, Huang J, Dong B, Beauchamp M, Hao Q
J Cachexia Sarcopenia Muscle 2023 Jun;14(3):1199-1211. Epub 2023 Apr 14 doi: 10.1002/jcsm.13225. PMID: 37057640Free PMC Article
Karam G, Agarwal A, Sadeghirad B, Jalink M, Hitchcock CL, Ge L, Kiflen R, Ahmed W, Zea AM, Milenkovic J, Chedrawe MA, Rabassa M, El Dib R, Goldenberg JZ, Guyatt GH, Boyce E, Johnston BC
BMJ 2023 Mar 29;380:e072003. doi: 10.1136/bmj-2022-072003. PMID: 36990505Free PMC Article
Wong CK, Mak RY, Kwok TS, Tsang JS, Leung MY, Funabashi M, Macedo LG, Dennett L, Wong AY
J Pain 2022 Apr;23(4):509-534. Epub 2021 Aug 24 doi: 10.1016/j.jpain.2021.07.012. PMID: 34450274
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Yamato TP, Maher CG, Saragiotto BT, Hancock MJ, Ostelo RW, Cabral CM, Menezes Costa LC, Costa LO
Cochrane Database Syst Rev 2015 Jul 2;2015(7):CD010265. doi: 10.1002/14651858.CD010265.pub2. PMID: 26133923Free PMC Article

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