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Gastric Neuroendocrine Carcinoma

MedGen UID:
474042
Concept ID:
C3272409
Neoplastic Process
Synonym: Gastric NEC

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the stomach. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [from NCI]

Professional guidelines

PubMed

Kawasaki K, Toshimitsu K, Matano M, Fujita M, Fujii M, Togasaki K, Ebisudani T, Shimokawa M, Takano A, Takahashi S, Ohta Y, Nanki K, Igarashi R, Ishimaru K, Ishida H, Sukawa Y, Sugimoto S, Saito Y, Maejima K, Sasagawa S, Lee H, Kim HG, Ha K, Hamamoto J, Fukunaga K, Maekawa A, Tanabe M, Ishihara S, Hamamoto Y, Yasuda H, Sekine S, Kudo A, Kitagawa Y, Kanai T, Nakagawa H, Sato T
Cell 2020 Nov 25;183(5):1420-1435.e21. Epub 2020 Nov 6 doi: 10.1016/j.cell.2020.10.023. PMID: 33159857
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla JB, Caplin M, O'Toole D, Perren A; Vienna Consensus Conference participants
Neuroendocrinology 2016;103(2):186-94. Epub 2016 Jan 5 doi: 10.1159/000443172. PMID: 26731334

Recent clinical studies

Etiology

Matsueda K, Uedo N, Kitamura M, Shichijo S, Maekawa A, Kanesaka T, Takeuchi Y, Higashino K, Ishihara R, Michida T, Kawano S, Kawahara Y
J Gastroenterol Hepatol 2023 Oct;38(10):1808-1817. Epub 2023 Aug 1 doi: 10.1111/jgh.16309. PMID: 37527834
Chen S, Sun L, Chen H, Li J, Lu C, Yang Y, Sun Y
Histopathology 2023 Nov;83(5):700-711. Epub 2023 Jul 5 doi: 10.1111/his.15002. PMID: 37403531
Xing J, Chen J, You T, Sun Z, Lu T, Cheng Y, Wu H, Bai C
J Neuroendocrinol 2023 Apr;35(4):e13257. Epub 2023 Mar 25 doi: 10.1111/jne.13257. PMID: 36964649
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
Xu B, Chu Y, Hu Q, Song Q
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211055340. doi: 10.1177/15330338211055340. PMID: 34806493Free PMC Article

Diagnosis

Matsueda K, Uedo N, Kitamura M, Shichijo S, Maekawa A, Kanesaka T, Takeuchi Y, Higashino K, Ishihara R, Michida T, Kawano S, Kawahara Y
J Gastroenterol Hepatol 2023 Oct;38(10):1808-1817. Epub 2023 Aug 1 doi: 10.1111/jgh.16309. PMID: 37527834
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Nasr S, Khsiba A, Mahmoudi M, Mohamed AB, Bouasida M, Hamzaoui L
Pan Afr Med J 2022;42:131. Epub 2022 Jun 16 doi: 10.11604/pamj.2022.42.131.34091. PMID: 36060838Free PMC Article
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
Iwamoto M, Gotoda T, Noda Y, Esaki M, Moriyama M, Yoshida N, Takayama T, Kobayashi H, Masuda S
Intern Med 2020 May 15;59(10):1271-1276. Epub 2020 Feb 19 doi: 10.2169/internalmedicine.3961-19. PMID: 32074574Free PMC Article

Therapy

Zhao Y, Yang R, Lu H
Medicine (Baltimore) 2023 Dec 15;102(50):e36568. doi: 10.1097/MD.0000000000036568. PMID: 38115336Free PMC Article
Föhse K, Debisarun PA, Kilic G, van Dodewaard-de Jong JM, Netea MG
J Med Case Rep 2023 Sep 4;17(1):377. doi: 10.1186/s13256-023-04117-3. PMID: 37661259Free PMC Article
Song X, Xie Y, Lou Y
BMC Gastroenterol 2023 Jul 14;23(1):238. doi: 10.1186/s12876-023-02875-4. PMID: 37452300Free PMC Article
Xu BB, He XY, Zhou YB, He QL, Tian YT, Hao HK, Qiu XT, Jiang LX, Zhao G, Li Z, Xu YC, Fu WH, Xue FQ, Li SL, Xu ZK, Zhu ZG, Li Y, Li E, Chen JP, Li HL, Cai LS, Wu D, Li P, Zheng CH, Xie JW, Lu J, Huang CM
Int J Surg 2023 Jun 1;109(6):1668-1676. doi: 10.1097/JS9.0000000000000401. PMID: 37076132Free PMC Article
Yamashita S, Abe H, Kunita A, Yamashita H, Seto Y, Ushiku T
Histopathology 2021 Feb;78(3):381-391. Epub 2020 Sep 26 doi: 10.1111/his.14230. PMID: 32767778

Prognosis

Lin Z, Kwok HF
Cell Death Dis 2022 Oct 1;13(10):840. doi: 10.1038/s41419-022-05294-7. PMID: 36182960Free PMC Article
Li Z, Ren H, Zhao L, Zhang X, Wang T, Sun C, Niu P, Wang W, Fei H, Guo C, Chen Y, Zhao D
Curr Oncol 2022 Jul 11;29(7):4879-4892. doi: 10.3390/curroncol29070387. PMID: 35877247Free PMC Article
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
Xu B, Chu Y, Hu Q, Song Q
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211055340. doi: 10.1177/15330338211055340. PMID: 34806493Free PMC Article
Han D, Li YL, Zhou ZW, Yin F, Chen J, Liu F, Shi YF, Wang W, Zhang Y, Yu XJ, Xu JM, Yang RX, Tian C, Luo J, Tan HY
World J Gastroenterol 2021 Jun 7;27(21):2895-2909. doi: 10.3748/wjg.v27.i21.2895. PMID: 34135560Free PMC Article

Clinical prediction guides

Du D, Xie Y, Li X, Ni Z, Shi J, Huang H
World J Surg Oncol 2023 May 6;21(1):142. doi: 10.1186/s12957-023-03029-2. PMID: 37149679Free PMC Article
Xing J, Chen J, You T, Sun Z, Lu T, Cheng Y, Wu H, Bai C
J Neuroendocrinol 2023 Apr;35(4):e13257. Epub 2023 Mar 25 doi: 10.1111/jne.13257. PMID: 36964649
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
Xu B, Chu Y, Hu Q, Song Q
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211055340. doi: 10.1177/15330338211055340. PMID: 34806493Free PMC Article
Iwamoto M, Gotoda T, Noda Y, Esaki M, Moriyama M, Yoshida N, Takayama T, Kobayashi H, Masuda S
Intern Med 2020 May 15;59(10):1271-1276. Epub 2020 Feb 19 doi: 10.2169/internalmedicine.3961-19. PMID: 32074574Free PMC Article

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