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Gastric Gastrointestinal Stromal Tumor of Uncertain Malignant Potential

MedGen UID:
474055
•Concept ID:
C3272422
•
Neoplastic Process

Definition

A gastrointestinal stromal tumor arising from the stomach. It is characterized by a maximum diameter greater than 5 cm and equal or less than 10 cm and no more than 5 mitotic figures per 50 high power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Gastrointestinal Stromal Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Prevalence and management of gastrointestinal stromal tumors.
Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK
Am Surg 2009 Jan;75(1):55-60. PMID: 19213398

Recent clinical studies

Etiology

Gastrointestinal Glomus Tumors: A Single Institution, 20-Year Retrospective Study.
Zironda A, Grotz TE, Folpe AL, Thiels CA
J Surg Res 2023 Mar;283:982-991. Epub 2022 Dec 10 doi: 10.1016/j.jss.2022.10.070. PMID: 36915027
Gastrointestinal stromal tumors: a 19 year experience.
Rabin I, Chikman B, Lavy R, Sandbank J, Maklakovsky M, Gold-Deutch R, Halpren Z, Wassermann I, Halevy A
Isr Med Assoc J 2009 Feb;11(2):98-102. PMID: 19432038
Prevalence and management of gastrointestinal stromal tumors.
Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK
Am Surg 2009 Jan;75(1):55-60. PMID: 19213398
Gastrointestinal stromal tumors: an ultrastructural study.
Yantiss RK, Rosenberg AE, Selig MK, Nielsen GP
Int J Surg Pathol 2002 Apr;10(2):101-13. doi: 10.1177/106689690201000203. PMID: 12075403
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Gastritis Cystica Profunda: A Rare Disease, a Challenging Diagnosis, and an Uncertain Malignant Potential: A Case Report and Review of the Literature.
De Stefano F, Graziano GMP, Viganò J, Mauro A, Peloso A, Peverada J, Fellegara R, Vanoli A, Faillace GG, Ansaloni L
Medicina (Kaunas) 2023 Oct 4;59(10) doi: 10.3390/medicina59101770. PMID: 37893488Free PMC Article
Gastrointestinal Glomus Tumors: A Single Institution, 20-Year Retrospective Study.
Zironda A, Grotz TE, Folpe AL, Thiels CA
J Surg Res 2023 Mar;283:982-991. Epub 2022 Dec 10 doi: 10.1016/j.jss.2022.10.070. PMID: 36915027
Gastrointestinal stromal tumors: a 19 year experience.
Rabin I, Chikman B, Lavy R, Sandbank J, Maklakovsky M, Gold-Deutch R, Halpren Z, Wassermann I, Halevy A
Isr Med Assoc J 2009 Feb;11(2):98-102. PMID: 19432038
Prevalence and management of gastrointestinal stromal tumors.
Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK
Am Surg 2009 Jan;75(1):55-60. PMID: 19213398
Current clinical and pathologic perspectives on gastric stromal tumors.
Basson MD, Modlin IM, Flynn SD
Surg Gynecol Obstet 1992 Nov;175(5):477-89. PMID: 1440180

Therapy

Prevalence and management of gastrointestinal stromal tumors.
Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK
Am Surg 2009 Jan;75(1):55-60. PMID: 19213398

Prognosis

Gastrointestinal stromal tumors: a 19 year experience.
Rabin I, Chikman B, Lavy R, Sandbank J, Maklakovsky M, Gold-Deutch R, Halpren Z, Wassermann I, Halevy A
Isr Med Assoc J 2009 Feb;11(2):98-102. PMID: 19432038
Prevalence and management of gastrointestinal stromal tumors.
Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK
Am Surg 2009 Jan;75(1):55-60. PMID: 19213398
Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course.
Lasota J, Dansonka-Mieszkowska A, Stachura T, Schneider-Stock R, Kallajoki M, Steigen SE, Sarlomo-Rikala M, Boltze C, Kordek R, Roessner A, Stachura J, Miettinen M
Mod Pathol 2003 Dec;16(12):1257-64. doi: 10.1097/01.MP.0000097365.72526.3E. PMID: 14681327
Gastrointestinal mesenchymal tumors - immunophenotypic classification and survival analysis.
Rudolph P, Chiaravalli AM, Pauser U, Oschlies I, Hillemanns M, Gobbo M, Marichal M, Eusebi V, Höfler H, Capella C, Klöppel G
Virchows Arch 2002 Sep;441(3):238-48. Epub 2002 Jul 6 doi: 10.1007/s00428-002-0673-2. PMID: 12242520
Current clinical and pathologic perspectives on gastric stromal tumors.
Basson MD, Modlin IM, Flynn SD
Surg Gynecol Obstet 1992 Nov;175(5):477-89. PMID: 1440180

Clinical prediction guides

Prevalence and management of gastrointestinal stromal tumors.
Machado-Aranda D, Malamet M, Chang YJ, Jacobs MJ, Ferguson L, Silapaswan S, Goriel Y, Kolachalam R, Mittal VK
Am Surg 2009 Jan;75(1):55-60. PMID: 19213398
Gastrointestinal mesenchymal tumors - immunophenotypic classification and survival analysis.
Rudolph P, Chiaravalli AM, Pauser U, Oschlies I, Hillemanns M, Gobbo M, Marichal M, Eusebi V, Höfler H, Capella C, Klöppel G
Virchows Arch 2002 Sep;441(3):238-48. Epub 2002 Jul 6 doi: 10.1007/s00428-002-0673-2. PMID: 12242520

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