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Colorectal Large Cell Neuroendocrine Carcinoma

MedGen UID:
474241
Concept ID:
C3272608
Neoplastic Process
Synonym: Large Intestinal Large Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon or rectum. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518
Zamecnik J, Kodet R
Virchows Arch 2002 Apr;440(4):353-61. Epub 2001 Oct 19 doi: 10.1007/s00428-001-0552-2. PMID: 11956814
Kemeny N, Schneider A
Curr Probl Cancer 1989 Jul-Aug;13(4):197-283. doi: 10.1016/0147-0272(89)90007-x. PMID: 2548812

Recent clinical studies

Etiology

Shamir ER, Devine WP, Pekmezci M, Umetsu SE, Krings G, Federman S, Cho SJ, Saunders TA, Jen KY, Bergsland E, Jones K, Kim GE, Kakar S, Chiu CY, Joseph NM
Mod Pathol 2019 Feb;32(2):290-305. Epub 2018 Sep 20 doi: 10.1038/s41379-018-0131-6. PMID: 30237525
Pattison DA, Bozin M, Gorelik A, Hofman MS, Hicks RJ, Skandarajah A
J Nucl Med 2018 May;59(5):749-755. Epub 2017 Oct 12 doi: 10.2967/jnumed.117.198085. PMID: 29025986
Stoner P, Ghaffaripour T, Cohen D
BMJ Case Rep 2017 Aug 7;2017 doi: 10.1136/bcr-2017-220093. PMID: 28790093Free PMC Article
Kang JH, Kim SH, Han JK
Eur Radiol 2017 Sep;27(9):3867-3876. Epub 2017 Feb 16 doi: 10.1007/s00330-017-4764-5. PMID: 28210802
Schottenfeld D, Beebe-Dimmer JL, Vigneau FD
Ann Epidemiol 2009 Jan;19(1):58-69. doi: 10.1016/j.annepidem.2008.10.004. PMID: 19064190Free PMC Article

Diagnosis

Wang Y, Jin Y, Shen X, Zheng Q, Xue Q, Chen L, Lin Y, Li Y
Am J Surg Pathol 2023 Sep 1;47(9):1059-1066. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002081. PMID: 37357936
Fukushima N, Furukawa K, Takano Y, Suzuki T, Yoshinobu M, Hanyu K, Kobayashi S
Asian J Endosc Surg 2022 Apr;15(2):405-409. Epub 2022 Jan 9 doi: 10.1111/ases.13025. PMID: 35001529
Inoue H, Matsushima J, Kobayashi S, Sairenchi T, Hirata H, Chida M, Ota S, Ban S, Matsumura Y
Int J Surg Pathol 2022 Apr;30(2):151-159. Epub 2021 Dec 16 doi: 10.1177/10668969211065757. PMID: 34913369
Kang JH, Kim SH, Han JK
Eur Radiol 2017 Sep;27(9):3867-3876. Epub 2017 Feb 16 doi: 10.1007/s00330-017-4764-5. PMID: 28210802
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813

Therapy

Chen X, Wang X, Abadi M, Kumar A
Clin Colorectal Cancer 2020 Mar;19(1):61-64. Epub 2019 Oct 31 doi: 10.1016/j.clcc.2019.10.005. PMID: 31761668
Fields AC, Lu P, Vierra BM, Hu F, Irani J, Bleday R, Goldberg JE, Nash GM, Melnitchouk N
Ann Surg Oncol 2019 Apr;26(4):1127-1133. Epub 2019 Jan 31 doi: 10.1245/s10434-019-07203-3. PMID: 30706232Free PMC Article
Stoner P, Ghaffaripour T, Cohen D
BMJ Case Rep 2017 Aug 7;2017 doi: 10.1136/bcr-2017-220093. PMID: 28790093Free PMC Article
Burón Pust A, Alison R, Blanks R, Pirie K, Gaitskell K, Barnes I, Gathani T, Reeves G, Beral V, Green J; Million Women Study Collaborators
Int J Cancer 2017 Mar 1;140(5):1082-1090. doi: 10.1002/ijc.30527. PMID: 27859268Free PMC Article
Kemeny N, Schneider A
Curr Probl Cancer 1989 Jul-Aug;13(4):197-283. doi: 10.1016/0147-0272(89)90007-x. PMID: 2548812

Prognosis

Wu H, Yu Z, Liu Y, Guo L, Teng L, Guo L, Liang L, Wang J, Gao J, Li R, Yang L, Nie X, Su D, Liang Z
Cancer Commun (Lond) 2022 Dec;42(12):1367-1386. Epub 2022 Oct 20 doi: 10.1002/cac2.12372. PMID: 36264285Free PMC Article
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Chetty R, Capo-Chichi JM, Serra S
Histopathology 2019 Aug;75(2):247-253. Epub 2019 Jul 2 doi: 10.1111/his.13875. PMID: 30990915
Kang JH, Kim SH, Han JK
Eur Radiol 2017 Sep;27(9):3867-3876. Epub 2017 Feb 16 doi: 10.1007/s00330-017-4764-5. PMID: 28210802
Schottenfeld D, Beebe-Dimmer JL, Vigneau FD
Ann Epidemiol 2009 Jan;19(1):58-69. doi: 10.1016/j.annepidem.2008.10.004. PMID: 19064190Free PMC Article

Clinical prediction guides

Wang Y, Jin Y, Shen X, Zheng Q, Xue Q, Chen L, Lin Y, Li Y
Am J Surg Pathol 2023 Sep 1;47(9):1059-1066. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002081. PMID: 37357936
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
Park JG, Gazdar AF
J Cell Biochem Suppl 1996;24:131-41. doi: 10.1002/jcb.240630508. PMID: 8806095

Recent systematic reviews

Girardi DM, Silva ACB, Rêgo JFM, Coudry RA, Riechelmann RP
Cancer Treat Rev 2017 May;56:28-35. Epub 2017 Apr 17 doi: 10.1016/j.ctrv.2017.04.002. PMID: 28456055

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