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Colorectal Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
474242
•Concept ID:
C3272609
•
Neoplastic Process
Synonym: Colorectal MANEC

Definition

A carcinoma that arises from the colon or rectum and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.
Jesinghaus M, Schmitt M, Lang C, Reiser M, Scheiter A, Konukiewitz B, Steiger K, Silva M, Tschurtschenthaler M, Lange S, Foersch S, Becker KF, Saur D, Friess H, Halfter K, Engel J, Boxberg M, Pfarr N, Wilhelm D, Weichert W
Am J Surg Pathol 2021 Jul 1;45(7):969-978. doi: 10.1097/PAS.0000000000001692. PMID: 34105518

Recent clinical studies

Diagnosis

Diagnosis, Assessment, and Therapeutic Strategy for Colorectal Mixed Adenoneuroendocrine Carcinoma.
Tanaka T, Kaneko M, Nozawa H, Emoto S, Murono K, Otani K, Sasaki K, Nishikawa T, Kiyomatsu T, Hata K, Morikawa T, Kawai K, Watanabe T
Neuroendocrinology 2017;105(4):426-434. Epub 2017 Jun 23 doi: 10.1159/000478743. PMID: 28641295

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