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Appendix High Grade Intraepithelial Neoplasia

MedGen UID:
474398
Concept ID:
C3272765
Neoplastic Process
Synonyms: Appendiceal High Grade Dysplasia; Appendiceal High Grade Intraepithelial Neoplasia; Appendix High Grade Dysplasia

Definition

A precancerous intraepithelial neoplastic lesion that affects the appendix. It is characterized by the presence of moderate or severe dysplasia and complex architectural alterations of the mucosal epithelium. There is no evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix High Grade Intraepithelial Neoplasia

Professional guidelines

PubMed

Levine M, Moutquin JM, Walton R, Feightner J; Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
CMAJ 2001 Jun 12;164(12):1681-90. PMID: 11450210Free PMC Article

Recent clinical studies

Etiology

Akita M, Yanagimoto H, Tsugawa D, Ajiki T, Masuda A, Komatsu M, Goto T, Kido M, Toyama H, Fukumoto T
Clin J Gastroenterol 2023 Jun;16(3):476-481. Epub 2023 Mar 3 doi: 10.1007/s12328-023-01778-x. PMID: 36867354
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Levine M, Moutquin JM, Walton R, Feightner J; Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
CMAJ 2001 Jun 12;164(12):1681-90. PMID: 11450210Free PMC Article

Diagnosis

Bennett C, Green S, DeCaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2020 May 22;5(5):CD007334. doi: 10.1002/14651858.CD007334.pub5. PMID: 32442322Free PMC Article
Liu X, Liu G, Liu Y, Zhou H, Yu L, Xu Y, Song X, Zhang J
BMC Surg 2019 Nov 11;19(1):168. doi: 10.1186/s12893-019-0632-3. PMID: 31711462Free PMC Article
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Bennett C, Green S, Decaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2012 Nov 14;11:CD007334. doi: 10.1002/14651858.CD007334.pub4. PMID: 23152243
Bennett C, Green S, Barr H, Bhandari P, Decaestecker J, Ragunath K, Singh R, Tawil A, Jankowski J
Cochrane Database Syst Rev 2010 May 12;(5):CD007334. doi: 10.1002/14651858.CD007334.pub3. PMID: 20464752

Therapy

Bennett C, Green S, DeCaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2020 May 22;5(5):CD007334. doi: 10.1002/14651858.CD007334.pub5. PMID: 32442322Free PMC Article
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Bennett C, Green S, Decaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2012 Nov 14;11:CD007334. doi: 10.1002/14651858.CD007334.pub4. PMID: 23152243
Bennett C, Green S, Barr H, Bhandari P, Decaestecker J, Ragunath K, Singh R, Tawil A, Jankowski J
Cochrane Database Syst Rev 2010 May 12;(5):CD007334. doi: 10.1002/14651858.CD007334.pub3. PMID: 20464752
Green S, Tawil A, Barr H, Bennett C, Bhandari P, Decaestecker J, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2009 Apr 15;(2):CD007334. doi: 10.1002/14651858.CD007334.pub2. PMID: 19370683

Prognosis

Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article

Clinical prediction guides

Akita M, Yanagimoto H, Tsugawa D, Ajiki T, Masuda A, Komatsu M, Goto T, Kido M, Toyama H, Fukumoto T
Clin J Gastroenterol 2023 Jun;16(3):476-481. Epub 2023 Mar 3 doi: 10.1007/s12328-023-01778-x. PMID: 36867354

Recent systematic reviews

Bennett C, Green S, DeCaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2020 May 22;5(5):CD007334. doi: 10.1002/14651858.CD007334.pub5. PMID: 32442322Free PMC Article
Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group
Lancet 2019 Aug 10;394(10197):497-509. Epub 2019 Jun 26 doi: 10.1016/S0140-6736(19)30298-3. PMID: 31255301Free PMC Article
Bennett C, Green S, Decaestecker J, Almond M, Barr H, Bhandari P, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2012 Nov 14;11:CD007334. doi: 10.1002/14651858.CD007334.pub4. PMID: 23152243
Bennett C, Green S, Barr H, Bhandari P, Decaestecker J, Ragunath K, Singh R, Tawil A, Jankowski J
Cochrane Database Syst Rev 2010 May 12;(5):CD007334. doi: 10.1002/14651858.CD007334.pub3. PMID: 20464752
Green S, Tawil A, Barr H, Bennett C, Bhandari P, Decaestecker J, Ragunath K, Singh R, Jankowski J
Cochrane Database Syst Rev 2009 Apr 15;(2):CD007334. doi: 10.1002/14651858.CD007334.pub2. PMID: 19370683

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