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Colon sessile serrated adenoma/polyp

MedGen UID:
474424
•Concept ID:
C3272791
•
Neoplastic Process
Synonyms: Colon Serrated Lesions and Polyps; Colon Sessile Serrated Adenoma; colon sessile serrated adenoma; Colon Sessile Serrated Adenoma/Polyp; colon sessile serrated adenoma/polyp; Colon Sessile Serrated Polyp; colon sessile serrated polyp; Colon SSA; colon SSA; Colon SSA/P; colon SSA/P; Colon SSP; colon SSP; Sessile serrated adenoma of colon; Sessile serrated colon polyp; Sessile serrated polyp of colon
SNOMED CT: Sessile serrated polyp of colon (1230009008); Sessile serrated adenoma of colon (1230009008); Sessile serrated colon polyp (1230009008)
 
Monarch Initiative: MONDO:0006156

Definition

Polyps that arise from the colon, and are characterized by the presence of serrated glands and the absence of generalized dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon sessile serrated adenoma/polyp

Professional guidelines

PubMed

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management.
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Prospective evaluation of endoscopic criteria characteristic of sessile serrated adenomas/polyps.
Uraoka T, Higashi R, Horii J, Harada K, Hori K, Okada H, Mizuno M, Tomoda J, Ohara N, Tanaka T, Chiu HM, Yahagi N, Yamamoto K
J Gastroenterol 2015 May;50(5):555-63. Epub 2014 Oct 1 doi: 10.1007/s00535-014-0999-y. PMID: 25270966

Recent clinical studies

Etiology

Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Cold snare polypectomy: Indications, devices, techniques, outcomes and future.
Horiuchi A, Ikuse T, Tanaka N
Dig Endosc 2019 Jul;31(4):372-377. Epub 2019 Jan 8 doi: 10.1111/den.13314. PMID: 30549318
Clinical and endoscopic evaluations of sessile serrated adenoma/polyps with cytological dysplasia.
Sano W, Fujimori T, Ichikawa K, Sunakawa H, Utsumi T, Iwatate M, Hasuike N, Hattori S, Kosaka H, Sano Y
J Gastroenterol Hepatol 2018 Aug;33(8):1454-1460. Epub 2018 Mar 25 doi: 10.1111/jgh.14099. PMID: 29377243
Serrated Polyps of Colon and Rectum: a Clinicopathologic Review.
Geramizadeh B, Robertson S
J Gastrointest Cancer 2017 Dec;48(4):291-298. doi: 10.1007/s12029-017-9977-y. PMID: 28639142
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827

Diagnosis

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management.
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Endoscopic diagnosis of sessile serrated adenoma/polyp with and without dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
World J Gastroenterol 2018 Aug 7;24(29):3250-3259. doi: 10.3748/wjg.v24.i29.3250. PMID: 30090005Free PMC Article
Sessile serrated adenoma/polyps: Where are we at in 2016?
Singh R, Zorrón Cheng Tao Pu L, Koay D, Burt A
World J Gastroenterol 2016 Sep 14;22(34):7754-9. doi: 10.3748/wjg.v22.i34.7754. PMID: 27678358Free PMC Article

Therapy

Sessile serrated adenoma/polyp detection rate of water exchange, Endocuff, and cap colonoscopy: A network meta-analysis.
Shao PP, Shao CR, Romero T, Leung FW
J Gastroenterol Hepatol 2021 Dec;36(12):3268-3277. Epub 2021 Oct 25 doi: 10.1111/jgh.15702. PMID: 34622488
Improving serrated adenoma detection rate in the colon by electronic chromoendoscopy and distal attachment: systematic review and meta-analysis.
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Clinicopathological features, diagnosis, and treatment of sessile serrated adenoma/polyp with dysplasia/carcinoma.
Murakami T, Sakamoto N, Nagahara A
J Gastroenterol Hepatol 2019 Oct;34(10):1685-1695. Epub 2019 Jun 30 doi: 10.1111/jgh.14752. PMID: 31158302
Impact of an Endoscopic Quality Improvement Program Focused on Adenoma Detection on Sessile Serrated Adenoma/Polyp Detection.
Racho RG, Krishna M, Coe SG, Thomas CS, Crook JE, Diehl NN, Wallace MB
Dig Dis Sci 2017 Jun;62(6):1464-1471. Epub 2017 Apr 25 doi: 10.1007/s10620-017-4582-2. PMID: 28444509
Impact of cap-assisted colonoscopy on detection of proximal colon adenomas: systematic review and meta-analysis.
Desai M, Sanchez-Yague A, Choudhary A, Pervez A, Gupta N, Vennalaganti P, Vennelaganti S, Fugazza A, Repici A, Hassan C, Sharma P
Gastrointest Endosc 2017 Aug;86(2):274-281.e3. Epub 2017 Mar 29 doi: 10.1016/j.gie.2017.03.1524. PMID: 28365356

Prognosis

Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study.
Murakami T, Akazawa Y, Yatagai N, Hiromoto T, Sasahara N, Saito T, Sakamoto N, Nagahara A, Yao T
Diagn Pathol 2018 Nov 20;13(1):88. doi: 10.1186/s13000-018-0771-3. PMID: 30458818Free PMC Article
Clinical and endoscopic evaluations of sessile serrated adenoma/polyps with cytological dysplasia.
Sano W, Fujimori T, Ichikawa K, Sunakawa H, Utsumi T, Iwatate M, Hasuike N, Hattori S, Kosaka H, Sano Y
J Gastroenterol Hepatol 2018 Aug;33(8):1454-1460. Epub 2018 Mar 25 doi: 10.1111/jgh.14099. PMID: 29377243
Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps.
Ponugoti P, Lin J, Odze R, Snover D, Kahi C, Rex DK
Gastrointest Endosc 2017 Mar;85(3):622-627. Epub 2016 Oct 19 doi: 10.1016/j.gie.2016.10.022. PMID: 27771216
Advantages of magnifying narrow-band imaging for diagnosing colorectal cancer coexisting with sessile serrated adenoma/polyp.
Chino A, Osumi H, Kishihara T, Morishige K, Ishikawa H, Tamegai Y, Igarashi M
Dig Endosc 2016 Apr;28 Suppl 1:53-9. doi: 10.1111/den.12631. PMID: 26864801
Loss of Hes1 Differentiates Sessile Serrated Adenoma/Polyp From Hyperplastic Polyp.
Cui M, Awadallah A, Liu W, Zhou L, Xin W
Am J Surg Pathol 2016 Jan;40(1):113-9. doi: 10.1097/PAS.0000000000000531. PMID: 26448192Free PMC Article

Clinical prediction guides

Sessile serrated adenoma/polyp detection rate of water exchange, Endocuff, and cap colonoscopy: A network meta-analysis.
Shao PP, Shao CR, Romero T, Leung FW
J Gastroenterol Hepatol 2021 Dec;36(12):3268-3277. Epub 2021 Oct 25 doi: 10.1111/jgh.15702. PMID: 34622488
Clinical and endoscopic evaluations of sessile serrated adenoma/polyps with cytological dysplasia.
Sano W, Fujimori T, Ichikawa K, Sunakawa H, Utsumi T, Iwatate M, Hasuike N, Hattori S, Kosaka H, Sano Y
J Gastroenterol Hepatol 2018 Aug;33(8):1454-1460. Epub 2018 Mar 25 doi: 10.1111/jgh.14099. PMID: 29377243
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Prevalence of sessile serrated adenoma/polyp in hyperplastic-appearing diminutive rectosigmoid polyps.
Ponugoti P, Lin J, Odze R, Snover D, Kahi C, Rex DK
Gastrointest Endosc 2017 Mar;85(3):622-627. Epub 2016 Oct 19 doi: 10.1016/j.gie.2016.10.022. PMID: 27771216
Loss of Hes1 Differentiates Sessile Serrated Adenoma/Polyp From Hyperplastic Polyp.
Cui M, Awadallah A, Liu W, Zhou L, Xin W
Am J Surg Pathol 2016 Jan;40(1):113-9. doi: 10.1097/PAS.0000000000000531. PMID: 26448192Free PMC Article

Recent systematic reviews

Improving serrated adenoma detection rate in the colon by electronic chromoendoscopy and distal attachment: systematic review and meta-analysis.
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Impact of cap-assisted colonoscopy on detection of proximal colon adenomas: systematic review and meta-analysis.
Desai M, Sanchez-Yague A, Choudhary A, Pervez A, Gupta N, Vennalaganti P, Vennelaganti S, Fugazza A, Repici A, Hassan C, Sharma P
Gastrointest Endosc 2017 Aug;86(2):274-281.e3. Epub 2017 Mar 29 doi: 10.1016/j.gie.2017.03.1524. PMID: 28365356

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