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Colon Serrated Adenocarcinoma

MedGen UID:
474443
•Concept ID:
C3272810
•
Neoplastic Process

Definition

A rare, invasive colon adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Serrated Adenocarcinoma

Professional guidelines

PubMed

Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp.
Boylan KE, Kanth P, Delker D, Hazel MW, Boucher KM, Affolter K, Clayton F, Evason KJ, Jedrzkiewicz J, Pletneva M, Samowitz W, Swanson E, Bronner MP
Hum Pathol 2023 Jul;137:25-35. Epub 2023 Apr 11 doi: 10.1016/j.humpath.2023.04.002. PMID: 37044202Free PMC Article
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Bowel cancer screening-generated diagnostic conundrum of the century: pseudoinvasion in sigmoid colonic polyps.
Shepherd NA, Griggs RK
Mod Pathol 2015 Jan;28 Suppl 1:S88-94. doi: 10.1038/modpathol.2014.138. PMID: 25560603

Recent clinical studies

Etiology

Exploring the spectrum of serrated epithelium encountered in inflammatory bowel disease.
Waters KM, Singhi AD, Montgomery EA
Hum Pathol 2023 Feb;132:126-134. Epub 2022 Jun 23 doi: 10.1016/j.humpath.2022.06.018. PMID: 35753410
The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
An Update on Inherited Colon Cancer and Gastrointestinal Polyposis.
Plevová P
Klin Onkol 2019 Summer;32(Supplementum2):97-108. doi: 10.14735/amko2019S97. PMID: 31409085
Sessile serrated adenoma: from identification to resection.
Bordaçahar B, Barret M, Terris B, Dhooge M, Dreanic J, Prat F, Coriat R, Chaussade S
Dig Liver Dis 2015 Feb;47(2):95-102. Epub 2014 Oct 25 doi: 10.1016/j.dld.2014.09.006. PMID: 25445408
Serrated pathway in colorectal carcinogenesis.
Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP
World J Gastroenterol 2014 Mar 14;20(10):2634-40. doi: 10.3748/wjg.v20.i10.2634. PMID: 24627599Free PMC Article

Diagnosis

Clinical, pathological genetics and intratumoral immune milieu of serrated adenocarcinoma of the colon.
Yılmaz O, Crabbe A, Neyaz A, Pankaj A, Lee SH, Hosseini S, Rickelt S, Cerda S, Zhao Q, Leijsen L, Dineaux A, Shroff SG, Crotty R, Zhang ML, Yilmaz OH, Patil DT, Berger D, Deshpande V
Histopathology 2022 Sep;81(3):380-388. Epub 2022 Jul 20 doi: 10.1111/his.14719. PMID: 35789111
The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
The histomorphological and molecular landscape of colorectal adenomas and serrated lesions.
Galuppini F, Fassan M, Mastracci L, Gafà R, Lo Mele M, Lazzi S, Remo A, Parente P, D'Amuri A, Mescoli C, Tatangelo F, Lanza G
Pathologica 2021 Jun;113(3):218-229. doi: 10.32074/1591-951X-270. PMID: 34294939Free PMC Article
An Update on Inherited Colon Cancer and Gastrointestinal Polyposis.
Plevová P
Klin Onkol 2019 Summer;32(Supplementum2):97-108. doi: 10.14735/amko2019S97. PMID: 31409085
The pathology of bowel cancer screening.
Loughrey MB, Shepherd NA
Histopathology 2015 Jan;66(1):66-77. doi: 10.1111/his.12530. PMID: 25123305

Therapy

Endoluminal management of colon perforations during advanced endoscopic procedures.
Ozgur I, Yilmaz S, Bhatt A, Holubar SD, Steele SR, Gorgun E
Surgery 2023 Mar;173(3):687-692. Epub 2022 Oct 18 doi: 10.1016/j.surg.2022.07.040. PMID: 36266121
Timed screening colonoscopy: a randomized trial of two colonoscopic withdrawal techniques.
Coghlan E, Laferrere L, Zenon E, Marini JM, Rainero G, San Roman A, Posadas Martinez ML, Nadales A
Surg Endosc 2020 Mar;34(3):1200-1205. Epub 2019 May 29 doi: 10.1007/s00464-019-06873-0. PMID: 31144121
Smoking and Other Risk Factors in Individuals With Synchronous Conventional High-Risk Adenomas and Clinically Significant Serrated Polyps.
Anderson JC, Calderwood AH, Christensen BC, Robinson CM, Amos CI, Butterly L
Am J Gastroenterol 2018 Dec;113(12):1828-1835. Epub 2018 Nov 1 doi: 10.1038/s41395-018-0393-0. PMID: 30385834Free PMC Article
Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma.
Wang Y, Huang D, Chen KY, Cui M, Wang W, Huang X, Awadellah A, Li Q, Friedman A, Xin WW, Di Martino L, Cominelli F, Miron A, Chan R, Fox JG, Xu Y, Shen X, Kalady MF, Markowitz S, Maillard I, Lowe JB, Xin W, Zhou L
Gastroenterology 2017 Jan;152(1):193-205.e10. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.004. PMID: 27639802Free PMC Article
Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features.
Missiaglia E, Jacobs B, D'Ario G, Di Narzo AF, Soneson C, Budinska E, Popovici V, Vecchione L, Gerster S, Yan P, Roth AD, Klingbiel D, Bosman FT, Delorenzi M, Tejpar S
Ann Oncol 2014 Oct;25(10):1995-2001. Epub 2014 Jul 23 doi: 10.1093/annonc/mdu275. PMID: 25057166

Prognosis

Clinical, pathological genetics and intratumoral immune milieu of serrated adenocarcinoma of the colon.
Yılmaz O, Crabbe A, Neyaz A, Pankaj A, Lee SH, Hosseini S, Rickelt S, Cerda S, Zhao Q, Leijsen L, Dineaux A, Shroff SG, Crotty R, Zhang ML, Yilmaz OH, Patil DT, Berger D, Deshpande V
Histopathology 2022 Sep;81(3):380-388. Epub 2022 Jul 20 doi: 10.1111/his.14719. PMID: 35789111
The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival.
Lee CT, Huang YC, Hung LY, Chow NH, Su PF, Ho CL, Tsai HW, Chen YL, Lin SC, Lin BW, Lin PC, Lee JC
Oncotarget 2017 May 23;8(21):35165-35175. doi: 10.18632/oncotarget.16815. PMID: 28422723Free PMC Article
Serrated pathway in colorectal carcinogenesis.
Yamane L, Scapulatempo-Neto C, Reis RM, Guimarães DP
World J Gastroenterol 2014 Mar 14;20(10):2634-40. doi: 10.3748/wjg.v20.i10.2634. PMID: 24627599Free PMC Article

Clinical prediction guides

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Hereditary gastrointestinal carcinomas and their precursors: An algorithm for genetic testing.
Spoto CPE, Gullo I, Carneiro F, Montgomery EA, Brosens LAA
Semin Diagn Pathol 2018 May;35(3):170-183. Epub 2018 Jan 31 doi: 10.1053/j.semdp.2018.01.004. PMID: 29397239
Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival.
Lee CT, Huang YC, Hung LY, Chow NH, Su PF, Ho CL, Tsai HW, Chen YL, Lin SC, Lin BW, Lin PC, Lee JC
Oncotarget 2017 May 23;8(21):35165-35175. doi: 10.18632/oncotarget.16815. PMID: 28422723Free PMC Article
UK guidance for the pathological reporting of serrated lesions of the colorectum.
Bateman AC, Shepherd NA
J Clin Pathol 2015 Aug;68(8):585-91. Epub 2015 Apr 30 doi: 10.1136/jclinpath-2015-203016. PMID: 25934843
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article

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