U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hepatocellular Small Cell Change

MedGen UID:
474647
Concept ID:
C3273014
Finding
Synonym: Small Cell Dysplasia

Definition

A premalignant neoplastic lesion of the liver. It is characterized by the presence of hepatocytes with decreased cell volume, increased nuclear/cytoplasmic ratio, basophilia, mild nuclear pleomorphism, and hyperchromasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatocellular Small Cell Change

Professional guidelines

PubMed

Akhbariyoon H, Azizpour Y, Esfahani MF, Firoozabad MSM, Rad MR, Esfahani KS, Khoshavi N, Karimi N, Shirinisaz A, Abedi F, Rad MR, Sharifi P
Clin Immunol 2021 Nov;232:108873. Epub 2021 Oct 21 doi: 10.1016/j.clim.2021.108873. PMID: 34688855
Khwairakpam AD, Shyamananda MS, Sailo BL, Rathnakaram SR, Padmavathi G, Kotoky J, Kunnumakkara AB
Curr Drug Targets 2015;16(2):156-63. doi: 10.2174/1389450115666141224125117. PMID: 25537655
Karkar AM, Tang LH, Kashikar ND, Gonen M, Solomon SB, Dematteo RP, D' Angelica MI, Correa-Gallego C, Jarnagin WR, Fong Y, Getrajdman GI, Allen P, Kingham TP
HPB (Oxford) 2013 Mar;15(3):235-43. Epub 2012 Oct 9 doi: 10.1111/j.1477-2574.2012.00584.x. PMID: 23374365Free PMC Article

Recent clinical studies

Etiology

Nalbant MA, Eroğlu O
Cell Mol Biol (Noisy-le-grand) 2023 Apr 30;69(4):60-69. doi: 10.14715/cmb/2023.69.4.9. PMID: 37329547
Chen D, Li Z, Zhu W, Cheng Q, Song Q, Qian L, Zhu JY
J Clin Pathol 2019 Apr;72(4):295-303. Epub 2019 Jan 4 doi: 10.1136/jclinpath-2018-205611. PMID: 30610005
Niu ZS, Niu XJ, Wang WH, Zhao J
World J Gastroenterol 2016 Mar 28;22(12):3305-14. doi: 10.3748/wjg.v22.i12.3305. PMID: 27022212Free PMC Article
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Seitz HK, Pöschl G, Simanowski UA
Recent Dev Alcohol 1998;14:67-95. doi: 10.1007/0-306-47148-5_4. PMID: 9751943

Diagnosis

Hochreuter MY, Dall M, Treebak JT, Barrès R
Mol Metab 2022 Nov;65:101581. Epub 2022 Aug 23 doi: 10.1016/j.molmet.2022.101581. PMID: 36028120Free PMC Article
Tanaka A
Clin Mol Hepatol 2021 Jan;27(1):1-21. Epub 2020 Dec 3 doi: 10.3350/cmh.2020.0028. PMID: 33264835Free PMC Article
Choi WT, Kakar S
Adv Anat Pathol 2018 Jul;25(4):254-262. doi: 10.1097/PAP.0000000000000189. PMID: 29649004
Niu ZS, Niu XJ, Wang WH, Zhao J
World J Gastroenterol 2016 Mar 28;22(12):3305-14. doi: 10.3748/wjg.v22.i12.3305. PMID: 27022212Free PMC Article
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article

Therapy

Hack SP, Zhu AX, Wang Y
Front Immunol 2020;11:598877. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.598877. PMID: 33250900Free PMC Article
Giannone G, Ghisoni E, Genta S, Scotto G, Tuninetti V, Turinetto M, Valabrega G
Int J Mol Sci 2020 Jun 21;21(12) doi: 10.3390/ijms21124414. PMID: 32575899Free PMC Article
Russo FP, Imondi A, Lynch EN, Farinati F
Dig Liver Dis 2018 Jul;50(7):640-646. Epub 2018 Mar 20 doi: 10.1016/j.dld.2018.03.014. PMID: 29636240
Muntané J, De la Rosa AJ, Docobo F, García-Carbonero R, Padillo FJ
Curr Cancer Drug Targets 2013 Mar;13(3):300-12. doi: 10.2174/15680096113139990075. PMID: 23016985
Seitz HK, Pöschl G, Simanowski UA
Recent Dev Alcohol 1998;14:67-95. doi: 10.1007/0-306-47148-5_4. PMID: 9751943

Prognosis

Shi F, Wu Y, Wang K, Wang J, Liu M, Sun X
J Cell Mol Med 2023 Nov;27(21):3296-3312. Epub 2023 Aug 8 doi: 10.1111/jcmm.17900. PMID: 37551845Free PMC Article
Hochreuter MY, Dall M, Treebak JT, Barrès R
Mol Metab 2022 Nov;65:101581. Epub 2022 Aug 23 doi: 10.1016/j.molmet.2022.101581. PMID: 36028120Free PMC Article
Tanaka A
Clin Mol Hepatol 2021 Jan;27(1):1-21. Epub 2020 Dec 3 doi: 10.3350/cmh.2020.0028. PMID: 33264835Free PMC Article
Hack SP, Zhu AX, Wang Y
Front Immunol 2020;11:598877. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.598877. PMID: 33250900Free PMC Article
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article

Clinical prediction guides

Shi F, Wu Y, Wang K, Wang J, Liu M, Sun X
J Cell Mol Med 2023 Nov;27(21):3296-3312. Epub 2023 Aug 8 doi: 10.1111/jcmm.17900. PMID: 37551845Free PMC Article
Hack SP, Zhu AX, Wang Y
Front Immunol 2020;11:598877. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.598877. PMID: 33250900Free PMC Article
Chen D, Li Z, Zhu W, Cheng Q, Song Q, Qian L, Zhu JY
J Clin Pathol 2019 Apr;72(4):295-303. Epub 2019 Jan 4 doi: 10.1136/jclinpath-2018-205611. PMID: 30610005
Yu FX, Meng Z, Plouffe SW, Guan KL
Annu Rev Physiol 2015;77:201-27. Epub 2014 Sep 29 doi: 10.1146/annurev-physiol-021014-071733. PMID: 25293527
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article

Recent systematic reviews

Kim MJ, Hong SPD, Park Y, Chae YK
Cancer Med 2024 Feb;13(3):e6970. doi: 10.1002/cam4.6970. PMID: 38400685Free PMC Article
Son J, Hsieh RC, Lin HY, Krause KJ, Yuan Y, Biter AB, Welsh J, Curran MA, Hong DS
Front Immunol 2022;13:1027235. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1027235. PMID: 36439116Free PMC Article
Van de Wiele C, Sathekge M, de Spiegeleer B, de Jonghe PJ, Beels L, Maes A
Int J Mol Sci 2019 Oct 2;20(19) doi: 10.3390/ijms20194886. PMID: 31581638Free PMC Article
Zhang Q, Wang Q, Sun W, Gao F, Liu L, Cheng L, Li Z
Biomed Res Int 2018;2018:6124927. Epub 2018 Nov 25 doi: 10.1155/2018/6124927. PMID: 30596096Free PMC Article
Kapp N, Curtis KM
Contraception 2009 Oct;80(4):387-90. Epub 2009 Jun 10 doi: 10.1016/j.contraception.2009.01.021. PMID: 19751862

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...