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Early Hepatocellular Carcinoma

MedGen UID:
474652
•Concept ID:
C3273019
•
Neoplastic Process

Definition

A low grade, well differentiated small hepatocellular carcinoma. It lacks obvious stromal invasion and significant atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Hepatocellular Carcinoma

Professional guidelines

PubMed

Liquid biopsy in the clinical management of hepatocellular carcinoma.
von Felden J, Garcia-Lezana T, Schulze K, Losic B, Villanueva A
Gut 2020 Nov;69(11):2025-2034. Epub 2020 Sep 3 doi: 10.1136/gutjnl-2019-320282. PMID: 32883873
Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management.
Huang TD, Behary J, Zekry A
Intern Med J 2020 Sep;50(9):1038-1047. doi: 10.1111/imj.14709. PMID: 31760676
Management of people with early- or very early-stage hepatocellular carcinoma: an attempted network meta-analysis.
Majumdar A, Roccarina D, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 28;3(3):CD011650. doi: 10.1002/14651858.CD011650.pub2. PMID: 28351116Free PMC Article

Recent clinical studies

Etiology

An automated and mobile magnetoresistive biosensor system for early hepatocellular carcinoma diagnosis.
Yao C, Ng E, Wang SX
Biosens Bioelectron 2022 Apr 15;202:113982. Epub 2022 Jan 10 doi: 10.1016/j.bios.2022.113982. PMID: 35033828
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma.
Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H, Xie H, Chen X, Shao L, Zhang R, Xu S, Zhang H, Cui G, Chen X, Sun R, Wen H, Lerut JP, Kan Q, Li L, Zheng S
Gut 2019 Jun;68(6):1014-1023. Epub 2018 Jul 25 doi: 10.1136/gutjnl-2017-315084. PMID: 30045880Free PMC Article
Management of people with early- or very early-stage hepatocellular carcinoma: an attempted network meta-analysis.
Majumdar A, Roccarina D, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 28;3(3):CD011650. doi: 10.1002/14651858.CD011650.pub2. PMID: 28351116Free PMC Article
Early hepatocellular carcinoma on the procrustean bed of ablation, resection, and transplantation.
Mazzaferro V, Lencioni R, Majno P
Semin Liver Dis 2014 Nov;34(4):415-26. Epub 2014 Nov 4 doi: 10.1055/s-0034-1394365. PMID: 25369303
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Diagnosis

An automated and mobile magnetoresistive biosensor system for early hepatocellular carcinoma diagnosis.
Yao C, Ng E, Wang SX
Biosens Bioelectron 2022 Apr 15;202:113982. Epub 2022 Jan 10 doi: 10.1016/j.bios.2022.113982. PMID: 35033828
AFP-L3 for the diagnosis of early hepatocellular carcinoma: A meta-analysis.
Zhou JM, Wang T, Zhang KH
Medicine (Baltimore) 2021 Oct 29;100(43):e27673. doi: 10.1097/MD.0000000000027673. PMID: 34713864Free PMC Article
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma.
Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H, Xie H, Chen X, Shao L, Zhang R, Xu S, Zhang H, Cui G, Chen X, Sun R, Wen H, Lerut JP, Kan Q, Li L, Zheng S
Gut 2019 Jun;68(6):1014-1023. Epub 2018 Jul 25 doi: 10.1136/gutjnl-2017-315084. PMID: 30045880Free PMC Article
Early hepatocellular carcinoma: pathology, imaging, and therapy.
Takayama T, Makuuchi M, Kojiro M, Lauwers GY, Adams RB, Wilson SR, Jang HJ, Charnsangavej C, Taouli B
Ann Surg Oncol 2008 Apr;15(4):972-8. Epub 2008 Jan 31 doi: 10.1245/s10434-007-9685-0. PMID: 18236118
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Therapy

An overview of stereotactic body radiation therapy for hepatocellular carcinoma.
Kimura T, Doi Y, Takahashi S, Kubo K, Imano N, Takeuchi Y, Takahashi I, Nishibuchi I, Murakami Y, Kenjo M, Nagata Y
Expert Rev Gastroenterol Hepatol 2020 Apr;14(4):271-279. doi: 10.1080/17474124.2020.1744434. PMID: 32223683
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma.
Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H, Xie H, Chen X, Shao L, Zhang R, Xu S, Zhang H, Cui G, Chen X, Sun R, Wen H, Lerut JP, Kan Q, Li L, Zheng S
Gut 2019 Jun;68(6):1014-1023. Epub 2018 Jul 25 doi: 10.1136/gutjnl-2017-315084. PMID: 30045880Free PMC Article
Management of people with early- or very early-stage hepatocellular carcinoma: an attempted network meta-analysis.
Majumdar A, Roccarina D, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 28;3(3):CD011650. doi: 10.1002/14651858.CD011650.pub2. PMID: 28351116Free PMC Article
Early hepatocellular carcinoma on the procrustean bed of ablation, resection, and transplantation.
Mazzaferro V, Lencioni R, Majno P
Semin Liver Dis 2014 Nov;34(4):415-26. Epub 2014 Nov 4 doi: 10.1055/s-0034-1394365. PMID: 25369303
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Prognosis

Preoperative serum ctDNA predicts early hepatocellular carcinoma recurrence and response to systemic therapies.
Fu Y, Yang Z, Hu Z, Yang Z, Pan Y, Chen J, Wang J, Hu D, Zhou Z, Xu L, Chen M, Zhang Y
Hepatol Int 2022 Aug;16(4):868-878. Epub 2022 Jun 8 doi: 10.1007/s12072-022-10348-1. PMID: 35674872
Liquid biopsy in the clinical management of hepatocellular carcinoma.
von Felden J, Garcia-Lezana T, Schulze K, Losic B, Villanueva A
Gut 2020 Nov;69(11):2025-2034. Epub 2020 Sep 3 doi: 10.1136/gutjnl-2019-320282. PMID: 32883873
Management of people with early- or very early-stage hepatocellular carcinoma: an attempted network meta-analysis.
Majumdar A, Roccarina D, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 28;3(3):CD011650. doi: 10.1002/14651858.CD011650.pub2. PMID: 28351116Free PMC Article
Hepatocellular carcinoma: latest developments.
Walzer N, Kulik LM
Curr Opin Gastroenterol 2008 May;24(3):312-9. doi: 10.1097/MOG.0b013e3282fafef3. PMID: 18408459
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Clinical prediction guides

AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation.
Norman JS, Li PJ, Kotwani P, Shui AM, Yao F, Mehta N
J Hepatol 2023 Dec;79(6):1469-1477. Epub 2023 Sep 7 doi: 10.1016/j.jhep.2023.08.020. PMID: 37683735
Preoperative serum ctDNA predicts early hepatocellular carcinoma recurrence and response to systemic therapies.
Fu Y, Yang Z, Hu Z, Yang Z, Pan Y, Chen J, Wang J, Hu D, Zhou Z, Xu L, Chen M, Zhang Y
Hepatol Int 2022 Aug;16(4):868-878. Epub 2022 Jun 8 doi: 10.1007/s12072-022-10348-1. PMID: 35674872
Liquid biopsy in the clinical management of hepatocellular carcinoma.
von Felden J, Garcia-Lezana T, Schulze K, Losic B, Villanueva A
Gut 2020 Nov;69(11):2025-2034. Epub 2020 Sep 3 doi: 10.1136/gutjnl-2019-320282. PMID: 32883873
Personalized treatment of patients with very early hepatocellular carcinoma.
Vitale A, Peck-Radosavljevic M, Giannini EG, Vibert E, Sieghart W, Van Poucke S, Pawlik TM
J Hepatol 2017 Feb;66(2):412-423. Epub 2016 Sep 24 doi: 10.1016/j.jhep.2016.09.012. PMID: 27677712
Early hepatocellular carcinoma and dysplastic nodules.
Kojiro M, Roskams T
Semin Liver Dis 2005;25(2):133-42. doi: 10.1055/s-2005-871193. PMID: 15918142

Recent systematic reviews

Comparison of Transarterial Chemoembolization Combined with Radiofrequency Ablation Therapy versus Surgical Resection for Early Hepatocellular Carcinoma.
Yi PS, Huang M, Zhang M, Xu L, Xu MQ
Am Surg 2018 Feb 1;84(2):282-288. PMID: 29580359
Management of people with early- or very early-stage hepatocellular carcinoma: an attempted network meta-analysis.
Majumdar A, Roccarina D, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 28;3(3):CD011650. doi: 10.1002/14651858.CD011650.pub2. PMID: 28351116Free PMC Article
External beam radiotherapy for unresectable hepatocellular carcinoma.
Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2017 Mar 7;3(3):CD011314. doi: 10.1002/14651858.CD011314.pub2. PMID: 28267205Free PMC Article
Percutaneous ethanol injection or percutaneous acetic acid injection for early hepatocellular carcinoma.
Weis S, Franke A, Berg T, Mössner J, Fleig WE, Schoppmeyer K
Cochrane Database Syst Rev 2015 Jan 26;1(1):CD006745. doi: 10.1002/14651858.CD006745.pub3. PMID: 25620061Free PMC Article
Systematic review of outcomes of liver resection for early hepatocellular carcinoma within the Milan criteria.
Lim KC, Chow PK, Allen JC, Siddiqui FJ, Chan ES, Tan SB
Br J Surg 2012 Dec;99(12):1622-9. Epub 2012 Sep 28 doi: 10.1002/bjs.8915. PMID: 23023956

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