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Well Differentiated Hepatocellular Carcinoma

MedGen UID:
474666
Concept ID:
C3273033
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant cells with mild atypia and an increased nuclear/cytoplasmic ratio forming thin trabecular patterns. It is usually associated with small tumors and an early stage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Larson BK, Guindi M
Ann Diagn Pathol 2021 Dec;55:151833. Epub 2021 Sep 25 doi: 10.1016/j.anndiagpath.2021.151833. PMID: 34597957
Deniz K, Umetsu SE, Ferrell L, Yılmaz F, Güllüoğlu M, Sağol Ö, Doğusoy GB, Kırımlıoğlu H, Turhan N, Doran F, Kepil N, Çelikel ÇA, Nart D, Özgüven BY, Ceyran B, Karadağ N, Kır G, Erden E, Yılmaz G, Akyol G
Histopathology 2021 Jul;79(1):23-33. Epub 2021 Apr 12 doi: 10.1111/his.14330. PMID: 33406290
Hytiroglou P, Theise ND
Semin Diagn Pathol 1998 Nov;15(4):285-99. PMID: 9845429

Recent clinical studies

Etiology

Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Yasir S, Chen ZE, Said S, Wu TT, Torbenson M
Hum Pathol 2021 Jan;107:20-28. Epub 2020 Oct 8 doi: 10.1016/j.humpath.2020.09.015. PMID: 33039370Free PMC Article
Roncalli M, Sciarra A, Tommaso LD
Clin Mol Hepatol 2016 Jun;22(2):199-211. Epub 2016 May 18 doi: 10.3350/cmh.2016.0101. PMID: 27189732Free PMC Article
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269

Diagnosis

Umetsu SE, Kakar S
Surg Pathol Clin 2023 Sep;16(3):581-598. Epub 2023 Jun 9 doi: 10.1016/j.path.2023.04.011. PMID: 37536890
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Roncalli M, Sciarra A, Tommaso LD
Clin Mol Hepatol 2016 Jun;22(2):199-211. Epub 2016 May 18 doi: 10.3350/cmh.2016.0101. PMID: 27189732Free PMC Article
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269

Therapy

Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Ikeda N, Oka K, Yonekawa N, Takaku H, Suzuki T, Saitoh T, Nagakura S, Nakano M
Surg Today 2011 Sep;41(9):1270-4. Epub 2011 Aug 26 doi: 10.1007/s00595-010-4465-z. PMID: 21874429
Boozari B, Soudah B, Rifai K, Schneidewind S, Vogel A, Hecker H, Hahn A, Schlue J, Dietrich CF, Bahr MJ, Kubicka S, Manns MP, Gebel M
Dig Liver Dis 2011 Jun;43(6):484-90. Epub 2011 Mar 5 doi: 10.1016/j.dld.2011.01.001. PMID: 21377941
Henderson BE, Preston-Martin S, Edmondson HA, Peters RL, Pike MC
Br J Cancer 1983 Sep;48(3):437-40. doi: 10.1038/bjc.1983.210. PMID: 6311235Free PMC Article

Prognosis

Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Okuno M, Newhook TE, Joechle K, Kawaguchi Y, De Bellis M, Tzeng CD, Chun YS, Aloia TA, Shindoh J, Kaseb AO, Vauthey JN
HPB (Oxford) 2020 Apr;22(4):545-552. Epub 2019 Sep 16 doi: 10.1016/j.hpb.2019.08.012. PMID: 31533893
Zhao S, Su G, Yang W, Yue P, Bai B, Lin Y, Zhang J, Ba Y, Luo Z, Liu X, Zhao L, Xie Y, Xu Y, Li S, Meng W, Xie X, Li X
Technol Cancer Res Treat 2017 Dec;16(6):1092-1101. Epub 2017 Sep 25 doi: 10.1177/1533034617732426. PMID: 29332450Free PMC Article
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475

Clinical prediction guides

Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Suzuki H, Kohjima M, Tanaka M, Goya T, Itoh S, Yoshizumi T, Mori M, Tsuda M, Takahashi M, Kurokawa M, Imoto K, Tashiro S, Kuwano A, Kato M, Okada S, Nakamuta M, Ogawa Y
Can J Gastroenterol Hepatol 2021;2021:8813410. Epub 2021 Feb 18 doi: 10.1155/2021/8813410. PMID: 33681091Free PMC Article
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475
Kudo M
Intervirology 2004;47(3-5):227-37. doi: 10.1159/000078475. PMID: 15383732

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