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Well Differentiated Hepatocellular Carcinoma

MedGen UID:
474666
•Concept ID:
C3273033
•
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant cells with mild atypia and an increased nuclear/cytoplasmic ratio forming thin trabecular patterns. It is usually associated with small tumors and an early stage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWell Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Applying criteria for hepatocellular neoplasm of uncertain malignant potential reclassifies more than half of hepatocellular adenomas.
Larson BK, Guindi M
Ann Diagn Pathol 2021 Dec;55:151833. Epub 2021 Sep 25 doi: 10.1016/j.anndiagpath.2021.151833. PMID: 34597957
Hepatocellular adenomas in the Turkish population: reclassification according to updated World Health Organization criteria.
Deniz K, Umetsu SE, Ferrell L, Yılmaz F, Güllüoğlu M, Sağol Ö, Doğusoy GB, Kırımlıoğlu H, Turhan N, Doran F, Kepil N, Çelikel ÇA, Nart D, Özgüven BY, Ceyran B, Karadağ N, Kır G, Erden E, Yılmaz G, Akyol G
Histopathology 2021 Jul;79(1):23-33. Epub 2021 Apr 12 doi: 10.1111/his.14330. PMID: 33406290
Differential diagnosis of hepatocellular nodular lesions.
Hytiroglou P, Theise ND
Semin Diagn Pathol 1998 Nov;15(4):285-99. PMID: 9845429

Recent clinical studies

Etiology

Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Characteristics of atypical large well-differentiated hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma?
Okuno M, Newhook TE, Joechle K, Kawaguchi Y, De Bellis M, Tzeng CD, Chun YS, Aloia TA, Shindoh J, Kaseb AO, Vauthey JN
HPB (Oxford) 2020 Apr;22(4):545-552. Epub 2019 Sep 16 doi: 10.1016/j.hpb.2019.08.012. PMID: 31533893
Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma.
Roncalli M, Sciarra A, Tommaso LD
Clin Mol Hepatol 2016 Jun;22(2):199-211. Epub 2016 May 18 doi: 10.3350/cmh.2016.0101. PMID: 27189732Free PMC Article
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269

Diagnosis

Evaluating Liver Biopsies with Well-Differentiated Hepatocellular Lesions.
Umetsu SE, Kakar S
Surg Pathol Clin 2023 Sep;16(3):581-598. Epub 2023 Jun 9 doi: 10.1016/j.path.2023.04.011. PMID: 37536890
Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma.
Roncalli M, Sciarra A, Tommaso LD
Clin Mol Hepatol 2016 Jun;22(2):199-211. Epub 2016 May 18 doi: 10.3350/cmh.2016.0101. PMID: 27189732Free PMC Article
Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques.
Shafizadeh N, Kakar S
Adv Anat Pathol 2011 Nov;18(6):438-45. doi: 10.1097/PAP.0b013e318234abb4. PMID: 21993269

Therapy

Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Diagnosis of hepatocellular carcinoma nodules in patients with chronic liver disease using contrast-enhanced sonography: usefulness of the combination of arterial- and kupffer-phase enhancement patterns.
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Pelioid-type well-differentiated hepatocellular carcinoma in a patient with a history of taking oral contraceptives: report of a case.
Ikeda N, Oka K, Yonekawa N, Takaku H, Suzuki T, Saitoh T, Nagakura S, Nakano M
Surg Today 2011 Sep;41(9):1270-4. Epub 2011 Aug 26 doi: 10.1007/s00595-010-4465-z. PMID: 21874429
Grading of hypervascular hepatocellular carcinoma using late phase of contrast enhanced sonography - a prospective study.
Boozari B, Soudah B, Rifai K, Schneidewind S, Vogel A, Hecker H, Hahn A, Schlue J, Dietrich CF, Bahr MJ, Kubicka S, Manns MP, Gebel M
Dig Liver Dis 2011 Jun;43(6):484-90. Epub 2011 Mar 5 doi: 10.1016/j.dld.2011.01.001. PMID: 21377941
Hepatocellular carcinoma and oral contraceptives.
Henderson BE, Preston-Martin S, Edmondson HA, Peters RL, Pike MC
Br J Cancer 1983 Sep;48(3):437-40. doi: 10.1038/bjc.1983.210. PMID: 6311235Free PMC Article

Prognosis

Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Characteristics of atypical large well-differentiated hepatocellular carcinoma: a specific subtype of hepatocellular carcinoma?
Okuno M, Newhook TE, Joechle K, Kawaguchi Y, De Bellis M, Tzeng CD, Chun YS, Aloia TA, Shindoh J, Kaseb AO, Vauthey JN
HPB (Oxford) 2020 Apr;22(4):545-552. Epub 2019 Sep 16 doi: 10.1016/j.hpb.2019.08.012. PMID: 31533893
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.
Zhao S, Su G, Yang W, Yue P, Bai B, Lin Y, Zhang J, Ba Y, Luo Z, Liu X, Zhao L, Xie Y, Xu Y, Li S, Meng W, Xie X, Li X
Technol Cancer Res Treat 2017 Dec;16(6):1092-1101. Epub 2017 Sep 25 doi: 10.1177/1533034617732426. PMID: 29332450Free PMC Article
Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens.
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475

Clinical prediction guides

Deep Learning-Based Classification of Hepatocellular Nodular Lesions on Whole-Slide Histopathologic Images.
Cheng N, Ren Y, Zhou J, Zhang Y, Wang D, Zhang X, Chen B, Liu F, Lv J, Cao Q, Chen S, Du H, Hui D, Weng Z, Liang Q, Su B, Tang L, Han L, Chen J, Shao C
Gastroenterology 2022 Jun;162(7):1948-1961.e7. Epub 2022 Feb 22 doi: 10.1053/j.gastro.2022.02.025. PMID: 35202643
Characteristics and prognosis of patients with large well-differentiated hepatocellular carcinoma who have undergone resection.
Lin SH, Eng HL, Liu YW, Lin CC, Yong CC, Wang CC, Chen CL, Kuo FY, Cheng YF, Wang JH, Yen YH, Liu TT, Li WF, Chen CH
Am J Surg 2022 Feb;223(2):339-345. Epub 2021 Apr 5 doi: 10.1016/j.amjsurg.2021.03.065. PMID: 33840448
Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma.
Suzuki H, Kohjima M, Tanaka M, Goya T, Itoh S, Yoshizumi T, Mori M, Tsuda M, Takahashi M, Kurokawa M, Imoto K, Tashiro S, Kuwano A, Kato M, Okada S, Nakamuta M, Ogawa Y
Can J Gastroenterol Hepatol 2021;2021:8813410. Epub 2021 Feb 18 doi: 10.1155/2021/8813410. PMID: 33681091Free PMC Article
Immunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens.
Choi WT, Ramachandran R, Kakar S
Hum Pathol 2017 May;63:1-13. Epub 2017 Jan 11 doi: 10.1016/j.humpath.2016.12.025. PMID: 28087475
Atypical large well-differentiated hepatocellular carcinoma with benign nature: a new clinical entity.
Kudo M
Intervirology 2004;47(3-5):227-37. doi: 10.1159/000078475. PMID: 15383732

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