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Moderately Differentiated Hepatocellular Carcinoma

MedGen UID:
474667
Concept ID:
C3273034
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns. It is usually associated with tumors that are larger than 3 cm in diameter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Bakheet AMH, Zhao C, Chen JN, Zhang JY, Huang JT, Du Y, Gong LP, Bi YH, Shao CK
Hepatol Int 2020 Jan;14(1):96-104. Epub 2019 Dec 12 doi: 10.1007/s12072-019-10006-z. PMID: 31832976
D'Souza AM, Shah R, Gupta A, Towbin AJ, Alonso M, Nathan JD, Bondoc A, Tiao G, Geller JI
Pediatr Blood Cancer 2018 Nov;65(11):e27293. Epub 2018 Jul 3 doi: 10.1002/pbc.27293. PMID: 29968976
vom Dahl S, Mengel E
Best Pract Res Clin Gastroenterol 2010 Oct;24(5):619-28. doi: 10.1016/j.bpg.2010.09.001. PMID: 20955964

Recent clinical studies

Etiology

Surdea-Blaga T, Cărăguț RL, Caraiani C, Spârchez Z, Al Hajjar N, Dumitrașcu DL
J Med Case Rep 2023 Jul 25;17(1):328. doi: 10.1186/s13256-023-03932-y. PMID: 37488645Free PMC Article
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Murata K, Shiraki K, Kawakita T, Yamamoto N, Okano H, Sakai T, Ohmori S, Deguchi M, Shimizu A, Nakano T
Hepatogastroenterology 2003 Nov-Dec;50(54):2057-60. PMID: 14696464
Horigome H, Nomura T, Saso K, Joh T, Ohara H, Akita S, Sobue S, Mizuno Y, Kato Y, Kanematsu T, Murasaki G, Itoh M
Hepatogastroenterology 2000 Nov-Dec;47(36):1659-62. PMID: 11149027

Diagnosis

Surdea-Blaga T, Cărăguț RL, Caraiani C, Spârchez Z, Al Hajjar N, Dumitrașcu DL
J Med Case Rep 2023 Jul 25;17(1):328. doi: 10.1186/s13256-023-03932-y. PMID: 37488645Free PMC Article
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Inagawa S, Shimazaki J, Hori M, Yoshimi F, Adachi S, Kawamoto T, Fukao K, Itabashi M
Gastric Cancer 2001;4(1):43-52. doi: 10.1007/s101200100016. PMID: 11706627

Therapy

El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Marijon H, Dokmak S, Paradis V, Zappa M, Bieche I, Bouattour M, Raymond E, Faivre S
J Hepatol 2011 May;54(5):1073-8. Epub 2010 Dec 2 doi: 10.1016/j.jhep.2010.11.011. PMID: 21145871
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Uenishi T, Kubo S, Hirohashi K, Tanaka H, Ohba K, Kinoshita H
Dig Surg 2001;18(3):225-7. doi: 10.1159/000050137. PMID: 11464017

Prognosis

Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Murata K, Shiraki K, Kawakita T, Yamamoto N, Okano H, Sakai T, Ohmori S, Deguchi M, Shimizu A, Nakano T
Hepatogastroenterology 2003 Nov-Dec;50(54):2057-60. PMID: 14696464
Zeng WJ, Liu GY, Xu J, Zhou XD, Zhang YE, Zhang N
World J Gastroenterol 2002 Dec;8(6):1040-4. doi: 10.3748/wjg.v8.i6.1040. PMID: 12439921Free PMC Article
Inagawa S, Shimazaki J, Hori M, Yoshimi F, Adachi S, Kawamoto T, Fukao K, Itabashi M
Gastric Cancer 2001;4(1):43-52. doi: 10.1007/s101200100016. PMID: 11706627

Clinical prediction guides

El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
Goto H, Tanaka A, Kondo F, Takeshita K, Nagashima I, Hanawa N, Aiso M, Takamori Y, Kato K, Takahashi Y, Fukushima J, Furui S, Fukusato T, Asano T, Takikawa H
Intern Med 2010;49(23):2577-82. Epub 2010 Dec 1 doi: 10.2169/internalmedicine.49.3581. PMID: 21139295
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Murata K, Shiraki K, Kawakita T, Yamamoto N, Okano H, Sakai T, Ohmori S, Deguchi M, Shimizu A, Nakano T
Hepatogastroenterology 2003 Nov-Dec;50(54):2057-60. PMID: 14696464
Morinaga S, Imada T, Shimizu A, Akaike M, Sugimasa Y, Takemiya S, Takanashi Y
Hepatogastroenterology 2001 Jan-Feb;48(37):224-8. PMID: 11268971

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