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Moderately Differentiated Hepatocellular Carcinoma

MedGen UID:
474667
•Concept ID:
C3273034
•
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant cells with abundant eosinophilic cytoplasm forming trabecular and pseudoglandular patterns. It is usually associated with tumors that are larger than 3 cm in diameter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Improving pathological early diagnosis and differential biomarker value for hepatocellular carcinoma via RNAscope technology.
Bakheet AMH, Zhao C, Chen JN, Zhang JY, Huang JT, Du Y, Gong LP, Bi YH, Shao CK
Hepatol Int 2020 Jan;14(1):96-104. Epub 2019 Dec 12 doi: 10.1007/s12072-019-10006-z. PMID: 31832976
Surgical management of children and adolescents with upfront completely resected hepatocellular carcinoma.
D'Souza AM, Shah R, Gupta A, Towbin AJ, Alonso M, Nathan JD, Bondoc A, Tiao G, Geller JI
Pediatr Blood Cancer 2018 Nov;65(11):e27293. Epub 2018 Jul 3 doi: 10.1002/pbc.27293. PMID: 29968976
Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management.
Shanbhogue AK, Prasad SR, Takahashi N, Vikram R, Sahani DV
Radiology 2011 Mar;258(3):673-93. doi: 10.1148/radiol.10100376. PMID: 21339346

Recent clinical studies

Etiology

Overlap syndrome of autoimmune hepatitis and primary biliary cholangitis complicated with atypical hepatocellular carcinoma: a case report.
Surdea-Blaga T, Cărăguț RL, Caraiani C, Spârchez Z, Al Hajjar N, Dumitrașcu DL
J Med Case Rep 2023 Jul 25;17(1):328. doi: 10.1186/s13256-023-03932-y. PMID: 37488645Free PMC Article
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Diagnosis of small hepatocellular carcinoma--imaging diagnosis and significance of tumor biopsy.
Horigome H, Nomura T, Saso K, Joh T, Ohara H, Akita S, Sobue S, Mizuno Y, Kato Y, Kanematsu T, Murasaki G, Itoh M
Hepatogastroenterology 2000 Nov-Dec;47(36):1659-62. PMID: 11149027
Sinusoidal capillarization in small hepatocellular carcinoma.
Kin M, Torimura T, Ueno T, Inuzuka S, Tanikawa K
Pathol Int 1994 Oct-Nov;44(10-11):771-8. doi: 10.1111/j.1440-1827.1994.tb02925.x. PMID: 7530563

Diagnosis

Diagnosis of hepatocellular carcinoma nodules in patients with chronic liver disease using contrast-enhanced sonography: usefulness of the combination of arterial- and kupffer-phase enhancement patterns.
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Carcinosarcoma of the liver.
Goto H, Tanaka A, Kondo F, Takeshita K, Nagashima I, Hanawa N, Aiso M, Takamori Y, Kato K, Takahashi Y, Fukushima J, Furui S, Fukusato T, Asano T, Takikawa H
Intern Med 2010;49(23):2577-82. Epub 2010 Dec 1 doi: 10.2169/internalmedicine.49.3581. PMID: 21139295
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
A hepatocellular carcinoma with lymph node metastasis and invasion into the gallbladder: preoperative difficulty ruling out a gallbladder carcinoma.
Ueno N, Kanamaru T, Kawaguchi K, Tanaka K, Inoue K, Idei Y, Yamamoto M
Oncol Rep 2001 Mar-Apr;8(2):331-5. doi: 10.3892/or.8.2.331. PMID: 11182050

Therapy

De novo hepatocellular carcinoma in a non-cirrhotic allograft 27 years after liver transplantation: A case report.
El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
Diagnosis of hepatocellular carcinoma nodules in patients with chronic liver disease using contrast-enhanced sonography: usefulness of the combination of arterial- and kupffer-phase enhancement patterns.
Suzuki K, Okuda Y, Ota M, Kojima F, Horimoto M
J Ultrasound Med 2015 Mar;34(3):423-33. doi: 10.7863/ultra.34.3.423. PMID: 25715363
Epithelial-to-mesenchymal transition and acquired resistance to sunitinib in a patient with hepatocellular carcinoma.
Marijon H, Dokmak S, Paradis V, Zappa M, Bieche I, Bouattour M, Raymond E, Faivre S
J Hepatol 2011 May;54(5):1073-8. Epub 2010 Dec 2 doi: 10.1016/j.jhep.2010.11.011. PMID: 21145871
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Successful treatment of dissemination of hepatocellular carcinoma to the pleura and diaphragm after percutaneous liver biopsy.
Uenishi T, Kubo S, Hirohashi K, Tanaka H, Ohba K, Kinoshita H
Dig Surg 2001;18(3):225-7. doi: 10.1159/000050137. PMID: 11464017

Prognosis

Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development.
Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
Hum Pathol 2010 Jun;41(6):838-47. Epub 2010 Feb 25 doi: 10.1016/j.humpath.2009.11.011. PMID: 20185161
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Metastasis of hepatocellular carcinoma to the supramaxillary gingiva and right ventricle.
Arai R, Otsuka T, Mori K, Kobayashi R, Tomizawa Y, Sohara N, Kakizaki S, Hirokawa T, Kanda D, Nakayama H, Nakajima T, Takagi H, Mori M
Hepatogastroenterology 2004 Jul-Aug;51(58):1159-61. PMID: 15239267
Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma.
Zeng WJ, Liu GY, Xu J, Zhou XD, Zhang YE, Zhang N
World J Gastroenterol 2002 Dec;8(6):1040-4. doi: 10.3748/wjg.v8.i6.1040. PMID: 12439921Free PMC Article
Hepatoid adenocarcinoma of the stomach.
Inagawa S, Shimazaki J, Hori M, Yoshimi F, Adachi S, Kawamoto T, Fukao K, Itabashi M
Gastric Cancer 2001;4(1):43-52. doi: 10.1007/s101200100016. PMID: 11706627

Clinical prediction guides

De novo hepatocellular carcinoma in a non-cirrhotic allograft 27 years after liver transplantation: A case report.
El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
Carcinosarcoma of the liver.
Goto H, Tanaka A, Kondo F, Takeshita K, Nagashima I, Hanawa N, Aiso M, Takamori Y, Kato K, Takahashi Y, Fukushima J, Furui S, Fukusato T, Asano T, Takikawa H
Intern Med 2010;49(23):2577-82. Epub 2010 Dec 1 doi: 10.2169/internalmedicine.49.3581. PMID: 21139295
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma.
Zeng WJ, Liu GY, Xu J, Zhou XD, Zhang YE, Zhang N
World J Gastroenterol 2002 Dec;8(6):1040-4. doi: 10.3748/wjg.v8.i6.1040. PMID: 12439921Free PMC Article
Sinusoidal capillarization in small hepatocellular carcinoma.
Kin M, Torimura T, Ueno T, Inuzuka S, Tanikawa K
Pathol Int 1994 Oct-Nov;44(10-11):771-8. doi: 10.1111/j.1440-1827.1994.tb02925.x. PMID: 7530563

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