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Poorly Differentiated Hepatocellular Carcinoma

MedGen UID:
474668
•Concept ID:
C3273035
•
Neoplastic Process

Definition

A hepatocellular carcinoma characterized by the presence of malignant pleomorphic cells forming solid patterns. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoorly Differentiated Hepatocellular Carcinoma

Professional guidelines

PubMed

Predicting Poorly Differentiated Hepatocellular Carcinoma that Meets the Milan Criteria.
Koga Y, Beppu T, Miyata T, Kitano Y, Tsuji A, Nakagawa S, Arima K, Kuramoto K, Okabe H, Imai K, Hayashi H, Nitta H, Yamashita YI, Chikamoto A, Ishiko T, Baba H
Anticancer Res 2018 Jul;38(7):4093-4099. doi: 10.21873/anticanres.12699. PMID: 29970535
Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasms.
Kakar S, Gown AM, Goodman ZD, Ferrell LD
Arch Pathol Lab Med 2007 Nov;131(11):1648-54. doi: 10.5858/2007-131-1648-BPIDIH. PMID: 17979482
Differential diagnosis of hepatocellular nodular lesions.
Hytiroglou P, Theise ND
Semin Diagn Pathol 1998 Nov;15(4):285-99. PMID: 9845429

Recent clinical studies

Etiology

Nomogram based on Sonazoid contrast-enhanced ultrasound to differentiate intrahepatic cholangiocarcinoma and poorly differentiated hepatocellular carcinoma: a prospective multicenter study.
Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Poorly differentiated hepatocellular carcinoma: resection is equivalent to transplantation in patients with low liver fibrosis.
Salehi O, Vega EA, Kutlu OC, Lunsford K, Freeman R, Ladin K, Alarcon SV, Kazakova V, Conrad C
HPB (Oxford) 2022 Jul;24(7):1100-1109. Epub 2021 Dec 10 doi: 10.1016/j.hpb.2021.12.001. PMID: 34969618
Contrast-Enhanced Ultrasound for Differentiation Between Poorly Differentiated Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Guo HL, Zheng X, Cheng MQ, Zeng D, Huang H, Xie XY, Lu MD, Kuang M, Wang W, Xian MF, Chen LD
J Ultrasound Med 2022 May;41(5):1213-1225. Epub 2021 Aug 23 doi: 10.1002/jum.15812. PMID: 34423864
Outcomes of Patients With Poorly Differentiated Hepatocellular Carcinoma After Liver Transplantation.
Krasnodębski M, Grąt M, Masior Ł, Wronka KM, Grąt K, Stypułkowski J, Bik E, Patkowski W, Krawczyk M
Transplant Proc 2016 Jun;48(5):1713-6. doi: 10.1016/j.transproceed.2016.01.067. PMID: 27496477
Prediction of poorly differentiated hepatocellular carcinoma using contrast computed tomography.
Nakachi K, Tamai H, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M
Cancer Imaging 2014 Apr 22;14(1):7. doi: 10.1186/1470-7330-14-7. PMID: 25608454Free PMC Article

Diagnosis

Nomogram based on Sonazoid contrast-enhanced ultrasound to differentiate intrahepatic cholangiocarcinoma and poorly differentiated hepatocellular carcinoma: a prospective multicenter study.
Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Hemophagocytic lymphohistiocytosis associated with hepatocellular carcinoma.
Nagao M, Fukuda A, Tsujimura M, Nishioka Y, Umeda M, Matsumura T, Seno H
Clin J Gastroenterol 2023 Oct;16(5):698-701. Epub 2023 May 11 doi: 10.1007/s12328-023-01813-x. PMID: 37166565
Contrast-Enhanced Ultrasound for Differentiation Between Poorly Differentiated Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma.
Guo HL, Zheng X, Cheng MQ, Zeng D, Huang H, Xie XY, Lu MD, Kuang M, Wang W, Xian MF, Chen LD
J Ultrasound Med 2022 May;41(5):1213-1225. Epub 2021 Aug 23 doi: 10.1002/jum.15812. PMID: 34423864
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Prediction of poorly differentiated hepatocellular carcinoma using contrast computed tomography.
Nakachi K, Tamai H, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M
Cancer Imaging 2014 Apr 22;14(1):7. doi: 10.1186/1470-7330-14-7. PMID: 25608454Free PMC Article

Therapy

Machine learning based on gadoxetic acid-enhanced MRI for differentiating atypical intrahepatic mass-forming cholangiocarcinoma from poorly differentiated hepatocellular carcinoma.
Chen X, Chen Y, Chen H, Zhu J, Huang R, Xie J, Zhang T, Xie A, Li Y
Abdom Radiol (NY) 2023 Aug;48(8):2525-2536. Epub 2023 May 11 doi: 10.1007/s00261-023-03870-9. PMID: 37169988
Magnetic resonance radiomics signatures for predicting poorly differentiated hepatocellular carcinoma: A SQUIRE-compliant study.
Yang X, Yuan C, Zhang Y, Wang Z
Medicine (Baltimore) 2021 May 14;100(19):e25838. doi: 10.1097/MD.0000000000025838. PMID: 34106622Free PMC Article
Long-term complete response of advanced hepatocellular carcinoma treated with multidisciplinary therapy including reduced dose of sorafenib: case report and review of the literature.
Shinoda M, Kishida N, Itano O, Ei S, Ueno A, Kitago M, Abe Y, Hibi T, Yagi H, Masugi Y, Tanabe M, Aiura K, Sakamaoto M, Tanimoto A, Kitagawa Y
World J Surg Oncol 2015 Apr 9;13:144. doi: 10.1186/s12957-015-0559-9. PMID: 25889667Free PMC Article
Poorly versus moderately differentiated hepatocellular carcinoma: vascularity assessment by computed tomographic hepatic angiography in correlation with histologically counted number of unpaired arteries.
Asayama Y, Yoshimitsu K, Irie H, Nishihara Y, Aishima S, Tajima T, Hirakawa M, Ishigami K, Kakihara D, Taketomi A, Honda H
J Comput Assist Tomogr 2007 Mar-Apr;31(2):188-92. doi: 10.1097/01.rct.0000236417.82395.57. PMID: 17414751
Factors predisposing to poorly differentiated hepatocellular carcinoma and its recurrence.
Akamatsu M, Ishikawa T, Shiratori Y, Koike Y, Shiina S, Teratani T, Hamamura K, Obi S, Sato S, Tateishi R, Fujishima T, Imai Y, Yoshida H, Omata M
Hepatogastroenterology 2005 Mar-Apr;52(62):391-7. PMID: 15816443

Prognosis

Nomogram based on Sonazoid contrast-enhanced ultrasound to differentiate intrahepatic cholangiocarcinoma and poorly differentiated hepatocellular carcinoma: a prospective multicenter study.
Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Magnetic resonance radiomics signatures for predicting poorly differentiated hepatocellular carcinoma: A SQUIRE-compliant study.
Yang X, Yuan C, Zhang Y, Wang Z
Medicine (Baltimore) 2021 May 14;100(19):e25838. doi: 10.1097/MD.0000000000025838. PMID: 34106622Free PMC Article
Predicting Poorly Differentiated Hepatocellular Carcinoma that Meets the Milan Criteria.
Koga Y, Beppu T, Miyata T, Kitano Y, Tsuji A, Nakagawa S, Arima K, Kuramoto K, Okabe H, Imai K, Hayashi H, Nitta H, Yamashita YI, Chikamoto A, Ishiko T, Baba H
Anticancer Res 2018 Jul;38(7):4093-4099. doi: 10.21873/anticanres.12699. PMID: 29970535
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.
Zhao S, Su G, Yang W, Yue P, Bai B, Lin Y, Zhang J, Ba Y, Luo Z, Liu X, Zhao L, Xie Y, Xu Y, Li S, Meng W, Xie X, Li X
Technol Cancer Res Treat 2017 Dec;16(6):1092-1101. Epub 2017 Sep 25 doi: 10.1177/1533034617732426. PMID: 29332450Free PMC Article
Prediction of poorly differentiated hepatocellular carcinoma using contrast computed tomography.
Nakachi K, Tamai H, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M
Cancer Imaging 2014 Apr 22;14(1):7. doi: 10.1186/1470-7330-14-7. PMID: 25608454Free PMC Article

Clinical prediction guides

Nomogram based on Sonazoid contrast-enhanced ultrasound to differentiate intrahepatic cholangiocarcinoma and poorly differentiated hepatocellular carcinoma: a prospective multicenter study.
Wang S, Yao J, Li K, Yang H, Lu S, He G, Wu W, Cheng W, Jiang T, Ding H, Jing X, Yan Y, Liu F, Yu J, Han Z, Cheng Z, Tan S, Li X, Dou J, Li Y, Qi E, Zhang Y, Liang P, Yu X
Abdom Radiol (NY) 2023 Oct;48(10):3101-3113. Epub 2023 Jul 12 doi: 10.1007/s00261-023-03993-z. PMID: 37436451
Magnetic resonance radiomics signatures for predicting poorly differentiated hepatocellular carcinoma: A SQUIRE-compliant study.
Yang X, Yuan C, Zhang Y, Wang Z
Medicine (Baltimore) 2021 May 14;100(19):e25838. doi: 10.1097/MD.0000000000025838. PMID: 34106622Free PMC Article
Predicting Poorly Differentiated Hepatocellular Carcinoma that Meets the Milan Criteria.
Koga Y, Beppu T, Miyata T, Kitano Y, Tsuji A, Nakagawa S, Arima K, Kuramoto K, Okabe H, Imai K, Hayashi H, Nitta H, Yamashita YI, Chikamoto A, Ishiko T, Baba H
Anticancer Res 2018 Jul;38(7):4093-4099. doi: 10.21873/anticanres.12699. PMID: 29970535
Prediction of poorly differentiated hepatocellular carcinoma using contrast computed tomography.
Nakachi K, Tamai H, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M
Cancer Imaging 2014 Apr 22;14(1):7. doi: 10.1186/1470-7330-14-7. PMID: 25608454Free PMC Article
Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature.
Shinoda M, Kadota Y, Tsujikawa H, Masugi Y, Itano O, Ueno A, Mihara K, Hibi T, Abe Y, Yagi H, Kitago M, Kawachi S, Tanimoto A, Sakamoto M, Tanabe M, Kitagawa Y
World J Surg Oncol 2013 May 4;11:97. doi: 10.1186/1477-7819-11-97. PMID: 23642182Free PMC Article

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