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Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma

MedGen UID:
474685
•Concept ID:
C3273052
•
Neoplastic Process
Synonyms: Bile Duct IPN with an Associated Invasive Carcinoma; Bile Duct Papillary Adenocarcinoma; Bile Duct Papillary Neoplasm with an Associated Invasive Carcinoma; Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma

Definition

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts and it is associated with an invasive carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma

Professional guidelines

PubMed

Intraductal tubulopapillary neoplasms of the bile ducts: identity, clinicopathologic characteristics, and differential diagnosis of a distinct entity among intraductal tumors.
Pehlivanoglu B, Adsay V
Hum Pathol 2023 Feb;132:12-19. Epub 2022 Aug 5 doi: 10.1016/j.humpath.2022.07.019. PMID: 35934108
Proposed indications for limited resection of early ampulla of Vater carcinoma: clinico-histopathological criteria to confirm cure.
Aiura K, Hibi T, Fujisaki H, Kitago M, Tanabe M, Kawachi S, Itano O, Shinoda M, Yagi H, Masugi Y, Sakamoto M, Kitagawa Y
J Hepatobiliary Pancreat Sci 2012 Nov;19(6):707-16. doi: 10.1007/s00534-011-0492-4. PMID: 22203456Free PMC Article

Recent clinical studies

Etiology

Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis.
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Clinicopathological characteristics of intraductal papillary neoplasm of the bile duct: a Japan-Korea collaborative study.
Kubota K, Jang JY, Nakanuma Y, Jang KT, Haruyama Y, Fukushima N, Furukawa T, Hong SM, Sakuraoka Y, Kim H, Matsumoto T, Lee KB, Zen Y, Kim J, Miyazaki M, Choi DW, Heo JS, Endo I, Hwang S, Nakamura M, Han HS, Uemoto S, Park SJ, Hong EK, Nanashima A, Kim DS, Kim JY, Ohta T, Kang KJ, Fukumoto T, Nah YW, Seo HI, Inui K, Yoon DS, Unno M
J Hepatobiliary Pancreat Sci 2020 Sep;27(9):581-597. Epub 2020 Jul 2 doi: 10.1002/jhbp.785. PMID: 32511838
Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation.
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
Intraductal papillary neoplasm of the bile duct: Assessment of invasive carcinoma and long-term outcomes using MRI.
Lee S, Kim MJ, Kim S, Choi D, Jang KT, Park YN
J Hepatol 2019 Apr;70(4):692-699. Epub 2018 Dec 14 doi: 10.1016/j.jhep.2018.12.005. PMID: 30553839
Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern.
Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M
Mod Pathol 2016 Mar;29(3):293-301. Epub 2016 Jan 15 doi: 10.1038/modpathol.2015.152. PMID: 26769137

Diagnosis

Bile duct dysplasia and associated invasive carcinoma: clinicopathological features, diagnosis, and practical challenges.
Liu Y, Yeh MM
Hum Pathol 2023 Feb;132:158-168. Epub 2022 Jun 14 doi: 10.1016/j.humpath.2022.06.012. PMID: 35714833
Intraductal papillary neoplasia of the bile duct (IPNB): case report and literature review.
Vargas R, Patarroyo O, Cañadas R, Ovalle A
Rev Gastroenterol Peru 2020 Jul-Sep;40(3):278-283. PMID: 33181817
Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation.
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
Intraductal neoplasms of the bile duct. A new challenge to biliary tract tumor pathology.
Nakanuma Y, Uesaka K, Miyayama S, Yamaguchi H, Ohtsuka M
Histol Histopathol 2017 Oct;32(10):1001-1015. Epub 2017 Mar 24 doi: 10.14670/HH-11-892. PMID: 28337739
Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT?
Kawamoto S, Horton KM, Lawler LP, Hruban RH, Fishman EK
Radiographics 2005 Nov-Dec;25(6):1451-68; discussion 1468-70. doi: 10.1148/rg.256055036. PMID: 16284127

Therapy

Outcome Determining Factors of Intraductal Papillary Neoplasm of the Biliary Tract (IPNB)-a Single Center Survey and Analysis of Current Literature.
Höhn P, Braumann C, Munding J, Tannapfel A, Uhl W, Künzli BM
J Gastrointest Cancer 2019 Mar;50(1):160-169. doi: 10.1007/s12029-018-00199-1. PMID: 30628030
Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.
Sato Y, Kubo S, Takemura S, Sugawara Y, Tanaka S, Fujikawa M, Arimoto A, Harada K, Sasaki M, Nakanuma Y
Int J Clin Exp Pathol 2014;7(8):4745-54. Epub 2014 Jul 15 PMID: 25197345Free PMC Article
Evaluation of surgical resection for pancreatic carcinoma at a Japanese single cancer institute.
Nanashima A, Tobinaga S, Abo T, Hatano K, Takeshita H, Nonaka T, Hidaka S, Tanaka K, Kunizaki M, Sawai T, Yasutake T, Nagayasu T
Hepatogastroenterology 2012 May;59(115):911-5. doi: 10.5754/hge10038. PMID: 22469741

Prognosis

Intraductal papillary neoplasm of the bile duct - A comprehensive review.
Krawczyk M, Ziarkiewicz-Wróblewska B, Podgórska J, Grzybowski J, Gierej B, Krawczyk P, Grąt M, Kornasiewicz O, Skalski M, Wróblewski T
Adv Med Sci 2021 Mar;66(1):138-147. Epub 2021 Feb 6 doi: 10.1016/j.advms.2021.01.005. PMID: 33556909
Intraductal papillary neoplasm of the bile duct: Assessment of invasive carcinoma and long-term outcomes using MRI.
Lee S, Kim MJ, Kim S, Choi D, Jang KT, Park YN
J Hepatol 2019 Apr;70(4):692-699. Epub 2018 Dec 14 doi: 10.1016/j.jhep.2018.12.005. PMID: 30553839
Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern.
Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M
Mod Pathol 2016 Mar;29(3):293-301. Epub 2016 Jan 15 doi: 10.1038/modpathol.2015.152. PMID: 26769137
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286
Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT?
Kawamoto S, Horton KM, Lawler LP, Hruban RH, Fishman EK
Radiographics 2005 Nov-Dec;25(6):1451-68; discussion 1468-70. doi: 10.1148/rg.256055036. PMID: 16284127

Clinical prediction guides

Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation.
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern.
Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M
Mod Pathol 2016 Mar;29(3):293-301. Epub 2016 Jan 15 doi: 10.1038/modpathol.2015.152. PMID: 26769137
Intraductal neoplasm of the intrahepatic bile duct: clinicopathological study of 24 cases.
Naito Y, Kusano H, Nakashima O, Sadashima E, Hattori S, Taira T, Kawahara A, Okabe Y, Shimamatsu K, Taguchi J, Momosaki S, Irie K, Yamaguchi R, Yokomizo H, Nagamine M, Fukuda S, Sugiyama S, Nishida N, Higaki K, Yoshitomi M, Yasunaga M, Okuda K, Kinoshita H, Nakayama M, Yasumoto M, Akiba J, Kage M, Yano H
World J Gastroenterol 2012 Jul 28;18(28):3673-80. doi: 10.3748/wjg.v18.i28.3673. PMID: 22851859Free PMC Article
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286
Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT?
Kawamoto S, Horton KM, Lawler LP, Hruban RH, Fishman EK
Radiographics 2005 Nov-Dec;25(6):1451-68; discussion 1468-70. doi: 10.1148/rg.256055036. PMID: 16284127

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