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Liver Germ Cell Tumor

MedGen UID:
474710
•Concept ID:
C3273077
•
Neoplastic Process
Synonym: Hepatic Germ Cell Tumor

Definition

A benign or malignant extragonadal germ cell tumor that arises from the liver. Representative examples include teratoma and yolk sac tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Germ Cell Tumor

Professional guidelines

PubMed

Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance.
Gallo C, Rossi RE, Cavalcoli F, Barbaro F, Boškoski I, Invernizzi P, Massironi S
World J Gastroenterol 2022 Mar 21;28(11):1123-1138. doi: 10.3748/wjg.v28.i11.1123. PMID: 35431507Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776

Recent clinical studies

Etiology

Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance.
Gallo C, Rossi RE, Cavalcoli F, Barbaro F, Boškoski I, Invernizzi P, Massironi S
World J Gastroenterol 2022 Mar 21;28(11):1123-1138. doi: 10.3748/wjg.v28.i11.1123. PMID: 35431507Free PMC Article
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Diagnosis

Management of extraretroperitoneal masses in germ cell tumor.
Shah A, Nassiri N, Daneshmand S
Curr Opin Urol 2019 Jan;29(1):33-41. doi: 10.1097/MOU.0000000000000563. PMID: 30334834
Choriocarcinoma syndrome.
Medina A, Ramos M, Amenedo M, París L
Arch Esp Urol 2014 Oct;67(8):711-4. PMID: 25306991
Gonadoblastoma and hepatoid and endometrioid-like yolk sac tumor: an update.
Ulbright TM
Int J Gynecol Pathol 2014 Jul;33(4):365-73. doi: 10.1097/PGP.0000000000000134. PMID: 24901396
Neonatal cancer.
Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134
Malignant liver tumors.
Ros PR, Rasmussen JF
Curr Probl Diagn Radiol 1989 May-Jun;18(3):95-124. doi: 10.1016/0363-0188(89)90026-1. PMID: 2544348

Therapy

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma.
Song Q, Zhang X, Liu W, Wei H, Liang W, Zhou Y, Ding Y, Ji F, Ho-Kwan Cheung A, Wong N, Yu J
J Hepatol 2023 Dec;79(6):1352-1365. Epub 2023 Jul 17 doi: 10.1016/j.jhep.2023.07.005. PMID: 37459922
Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation.
Wang Y, Chen C, Chen J, Sang T, Peng H, Lin X, Zhao Q, Chen S, Eling T, Wang X
Redox Biol 2022 Jun;52:102322. Epub 2022 Apr 27 doi: 10.1016/j.redox.2022.102322. PMID: 35504134Free PMC Article
Metastatic uveal melanoma: The final frontier.
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Prognosis

Chronic Immune-Related Adverse Events Following Adjuvant Anti-PD-1 Therapy for High-risk Resected Melanoma.
Patrinely JR Jr, Johnson R, Lawless AR, Bhave P, Sawyers A, Dimitrova M, Yeoh HL, Palmeri M, Ye F, Fan R, Davis EJ, Rapisuwon S, Long GV, Haydon A, Osman I, Mehnert JM, Carlino MS, Sullivan RJ, Menzies AM, Johnson DB
JAMA Oncol 2021 May 1;7(5):744-748. doi: 10.1001/jamaoncol.2021.0051. PMID: 33764387Free PMC Article
Endocrine pathology: past, present and future.
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Liver transplantation for unresectable neuroendocrine tumor liver metastases.
Rossi RE, Burroughs AK, Caplin ME
Ann Surg Oncol 2014 Jul;21(7):2398-405. Epub 2014 Feb 22 doi: 10.1245/s10434-014-3523-y. PMID: 24562931
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Clinical prediction guides

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma.
Song Q, Zhang X, Liu W, Wei H, Liang W, Zhou Y, Ding Y, Ji F, Ho-Kwan Cheung A, Wong N, Yu J
J Hepatol 2023 Dec;79(6):1352-1365. Epub 2023 Jul 17 doi: 10.1016/j.jhep.2023.07.005. PMID: 37459922
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors.
Strosberg JR, Halfdanarson TR, Bellizzi AM, Chan JA, Dillon JS, Heaney AP, Kunz PL, O'Dorisio TM, Salem R, Segelov E, Howe JR, Pommier RF, Brendtro K, Bashir MA, Singh S, Soulen MC, Tang L, Zacks JS, Yao JC, Bergsland EK
Pancreas 2017 Jul;46(6):707-714. doi: 10.1097/MPA.0000000000000850. PMID: 28609356Free PMC Article
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent systematic reviews

Management of neuroendocrine tumor liver metastases.
Harrelson A, Wang R, Stewart A, Ingram C, Gillis A, Rose JB, El-Rayes B, Azmi A, Chen H
Am J Surg 2023 Nov;226(5):623-630. Epub 2023 Aug 16 doi: 10.1016/j.amjsurg.2023.08.011. PMID: 37657968
Systematic review of fetal and placental metastases among pregnant patients with cancer.
Khazzaka A, Rassy E, Sleiman Z, Boussios S, Pavlidis N
Cancer Treat Rev 2022 Mar;104:102356. Epub 2022 Feb 11 doi: 10.1016/j.ctrv.2022.102356. PMID: 35182890
Combined liver-intestinal and multivisceral transplantation for neuroendocrine tumors extending beyond the liver: A systematic literature review.
Duchateau NM, Canovai E, Vianna RM, Vanuytsel T, Verslype C, Mazariegos GV, Monbaliu D, Pirenne J, Ceulemans LJ
Transplant Rev (Orlando) 2022 Jan;36(1):100678. Epub 2022 Jan 21 doi: 10.1016/j.trre.2022.100678. PMID: 35090785
Yttrium-90 radioembolization for unresectable metastatic neuroendocrine liver tumor: A systematic review.
Jia Z, Wang W
Eur J Radiol 2018 Mar;100:23-29. Epub 2018 Jan 9 doi: 10.1016/j.ejrad.2018.01.012. PMID: 29496075
Liver transplantation in patients with liver metastases from neuroendocrine tumors: A systematic review.
Moris D, Tsilimigras DI, Ntanasis-Stathopoulos I, Beal EW, Felekouras E, Vernadakis S, Fung JJ, Pawlik TM
Surgery 2017 Sep;162(3):525-536. Epub 2017 Jun 16 doi: 10.1016/j.surg.2017.05.006. PMID: 28624178

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