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Liver Yolk Sac Tumor

MedGen UID:
474711
•Concept ID:
C3273078
•
Neoplastic Process
Synonym: Hepatic Yolk Sac Tumor

Definition

A yolk sac tumor that arises from the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiver Yolk Sac Tumor

Professional guidelines

PubMed

Immunohistochemical expression of SALL4 in hepatocellular carcinoma, a potential pitfall in the differential diagnosis of yolk sac tumors.
Gonzalez-Roibon N, Katz B, Chaux A, Sharma R, Munari E, Faraj SF, Illei PB, Torbenson M, Netto GJ
Hum Pathol 2013 Jul;44(7):1293-9. Epub 2013 Jan 21 doi: 10.1016/j.humpath.2012.10.017. PMID: 23347651
Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections.
Fan Z, van de Rijn M, Montgomery K, Rouse RV
Mod Pathol 2003 Feb;16(2):137-44. doi: 10.1097/01.MP.0000052103.13730.20. PMID: 12591966
An improved sensitive assay method for the heterogeneity of alpha-foetoprotein: possible application for early differential diagnosis.
Ohkawa K, Abe T, Tsukada Y, Taketa K, Kimura E, Terashima Y
J Clin Chem Clin Biochem 1989 May;27(5):337-41. doi: 10.1515/cclm.1989.27.5.337. PMID: 2474625

Recent clinical studies

Etiology

Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry.
Sekar MD, Pradeep I, Srinivas BH, Toi PC, Govindarajan K, Kayal S
Int J Surg Pathol 2023 Dec;31(8):1618-1625. Epub 2023 Apr 3 doi: 10.1177/10668969231157777. PMID: 37013352
Clinicopathologic and prognostic characteristics of alpha-fetoprotein-producing gastric cancer.
He R, Yang Q, Dong X, Wang Y, Zhang W, Shen L, Zhang Z
Oncotarget 2017 Apr 4;8(14):23817-23830. doi: 10.18632/oncotarget.15909. PMID: 28423604Free PMC Article
Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma.
Damato S, Haldar K, McCluggage WG
Int J Gynecol Pathol 2016 Jul;35(4):316-20. doi: 10.1097/PGP.0000000000000236. PMID: 26598980
Primary yolk sac tumor of the common bile duct.
Munghate GS, Agarwala S, Bhatnagar V
J Pediatr Surg 2011 Jun;46(6):1271-3. doi: 10.1016/j.jpedsurg.2011.02.001. PMID: 21683236
Markers for hepatocellular carcinoma.
Wu AH, Sell S
Immunol Ser 1990;53:403-22. PMID: 1713067

Diagnosis

Liver transplantation for advanced-stage primary hepatic yolk sac tumor: A case report and literature review.
Liu GH, Qiu MK, Wang Y, Zhang TT, Wang LJ, Guan WB, Ou JM, Chen LT
Medicine (Baltimore) 2023 Dec 15;102(50):e35821. doi: 10.1097/MD.0000000000035821. PMID: 38115376Free PMC Article
A yolk sac tumor of the pancreas and derived xenograft model effectively responded to VIP chemotherapy.
Yonemaru J, Takahashi M, Nara S, Ichikawa H, Ishigamori R, Imai T, Hiraoka N
Pancreatology 2020 Apr;20(3):551-557. Epub 2019 Dec 31 doi: 10.1016/j.pan.2019.12.021. PMID: 31917123
Gonadoblastoma and hepatoid and endometrioid-like yolk sac tumor: an update.
Ulbright TM
Int J Gynecol Pathol 2014 Jul;33(4):365-73. doi: 10.1097/PGP.0000000000000134. PMID: 24901396
Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?
Rittiluechai K, Wilcox R, Lisle J, Everett E, Wallace HJ 3rd, Verschraegen CF
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:25-9. Epub 2014 Jan 3 doi: 10.1016/j.ejogrb.2013.12.029. PMID: 24462393
Hepatic tumors in children.
Stocker JT
Clin Liver Dis 2001 Feb;5(1):259-81, viii-ix. doi: 10.1016/s1089-3261(05)70163-x. PMID: 11218918

Therapy

Icaritin promotes apoptosis and inhibits proliferation by down-regulating AFP gene expression in hepatocellular carcinoma.
Li H, Liu Y, Jiang W, Xue J, Cheng Y, Wang J, Yang R, Zhang X
BMC Cancer 2021 Mar 25;21(1):318. doi: 10.1186/s12885-021-08043-9. PMID: 33765973Free PMC Article
A yolk sac tumor of the pancreas and derived xenograft model effectively responded to VIP chemotherapy.
Yonemaru J, Takahashi M, Nara S, Ichikawa H, Ishigamori R, Imai T, Hiraoka N
Pancreatology 2020 Apr;20(3):551-557. Epub 2019 Dec 31 doi: 10.1016/j.pan.2019.12.021. PMID: 31917123
Primary yolk sac tumour of the prostate mimicking small round blue cell tumour.
Gui H, Kolster RA, Palmer MB, Brooks JS, Zhang M, Husson MA
Curr Oncol 2019 Oct;26(5):e707. Epub 2019 Oct 1 doi: 10.3747/co.26.5179. PMID: 31708666Free PMC Article
Primary orbital endodermal sinus tumor (yolk sac tumor).
Kiratli H, Erkan Balci K, Güler G
J AAPOS 2008 Dec;12(6):623-5. Epub 2008 Oct 4 doi: 10.1016/j.jaapos.2008.06.011. PMID: 18835732
Successful orthotopic liver transplantation for treatment of a hepatic yolk sac tumor.
Abramson LP, Pillai S, Acton R, Melin-Aldana H, Superina R
J Pediatr Surg 2005 Jul;40(7):1185-7. doi: 10.1016/j.jpedsurg.2005.03.065. PMID: 16034768

Prognosis

Discovery and diagnostic value of a novel oncofetal protein: glypican 3.
Wang SK, Zynger DL, Hes O, Yang XJ
Adv Anat Pathol 2014 Nov;21(6):450-60. doi: 10.1097/PAP.0000000000000043. PMID: 25299314
Prognosis of hepatoid yolk sac tumor in women: what's up, Doc?
Rittiluechai K, Wilcox R, Lisle J, Everett E, Wallace HJ 3rd, Verschraegen CF
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:25-9. Epub 2014 Jan 3 doi: 10.1016/j.ejogrb.2013.12.029. PMID: 24462393
Newly available antibodies with practical applications in surgical pathology.
Chan JK
Int J Surg Pathol 2013 Dec;21(6):553-72. doi: 10.1177/1066896913507601. PMID: 24225578
Hepatic tumors in children.
Stocker JT
Clin Liver Dis 2001 Feb;5(1):259-81, viii-ix. doi: 10.1016/s1089-3261(05)70163-x. PMID: 11218918
Yolk sac tumor of the liver combined with hepatocellular carcinoma.
Morinaga S, Nishiya H, Inafuku T
Arch Pathol Lab Med 1996 Jul;120(7):687-90. PMID: 8757478

Clinical prediction guides

Liver transplantation for advanced-stage primary hepatic yolk sac tumor: A case report and literature review.
Liu GH, Qiu MK, Wang Y, Zhang TT, Wang LJ, Guan WB, Ou JM, Chen LT
Medicine (Baltimore) 2023 Dec 15;102(50):e35821. doi: 10.1097/MD.0000000000035821. PMID: 38115376Free PMC Article
Discovery and diagnostic value of a novel oncofetal protein: glypican 3.
Wang SK, Zynger DL, Hes O, Yang XJ
Adv Anat Pathol 2014 Nov;21(6):450-60. doi: 10.1097/PAP.0000000000000043. PMID: 25299314
Newly available antibodies with practical applications in surgical pathology.
Chan JK
Int J Surg Pathol 2013 Dec;21(6):553-72. doi: 10.1177/1066896913507601. PMID: 24225578
Oncofetal protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary.
Esheba GE, Pate LL, Longacre TA
Am J Surg Pathol 2008 Apr;32(4):600-7. doi: 10.1097/PAS.0b013e31815a565a. PMID: 18277882
Yolk sac tumor of the liver combined with hepatocellular carcinoma.
Morinaga S, Nishiya H, Inafuku T
Arch Pathol Lab Med 1996 Jul;120(7):687-90. PMID: 8757478

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