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Gallbladder Neuroendocrine Carcinoma

MedGen UID:
474750
•Concept ID:
C3273117
•
Neoplastic Process
Synonyms: Gallbladder G3; Gallbladder High Grade Neuroendocrine Carcinoma; Gallbladder NEC; Gallbladder Poorly Differentiated Endocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the gallbladder. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [from NCI]

Professional guidelines

PubMed

Clinical diagnosis and treatment of 37 cases of gallbladder neuroendocrine carcinoma.
Liu F, Miao W, Nan J, Shi Z, Zhang A, Bo Y, Xu J
World J Surg Oncol 2024 Jun 14;22(1):157. doi: 10.1186/s12957-024-03436-z. PMID: 38877554Free PMC Article
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article

Recent clinical studies

Etiology

Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?
Hu YF, Wang JK, Ma WJ, Hu HJ, Gu HF, Liu F, Lv TR, Yang SQ, Dai YS, Zou RQ, Jin YW, Li FY
Front Endocrinol (Lausanne) 2024;15:1217250. Epub 2024 Jul 22 doi: 10.3389/fendo.2024.1217250. PMID: 39104815Free PMC Article
Clinical diagnosis and treatment of 37 cases of gallbladder neuroendocrine carcinoma.
Liu F, Miao W, Nan J, Shi Z, Zhang A, Bo Y, Xu J
World J Surg Oncol 2024 Jun 14;22(1):157. doi: 10.1186/s12957-024-03436-z. PMID: 38877554Free PMC Article
Comparison of the clinical features and long-term prognosis of gallbladder neuroendocrine carcinoma versus gallbladder adenocarcinoma: A propensity score-matched analysis.
Hu YF, Ma WJ, Hu HJ, Gu HF, Jin YW, Li FY
Biomol Biomed 2023 Nov 3;23(6):1096-1107. doi: 10.17305/bb.2023.9582. PMID: 37724922Free PMC Article
Gallbladder neuroendocrine carcinoma: A single center experience.
Chu H, Zhang C, Shi Y, Wu W, Hu Z, Zhang J, Huang D
Medicine (Baltimore) 2020 Sep 4;99(36):e21912. doi: 10.1097/MD.0000000000021912. PMID: 32899024Free PMC Article
Gallbladder neuroendocrine carcinoma: report of 10 cases and comparision of clinicopathologic features with gallbladder adenocarcinoma.
Chen C, Wang L, Liu X, Zhang G, Zhao Y, Geng Z
Int J Clin Exp Pathol 2015;8(7):8218-26. Epub 2015 Jul 1 PMID: 26339390Free PMC Article

Diagnosis

Neuroendocrine carcinoma of the gallbladder: A case report and literature review.
Yao X, Wu K, Lu B, Lin F
Medicine (Baltimore) 2024 Aug 2;103(31):e39147. doi: 10.1097/MD.0000000000039147. PMID: 39093760Free PMC Article
Clinical diagnosis and treatment of 37 cases of gallbladder neuroendocrine carcinoma.
Liu F, Miao W, Nan J, Shi Z, Zhang A, Bo Y, Xu J
World J Surg Oncol 2024 Jun 14;22(1):157. doi: 10.1186/s12957-024-03436-z. PMID: 38877554Free PMC Article
Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
Brain metastasis from gallbladder neuroendocrine carcinoma.
Sasaki H, Goto T, Hirao M, Fujimoto Y
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-238114. PMID: 33257386Free PMC Article

Therapy

Immune checkpoint inhibitor therapy for primary neuroendocrine carcinoma of the gallbladder: A case report and literature review.
Li C, Lv P, Yanyan L, Yin M, Li H
Medicine (Baltimore) 2024 Oct 25;103(43):e40178. doi: 10.1097/MD.0000000000040178. PMID: 39470513Free PMC Article
Neuroendocrine carcinoma of the gallbladder: A case report and literature review.
Yao X, Wu K, Lu B, Lin F
Medicine (Baltimore) 2024 Aug 2;103(31):e39147. doi: 10.1097/MD.0000000000039147. PMID: 39093760Free PMC Article
Brain metastasis from gallbladder neuroendocrine carcinoma.
Sasaki H, Goto T, Hirao M, Fujimoto Y
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-238114. PMID: 33257386Free PMC Article

Prognosis

Neuroendocrine carcinoma of the gallbladder: A case report and literature review.
Yao X, Wu K, Lu B, Lin F
Medicine (Baltimore) 2024 Aug 2;103(31):e39147. doi: 10.1097/MD.0000000000039147. PMID: 39093760Free PMC Article
Clinical diagnosis and treatment of 37 cases of gallbladder neuroendocrine carcinoma.
Liu F, Miao W, Nan J, Shi Z, Zhang A, Bo Y, Xu J
World J Surg Oncol 2024 Jun 14;22(1):157. doi: 10.1186/s12957-024-03436-z. PMID: 38877554Free PMC Article
Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma.
Jiang M, Zhang Y
J Cancer Res Ther 2023 Aug;19(4):910-916. doi: 10.4103/jcrt.jcrt_1959_21. PMID: 37675716
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
Gallbladder neuroendocrine carcinoma: A single center experience.
Chu H, Zhang C, Shi Y, Wu W, Hu Z, Zhang J, Huang D
Medicine (Baltimore) 2020 Sep 4;99(36):e21912. doi: 10.1097/MD.0000000000021912. PMID: 32899024Free PMC Article

Clinical prediction guides

Clinical diagnosis and treatment of 37 cases of gallbladder neuroendocrine carcinoma.
Liu F, Miao W, Nan J, Shi Z, Zhang A, Bo Y, Xu J
World J Surg Oncol 2024 Jun 14;22(1):157. doi: 10.1186/s12957-024-03436-z. PMID: 38877554Free PMC Article
Comparison of the clinical features and long-term prognosis of gallbladder neuroendocrine carcinoma versus gallbladder adenocarcinoma: A propensity score-matched analysis.
Hu YF, Ma WJ, Hu HJ, Gu HF, Jin YW, Li FY
Biomol Biomed 2023 Nov 3;23(6):1096-1107. doi: 10.17305/bb.2023.9582. PMID: 37724922Free PMC Article
Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article
Gallbladder neuroendocrine carcinoma: A single center experience.
Chu H, Zhang C, Shi Y, Wu W, Hu Z, Zhang J, Huang D
Medicine (Baltimore) 2020 Sep 4;99(36):e21912. doi: 10.1097/MD.0000000000021912. PMID: 32899024Free PMC Article
Whole-genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC).
Li M, Liu F, Zhang Y, Wu X, Wu W, Wang XA, Zhao S, Liu S, Liang H, Zhang F, Ma Q, Xiang S, Li H, Jiang L, Hu Y, Gong W, Zhang Y, Ma T, Zhang K, Liu Y, Liu Y
Cancer Lett 2017 Apr 10;391:20-27. Epub 2016 Dec 29 doi: 10.1016/j.canlet.2016.12.027. PMID: 28040546

Recent systematic reviews

Update in clinical management for gallbladder neuroendocrine carcinoma.
Chu H, Shi Y, Liu J, Huang D, Zhang J, Dou C
Medicine (Baltimore) 2021 Apr 9;100(14):e25449. doi: 10.1097/MD.0000000000025449. PMID: 33832150Free PMC Article

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