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Gallbladder Mixed Adenoneuroendocrine Carcinoma

MedGen UID:
474755
•Concept ID:
C3273122
•
Neoplastic Process
Synonym: Gallbladder MANEC

Definition

A carcinoma that arises from the gallbladder and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Mixed Adenoneuroendocrine Carcinoma

Professional guidelines

PubMed

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article

Recent clinical studies

Etiology

Neuroendocrine Carcinoma of Gallbladder: A Step Beyond Palliative Therapy, Experience of 25 Cases.
Kanetkar AV, Patkar S, Khobragade KH, Ostwal V, Ramaswamy A, Goel M
J Gastrointest Cancer 2019 Jun;50(2):298-303. doi: 10.1007/s12029-018-0070-y. PMID: 29435905
Neuroendocrine Carcinoma of Gall Bladder: A Series of 19 Cases with Review of Literature.
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508
Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity.
Sahnane N, Furlan D, Monti M, Romualdi C, Vanoli A, Vicari E, Solcia E, Capella C, Sessa F, La Rosa S
Endocr Relat Cancer 2015 Feb;22(1):35-45. Epub 2014 Dec 2 doi: 10.1530/ERC-14-0410. PMID: 25465415
Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy.
Song W, Chen W, Zhang S, Peng J, He Y
Diagn Pathol 2012 Nov 27;7:163. doi: 10.1186/1746-1596-7-163. PMID: 23186166Free PMC Article
Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours.
Kim J, Lee WJ, Lee SH, Lee KB, Ryu JK, Kim YT, Kim SW, Yoon YB, Hwang JH, Han HS, Woo SM, Park SJ
Dig Liver Dis 2011 Dec;43(12):965-70. doi: 10.1016/j.dld.2011.07.010. PMID: 21856258

Diagnosis

Rare Mixed Adenoneuroendocrine Carcinoma of the Gallbladder: Case Report and Review of Literature.
Costa AC, Cavalcanti CLC, Coelho HGB, Leão LHA, Soares DTC, Santa-Cruz F, Paz AR, Ferraz ÁAB
Am J Case Rep 2021 May 4;22:e929511. doi: 10.12659/AJCR.929511. PMID: 33945521Free PMC Article
Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article
Mixed Adenoneuroendocrine Carcinoma of the Gallbladder.
Lin YX, Jia QB, Fu YY, Cheng NS
J Gastrointest Surg 2018 Aug;22(8):1452-1454. Epub 2018 Jan 8 doi: 10.1007/s11605-017-3664-y. PMID: 29313288
Cytomorphology of neuroendocrine tumours of the gallbladder.
Yadav R, Jain D, Mathur SR, Iyer VK
Cytopathology 2016 Apr;27(2):97-102. Epub 2015 Feb 18 doi: 10.1111/cyt.12239. PMID: 25689921
Neuroendocrine Carcinoma of Gall Bladder: A Series of 19 Cases with Review of Literature.
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508

Therapy

Neuroendocrine Carcinoma of Gallbladder: A Step Beyond Palliative Therapy, Experience of 25 Cases.
Kanetkar AV, Patkar S, Khobragade KH, Ostwal V, Ramaswamy A, Goel M
J Gastrointest Cancer 2019 Jun;50(2):298-303. doi: 10.1007/s12029-018-0070-y. PMID: 29435905
Two cases of neuroendocrine carcinoma of the gallbladder.
Chen H, Shen YY, Ni XZ
World J Gastroenterol 2014 Sep 7;20(33):11916-20. doi: 10.3748/wjg.v20.i33.11916. PMID: 25206300Free PMC Article
Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy.
Song W, Chen W, Zhang S, Peng J, He Y
Diagn Pathol 2012 Nov 27;7:163. doi: 10.1186/1746-1596-7-163. PMID: 23186166Free PMC Article

Prognosis

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article
Cytomorphology of neuroendocrine tumours of the gallbladder.
Yadav R, Jain D, Mathur SR, Iyer VK
Cytopathology 2016 Apr;27(2):97-102. Epub 2015 Feb 18 doi: 10.1111/cyt.12239. PMID: 25689921
Neuroendocrine Carcinoma of Gall Bladder: A Series of 19 Cases with Review of Literature.
Kamboj M, Gandhi JS, Gupta G, Sharma A, Pasricha S, Mehta A, Chandragouda D, Sinha R
J Gastrointest Cancer 2015 Dec;46(4):356-64. doi: 10.1007/s12029-015-9745-9. PMID: 26208508
Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity.
Sahnane N, Furlan D, Monti M, Romualdi C, Vanoli A, Vicari E, Solcia E, Capella C, Sessa F, La Rosa S
Endocr Relat Cancer 2015 Feb;22(1):35-45. Epub 2014 Dec 2 doi: 10.1530/ERC-14-0410. PMID: 25465415
Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy.
Song W, Chen W, Zhang S, Peng J, He Y
Diagn Pathol 2012 Nov 27;7:163. doi: 10.1186/1746-1596-7-163. PMID: 23186166Free PMC Article

Clinical prediction guides

Focal neuroendocrine carcinoma mixed with adenocarcinoma of the gallbladder with aggressive lymph node metastasis in a patient who did not meet the mixed neuroendocrine-non-neuroendocrine neoplasm criteria.
Kadota Y, Funakoshi S, Hirose S, Shiomi E, Odaira M, Yagishita H, Kobayashi Y, Toriumi F, Tamai S, Endo T, Harada H
Clin J Gastroenterol 2022 Feb;15(1):185-191. Epub 2021 Nov 12 doi: 10.1007/s12328-021-01547-8. PMID: 34767241Free PMC Article
The role of next-generation sequencing in the differential diagnosis of composite neoplasms.
Acosta AM, Al Rasheed MRH, Pins MR, Borgen KR, Panchal D, Rogozinska M, Wiley EL, Behm FG, Mohapatra G
Hum Pathol 2018 Nov;81:78-88. Epub 2018 Jun 26 doi: 10.1016/j.humpath.2018.06.022. PMID: 29958927
Mixed Adenoneuroendocrine Carcinoma of the Gallbladder.
Lin YX, Jia QB, Fu YY, Cheng NS
J Gastrointest Surg 2018 Aug;22(8):1452-1454. Epub 2018 Jan 8 doi: 10.1007/s11605-017-3664-y. PMID: 29313288
Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity.
Sahnane N, Furlan D, Monti M, Romualdi C, Vanoli A, Vicari E, Solcia E, Capella C, Sessa F, La Rosa S
Endocr Relat Cancer 2015 Feb;22(1):35-45. Epub 2014 Dec 2 doi: 10.1530/ERC-14-0410. PMID: 25465415
Mixed adenoneuroendocrine carcinoma of the gallbladder with squamous cell carcinomatous and osteosarcomatous differentiation: report of a case.
Shintaku M, Kataoka K, Kawabata K
Pathol Int 2013 Feb;63(2):113-9. Epub 2013 Feb 22 doi: 10.1111/pin.12029. PMID: 23464969

Recent systematic reviews

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.
Machairas N, Paspala A, Frountzas M, Tsilimigras DI, Moris D, Ntomi V, Tsapralis D, Schizas D
In Vivo 2019 Nov-Dec;33(6):1721-1726. doi: 10.21873/invivo.11662. PMID: 31662496Free PMC Article

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