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Intrahepatic Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma

MedGen UID:
474769
Concept ID:
C3273136
Neoplastic Process
Synonyms: Intrahepatic Bile Duct IPN with an Associated Invasive Carcinoma; Intrahepatic Bile Duct Papillary Neoplasm with an Associated Invasive Carcinoma

Definition

A papillary neoplasm that arises from the epithelium of the intrahepatic bile ducts and it is associated with an invasive carcinomatous component. The carcinomatous component is an intrahepatic cholangiocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntrahepatic Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma

Professional guidelines

Recent clinical studies

Etiology

Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Kubota K, Jang JY, Nakanuma Y, Jang KT, Haruyama Y, Fukushima N, Furukawa T, Hong SM, Sakuraoka Y, Kim H, Matsumoto T, Lee KB, Zen Y, Kim J, Miyazaki M, Choi DW, Heo JS, Endo I, Hwang S, Nakamura M, Han HS, Uemoto S, Park SJ, Hong EK, Nanashima A, Kim DS, Kim JY, Ohta T, Kang KJ, Fukumoto T, Nah YW, Seo HI, Inui K, Yoon DS, Unno M
J Hepatobiliary Pancreat Sci 2020 Sep;27(9):581-597. Epub 2020 Jul 2 doi: 10.1002/jhbp.785. PMID: 32511838
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
Tanaka M, Shibahara J, Ishikawa S, Ushiku T, Morikawa T, Shinozaki-Ushiku A, Hayashi A, Misumi K, Tanaka A, Katoh H, Sakuma K, Kokudo T, Inagaki Y, Arita J, Sakamoto Y, Hasegawa K, Fukayama M
Virchows Arch 2019 Jan;474(1):39-46. Epub 2018 Oct 23 doi: 10.1007/s00428-018-2476-0. PMID: 30349952
Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M
Mod Pathol 2016 Mar;29(3):293-301. Epub 2016 Jan 15 doi: 10.1038/modpathol.2015.152. PMID: 26769137

Diagnosis

Liu Y, Yeh MM
Hum Pathol 2023 Feb;132:158-168. Epub 2022 Jun 14 doi: 10.1016/j.humpath.2022.06.012. PMID: 35714833
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Kubota K, Jang JY, Nakanuma Y, Jang KT, Haruyama Y, Fukushima N, Furukawa T, Hong SM, Sakuraoka Y, Kim H, Matsumoto T, Lee KB, Zen Y, Kim J, Miyazaki M, Choi DW, Heo JS, Endo I, Hwang S, Nakamura M, Han HS, Uemoto S, Park SJ, Hong EK, Nanashima A, Kim DS, Kim JY, Ohta T, Kang KJ, Fukumoto T, Nah YW, Seo HI, Inui K, Yoon DS, Unno M
J Hepatobiliary Pancreat Sci 2020 Sep;27(9):581-597. Epub 2020 Jul 2 doi: 10.1002/jhbp.785. PMID: 32511838
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article

Therapy

Sato Y, Kubo S, Takemura S, Sugawara Y, Tanaka S, Fujikawa M, Arimoto A, Harada K, Sasaki M, Nakanuma Y
Int J Clin Exp Pathol 2014;7(8):4745-54. Epub 2014 Jul 15 PMID: 25197345Free PMC Article

Prognosis

Goeppert B, Stichel D, Toth R, Fritzsche S, Loeffler MA, Schlitter AM, Neumann O, Assenov Y, Vogel MN, Mehrabi A, Hoffmann K, Köhler B, Springfeld C, Weichenhan D, Plass C, Esposito I, Schirmacher P, von Deimling A, Roessler S
Gut 2022 Feb;71(2):391-401. Epub 2021 Jan 19 doi: 10.1136/gutjnl-2020-322983. PMID: 33468537Free PMC Article
Kubota K, Jang JY, Nakanuma Y, Jang KT, Haruyama Y, Fukushima N, Furukawa T, Hong SM, Sakuraoka Y, Kim H, Matsumoto T, Lee KB, Zen Y, Kim J, Miyazaki M, Choi DW, Heo JS, Endo I, Hwang S, Nakamura M, Han HS, Uemoto S, Park SJ, Hong EK, Nanashima A, Kim DS, Kim JY, Ohta T, Kang KJ, Fukumoto T, Nah YW, Seo HI, Inui K, Yoon DS, Unno M
J Hepatobiliary Pancreat Sci 2020 Sep;27(9):581-597. Epub 2020 Jul 2 doi: 10.1002/jhbp.785. PMID: 32511838
Lee S, Kim MJ, Kim S, Choi D, Jang KT, Park YN
J Hepatol 2019 Apr;70(4):692-699. Epub 2018 Dec 14 doi: 10.1016/j.jhep.2018.12.005. PMID: 30553839
Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M
Mod Pathol 2016 Mar;29(3):293-301. Epub 2016 Jan 15 doi: 10.1038/modpathol.2015.152. PMID: 26769137
Bennett S, Marginean EC, Paquin-Gobeil M, Wasserman J, Weaver J, Mimeault R, Balaa FK, Martel G
HPB (Oxford) 2015 Sep;17(9):811-8. doi: 10.1111/hpb.12460. PMID: 26278323Free PMC Article

Clinical prediction guides

Lluís N, Onoe S, Serradilla-Martín M, Achalandabaso M, Mizuno T, Jehaes F, Dasari BVM, Mambrilla-Herrero S, Sparrelid E, Balakrishnan A, Hoogwater FJH, Amaral MJ, Andersson B, Berrevoet F, Doussot A, López-López V, Detry O, Pozo CD, Machairas N, Pekli D, Alcázar-López CF, Asbun H, Björnsson B, Christophides T, Díez-Caballero A, Francart D, Noel CB, Sousa-Silva D, Toledo-Martínez E, Tzimas GN, Yaqub S, Yamaguchi J, Dokmak S, Prieto-Calvo M, D'Souza MA, Spiers HVM, van den Heuvel MC, Charco R, Lesurtel M, Ebata T, Ramia JM
HPB (Oxford) 2024 Apr;26(4):565-575. Epub 2024 Jan 19 doi: 10.1016/j.hpb.2024.01.009. PMID: 38307773
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
Tsukahara T, Shimoyama Y, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T, Yamaguchi J, Nakamura S, Nagino M
Mod Pathol 2016 Mar;29(3):293-301. Epub 2016 Jan 15 doi: 10.1038/modpathol.2015.152. PMID: 26769137
Naito Y, Kusano H, Nakashima O, Sadashima E, Hattori S, Taira T, Kawahara A, Okabe Y, Shimamatsu K, Taguchi J, Momosaki S, Irie K, Yamaguchi R, Yokomizo H, Nagamine M, Fukuda S, Sugiyama S, Nishida N, Higaki K, Yoshitomi M, Yasunaga M, Okuda K, Kinoshita H, Nakayama M, Yasumoto M, Akiba J, Kage M, Yano H
World J Gastroenterol 2012 Jul 28;18(28):3673-80. doi: 10.3748/wjg.v18.i28.3673. PMID: 22851859Free PMC Article

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