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Adult Extramedullary Hematopoiesis

MedGen UID:
474857
•Concept ID:
C3273224
•
Finding

Definition

Extramedullary hematopoiesis occurring during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Extramedullary Hematopoiesis

Professional guidelines

PubMed

Management of pyruvate kinase deficiency in children and adults.
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency.
Bianchi P, Fermo E, Lezon-Geyda K, van Beers EJ, Morton HD, Barcellini W, Glader B, Chonat S, Ravindranath Y, Newburger PE, Kollmar N, Despotovic JM, Verhovsek M, Sharma M, Kwiatkowski JL, Kuo KHM, Wlodarski MW, Yaish HM, Holzhauer S, Wang H, Kunz J, Addonizio K, Al-Sayegh H, London WB, Andres O, van Wijk R, Gallagher PG, Grace RFF
Am J Hematol 2020 May;95(5):472-482. Epub 2020 Mar 6 doi: 10.1002/ajh.25753. PMID: 32043619Free PMC Article
Cutaneous extramedullary haematopoiesis: Implications in human disease and treatment.
Khalil S, Ariel Gru A, Saavedra AP
Exp Dermatol 2019 Nov;28(11):1201-1209. Epub 2019 Aug 23 doi: 10.1111/exd.14013. PMID: 31351011

Recent clinical studies

Etiology

Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis.
Talpaz M, Kiladjian JJ
Leukemia 2021 Jan;35(1):1-17. Epub 2020 Jul 9 doi: 10.1038/s41375-020-0954-2. PMID: 32647323Free PMC Article
Cardiorenal syndrome in thalassemia patients.
Makmettakul S, Tantiworawit A, Phrommintikul A, Piriyakhuntorn P, Rattanathammethee T, Hantrakool S, Chai-Adisaksopha C, Rattarittamrong E, Norasetthada L, Fanhchaksai K, Charoenkwan P, Lekawanvijit S
BMC Nephrol 2020 Aug 3;21(1):325. doi: 10.1186/s12882-020-01990-8. PMID: 32746879Free PMC Article
Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis.
Huang Y, Liu R, Wei X, Liu J, Pan L, Yang G, Lai Y
Biomed Res Int 2019;2019:4504302. Epub 2019 Jan 30 doi: 10.1155/2019/4504302. PMID: 30834265Free PMC Article
Prognostication in MF: from CBC to cytogenetics to molecular markers.
Zhou A, Oh ST
Best Pract Res Clin Haematol 2014 Jun;27(2):155-64. Epub 2014 Jul 18 doi: 10.1016/j.beha.2014.07.008. PMID: 25189726
Thalassemia intermedia: revisited.
Taher A, Isma'eel H, Cappellini MD
Blood Cells Mol Dis 2006 Jul-Aug;37(1):12-20. Epub 2006 Jun 5 doi: 10.1016/j.bcmd.2006.04.005. PMID: 16737833

Diagnosis

The Quantification and Significance of Extramedullary Hematopoiesis Seen on Liver Biopsy Specimens.
Tremblay D, Saberi S, Mascarenhas J, Schiano TD, Fiel MI
Am J Clin Pathol 2022 Aug 4;158(2):277-282. doi: 10.1093/ajcp/aqac042. PMID: 35511690
Adult Hepatocellular Carcinoma Coexisting with Extramedullary Hematopoiesis.
Noguchi H, Higashi M, Desaki R, Tasaki T, Kirishima M, Kitazono I, Tabata K, Tanimoto A
Int J Surg Pathol 2022 May;30(3):339-345. Epub 2021 Oct 19 doi: 10.1177/10668969211050904. PMID: 34665056
Extramedullary hematopoiesis: Clinical and cytological features.
Kapatia G, Kaur A, Rastogi P, Sreedharanunni S, Gupta P, Rohilla M, Gupta N, Srinivasan R, Rajwanshi A, Dey P
Diagn Cytopathol 2020 Mar;48(3):191-196. Epub 2019 Nov 27 doi: 10.1002/dc.24353. PMID: 31774255
Extramedullary hemopoiesis.
Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS
Semin Ultrasound CT MR 2014 Jun;35(3):255-62. Epub 2013 Dec 19 doi: 10.1053/j.sult.2013.12.001. PMID: 24929265
Extramedullary hematopoiesis in pyogenic granuloma.
Waraasawapati S, Koonmee S, Kusama H, Kudo M
Pathol Int 2013 Oct;63(10):492-5. Epub 2013 Oct 18 doi: 10.1111/pin.12096. PMID: 24147429

Therapy

The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design.
Grace RF, van Beers EJ, Vives Corrons JL, Glader B, Glenthøj A, Kanno H, Kuo KHM, Lander C, Layton DM, Pospíŝilová D, Viprakasit V, Li J, Yan Y, Boscoe AN, Bowden C, Bianchi P
BMJ Open 2023 Mar 23;13(3):e063605. doi: 10.1136/bmjopen-2022-063605. PMID: 36958777Free PMC Article
Liver Regeneration by Hematopoietic Stem Cells: Have We Reached the End of the Road?
Siapati EK, Roubelakis MG, Vassilopoulos G
Cells 2022 Jul 27;11(15) doi: 10.3390/cells11152312. PMID: 35954155Free PMC Article
Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis.
Talpaz M, Kiladjian JJ
Leukemia 2021 Jan;35(1):1-17. Epub 2020 Jul 9 doi: 10.1038/s41375-020-0954-2. PMID: 32647323Free PMC Article
Management of pyruvate kinase deficiency in children and adults.
Grace RF, Barcellini W
Blood 2020 Sep 10;136(11):1241-1249. doi: 10.1182/blood.2019000945. PMID: 32702739
Pulmonary extramedullary hematopoiesis.
Bowling MR, Cauthen CG, Perry CD, Patel NP, Bergman S, Link KM, Sane AC, Conforti JF
J Thorac Imaging 2008 May;23(2):138-41. doi: 10.1097/RTI.0b013e31815b89aa. PMID: 18520574

Prognosis

The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design.
Grace RF, van Beers EJ, Vives Corrons JL, Glader B, Glenthøj A, Kanno H, Kuo KHM, Lander C, Layton DM, Pospíŝilová D, Viprakasit V, Li J, Yan Y, Boscoe AN, Bowden C, Bianchi P
BMJ Open 2023 Mar 23;13(3):e063605. doi: 10.1136/bmjopen-2022-063605. PMID: 36958777Free PMC Article
Sickle cell diseases: What can nuclear medicine offer?
Niccoli Asabella A, Altini C, Nappi AG, Lavelli V, Ferrari C, Marzullo A, Loiodice A, Rubini G
Hell J Nucl Med 2019 Jan-Apr;22(1):2-3. Epub 2019 Mar 7 doi: 10.1967/s002449910950. PMID: 30843001
Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis.
Huang Y, Liu R, Wei X, Liu J, Pan L, Yang G, Lai Y
Biomed Res Int 2019;2019:4504302. Epub 2019 Jan 30 doi: 10.1155/2019/4504302. PMID: 30834265Free PMC Article
Prognostication in MF: from CBC to cytogenetics to molecular markers.
Zhou A, Oh ST
Best Pract Res Clin Haematol 2014 Jun;27(2):155-64. Epub 2014 Jul 18 doi: 10.1016/j.beha.2014.07.008. PMID: 25189726
Extramedullary hematopoiesis in pyogenic granuloma.
Waraasawapati S, Koonmee S, Kusama H, Kudo M
Pathol Int 2013 Oct;63(10):492-5. Epub 2013 Oct 18 doi: 10.1111/pin.12096. PMID: 24147429

Clinical prediction guides

The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design.
Grace RF, van Beers EJ, Vives Corrons JL, Glader B, Glenthøj A, Kanno H, Kuo KHM, Lander C, Layton DM, Pospíŝilová D, Viprakasit V, Li J, Yan Y, Boscoe AN, Bowden C, Bianchi P
BMJ Open 2023 Mar 23;13(3):e063605. doi: 10.1136/bmjopen-2022-063605. PMID: 36958777Free PMC Article
Liver Regeneration by Hematopoietic Stem Cells: Have We Reached the End of the Road?
Siapati EK, Roubelakis MG, Vassilopoulos G
Cells 2022 Jul 27;11(15) doi: 10.3390/cells11152312. PMID: 35954155Free PMC Article
Adrenal myelolipoma: a comprehensive review.
Decmann Á, Perge P, Tóth M, Igaz P
Endocrine 2018 Jan;59(1):7-15. Epub 2017 Nov 21 doi: 10.1007/s12020-017-1473-4. PMID: 29164520
Prognostication in MF: from CBC to cytogenetics to molecular markers.
Zhou A, Oh ST
Best Pract Res Clin Haematol 2014 Jun;27(2):155-64. Epub 2014 Jul 18 doi: 10.1016/j.beha.2014.07.008. PMID: 25189726
Thalassemia intermedia: revisited.
Taher A, Isma'eel H, Cappellini MD
Blood Cells Mol Dis 2006 Jul-Aug;37(1):12-20. Epub 2006 Jun 5 doi: 10.1016/j.bcmd.2006.04.005. PMID: 16737833

Recent systematic reviews

Extramedullary haematopoiesis in patients with transfusion dependent β-thalassaemia (TDT): a systematic review.
A Subahi E, Ata F, Choudry H, Iqbal P, A AlHiyari M, T Soliman A, De Sanctis V, A Yassin M
Ann Med 2022 Dec;54(1):764-774. doi: 10.1080/07853890.2022.2048065. PMID: 35261317Free PMC Article
Comparison of Renal Anastomosing Hemangiomas in End-Stage and Non-End-Stage Kidneys: A Meta-Analysis With a Report of 2 Cases.
Berker NK, Bayram A, Tas S, Bakir B, Caliskan Y, Ozcan F, Kilicaslan I, Ozluk Y
Int J Surg Pathol 2017 Sep;25(6):488-496. Epub 2017 Apr 24 doi: 10.1177/1066896917706025. PMID: 28436289
A systematic review of presacral extramedullary haematopoiesis: a diagnosis to be considered for presacral masses.
Zhou PP, Clark E, Kapadia MR
Colorectal Dis 2016 Nov;18(11):1033-1040. doi: 10.1111/codi.13427. PMID: 27329993
Extramedullary hemopoiesis.
Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS
Semin Ultrasound CT MR 2014 Jun;35(3):255-62. Epub 2013 Dec 19 doi: 10.1053/j.sult.2013.12.001. PMID: 24929265

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