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Bronchial Epithelial Hyperplasia

MedGen UID:
474860
•Concept ID:
C3273227
•
Pathologic Function

Definition

Hyperplasia of the bronchial epithelial cells. It is often associated with squamous metaplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchial Epithelial Hyperplasia

Professional guidelines

PubMed

Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model.
Parker JC, Douglas I, Bell J, Comer D, Bailie K, Skibinski G, Heaney LG, Shields MD
PLoS One 2015;10(6):e0129546. Epub 2015 Jun 9 doi: 10.1371/journal.pone.0129546. PMID: 26057128Free PMC Article
Why do we not find polyps in the lungs? Bronchial mucosa as a model in the treatment of polyposis.
Pezato R, Voegels RL
Med Hypotheses 2012 Apr;78(4):468-70. Epub 2012 Jan 29 doi: 10.1016/j.mehy.2012.01.006. PMID: 22289339
What effect does asthma treatment have on airway remodeling? Current perspectives.
Durrani SR, Viswanathan RK, Busse WW
J Allergy Clin Immunol 2011 Sep;128(3):439-48; quiz 449-50. Epub 2011 Jul 12 doi: 10.1016/j.jaci.2011.06.002. PMID: 21752441

Recent clinical studies

Etiology

MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells.
Du C, Lu J, Zhou L, Wu B, Zhou F, Gu L, Xu D, Sun Y
Int J Chron Obstruct Pulmon Dis 2017;12:3341-3351. Epub 2017 Nov 21 doi: 10.2147/COPD.S143279. PMID: 29200841Free PMC Article

Therapy

MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells.
Du C, Lu J, Zhou L, Wu B, Zhou F, Gu L, Xu D, Sun Y
Int J Chron Obstruct Pulmon Dis 2017;12:3341-3351. Epub 2017 Nov 21 doi: 10.2147/COPD.S143279. PMID: 29200841Free PMC Article
The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung.
Piyathilake CJ, Frost AR, Weiss H, Manne U, Heimburger DC, Grizzle WE
Hum Pathol 2000 Apr;31(4):482-7. doi: 10.1053/hp.2000.6711. PMID: 10821496

Prognosis

The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung.
Piyathilake CJ, Frost AR, Weiss H, Manne U, Heimburger DC, Grizzle WE
Hum Pathol 2000 Apr;31(4):482-7. doi: 10.1053/hp.2000.6711. PMID: 10821496

Clinical prediction guides

MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells.
Du C, Lu J, Zhou L, Wu B, Zhou F, Gu L, Xu D, Sun Y
Int J Chron Obstruct Pulmon Dis 2017;12:3341-3351. Epub 2017 Nov 21 doi: 10.2147/COPD.S143279. PMID: 29200841Free PMC Article
The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung.
Piyathilake CJ, Frost AR, Weiss H, Manne U, Heimburger DC, Grizzle WE
Hum Pathol 2000 Apr;31(4):482-7. doi: 10.1053/hp.2000.6711. PMID: 10821496

Supplemental Content

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