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Muscle Cell Hypertrophy

MedGen UID:
474866
•Concept ID:
C3273233
•
Finding

Definition

A morphologic finding indicating the presence of enlarged muscle cells in a muscle tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMuscle Cell Hypertrophy

Professional guidelines

PubMed

Treatment for pulmonary hypertension including lung transplantation.
Kusano KF
Gen Thorac Cardiovasc Surg 2011 Aug;59(8):538-46. Epub 2011 Aug 18 doi: 10.1007/s11748-010-0747-z. PMID: 21850579
Management of overactive bladder--looking to the future.
Mattiasson A
Urology 1997 Dec;50(6A Suppl):111-3. doi: 10.1016/s0090-4295(97)00605-5. PMID: 9426765

Recent clinical studies

Etiology

Mitochondrial deacetylase Sirt3 in vascular dysfunction and hypertension.
Dikalov S, Dikalova A
Curr Opin Nephrol Hypertens 2022 Mar 1;31(2):151-156. doi: 10.1097/MNH.0000000000000771. PMID: 35086984Free PMC Article
Hypertension and cardiometabolic disease.
Tasic I, Lovic D
Front Biosci (Schol Ed) 2018 Jan 1;10(1):166-174. doi: 10.2741/s506. PMID: 28930524
Role of angiotensin II in bladder smooth muscle growth and function.
Cheng EY, Decker RS, Lee C
Adv Exp Med Biol 1999;462:183-91. doi: 10.1007/978-1-4615-4737-2_14. PMID: 10599423
Testosterone, body composition and aging.
Vermeulen A, Goemaere S, Kaufman JM
J Endocrinol Invest 1999;22(5 Suppl):110-6. PMID: 10442580
Insulin resistance in Pima Indians. A combined effect of genetic predisposition and obesity-related skeletal muscle cell hypertrophy.
Lillioja S, Bogardus C
Acta Med Scand Suppl 1988;723:103-19. PMID: 3134799

Diagnosis

Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.
Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM
Am J Respir Crit Care Med 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC. PMID: 29095649
Treatment for pulmonary hypertension including lung transplantation.
Kusano KF
Gen Thorac Cardiovasc Surg 2011 Aug;59(8):538-46. Epub 2011 Aug 18 doi: 10.1007/s11748-010-0747-z. PMID: 21850579
Vasculopathy in patients with Fabry disease: current controversies and research directions.
Rombach SM, Twickler TB, Aerts JM, Linthorst GE, Wijburg FA, Hollak CE
Mol Genet Metab 2010 Feb;99(2):99-108. Epub 2009 Oct 13 doi: 10.1016/j.ymgme.2009.10.004. PMID: 19900828
Endothelial dysfunction and the kidney: emerging risk factors for renal insufficiency and cardiovascular outcomes in essential hypertension.
Zoccali C
J Am Soc Nephrol 2006 Apr;17(4 Suppl 2):S61-3. doi: 10.1681/ASN.2005121344. PMID: 16565249
Skeletal muscle cell hypertrophy induced by inhibitors of metalloproteases; myostatin as a potential mediator.
Huet C, Li ZF, Liu HZ, Black RA, Galliano MF, Engvall E
Am J Physiol Cell Physiol 2001 Nov;281(5):C1624-34. doi: 10.1152/ajpcell.2001.281.5.C1624. PMID: 11600426

Therapy

Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.
Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM
Am J Respir Crit Care Med 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC. PMID: 29095649
Treatment for pulmonary hypertension including lung transplantation.
Kusano KF
Gen Thorac Cardiovasc Surg 2011 Aug;59(8):538-46. Epub 2011 Aug 18 doi: 10.1007/s11748-010-0747-z. PMID: 21850579
Nutrition and muscle catabolism in maintenance hemodialysis: does feeding make muscle cells selective self-eaters?
Franch HA
J Ren Nutr 2009 Jan;19(1):86-90. doi: 10.1053/j.jrn.2008.10.009. PMID: 19121779Free PMC Article
Adrenergic mechanisms and remodeling of subcutaneous small resistance arteries in humans.
Porteri E, Rizzoni D, Mulvany MJ, De Ciuceis C, Sleiman I, Boari GE, Castellano M, Muiesan ML, Zani F, Rosei EA
J Hypertens 2003 Dec;21(12):2345-52. doi: 10.1097/00004872-200312000-00024. PMID: 14654756
Pharmacological interference of vascular smooth muscle cell hypertrophy induced by glycosylated human oxyhaemoglobin.
Peiró C, Vallejo S, Nevado J, Angulo J, Llergo JL, Cercas E, Rodríguez-Mañas L, Sánchez-Ferrer CF
Eur J Pharmacol 1999 Dec 15;386(2-3):317-21. doi: 10.1016/s0014-2999(99)00781-5. PMID: 10618485

Prognosis

Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts.
Nisimura LM, Coelho LL, de Melo TG, Vieira PC, Victorino PH, Garzoni LR, Spray DC, Iacobas DA, Iacobas S, Tanowitz HB, Adesse D
Front Cell Infect Microbiol 2020;10:255. Epub 2020 Jun 17 doi: 10.3389/fcimb.2020.00255. PMID: 32626662Free PMC Article
Plasma miR-199a-5p is increased in neutrophilic phenotype asthma patients and negatively correlated with pulmonary function.
Huang Y, Zhang S, Fang X, Qin L, Fan Y, Ding D, Liu X, Xie M
PLoS One 2018;13(3):e0193502. Epub 2018 Mar 5 doi: 10.1371/journal.pone.0193502. PMID: 29505605Free PMC Article
Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures.
Flynn RS, Mahavadi S, Murthy KS, Grider JR, Kellum JM, Akbari H, Kuemmerle JF
Inflamm Bowel Dis 2011 Jan;17(1):193-201. doi: 10.1002/ibd.21351. PMID: 20848532Free PMC Article
An autopsy case of Brugada syndrome with significant lesions in the sinus node.
Morimoto S, Uemura A, Hishida H
J Cardiovasc Electrophysiol 2005 Mar;16(3):345-7. doi: 10.1046/j.1540-8167.2004.40378.x. PMID: 15817097
Adrenergic mechanisms and remodeling of subcutaneous small resistance arteries in humans.
Porteri E, Rizzoni D, Mulvany MJ, De Ciuceis C, Sleiman I, Boari GE, Castellano M, Muiesan ML, Zani F, Rosei EA
J Hypertens 2003 Dec;21(12):2345-52. doi: 10.1097/00004872-200312000-00024. PMID: 14654756

Clinical prediction guides

RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
do Carmo Costa A, Copola AGL, Carvalho E Souza C, Nogueira JM, Silva GAB, Jorge EC
In Vitro Cell Dev Biol Anim 2021 Apr;57(4):415-427. Epub 2021 Mar 21 doi: 10.1007/s11626-021-00555-9. PMID: 33748906
Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.
Graber TG, Fry CS, Brightwell CR, Moro T, Maroto R, Bhattarai N, Porter C, Wakamiya M, Rasmussen BB
J Biol Chem 2019 Mar 15;294(11):4091-4102. Epub 2019 Jan 11 doi: 10.1074/jbc.RA118.005970. PMID: 30635399Free PMC Article
Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.
Sheybani-Deloui S, Chi L, Staite MV, Cain JE, Nieman BJ, Henkelman RM, Wainwright BJ, Potter SS, Bagli DJ, Lorenzo AJ, Rosenblum ND
J Am Soc Nephrol 2018 Feb;29(2):532-544. Epub 2017 Nov 6 doi: 10.1681/ASN.2017050482. PMID: 29109083Free PMC Article
Rho kinase and hypertension.
Wirth A
Biochim Biophys Acta 2010 Dec;1802(12):1276-84. Epub 2010 May 9 doi: 10.1016/j.bbadis.2010.05.002. PMID: 20460153
Testosterone, body composition and aging.
Vermeulen A, Goemaere S, Kaufman JM
J Endocrinol Invest 1999;22(5 Suppl):110-6. PMID: 10442580

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