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Proliferative Inflammatory Atrophy

MedGen UID:
474872
Concept ID:
C3273239
Disease or Syndrome
Synonym: Prostate Proliferative Inflammatory Atrophy

Definition

A lesion in the prostate gland characterized by glandular atrophy, chronic inflammation, and epithelial hyperplasia. It has been suggested that it is a precancerous lesion and it may lead to the development of prostatic intraepithelial neoplasia and prostatic carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferative Inflammatory Atrophy

Professional guidelines

PubMed

Kim JA, Kim SM, Ha SE, Vetrivel P, Saralamma VVG, Kim EH, Kim GS
BMC Complement Altern Med 2019 Oct 28;19(1):287. doi: 10.1186/s12906-019-2714-2. PMID: 31660942Free PMC Article

Recent clinical studies

Etiology

Celma A, Servián P, Planas J, Placer J, Quilez MT, Arbós MA, de Torres I, Morote J
Actas Urol Esp 2014 Mar;38(2):122-6. Epub 2013 Oct 13 doi: 10.1016/j.acuro.2013.04.008. PMID: 24129226
Sfanos KS, De Marzo AM
Histopathology 2012 Jan;60(1):199-215. doi: 10.1111/j.1365-2559.2011.04033.x. PMID: 22212087Free PMC Article
De Marzo AM, Nakai Y, Nelson WG
Urol Oncol 2007 Sep-Oct;25(5):398-400. doi: 10.1016/j.urolonc.2007.05.007. PMID: 17826659
Nelson WG, De Marzo AM, DeWeese TL, Isaacs WB
J Urol 2004 Nov;172(5 Pt 2):S6-11; discussion S11-2. doi: 10.1097/01.ju.0000142058.99614.ff. PMID: 15535435
Hussain T, Gupta S, Mukhtar H
Cancer Lett 2003 Mar 10;191(2):125-35. doi: 10.1016/s0304-3835(02)00524-4. PMID: 12618325

Diagnosis

Huang FW, Song H, Weinstein HN, Xie J, Cooperberg MR, Hicks J, Mummert L, De Marzo AM, Sfanos KS
J Pathol 2023 Sep;261(1):85-95. Epub 2023 Aug 7 doi: 10.1002/path.6149. PMID: 37550827Free PMC Article
Packer JR, Maitland NJ
Biochim Biophys Acta 2016 Jun;1863(6 Pt A):1238-60. Epub 2016 Feb 26 doi: 10.1016/j.bbamcr.2016.02.016. PMID: 26921821
De Nunzio C, Kramer G, Marberger M, Montironi R, Nelson W, Schröder F, Sciarra A, Tubaro A
Eur Urol 2011 Jul;60(1):106-17. Epub 2011 Apr 9 doi: 10.1016/j.eururo.2011.03.055. PMID: 21497433
Sciarra A, Mariotti G, Salciccia S, Autran Gomez A, Monti S, Toscano V, Di Silverio F
J Steroid Biochem Mol Biol 2008 Feb;108(3-5):254-60. Epub 2007 Sep 7 doi: 10.1016/j.jsbmb.2007.09.013. PMID: 17935971
Sciarra A, Di Silverio F, Salciccia S, Autran Gomez AM, Gentilucci A, Gentile V
Eur Urol 2007 Oct;52(4):964-72. Epub 2007 Jul 2 doi: 10.1016/j.eururo.2007.06.038. PMID: 17618043

Therapy

Nelson WG, Demarzo AM, Yegnasubramanian S
Cancer Treat Res 2014;159:51-68. doi: 10.1007/978-3-642-38007-5_4. PMID: 24114474Free PMC Article
Bardia A, Platz EA, Yegnasubramanian S, De Marzo AM, Nelson WG
Curr Opin Pharmacol 2009 Aug;9(4):419-26. Epub 2009 Jul 1 doi: 10.1016/j.coph.2009.06.002. PMID: 19574101Free PMC Article
De Marzo AM, Nakai Y, Nelson WG
Urol Oncol 2007 Sep-Oct;25(5):398-400. doi: 10.1016/j.urolonc.2007.05.007. PMID: 17826659
Nelson WG, De Marzo AM, DeWeese TL, Isaacs WB
J Urol 2004 Nov;172(5 Pt 2):S6-11; discussion S11-2. doi: 10.1097/01.ju.0000142058.99614.ff. PMID: 15535435
Nelson WG, De Marzo AM, Deweese TL, Lin X, Brooks JD, Putzi MJ, Nelson CP, Groopman JD, Kensler TW
Ann N Y Acad Sci 2001 Dec;952:135-44. doi: 10.1111/j.1749-6632.2001.tb02734.x. PMID: 11795433

Prognosis

Russo GI, Cimino S, Giranio G, Regis F, Favilla V, Privitera S, Motta F, Caltabiano R, Stenzl A, Todenhöfer T, Morgia G
Urol Oncol 2018 May;36(5):240.e21-240.e26. Epub 2018 Feb 9 doi: 10.1016/j.urolonc.2018.01.012. PMID: 29429896
Benedetti I, De Marzo AM, Geliebter J, Reyes N
Int J Exp Pathol 2017 Aug;98(4):234-243. doi: 10.1111/iep.12241. PMID: 29027288Free PMC Article
Servian P, Celma A, Planas J, Placer J, de Torres IM, Morote J
Prostate 2016 Dec;76(16):1501-1506. Epub 2016 Jul 12 doi: 10.1002/pros.23234. PMID: 27404228
Keller EX, Delbue S, Tognon M, Provenzano M
Rev Med Virol 2015 Nov;25(6):366-78. Epub 2015 Aug 26 doi: 10.1002/rmv.1851. PMID: 26308483
De Nunzio C, Kramer G, Marberger M, Montironi R, Nelson W, Schröder F, Sciarra A, Tubaro A
Eur Urol 2011 Jul;60(1):106-17. Epub 2011 Apr 9 doi: 10.1016/j.eururo.2011.03.055. PMID: 21497433

Clinical prediction guides

Sfanos KS, Yegnasubramanian S, Nelson WG, De Marzo AM
Nat Rev Urol 2018 Jan;15(1):11-24. Epub 2017 Oct 31 doi: 10.1038/nrurol.2017.167. PMID: 29089606
Servian P, Celma A, Planas J, Placer J, de Torres IM, Morote J
Prostate 2016 Dec;76(16):1501-1506. Epub 2016 Jul 12 doi: 10.1002/pros.23234. PMID: 27404228
Servian P, Celma A, Planas J, Placer J, de Torres IM, Olivan M, Morote J
Prostate 2015 Oct;75(14):1669-75. Epub 2015 Jul 17 doi: 10.1002/pros.23047. PMID: 26184870
Celma A, Servián P, Planas J, Placer J, Quilez MT, Arbós MA, de Torres I, Morote J
Actas Urol Esp 2014 Mar;38(2):122-6. Epub 2013 Oct 13 doi: 10.1016/j.acuro.2013.04.008. PMID: 24129226
Hussain T, Gupta S, Mukhtar H
Cancer Lett 2003 Mar 10;191(2):125-35. doi: 10.1016/s0304-3835(02)00524-4. PMID: 12618325

Recent systematic reviews

Schwartzmann I, Celma A, Gallardo I, Moreno O, Regis L, Placer J, Planas J, Trilla Herrero E, Morote Robles J
Actas Urol Esp (Engl Ed) 2019 Sep;43(7):337-347. Epub 2019 May 17 doi: 10.1016/j.acuro.2019.01.010. PMID: 31109736
Keller EX, Delbue S, Tognon M, Provenzano M
Rev Med Virol 2015 Nov;25(6):366-78. Epub 2015 Aug 26 doi: 10.1002/rmv.1851. PMID: 26308483
Celma A, Servián P, Planas J, Placer J, Quilez MT, Arbós MA, de Torres I, Morote J
Actas Urol Esp 2014 Mar;38(2):122-6. Epub 2013 Oct 13 doi: 10.1016/j.acuro.2013.04.008. PMID: 24129226

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