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Folliculitis

MedGen UID:
4752
Concept ID:
C0016436
Disease or Syndrome
Synonym: Folliculitides
SNOMED CT: Folliculitis (13600006); Hair follicle inflammation (721130001)
 
HPO: HP:0025084
Monarch Initiative: MONDO:0006552

Definition

Inflammatory cells within the wall and ostia of the hair follicle, creating a follicular-based pustule. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFolliculitis

Conditions with this feature

Pachyonychia congenita 2
MedGen UID:
314107
Concept ID:
C1721007
Disease or Syndrome
Pachyonychia congenita (PC) is characterized by hypertrophic nail dystrophy, painful palmoplantar keratoderma and blistering, oral leukokeratosis, pilosebaceous cysts (including steatocystoma and vellus hair cysts), palmoplantar hyperhydrosis, and follicular keratoses on the trunk and extremities.
X-linked lymphoproliferative disease due to XIAP deficiency
MedGen UID:
336848
Concept ID:
C1845076
Disease or Syndrome
X-linked lymphoproliferative disease (XLP) has two recognizable subtypes, XLP1 and XLP2. XLP1 is characterized predominantly by one of three commonly recognized phenotypes: Inappropriate immune response to Epstein-Barr virus (EBV) infection leading to hemophagocytic lymphohistiocytosis (HLH) or severe mononucleosis. Dysgammaglobulinemia. Lymphoproliferative disease (malignant lymphoma). XLP2 is most often characterized by HLH (often associated with EBV), dysgammaglobulinemia, and inflammatory bowel disease. HLH resulting from EBV infection is associated with an unregulated and exaggerated immune response with widespread proliferation of cytotoxic T cells, EBV-infected B cells, and macrophages. Dysgammaglobulinemia is typically hypogammaglobulinemia of one or more immunoglobulin subclasses. The malignant lymphomas are typically B-cell lymphomas, non-Hodgkin type, often extranodal, and in particular involving the intestine.
Inflammatory bowel disease 25
MedGen UID:
393403
Concept ID:
C2675508
Disease or Syndrome
Any inflammatory bowel disease in which the cause of the disease is a mutation in the IL10RB gene.
Keratosis follicularis spinulosa decalvans, autosomal dominant
MedGen UID:
412573
Concept ID:
C2748527
Disease or Syndrome
Keratosis follicularis spinulosa decalvans (KFSD) is an uncommon genodermatosis characterized by follicular hyperkeratosis, progressive cicatricial alopecia, and photophobia. Most reported cases show X-linked inheritance (KFSDX; 308800) (Castori et al., 2009).
Inflammatory bowel disease 28
MedGen UID:
442630
Concept ID:
C2751053
Disease or Syndrome
An autosomal recessive condition caused by mutation(s) in the IL10RA gene, encoding interleukin-10 receptor subunit alpha. It is characterized by early-onset chronic relapsing intestinal inflammation.
Keratosis follicularis spinulosa decalvans, X-linked
MedGen UID:
854384
Concept ID:
C3887525
Congenital Abnormality
Keratosis follicularis spinulosa decalvans is an uncommon genodermatosis chiefly characterized by widespread keratosis pilaris, progressive cicatricial alopecia of the scalp, eyebrows, and eyelashes, and an excess of affected males. Photophobia, blepharitis/conjunctivitis, and corneal dystrophy are characteristic ancillary findings. It is most often inherited as an X-linked trait (summary by Castori et al., 2009). Autosomal dominant inheritance has also been reported (KFSD; 612843). The term 'cum ophiasi' means 'with ophiasis,' i.e., baldness in 1 or more winding streaks about the head, which comes from the Greek for snake. Decalvans refers to the loss of hair.
Immunodeficiency 51
MedGen UID:
934770
Concept ID:
C4310803
Disease or Syndrome
Immunodeficiency-51 (IMD51) is an autosomal recessive primary immune deficiency that is usually characterized by onset of chronic mucocutaneous candidiasis in the first years of life. Most patients also show recurrent Staphylococcal skin infections, and may show increased susceptibility to chronic bacterial respiratory infections. Patient cells show a lack of cellular responses to stimulation with certain IL17 isoforms, including IL17A (603149), IL17F (606496), IL17A/F, and IL17E (IL25; 605658) (summary by Levy et al., 2016).

Professional guidelines

PubMed

Nogueira S, Rodrigues MA, Vender R, Torres T
Dermatol Ther 2022 Dec;35(12):e15931. Epub 2022 Oct 21 doi: 10.1111/dth.15931. PMID: 36226669Free PMC Article
Wolff H, Fischer TW, Blume-Peytavi U
Dtsch Arztebl Int 2016 May 27;113(21):377-86. doi: 10.3238/arztebl.2016.0377. PMID: 27504707Free PMC Article
Luelmo-Aguilar J, Santandreu MS
Am J Clin Dermatol 2004;5(5):301-10. doi: 10.2165/00128071-200405050-00003. PMID: 15554731

Recent clinical studies

Etiology

Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Ogawa R
Int J Mol Sci 2017 Mar 10;18(3) doi: 10.3390/ijms18030606. PMID: 28287424Free PMC Article
Long H, Zhang G, Wang L, Lu Q
Clin Rev Allergy Immunol 2016 Apr;50(2):189-213. doi: 10.1007/s12016-015-8485-8. PMID: 25876839
Luelmo-Aguilar J, Santandreu MS
Am J Clin Dermatol 2004;5(5):301-10. doi: 10.2165/00128071-200405050-00003. PMID: 15554731

Diagnosis

Barbosa V, Hight R, Grullon K
Dermatol Clin 2023 Jul;41(3):539-545. Epub 2023 Apr 14 doi: 10.1016/j.det.2023.02.008. PMID: 37236720
Spernovasilis N, Psichogiou M, Poulakou G
Curr Opin Infect Dis 2021 Apr 1;34(2):72-79. doi: 10.1097/QCO.0000000000000717. PMID: 33492004
Saunte DML, Gaitanis G, Hay RJ
Front Cell Infect Microbiol 2020;10:112. Epub 2020 Mar 20 doi: 10.3389/fcimb.2020.00112. PMID: 32266163Free PMC Article
Stefanato CM
Histopathology 2010 Jan;56(1):24-38. doi: 10.1111/j.1365-2559.2009.03439.x. PMID: 20055903
Luelmo-Aguilar J, Santandreu MS
Am J Clin Dermatol 2004;5(5):301-10. doi: 10.2165/00128071-200405050-00003. PMID: 15554731

Therapy

Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Spernovasilis N, Psichogiou M, Poulakou G
Curr Opin Infect Dis 2021 Apr 1;34(2):72-79. doi: 10.1097/QCO.0000000000000717. PMID: 33492004
Reich K, Kabashima K, Peris K, Silverberg JI, Eichenfield LF, Bieber T, Kaszuba A, Kolodsick J, Yang FE, Gamalo M, Brinker DR, DeLozier AM, Janes JM, Nunes FP, Thyssen JP, Simpson EL
JAMA Dermatol 2020 Dec 1;156(12):1333-1343. doi: 10.1001/jamadermatol.2020.3260. PMID: 33001140Free PMC Article
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BWM
Cochrane Database Syst Rev 2017 Feb 6;2(2):CD012119. doi: 10.1002/14651858.CD012119.pub2. PMID: 28166390Free PMC Article

Prognosis

Spernovasilis N, Psichogiou M, Poulakou G
Curr Opin Infect Dis 2021 Apr 1;34(2):72-79. doi: 10.1097/QCO.0000000000000717. PMID: 33492004
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
Ogawa R
Int J Mol Sci 2017 Mar 10;18(3) doi: 10.3390/ijms18030606. PMID: 28287424Free PMC Article
Long H, Zhang G, Wang L, Lu Q
Clin Rev Allergy Immunol 2016 Apr;50(2):189-213. doi: 10.1007/s12016-015-8485-8. PMID: 25876839

Clinical prediction guides

Nogueira S, Rodrigues MA, Vender R, Torres T
Dermatol Ther 2022 Dec;35(12):e15931. Epub 2022 Oct 21 doi: 10.1111/dth.15931. PMID: 36226669Free PMC Article
Lebwohl MG, Stein Gold L, Strober B, Papp KA, Armstrong AW, Bagel J, Kircik L, Ehst B, Hong HC, Soung J, Fromowitz J, Guenthner S, Piscitelli SC, Rubenstein DS, Brown PM, Tallman AM, Bissonnette R
N Engl J Med 2021 Dec 9;385(24):2219-2229. doi: 10.1056/NEJMoa2103629. PMID: 34879448
Natsis NE, Cohen PR
Am J Clin Dermatol 2018 Oct;19(5):671-677. doi: 10.1007/s40257-018-0362-9. PMID: 29882122
Ogawa R
Int J Mol Sci 2017 Mar 10;18(3) doi: 10.3390/ijms18030606. PMID: 28287424Free PMC Article
Hartmann JT, Haap M, Kopp HG, Lipp HP
Curr Drug Metab 2009 Jun;10(5):470-81. doi: 10.2174/138920009788897975. PMID: 19689244

Recent systematic reviews

Kinoshita-Ise M, Sachdeva M
J Dermatol 2022 Jan;49(1):4-18. Epub 2021 Nov 22 doi: 10.1111/1346-8138.16233. PMID: 34806223
Lin HS, Lin PT, Tsai YS, Wang SH, Chi CC
Cochrane Database Syst Rev 2021 Feb 26;2(2):CD013099. doi: 10.1002/14651858.CD013099.pub2. PMID: 33634465Free PMC Article
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
Jacob S, VanDaele MA, Brown JN
Dermatol Ther 2019 Nov;32(6):e13103. Epub 2019 Oct 28 doi: 10.1111/dth.13103. PMID: 31583801
van Zuuren EJ, Fedorowicz Z, Christensen R, Lavrijsen A, Arents BWM
Cochrane Database Syst Rev 2017 Feb 6;2(2):CD012119. doi: 10.1002/14651858.CD012119.pub2. PMID: 28166390Free PMC Article

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