U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BRAF Protein Variant

MedGen UID:
475588
Concept ID:
C3273955
Cell or Molecular Dysfunction
Synonym: Serine/Threonine-Protein Kinase B-raf Protein Variant

Definition

A variation in the amino acid sequence for the serine/threonine-protein kinase B-raf protein. [from NCI]

Professional guidelines

PubMed

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:256-284. Epub 2022 May 24 doi: 10.1016/j.ejca.2022.04.018. PMID: 35623961
Troussard X, Maître E, Cornet E
Am J Hematol 2022 Feb 1;97(2):226-236. Epub 2021 Nov 8 doi: 10.1002/ajh.26390. PMID: 34710243
Goyal G, Heaney ML, Collin M, Cohen-Aubart F, Vaglio A, Durham BH, Hershkovitz-Rokah O, Girschikofsky M, Jacobsen ED, Toyama K, Goodman AM, Hendrie P, Cao XX, Estrada-Veras JI, Shpilberg O, Abdo A, Kurokawa M, Dagna L, McClain KL, Mazor RD, Picarsic J, Janku F, Go RS, Haroche J, Diamond EL
Blood 2020 May 28;135(22):1929-1945. doi: 10.1182/blood.2019003507. PMID: 32187362

Recent clinical studies

Etiology

Li H, Zhang Y, Xu Y, Huang Z, Cheng G, Xie M, Zhou Z, Yu Y, Xi W, Fan Y
Cell Death Dis 2022 Dec 21;13(12):1064. doi: 10.1038/s41419-022-05510-4. PMID: 36543792Free PMC Article
Kopetz S, Guthrie KA, Morris VK, Lenz HJ, Magliocco AM, Maru D, Yan Y, Lanman R, Manyam G, Hong DS, Sorokin A, Atreya CE, Diaz LA, Allegra C, Raghav KP, Wang SE, Lieu CH, McDonough SL, Philip PA, Hochster HS
J Clin Oncol 2021 Feb 1;39(4):285-294. Epub 2020 Dec 23 doi: 10.1200/JCO.20.01994. PMID: 33356422Free PMC Article
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C
Cancer Cell 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011. PMID: 32289278Free PMC Article
Yaeger R, Kotani D, Mondaca S, Parikh AR, Bando H, Van Seventer EE, Taniguchi H, Zhao H, Thant CN, de Stanchina E, Rosen N, Corcoran RB, Yoshino T, Yao Z, Ebi H
Clin Cancer Res 2019 Dec 1;25(23):7089-7097. Epub 2019 Sep 12 doi: 10.1158/1078-0432.CCR-19-2004. PMID: 31515458Free PMC Article
Planchard D, Smit EF, Groen HJM, Mazieres J, Besse B, Helland Å, Giannone V, D'Amelio AM Jr, Zhang P, Mookerjee B, Johnson BE
Lancet Oncol 2017 Oct;18(10):1307-1316. Epub 2017 Sep 11 doi: 10.1016/S1470-2045(17)30679-4. PMID: 28919011

Diagnosis

Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H
Cell 2022 May 26;185(11):1974-1985.e12. Epub 2022 May 4 doi: 10.1016/j.cell.2022.04.014. PMID: 35512704Free PMC Article
Cross M, Dearden C
Curr Oncol Rep 2020 Apr 16;22(5):42. doi: 10.1007/s11912-020-00911-0. PMID: 32297104
Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C
Cancer Cell 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011. PMID: 32289278Free PMC Article
Sukswai N, Khoury JD
Curr Hematol Malig Rep 2019 Oct;14(5):368-375. doi: 10.1007/s11899-019-00533-9. PMID: 31338668
Yao Z, Torres NM, Tao A, Gao Y, Luo L, Li Q, de Stanchina E, Abdel-Wahab O, Solit DB, Poulikakos PI, Rosen N
Cancer Cell 2015 Sep 14;28(3):370-83. Epub 2015 Sep 3 doi: 10.1016/j.ccell.2015.08.001. PMID: 26343582Free PMC Article

Therapy

Atkins MB, Lee SJ, Chmielowski B, Tarhini AA, Cohen GI, Truong TG, Moon HH, Davar D, O'Rourke M, Stephenson JJ, Curti BD, Urba WJ, Brell JM, Funchain P, Kendra KL, Ikeguchi AP, Jaslowski A, Bane CL, Taylor MA, Bajaj M, Conry RM, Ellis RJ, Logan TF, Laudi N, Sosman JA, Crockett DG, Pecora AL, Okazaki IJ, Reganti S, Chandra S, Guild S, Chen HX, Streicher HZ, Wolchok JD, Ribas A, Kirkwood JM
J Clin Oncol 2023 Jan 10;41(2):186-197. Epub 2022 Sep 27 doi: 10.1200/JCO.22.01763. PMID: 36166727Free PMC Article
Randic T, Kozar I, Margue C, Utikal J, Kreis S
Cancer Treat Rev 2021 Sep;99:102238. Epub 2021 May 29 doi: 10.1016/j.ctrv.2021.102238. PMID: 34098219
Tabernero J, Grothey A, Van Cutsem E, Yaeger R, Wasan H, Yoshino T, Desai J, Ciardiello F, Loupakis F, Hong YS, Steeghs N, Guren TK, Arkenau HT, Garcia-Alfonso P, Elez E, Gollerkeri A, Maharry K, Christy-Bittel J, Kopetz S
J Clin Oncol 2021 Feb 1;39(4):273-284. doi: 10.1200/JCO.20.02088. PMID: 33503393Free PMC Article
Corcoran RB, André T, Atreya CE, Schellens JHM, Yoshino T, Bendell JC, Hollebecque A, McRee AJ, Siena S, Middleton G, Muro K, Gordon MS, Tabernero J, Yaeger R, O'Dwyer PJ, Humblet Y, De Vos F, Jung AS, Brase JC, Jaeger S, Bettinger S, Mookerjee B, Rangwala F, Van Cutsem E
Cancer Discov 2018 Apr;8(4):428-443. Epub 2018 Feb 5 doi: 10.1158/2159-8290.CD-17-1226. PMID: 29431699Free PMC Article
Ascierto PA, Kirkwood JM, Grob JJ, Simeone E, Grimaldi AM, Maio M, Palmieri G, Testori A, Marincola FM, Mozzillo N
J Transl Med 2012 Jul 9;10:85. doi: 10.1186/1479-5876-10-85. PMID: 22554099Free PMC Article

Prognosis

Ciombor KK, Strickler JH, Bekaii-Saab TS, Yaeger R
J Clin Oncol 2022 Aug 20;40(24):2706-2715. Epub 2022 Jun 1 doi: 10.1200/JCO.21.02541. PMID: 35649231Free PMC Article
Scheffel RS, Dora JM, Maia AL
Curr Opin Oncol 2022 Jan 1;34(1):9-18. doi: 10.1097/CCO.0000000000000797. PMID: 34636352
Tabernero J, Grothey A, Van Cutsem E, Yaeger R, Wasan H, Yoshino T, Desai J, Ciardiello F, Loupakis F, Hong YS, Steeghs N, Guren TK, Arkenau HT, Garcia-Alfonso P, Elez E, Gollerkeri A, Maharry K, Christy-Bittel J, Kopetz S
J Clin Oncol 2021 Feb 1;39(4):273-284. doi: 10.1200/JCO.20.02088. PMID: 33503393Free PMC Article
Fois SS, Paliogiannis P, Zinellu A, Fois AG, Cossu A, Palmieri G
Int J Mol Sci 2021 Jan 9;22(2) doi: 10.3390/ijms22020612. PMID: 33435440Free PMC Article
Ritterhouse LL, Barletta JA
Semin Diagn Pathol 2015 Sep;32(5):400-8. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2015.02.010. PMID: 25744437

Clinical prediction guides

Grothey A, Fakih M, Tabernero J
Ann Oncol 2021 Aug;32(8):959-967. Epub 2021 Apr 7 doi: 10.1016/j.annonc.2021.03.206. PMID: 33836264
Fois SS, Paliogiannis P, Zinellu A, Fois AG, Cossu A, Palmieri G
Int J Mol Sci 2021 Jan 9;22(2) doi: 10.3390/ijms22020612. PMID: 33435440Free PMC Article
Yaeger R, Kotani D, Mondaca S, Parikh AR, Bando H, Van Seventer EE, Taniguchi H, Zhao H, Thant CN, de Stanchina E, Rosen N, Corcoran RB, Yoshino T, Yao Z, Ebi H
Clin Cancer Res 2019 Dec 1;25(23):7089-7097. Epub 2019 Sep 12 doi: 10.1158/1078-0432.CCR-19-2004. PMID: 31515458Free PMC Article
Ritterhouse LL, Barletta JA
Semin Diagn Pathol 2015 Sep;32(5):400-8. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2015.02.010. PMID: 25744437
Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM; International Cancer Genome Consortium PedBrain Tumor Project
Nat Genet 2013 Aug;45(8):927-32. Epub 2013 Jun 30 doi: 10.1038/ng.2682. PMID: 23817572Free PMC Article

Recent systematic reviews

Boutros A, Tanda ET, Croce E, Catalano F, Ceppi M, Bruzzone M, Cecchi F, Arecco L, Fraguglia M, Pronzato P, Genova C, Del Mastro L, Lambertini M, Spagnolo F
Eur J Cancer 2023 Jul;188:64-79. Epub 2023 Apr 24 doi: 10.1016/j.ejca.2023.04.010. PMID: 37196485
Ebeling M, Scheurer M, Sakkas A, Pietzka S, Schramm A, Wilde F
Med Oncol 2023 Apr 28;40(6):163. doi: 10.1007/s12032-023-01993-z. PMID: 37115331Free PMC Article
Dankner M, Wang Y, Fazelzad R, Johnson B, Nebhan CA, Dagogo-Jack I, Myall NJ, Richtig G, Bracht JWP, Gerlinger M, Shinozaki E, Yoshino T, Kotani D, Fangusaro JR, Gautschi O, Mazieres J, Sosman JA, Kopetz S, Subbiah V, Davies MA, Groover AL, Sullivan RJ, Flaherty KT, Johnson DB, Benedetti A, Cescon DW, Spreafico A, Zogopoulos G, Rose AAN
JCO Precis Oncol 2022 Aug;6:e2200107. doi: 10.1200/PO.22.00107. PMID: 35977349Free PMC Article
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...