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Sacral Myelocele

MedGen UID:
476119
•Concept ID:
C3274486
•
Disease or Syndrome

Definition

Herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSacral Myelocele

Professional guidelines

PubMed

Myelomeningocele genotype-phenotype correlation findings in cilia, HH, PCP, and WNT signaling pathways.
Ortiz-Cruz G, Aguayo-Gómez A, Luna-Muñoz L, Muñoz-Téllez LA, Mutchinick OM
Birth Defects Res 2021 Mar;113(4):371-381. Epub 2021 Jan 19 doi: 10.1002/bdr2.1872. PMID: 33470056
Evaluation and Long-term Management of Neurogenic Bladder in Spinal Dysraphism.
Le HK, Cardona-Grau D, Chiang G
Neoreviews 2019 Dec;20(12):e711-e724. doi: 10.1542/neo.20-12-e711. PMID: 31792158
Diagnosis and management of sacral agenesis.
Gotoh T, Shinno Y, Kobayashi S, Watarai Y, Koyanagi T
Eur Urol 1991;20(4):287-92. doi: 10.1159/000471719. PMID: 1814744

Recent clinical studies

Etiology

Kyphectomy in myelomeningocele revisited: risk factors for failure.
Ghanem I, Saliba I, Ghanem D, Assi A, Dubousset J, Bernstein S, Tolo V, Bassett G, Miladi L
Eur Spine J 2023 Dec;32(12):4128-4144. Epub 2023 Sep 12 doi: 10.1007/s00586-023-07924-w. PMID: 37698696
Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study.
Silva T, Queiroz JR, Turcio KHL, Tobelem DDC, Araújo TR, Coutinho KSL, Chavantes MC, Horliana ACRT, Deana AM, Silva DFTD, Castelo PM, Fernandes KPS, Motta LJ, Mesquita-Ferrari RA, Kalil Bussadori S
PLoS One 2021;16(10):e0253963. Epub 2021 Oct 6 doi: 10.1371/journal.pone.0253963. PMID: 34613973Free PMC Article
Anatomic factors predict urinary continence in patient with anorectal malformation.
Fuchs ME, Halleran DR, Shin YJ, Sebastião Y, Weaver L, Ahmad H, Booth K, Ching CB, Levitt MA, Wood RJ, Dajusta DG
J Pediatr Urol 2020 Oct;16(5):545.e1-545.e7. Epub 2020 Jun 21 doi: 10.1016/j.jpurol.2020.06.011. PMID: 32798105
Fractures in myelomeningocele.
Akbar M, Bresch B, Raiss P, Fürstenberg CH, Bruckner T, Seyler T, Carstens C, Abel R
J Orthop Traumatol 2010 Sep;11(3):175-82. Epub 2010 Aug 19 doi: 10.1007/s10195-010-0102-2. PMID: 20721596Free PMC Article
Cervical myelomeningocele.
Habibi Z, Nejat F, Tajik P, Kazmi SS, Kajbafzadeh AM
Neurosurgery 2006 Jun;58(6):1168-75; discussion 1168-75. doi: 10.1227/01.NEU.0000215955.18762.32. PMID: 16723896

Diagnosis

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study.
Silva T, Queiroz JR, Turcio KHL, Tobelem DDC, Araújo TR, Coutinho KSL, Chavantes MC, Horliana ACRT, Deana AM, Silva DFTD, Castelo PM, Fernandes KPS, Motta LJ, Mesquita-Ferrari RA, Kalil Bussadori S
PLoS One 2021;16(10):e0253963. Epub 2021 Oct 6 doi: 10.1371/journal.pone.0253963. PMID: 34613973Free PMC Article
Evaluation and Long-term Management of Neurogenic Bladder in Spinal Dysraphism.
Le HK, Cardona-Grau D, Chiang G
Neoreviews 2019 Dec;20(12):e711-e724. doi: 10.1542/neo.20-12-e711. PMID: 31792158
Caudal cell mass developmental aberrations: an imaging approach.
Chaturvedi A, Franco A, Chaturvedi A, Klionsky NB
Clin Imaging 2018 Nov-Dec;52:216-225. Epub 2018 Jul 21 doi: 10.1016/j.clinimag.2018.07.014. PMID: 30138861
Fractures in myelomeningocele.
Akbar M, Bresch B, Raiss P, Fürstenberg CH, Bruckner T, Seyler T, Carstens C, Abel R
J Orthop Traumatol 2010 Sep;11(3):175-82. Epub 2010 Aug 19 doi: 10.1007/s10195-010-0102-2. PMID: 20721596Free PMC Article
Cervical myelomeningocele.
Habibi Z, Nejat F, Tajik P, Kazmi SS, Kajbafzadeh AM
Neurosurgery 2006 Jun;58(6):1168-75; discussion 1168-75. doi: 10.1227/01.NEU.0000215955.18762.32. PMID: 16723896

Therapy

Effect of photobiomodulation combined with physical therapy on functional performance in children with myelomeningocele: A protocol randomized clinical blind study.
Silva T, Queiroz JR, Turcio KHL, Tobelem DDC, Araújo TR, Coutinho KSL, Chavantes MC, Horliana ACRT, Deana AM, Silva DFTD, Castelo PM, Fernandes KPS, Motta LJ, Mesquita-Ferrari RA, Kalil Bussadori S
PLoS One 2021;16(10):e0253963. Epub 2021 Oct 6 doi: 10.1371/journal.pone.0253963. PMID: 34613973Free PMC Article
Daily Physical Activity in Children and Adolescents with Low Lumbar and Sacral Level Myelomeningocele.
Gencer-Atalay K, Karadag-Saygi E, Uzuncakmak B, Keskin A, Furtun Y, Guven H, Uzunoglu I, Kurtel H
Dev Neurorehabil 2021 Apr;24(3):145-149. Epub 2020 Aug 4 doi: 10.1080/17518423.2020.1800855. PMID: 32748658
Evaluation and Long-term Management of Neurogenic Bladder in Spinal Dysraphism.
Le HK, Cardona-Grau D, Chiang G
Neoreviews 2019 Dec;20(12):e711-e724. doi: 10.1542/neo.20-12-e711. PMID: 31792158
Acute cardiovascular effects of fetal surgery in the human.
Rychik J, Tian Z, Cohen MS, Ewing SG, Cohen D, Howell LJ, Wilson RD, Johnson MP, Hedrick HL, Flake AW, Crombleholme TM, Adzick NS
Circulation 2004 Sep 21;110(12):1549-56. Epub 2004 Sep 7 doi: 10.1161/01.CIR.0000142294.95388.C4. PMID: 15353490
Conservative management in neurogenic bladder dysfunction.
Aslan AR, Kogan BA
Curr Opin Urol 2002 Nov;12(6):473-7. doi: 10.1097/00042307-200211000-00005. PMID: 12409875

Prognosis

Myelomeningocele in Slovenia: results of a 10-year follow-up.
Spazzapan P, Velnar T
J Neurosurg Sci 2021 Jun;65(3):369-376. Epub 2018 Sep 25 doi: 10.23736/S0390-5616.18.04481-8. PMID: 30259717
Anatomic factors predict urinary continence in patient with anorectal malformation.
Fuchs ME, Halleran DR, Shin YJ, Sebastião Y, Weaver L, Ahmad H, Booth K, Ching CB, Levitt MA, Wood RJ, Dajusta DG
J Pediatr Urol 2020 Oct;16(5):545.e1-545.e7. Epub 2020 Jun 21 doi: 10.1016/j.jpurol.2020.06.011. PMID: 32798105
Caudal cell mass developmental aberrations: an imaging approach.
Chaturvedi A, Franco A, Chaturvedi A, Klionsky NB
Clin Imaging 2018 Nov-Dec;52:216-225. Epub 2018 Jul 21 doi: 10.1016/j.clinimag.2018.07.014. PMID: 30138861
Fractures in myelomeningocele.
Akbar M, Bresch B, Raiss P, Fürstenberg CH, Bruckner T, Seyler T, Carstens C, Abel R
J Orthop Traumatol 2010 Sep;11(3):175-82. Epub 2010 Aug 19 doi: 10.1007/s10195-010-0102-2. PMID: 20721596Free PMC Article
Cervical myelomeningocele.
Habibi Z, Nejat F, Tajik P, Kazmi SS, Kajbafzadeh AM
Neurosurgery 2006 Jun;58(6):1168-75; discussion 1168-75. doi: 10.1227/01.NEU.0000215955.18762.32. PMID: 16723896

Clinical prediction guides

Prevalence of supratentorial anomalies assessed by magnetic resonance imaging in fetuses with open spina bifida.
Trigo L, Eixarch E, Bottura I, Dalaqua M, Barbosa AA, De Catte L, Demaerel P, Dymarkowski S, Deprest J, Lapa DA, Aertsen M, Gratacos E
Ultrasound Obstet Gynecol 2022 Jun;59(6):804-812. doi: 10.1002/uog.23761. PMID: 34396624
Anatomic factors predict urinary continence in patient with anorectal malformation.
Fuchs ME, Halleran DR, Shin YJ, Sebastião Y, Weaver L, Ahmad H, Booth K, Ching CB, Levitt MA, Wood RJ, Dajusta DG
J Pediatr Urol 2020 Oct;16(5):545.e1-545.e7. Epub 2020 Jun 21 doi: 10.1016/j.jpurol.2020.06.011. PMID: 32798105
A perspective in the management of myelomeningocoele in the KwaZulu-Natal Province of South Africa.
Mnguni MN, Enicker BC, Madiba TE
Childs Nerv Syst 2020 Jul;36(7):1521-1527. Epub 2020 Jan 23 doi: 10.1007/s00381-020-04506-9. PMID: 31974664Free PMC Article
Hip Status and Long-term Functional Outcomes in Spina Bifida.
Thompson RM, Foley J, Dias L, Swaroop VT
J Pediatr Orthop 2019 Mar;39(3):e168-e172. doi: 10.1097/BPO.0000000000001266. PMID: 30300276
Fractures in myelomeningocele.
Akbar M, Bresch B, Raiss P, Fürstenberg CH, Bruckner T, Seyler T, Carstens C, Abel R
J Orthop Traumatol 2010 Sep;11(3):175-82. Epub 2010 Aug 19 doi: 10.1007/s10195-010-0102-2. PMID: 20721596Free PMC Article

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