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Severe Bronchopulmonary Dysplasia

MedGen UID:
476148
Concept ID:
C3274515
Disease or Syndrome

Definition

Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere Bronchopulmonary Dysplasia

Professional guidelines

PubMed

Agarwal A, McKinney RL, Baker CD, Nelin LD, Abman SH; BPD Collaborative
Pediatr Pulmonol 2024 Jun;59(6):1803-1806. Epub 2024 Feb 27 doi: 10.1002/ppul.26945. PMID: 38411342
Dudoignon B, Khirani S, Vedrenne-Cloquet M, Amaddeo A, Bokov P, Renolleau S, Fauroux B
Pediatr Pulmonol 2024 Apr;59(4):1128-1132. Epub 2024 Feb 14 doi: 10.1002/ppul.26874. PMID: 38353385
Truog WE, Lewis TR, Bamat NA
Neoreviews 2020 Jul;21(7):e454-e468. doi: 10.1542/neo.21-7-e454. PMID: 32611563

Recent clinical studies

Etiology

Gupta S, Subhedar NV, Bell JL, Field D, Bowler U, Hutchison E, Johnson S, Kelsall W, Pepperell J, Roberts T, Sinha S, Stanbury K, Wyllie J, Hardy P, Juszczak E; Baby-OSCAR Collaborative Group
N Engl J Med 2024 Jan 25;390(4):314-325. doi: 10.1056/NEJMoa2305582. PMID: 38265644Free PMC Article
Giesinger RE, Rios DR, Chatmethakul T, Bischoff AR, Sandgren JA, Cunningham A, Beauchene M, Stanford AH, Klein JM, Ten Eyck P, McNamara PJ
Am J Respir Crit Care Med 2023 Aug 1;208(3):290-300. doi: 10.1164/rccm.202212-2291OC. PMID: 37209133Free PMC Article
Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators
N Engl J Med 2023 Mar 16;388(11):980-990. Epub 2022 Dec 6 doi: 10.1056/NEJMoa2207418. PMID: 36477458
Sehgal A, Elsayed K, Nugent M, Varma S
J Perinatol 2022 Jun;42(6):775-780. Epub 2022 Mar 30 doi: 10.1038/s41372-022-01372-y. PMID: 35354941Free PMC Article
Watterberg KL, Walsh MC, Li L, Chawla S, D'Angio CT, Goldberg RN, Hintz SR, Laughon MM, Yoder BA, Kennedy KA, McDavid GE, Backstrom-Lacy C, Das A, Crawford MM, Keszler M, Sokol GM, Poindexter BB, Ambalavanan N, Hibbs AM, Truog WE, Schmidt B, Wyckoff MH, Khan AM, Garg M, Chess PR, Reynolds AM, Moallem M, Bell EF, Meyer LR, Patel RM, Van Meurs KP, Cotten CM, McGowan EC, Hines AC, Merhar S, Peralta-Carcelen M, Wilson-Costello DE, Kilbride HW, DeMauro SB, Heyne RJ, Mosquera RA, Natarajan G, Purdy IB, Lowe JR, Maitre NL, Harmon HM, Hogden LA, Adams-Chapman I, Winter S, Malcolm WF, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network
N Engl J Med 2022 Mar 24;386(12):1121-1131. doi: 10.1056/NEJMoa2114897. PMID: 35320643Free PMC Article

Diagnosis

Levin JC, Cavanaugh C, Malpocher K, Leeman KT
Neoreviews 2022 Oct 1;23(10):e708-e715. doi: 10.1542/neo.23-10-e708. PMID: 36180733
Bamat NA, Zhang H, McKenna KJ, Morris H, Stoller JZ, Gibbs K
Neoreviews 2020 Jul;21(7):e442-e453. Epub 2020 Jul 1 doi: 10.1542/neo.21-7-e442. PMID: 32611562
Avitabile CM, Ansems S, Wang Y, Fraga MV, Kirpalani HM, Zhang H, Mercer-Rosa L, Jensen EA
Neonatology 2019;116(2):147-153. Epub 2019 May 16 doi: 10.1159/000499082. PMID: 31096210
Tkach EK, White AM, Dysart KC, Waber B, Nawab US, Zhang H, Jensen EA
Am J Perinatol 2017 Oct;34(12):1199-1204. Epub 2017 Apr 21 doi: 10.1055/s-0037-1602419. PMID: 28431438
Murthy K, Savani RC, Lagatta JM, Zaniletti I, Wadhawan R, Truog W, Grover TR, Zhang H, Asselin JM, Durand DJ, Short BL, Pallotto EK, Padula MA, Dykes FD, Reber KM, Evans JR
J Perinatol 2014 Jul;34(7):543-8. Epub 2014 Mar 20 doi: 10.1038/jp.2014.35. PMID: 24651732

Therapy

Meyer S, Bay J, Franz AR, Ehrhardt H, Klein L, Petzinger J, Binder C, Kirschenhofer S, Stein A, Hüning B, Heep A, Cloppenburg E, Muyimbwa J, Ott T, Sandkötter J, Teig N, Wiegand S, Schroth M, Kick A, Wurm D, Gebauer C, Linnemann K, Kittel J, Wieg C, Kiechl-Kohlendorfer U, Schmidt S, Böttger R, Thomas W, Brevis Nunez F, Stockmann A, Kriebel T, Müller A, Klotz D, Morhart P, Nohr D, Biesalski HK, Giannopoulou EZ, Hilt S, Poryo M, Wagenpfeil S, Haiden N, Ruckes C, Ehrlich A, Gortner L; NeoVitaA trial investigators
Lancet Respir Med 2024 Jul;12(7):544-555. Epub 2024 Apr 18 doi: 10.1016/S2213-2600(24)00073-0. PMID: 38643780
Gupta S, Subhedar NV, Bell JL, Field D, Bowler U, Hutchison E, Johnson S, Kelsall W, Pepperell J, Roberts T, Sinha S, Stanbury K, Wyllie J, Hardy P, Juszczak E; Baby-OSCAR Collaborative Group
N Engl J Med 2024 Jan 25;390(4):314-325. doi: 10.1056/NEJMoa2305582. PMID: 38265644Free PMC Article
Hundscheid T, Onland W, Kooi EMW, Vijlbrief DC, de Vries WB, Dijkman KP, van Kaam AH, Villamor E, Kroon AA, Visser R, Mulder-de Tollenaer SM, De Bisschop B, Dijk PH, Avino D, Hocq C, Zecic A, Meeus M, de Baat T, Derriks F, Henriksen TB, Kyng KJ, Donders R, Nuytemans DHGM, Van Overmeire B, Mulder AL, de Boode WP; BeNeDuctus Trial Investigators
N Engl J Med 2023 Mar 16;388(11):980-990. Epub 2022 Dec 6 doi: 10.1056/NEJMoa2207418. PMID: 36477458
Watterberg KL, Walsh MC, Li L, Chawla S, D'Angio CT, Goldberg RN, Hintz SR, Laughon MM, Yoder BA, Kennedy KA, McDavid GE, Backstrom-Lacy C, Das A, Crawford MM, Keszler M, Sokol GM, Poindexter BB, Ambalavanan N, Hibbs AM, Truog WE, Schmidt B, Wyckoff MH, Khan AM, Garg M, Chess PR, Reynolds AM, Moallem M, Bell EF, Meyer LR, Patel RM, Van Meurs KP, Cotten CM, McGowan EC, Hines AC, Merhar S, Peralta-Carcelen M, Wilson-Costello DE, Kilbride HW, DeMauro SB, Heyne RJ, Mosquera RA, Natarajan G, Purdy IB, Lowe JR, Maitre NL, Harmon HM, Hogden LA, Adams-Chapman I, Winter S, Malcolm WF, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network
N Engl J Med 2022 Mar 24;386(12):1121-1131. doi: 10.1056/NEJMoa2114897. PMID: 35320643Free PMC Article
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

Prognosis

Watterberg KL, Walsh MC, Li L, Chawla S, D'Angio CT, Goldberg RN, Hintz SR, Laughon MM, Yoder BA, Kennedy KA, McDavid GE, Backstrom-Lacy C, Das A, Crawford MM, Keszler M, Sokol GM, Poindexter BB, Ambalavanan N, Hibbs AM, Truog WE, Schmidt B, Wyckoff MH, Khan AM, Garg M, Chess PR, Reynolds AM, Moallem M, Bell EF, Meyer LR, Patel RM, Van Meurs KP, Cotten CM, McGowan EC, Hines AC, Merhar S, Peralta-Carcelen M, Wilson-Costello DE, Kilbride HW, DeMauro SB, Heyne RJ, Mosquera RA, Natarajan G, Purdy IB, Lowe JR, Maitre NL, Harmon HM, Hogden LA, Adams-Chapman I, Winter S, Malcolm WF, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network
N Engl J Med 2022 Mar 24;386(12):1121-1131. doi: 10.1056/NEJMoa2114897. PMID: 35320643Free PMC Article
Bell EF, Hintz SR, Hansen NI, Bann CM, Wyckoff MH, DeMauro SB, Walsh MC, Vohr BR, Stoll BJ, Carlo WA, Van Meurs KP, Rysavy MA, Patel RM, Merhar SL, Sánchez PJ, Laptook AR, Hibbs AM, Cotten CM, D'Angio CT, Winter S, Fuller J, Das A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA 2022 Jan 18;327(3):248-263. doi: 10.1001/jama.2021.23580. PMID: 35040888Free PMC Article
Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM; Children’s Hospitals Neonatal Consortium Severe BPD Focus Group
J Perinatol 2020 Jan;40(1):149-156. Epub 2019 Sep 30 doi: 10.1038/s41372-019-0508-5. PMID: 31570799Free PMC Article
Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D'Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L'Hélias L, Marchand-Martin L, Kaminski M
JAMA Pediatr 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351. PMID: 25621457
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

Clinical prediction guides

Fontijn S, Balink SJA, Bonte M, Andrinopoulou ER, Duijts L, Kroon AA, Ciet P, Pijnenburg MW
Eur J Radiol 2023 Dec;169:111168. Epub 2023 Oct 24 doi: 10.1016/j.ejrad.2023.111168. PMID: 37897957
Branescu I, Shetty S, Richards J, Vladareanu S, Kulkarni A
Acta Paediatr 2023 Sep;112(9):1877-1883. Epub 2023 Jun 12 doi: 10.1111/apa.16863. PMID: 37259611
Ambalavanan N, Weese-Mayer DE, Hibbs AM, Claure N, Carroll JL, Moorman JR, Bancalari E, Hamvas A, Martin RJ, Di Fiore JM, Indic P, Kemp JS, Dormishian A, Krahn KN, Qiu J, Dennery PA, Ratcliffe SJ, Troendle JF, Lake DE; Prematurity-related Ventilatory Control (Pre-Vent) Investigators
Am J Respir Crit Care Med 2023 Jul 1;208(1):79-97. doi: 10.1164/rccm.202210-1971OC. PMID: 37219236Free PMC Article
Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM; Children’s Hospitals Neonatal Consortium Severe BPD Focus Group
J Perinatol 2020 Jan;40(1):149-156. Epub 2019 Sep 30 doi: 10.1038/s41372-019-0508-5. PMID: 31570799Free PMC Article
Jensen EA, Munson DA, Zhang H, Blinman TA, Kirpalani H
Pediatr Pulmonol 2015 Jun;50(6):584-7. Epub 2014 Apr 21 doi: 10.1002/ppul.23052. PMID: 24753497Free PMC Article

Recent systematic reviews

Lim G, Kim YJ, Chung S, Park YM, Kim KS, Park HW
J Korean Med Sci 2022 Apr 25;37(16):e127. doi: 10.3346/jkms.2022.37.e127. PMID: 35470601Free PMC Article
Phattraprayoon N, Ungtrakul T, Soonklang K, Susantitaphong P
PLoS One 2022;17(4):e0265876. Epub 2022 Apr 4 doi: 10.1371/journal.pone.0265876. PMID: 35377893Free PMC Article
King BC, Gandhi BB, Jackson A, Katakam L, Pammi M, Suresh G
Neonatology 2019;116(2):100-114. Epub 2019 Jun 4 doi: 10.1159/000496462. PMID: 31163418
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

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