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Single Ventricle Defect

MedGen UID:
476149
•Concept ID:
C3274516
•
Congenital Abnormality

Definition

A diverse group of congenital cardiovascular abnormalities that share one characteristic, the presence of a single functional cardiac ventricle. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Single Ventricle Defect

Professional guidelines

PubMed

Clinical study of prenatal ultrasonography combined with T‑box transcription factor 1 as a biomarker for the diagnosis of congenital heart disease.
Guo B, Xiao J, Li L, Wang S, Wang L, Liu S
Mol Med Rep 2018 May;17(5):7346-7350. Epub 2018 Mar 14 doi: 10.3892/mmr.2018.8742. PMID: 29568912

Recent clinical studies

Etiology

Development and Validation of a Seizure Prediction Model in Neonates After Cardiac Surgery.
Naim MY, Putt M, Abend NS, Mastropietro CW, Frank DU, Chen JM, Fuller S, Gangemi JJ, Gaynor JW, Heinan K, Licht DJ, Mascio CE, Massey S, Roeser ME, Smith CJ, Kimmel SE
Ann Thorac Surg 2021 Jun;111(6):2041-2048. Epub 2020 Jul 29 doi: 10.1016/j.athoracsur.2020.05.157. PMID: 32738224
Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial.
Frommelt PC, Gerstenberger E, Cnota JF, Cohen MS, Gorentz J, Hill KD, John JB, Levine JC, Lu J, Mahle WT, McCandless RT, Mertens L, Pearson GD, Spencer C, Thacker D, Williams IA, Wong PC, Newburger JW; Pediatric Heart Network Investigators
J Am Coll Cardiol 2014 Nov 11;64(19):2026-35. Epub 2014 Nov 3 doi: 10.1016/j.jacc.2014.08.033. PMID: 25440099Free PMC Article
Coincidence of total anomalous pulmonary venous drainage to the superior vena cava, common atrium, and single ventricle: a very rare condition.
Nabati M, Bagheri B, Habibi V
Echocardiography 2013 Apr;30(4):E98-101. Epub 2013 Jan 30 doi: 10.1111/echo.12141. PMID: 23360092
Is heart transplantation for complex congenital heart disease a good option? A 25-year single centre experience.
Seddio F, Gorislavets N, Iacovoni A, Cugola D, Fontana A, Galletti L, Terzi A, Ferrazzi P
Eur J Cardiothorac Surg 2013 Mar;43(3):605-11; discussion 611. Epub 2012 Jun 24 doi: 10.1093/ejcts/ezs350. PMID: 22733841
The modified Blalock-Taussig shunt versus the right ventricle-to-pulmonary artery conduit for the Norwood procedure.
Ohye RG, Devaney EJ, Hirsch JC, Bove EL
Pediatr Cardiol 2007 Mar-Apr;28(2):122-5. Epub 2007 Feb 16 doi: 10.1007/s00246-006-1449-2. PMID: 17308942

Diagnosis

Development and Validation of a Seizure Prediction Model in Neonates After Cardiac Surgery.
Naim MY, Putt M, Abend NS, Mastropietro CW, Frank DU, Chen JM, Fuller S, Gangemi JJ, Gaynor JW, Heinan K, Licht DJ, Mascio CE, Massey S, Roeser ME, Smith CJ, Kimmel SE
Ann Thorac Surg 2021 Jun;111(6):2041-2048. Epub 2020 Jul 29 doi: 10.1016/j.athoracsur.2020.05.157. PMID: 32738224
Provider perspective on the role of palliative care in hypoplastic left heart syndrome.
Lowenstein S, Macauley R, Perko K, Ronai C
Cardiol Young 2020 Mar;30(3):377-382. doi: 10.1017/S1047951120000128. PMID: 32146916
Clinical study of prenatal ultrasonography combined with T‑box transcription factor 1 as a biomarker for the diagnosis of congenital heart disease.
Guo B, Xiao J, Li L, Wang S, Wang L, Liu S
Mol Med Rep 2018 May;17(5):7346-7350. Epub 2018 Mar 14 doi: 10.3892/mmr.2018.8742. PMID: 29568912
Coincidence of total anomalous pulmonary venous drainage to the superior vena cava, common atrium, and single ventricle: a very rare condition.
Nabati M, Bagheri B, Habibi V
Echocardiography 2013 Apr;30(4):E98-101. Epub 2013 Jan 30 doi: 10.1111/echo.12141. PMID: 23360092
Three-dimensional simulations in Glenn patients: clinically based boundary conditions, hemodynamic results and sensitivity to input data.
Troianowski G, Taylor CA, Feinstein JA, Vignon-Clementel IE
J Biomech Eng 2011 Nov;133(11):111006. doi: 10.1115/1.4005377. PMID: 22168738

Therapy

Development and Validation of a Seizure Prediction Model in Neonates After Cardiac Surgery.
Naim MY, Putt M, Abend NS, Mastropietro CW, Frank DU, Chen JM, Fuller S, Gangemi JJ, Gaynor JW, Heinan K, Licht DJ, Mascio CE, Massey S, Roeser ME, Smith CJ, Kimmel SE
Ann Thorac Surg 2021 Jun;111(6):2041-2048. Epub 2020 Jul 29 doi: 10.1016/j.athoracsur.2020.05.157. PMID: 32738224
Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial.
Frommelt PC, Gerstenberger E, Cnota JF, Cohen MS, Gorentz J, Hill KD, John JB, Levine JC, Lu J, Mahle WT, McCandless RT, Mertens L, Pearson GD, Spencer C, Thacker D, Williams IA, Wong PC, Newburger JW; Pediatric Heart Network Investigators
J Am Coll Cardiol 2014 Nov 11;64(19):2026-35. Epub 2014 Nov 3 doi: 10.1016/j.jacc.2014.08.033. PMID: 25440099Free PMC Article
The modified Blalock-Taussig shunt versus the right ventricle-to-pulmonary artery conduit for the Norwood procedure.
Ohye RG, Devaney EJ, Hirsch JC, Bove EL
Pediatr Cardiol 2007 Mar-Apr;28(2):122-5. Epub 2007 Feb 16 doi: 10.1007/s00246-006-1449-2. PMID: 17308942

Prognosis

Development and Validation of a Seizure Prediction Model in Neonates After Cardiac Surgery.
Naim MY, Putt M, Abend NS, Mastropietro CW, Frank DU, Chen JM, Fuller S, Gangemi JJ, Gaynor JW, Heinan K, Licht DJ, Mascio CE, Massey S, Roeser ME, Smith CJ, Kimmel SE
Ann Thorac Surg 2021 Jun;111(6):2041-2048. Epub 2020 Jul 29 doi: 10.1016/j.athoracsur.2020.05.157. PMID: 32738224
Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial.
Frommelt PC, Gerstenberger E, Cnota JF, Cohen MS, Gorentz J, Hill KD, John JB, Levine JC, Lu J, Mahle WT, McCandless RT, Mertens L, Pearson GD, Spencer C, Thacker D, Williams IA, Wong PC, Newburger JW; Pediatric Heart Network Investigators
J Am Coll Cardiol 2014 Nov 11;64(19):2026-35. Epub 2014 Nov 3 doi: 10.1016/j.jacc.2014.08.033. PMID: 25440099Free PMC Article
Three-dimensional simulations in Glenn patients: clinically based boundary conditions, hemodynamic results and sensitivity to input data.
Troianowski G, Taylor CA, Feinstein JA, Vignon-Clementel IE
J Biomech Eng 2011 Nov;133(11):111006. doi: 10.1115/1.4005377. PMID: 22168738

Clinical prediction guides

Development and Validation of a Seizure Prediction Model in Neonates After Cardiac Surgery.
Naim MY, Putt M, Abend NS, Mastropietro CW, Frank DU, Chen JM, Fuller S, Gangemi JJ, Gaynor JW, Heinan K, Licht DJ, Mascio CE, Massey S, Roeser ME, Smith CJ, Kimmel SE
Ann Thorac Surg 2021 Jun;111(6):2041-2048. Epub 2020 Jul 29 doi: 10.1016/j.athoracsur.2020.05.157. PMID: 32738224
Three-dimensional simulations in Glenn patients: clinically based boundary conditions, hemodynamic results and sensitivity to input data.
Troianowski G, Taylor CA, Feinstein JA, Vignon-Clementel IE
J Biomech Eng 2011 Nov;133(11):111006. doi: 10.1115/1.4005377. PMID: 22168738

Supplemental Content

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