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Neonatal Opiate Withdrawal Syndrome

MedGen UID:
476272
•Concept ID:
C3274639
•
Mental or Behavioral Dysfunction
Synonym: Neonatal Opiod Withdrawal Syndrome

Definition

A constellation of neurobehavioral features observed in a neonate following cessation or reduction of postnatal exposure to opioids. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal Opiate Withdrawal Syndrome

Professional guidelines

PubMed

Evaluating a web-based training curriculum for disseminating best practices for the care of newborns with neonatal opioid withdrawal syndrome in a rural hospital, the NOWS-NM Program.
Pratt-Chavez H, Rishel Brakey H, Sanders SG, Patel J, Ozechowski T, Stoffel C, Sussman AL, Marquez J, Smith DR, Kong AS
BMC Pediatr 2024 Apr 19;24(1):258. doi: 10.1186/s12887-024-04710-5. PMID: 38641785Free PMC Article

Recent clinical studies

Etiology

Evaluating a web-based training curriculum for disseminating best practices for the care of newborns with neonatal opioid withdrawal syndrome in a rural hospital, the NOWS-NM Program.
Pratt-Chavez H, Rishel Brakey H, Sanders SG, Patel J, Ozechowski T, Stoffel C, Sussman AL, Marquez J, Smith DR, Kong AS
BMC Pediatr 2024 Apr 19;24(1):258. doi: 10.1186/s12887-024-04710-5. PMID: 38641785Free PMC Article
Understanding barriers to timely identification of infants at risk of neonatal opiate withdrawal syndrome.
Howell MP, Smith AM, Lindsay EB, Drury SS
J Matern Fetal Neonatal Med 2021 Apr;34(7):1161-1166. Epub 2019 Jun 14 doi: 10.1080/14767058.2019.1627316. PMID: 31195865
Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome.
Lappen JR, Stark S, Bailit JL, Gibson KS
Am J Obstet Gynecol MFM 2020 Feb;2(1):100075. Epub 2019 Dec 10 doi: 10.1016/j.ajogmf.2019.100075. PMID: 33345989

Diagnosis

Understanding barriers to timely identification of infants at risk of neonatal opiate withdrawal syndrome.
Howell MP, Smith AM, Lindsay EB, Drury SS
J Matern Fetal Neonatal Med 2021 Apr;34(7):1161-1166. Epub 2019 Jun 14 doi: 10.1080/14767058.2019.1627316. PMID: 31195865
A Practical Approach to Neonatal Opiate Withdrawal Syndrome.
Devlin LA, Davis JM
Am J Perinatol 2018 Mar;35(4):324-330. Epub 2017 Nov 3 doi: 10.1055/s-0037-1608630. PMID: 29100261

Therapy

Understanding barriers to timely identification of infants at risk of neonatal opiate withdrawal syndrome.
Howell MP, Smith AM, Lindsay EB, Drury SS
J Matern Fetal Neonatal Med 2021 Apr;34(7):1161-1166. Epub 2019 Jun 14 doi: 10.1080/14767058.2019.1627316. PMID: 31195865
Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome.
Lappen JR, Stark S, Bailit JL, Gibson KS
Am J Obstet Gynecol MFM 2020 Feb;2(1):100075. Epub 2019 Dec 10 doi: 10.1016/j.ajogmf.2019.100075. PMID: 33345989
A Practical Approach to Neonatal Opiate Withdrawal Syndrome.
Devlin LA, Davis JM
Am J Perinatol 2018 Mar;35(4):324-330. Epub 2017 Nov 3 doi: 10.1055/s-0037-1608630. PMID: 29100261
Interpretation of hair findings in children after methadone poisoning.
Kintz P, Evans J, Villain M, Cirimele V
Forensic Sci Int 2010 Mar 20;196(1-3):51-4. Epub 2010 Jan 8 doi: 10.1016/j.forsciint.2009.12.033. PMID: 20060244

Clinical prediction guides

Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome.
Lappen JR, Stark S, Bailit JL, Gibson KS
Am J Obstet Gynecol MFM 2020 Feb;2(1):100075. Epub 2019 Dec 10 doi: 10.1016/j.ajogmf.2019.100075. PMID: 33345989
Interpretation of hair findings in children after methadone poisoning.
Kintz P, Evans J, Villain M, Cirimele V
Forensic Sci Int 2010 Mar 20;196(1-3):51-4. Epub 2010 Jan 8 doi: 10.1016/j.forsciint.2009.12.033. PMID: 20060244

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