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Severely Abnormal Ventricular Ejection Fraction

MedGen UID:
476410
•Concept ID:
C3274777
•
Finding

Definition

Severely less than normal amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered less than 30%. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSeverely Abnormal Ventricular Ejection Fraction

Professional guidelines

PubMed

Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management.
El-Sabrout H, Ganta S, Guyon P, Ratnayaka K, Vaughn G, Perry J, Kimball A, Ryan J, Thornburg CD, Tucker S, Mo J, Hegde S, Nigro J, El-Said H
Circ Cardiovasc Interv 2022 May;15(5):e011664. Epub 2022 Apr 29 doi: 10.1161/CIRCINTERVENTIONS.121.011664. PMID: 35485231
Genotype-phenotype correlation in arrhythmogenic right ventricular cardiomyopathy-risk of arrhythmias and heart failure.
Christensen AH, Platonov PG, Jensen HK, Chivulescu M, Svensson A, Dahlberg P, Madsen T, Frederiksen TC, Heliö T, Lie ØH, Haugaa KH, Hastrup Svendsen J, Bundgaard H
J Med Genet 2022 Sep;59(9):858-864. Epub 2021 Aug 16 doi: 10.1136/jmedgenet-2021-107911. PMID: 34400560
Heart failure with preserved ejection fraction: New approaches to diagnosis and management.
Upadhya B, Kitzman DW
Clin Cardiol 2020 Feb;43(2):145-155. Epub 2019 Dec 26 doi: 10.1002/clc.23321. PMID: 31880340Free PMC Article

Recent clinical studies

Etiology

Design and Baseline Characteristics of STEP-HFpEF Program Evaluating Semaglutide in Patients With Obesity HFpEF Phenotype.
Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Christensen L, Davies M, Hovingh KG, Kitzman DW, Lindegaard ML, Møller DV, Shah SJ, Treppendahl MB, Verma S, Petrie MC
JACC Heart Fail 2023 Aug;11(8 Pt 1):1000-1010. Epub 2023 May 21 doi: 10.1016/j.jchf.2023.05.010. PMID: 37294245
Heart Failure with Preserved Ejection Fraction in Children.
Das B, Deshpande S, Akam-Venkata J, Shakti D, Moskowitz W, Lipshultz SE
Pediatr Cardiol 2023 Mar;44(3):513-529. Epub 2022 Aug 17 doi: 10.1007/s00246-022-02960-7. PMID: 35978175
Heart failure with preserved ejection fraction: New approaches to diagnosis and management.
Upadhya B, Kitzman DW
Clin Cardiol 2020 Feb;43(2):145-155. Epub 2019 Dec 26 doi: 10.1002/clc.23321. PMID: 31880340Free PMC Article
Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea.
Sascău R, Zota IM, Stătescu C, Boișteanu D, Roca M, Maștaleru A, Leon Constantin MM, Vasilcu TF, Gavril RS, Mitu F
Can Respir J 2018;2018:1206217. Epub 2018 Nov 18 doi: 10.1155/2018/1206217. PMID: 30581512Free PMC Article
Imaging of the right heart--CT and CMR.
Kochav J, Simprini L, Weinsaft JW
Echocardiography 2015 Jan;32 Suppl 1:S53-68. Epub 2014 Sep 19 doi: 10.1111/echo.12212. PMID: 25244072

Diagnosis

Ventricular systolic dysfunction with and without altered myocardial contractility: Clinical value of echocardiography for diagnosis and therapeutic decision-making.
Dandel M, Hetzer R
Int J Cardiol 2021 Mar 15;327:236-250. Epub 2020 Dec 5 doi: 10.1016/j.ijcard.2020.11.068. PMID: 33285193
Heart failure with preserved ejection fraction: New approaches to diagnosis and management.
Upadhya B, Kitzman DW
Clin Cardiol 2020 Feb;43(2):145-155. Epub 2019 Dec 26 doi: 10.1002/clc.23321. PMID: 31880340Free PMC Article
Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea.
Sascău R, Zota IM, Stătescu C, Boișteanu D, Roca M, Maștaleru A, Leon Constantin MM, Vasilcu TF, Gavril RS, Mitu F
Can Respir J 2018;2018:1206217. Epub 2018 Nov 18 doi: 10.1155/2018/1206217. PMID: 30581512Free PMC Article
Heart Failure With Preserved Ejection Fraction.
Rogers FJ, Gundala T, Ramos JE, Serajian A
J Am Osteopath Assoc 2015 Jul;115(7):432-42. doi: 10.7556/jaoa.2015.089. PMID: 26111131
Endpoints of resuscitation.
Cestero RF, Dent DL
Surg Clin North Am 2015 Apr;95(2):319-36. Epub 2014 Dec 4 doi: 10.1016/j.suc.2014.10.004. PMID: 25814109

Therapy

Design and Baseline Characteristics of STEP-HFpEF Program Evaluating Semaglutide in Patients With Obesity HFpEF Phenotype.
Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Christensen L, Davies M, Hovingh KG, Kitzman DW, Lindegaard ML, Møller DV, Shah SJ, Treppendahl MB, Verma S, Petrie MC
JACC Heart Fail 2023 Aug;11(8 Pt 1):1000-1010. Epub 2023 May 21 doi: 10.1016/j.jchf.2023.05.010. PMID: 37294245
Sex, gender, and subclinical hypertensiveorgan damage-heart.
Cuspidi C, Gherbesi E, Sala C, Tadic M
J Hum Hypertens 2023 Aug;37(8):626-633. Epub 2022 Aug 27 doi: 10.1038/s41371-022-00750-5. PMID: 36030347
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Mitral valve regurgitation.
O'Rourke RA, Crawford MH
Curr Probl Cardiol 1984 May;9(2):1-52. doi: 10.1016/0146-2806(84)90021-5. PMID: 6375982

Prognosis

Heart Failure with Preserved Ejection Fraction in Children.
Das B, Deshpande S, Akam-Venkata J, Shakti D, Moskowitz W, Lipshultz SE
Pediatr Cardiol 2023 Mar;44(3):513-529. Epub 2022 Aug 17 doi: 10.1007/s00246-022-02960-7. PMID: 35978175
Liver tests and outcomes in heart failure with reduced ejection fraction: findings from DAPA-HF.
Adamson C, Cowan LM, de Boer RA, Diez M, Drożdż J, Dukát A, Inzucchi SE, Køber L, Kosiborod MN, Ljungman CEA, Martinez FA, Ponikowski P, Sabatine MS, Lindholm D, Bengtsson O, Boulton DW, Greasley PJ, Langkilde AM, Sjöstrand M, Solomon SD, McMurray JJV, Jhund PS
Eur J Heart Fail 2022 Oct;24(10):1856-1868. Epub 2022 Aug 22 doi: 10.1002/ejhf.2649. PMID: 36054568Free PMC Article
Heart failure with preserved ejection fraction: New approaches to diagnosis and management.
Upadhya B, Kitzman DW
Clin Cardiol 2020 Feb;43(2):145-155. Epub 2019 Dec 26 doi: 10.1002/clc.23321. PMID: 31880340Free PMC Article
Non-invasive cardiac mapping for non-response in cardiac resynchronization therapy.
Strik M, Ploux S, Jankelson L, Bordachar P
Ann Med 2019 Mar;51(2):109-117. Epub 2019 May 23 doi: 10.1080/07853890.2019.1616109. PMID: 31094217Free PMC Article
Evolution of a Geriatric Syndrome: Pathophysiology and Treatment of Heart Failure with Preserved Ejection Fraction.
Upadhya B, Pisani B, Kitzman DW
J Am Geriatr Soc 2017 Nov;65(11):2431-2440. doi: 10.1111/jgs.15141. PMID: 29124734Free PMC Article

Clinical prediction guides

Design and Baseline Characteristics of STEP-HFpEF Program Evaluating Semaglutide in Patients With Obesity HFpEF Phenotype.
Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Christensen L, Davies M, Hovingh KG, Kitzman DW, Lindegaard ML, Møller DV, Shah SJ, Treppendahl MB, Verma S, Petrie MC
JACC Heart Fail 2023 Aug;11(8 Pt 1):1000-1010. Epub 2023 May 21 doi: 10.1016/j.jchf.2023.05.010. PMID: 37294245
Heart Failure with Preserved Ejection Fraction in Children.
Das B, Deshpande S, Akam-Venkata J, Shakti D, Moskowitz W, Lipshultz SE
Pediatr Cardiol 2023 Mar;44(3):513-529. Epub 2022 Aug 17 doi: 10.1007/s00246-022-02960-7. PMID: 35978175
Heart failure with preserved ejection fraction: New approaches to diagnosis and management.
Upadhya B, Kitzman DW
Clin Cardiol 2020 Feb;43(2):145-155. Epub 2019 Dec 26 doi: 10.1002/clc.23321. PMID: 31880340Free PMC Article
Non-invasive cardiac mapping for non-response in cardiac resynchronization therapy.
Strik M, Ploux S, Jankelson L, Bordachar P
Ann Med 2019 Mar;51(2):109-117. Epub 2019 May 23 doi: 10.1080/07853890.2019.1616109. PMID: 31094217Free PMC Article
Review of Echocardiographic Findings in Patients with Obstructive Sleep Apnea.
Sascău R, Zota IM, Stătescu C, Boișteanu D, Roca M, Maștaleru A, Leon Constantin MM, Vasilcu TF, Gavril RS, Mitu F
Can Respir J 2018;2018:1206217. Epub 2018 Nov 18 doi: 10.1155/2018/1206217. PMID: 30581512Free PMC Article

Recent systematic reviews

Cardiac MRI Findings in COVID-19 Vaccine-Related Myocarditis: A Pooled Analysis of 468 Patients.
Samimisedeh P, Jafari Afshar E, Shafiabadi Hassani N, Rastad H
J Magn Reson Imaging 2022 Oct;56(4):971-982. Epub 2022 May 25 doi: 10.1002/jmri.28268. PMID: 35612967Free PMC Article
Risk Factors for Mortality and Ventricular Tachycardia in Patients With Repaired Tetralogy of Fallot: A Systematic Review and Meta-analysis.
Possner M, Tseng SY, Alahdab F, Bokma JP, Lubert AM, Khairy P, Murad MH, Ben Ali W, Prokop LJ, Czosek RJ, Veldtman GR, Alsaied T
Can J Cardiol 2020 Nov;36(11):1815-1825. Epub 2020 Feb 4 doi: 10.1016/j.cjca.2020.01.023. PMID: 32416063
Prognostic Significance of Left Ventricular Noncompaction: Systematic Review and Meta-Analysis of Observational Studies.
Aung N, Doimo S, Ricci F, Sanghvi MM, Pedrosa C, Woodbridge SP, Al-Balah A, Zemrak F, Khanji MY, Munroe PB, Naci H, Petersen SE
Circ Cardiovasc Imaging 2020 Jan;13(1):e009712. Epub 2020 Jan 21 doi: 10.1161/CIRCIMAGING.119.009712. PMID: 31959004Free PMC Article
Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis.
Egbe AC, Adigun R, Anand V, West CP, Montori VM, Murad MH, Akintoye E, Osman K, Connolly HM
Can J Cardiol 2019 Dec;35(12):1784-1790. Epub 2019 Aug 8 doi: 10.1016/j.cjca.2019.07.634. PMID: 31732195
Cardiac resynchronization therapy in congenital heart disease.
Khairy P, Fournier A, Thibault B, Dubuc M, Thérien J, Vobecky SJ
Int J Cardiol 2006 May 10;109(2):160-8. Epub 2005 Aug 10 doi: 10.1016/j.ijcard.2005.06.065. PMID: 16095734

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