U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Significant Arterial Dissection

MedGen UID:
476507
•Concept ID:
C3274874
•
Disease or Syndrome

Definition

A dissection that impairs flow. This includes Type C (a persisting contrast medium extravasation) in the presence of ischemia, Type D (a spiral filling defect with delayed but complete distal flow), Type E (persistent filling defect with delayed antegrade flow) and Type F (filling defect with impaired flow and total occlusion). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSignificant Arterial Dissection

Professional guidelines

PubMed

Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.
Kaufmann JE, Harshfield EL, Gensicke H, Wegener S, Michel P, Kägi G, Nedeltchev K, Kellert L, Rosenbaum S, Nolte CH, Christensen H, Arnold M, Lyrer P, Levi C, Bath PM, Engelter ST, Traenka C, Markus HS; CADISS and TREAT-CAD Investigators
JAMA Neurol 2024 Jun 1;81(6):630-637. doi: 10.1001/jamaneurol.2024.1141. PMID: 38739383Free PMC Article
Radial Artery Access Complications: Prevention, Diagnosis and Management.
Roy S, Kabach M, Patel DB, Guzman LA, Jovin IS
Cardiovasc Revasc Med 2022 Jul;40:163-171. Epub 2021 Dec 16 doi: 10.1016/j.carrev.2021.12.007. PMID: 34952824
Optimal Treatment of Uncomplicated Type B Aortic Dissection: JACC Review Topic of the Week.
Tadros RO, Tang GHL, Barnes HJ, Mousavi I, Kovacic JC, Faries P, Olin JW, Marin ML, Adams DH
J Am Coll Cardiol 2019 Sep 17;74(11):1494-1504. doi: 10.1016/j.jacc.2019.07.063. PMID: 31514953

Recent clinical studies

Etiology

OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection.
Lu J, Li P, Ma K, Li Y, Yuan H, Zhu J, Duan W, Ou J, Huang Y, Wu L, Pan X, Zhang H, Du J, Li Y
Nat Commun 2021 Jun 7;12(1):3401. doi: 10.1038/s41467-021-23787-5. PMID: 34099729Free PMC Article
Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances.
Sayed A, Munir M, Bahbah EI
Curr Cardiol Rev 2021;17(4):e230421186875. doi: 10.2174/1573403X16666201014142930. PMID: 33059568Free PMC Article
Acute type A aortic dissection - a review.
Gudbjartsson T, Ahlsson A, Geirsson A, Gunn J, Hjortdal V, Jeppsson A, Mennander A, Zindovic I, Olsson C
Scand Cardiovasc J 2020 Feb;54(1):1-13. Epub 2019 Sep 23 doi: 10.1080/14017431.2019.1660401. PMID: 31542960
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932
Type B Aortic Dissections: Current Guidelines for Treatment.
Alfson DB, Ham SW
Cardiol Clin 2017 Aug;35(3):387-410. Epub 2017 May 26 doi: 10.1016/j.ccl.2017.03.007. PMID: 28683909

Diagnosis

Loeys-Dietz Syndrome.
Velchev JD, Van Laer L, Luyckx I, Dietz H, Loeys B
Adv Exp Med Biol 2021;1348:251-264. doi: 10.1007/978-3-030-80614-9_11. PMID: 34807423
Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances.
Sayed A, Munir M, Bahbah EI
Curr Cardiol Rev 2021;17(4):e230421186875. doi: 10.2174/1573403X16666201014142930. PMID: 33059568Free PMC Article
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932
Hypertensive and acute aortic syndromes.
Li JZ, Eagle KA, Vaishnava P
Cardiol Clin 2013 Nov;31(4):493-501, vii. Epub 2013 Sep 20 doi: 10.1016/j.ccl.2013.07.011. PMID: 24188216
Acute aortic dissection.
Kamalakannan D, Rosman HS, Eagle KA
Crit Care Clin 2007 Oct;23(4):779-800, vi. doi: 10.1016/j.ccc.2007.07.002. PMID: 17964363

Therapy

Hybrid Approaches for Aortic Disease-Our Experience.
Khoynezhad A, Worthington T
Ann Vasc Surg 2023 Aug;94:56-60. Epub 2022 Oct 27 doi: 10.1016/j.avsg.2022.10.002. PMID: 36377067
Acute type A aortic dissection - a review.
Gudbjartsson T, Ahlsson A, Geirsson A, Gunn J, Hjortdal V, Jeppsson A, Mennander A, Zindovic I, Olsson C
Scand Cardiovasc J 2020 Feb;54(1):1-13. Epub 2019 Sep 23 doi: 10.1080/14017431.2019.1660401. PMID: 31542960
Anesthetic Considerations for Aortic Arch Stenting.
Zoller JK, Gregory SH, Stevens TW, Sanchez LA, Hueneke R
J Cardiothorac Vasc Anesth 2019 Nov;33(11):3163-3175. Epub 2019 Feb 8 doi: 10.1053/j.jvca.2019.01.058. PMID: 30867107
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160
Dissection complicating angioplasty.
Gardiner GA Jr, Meyerovitz MF, Harrington DP, Boxt LM, Taus RH, Marx M, Miller RH, Levin DC
AJR Am J Roentgenol 1985 Sep;145(3):627-31. doi: 10.2214/ajr.145.3.627. PMID: 3161308

Prognosis

Hybrid Approaches for Aortic Disease-Our Experience.
Khoynezhad A, Worthington T
Ann Vasc Surg 2023 Aug;94:56-60. Epub 2022 Oct 27 doi: 10.1016/j.avsg.2022.10.002. PMID: 36377067
OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection.
Lu J, Li P, Ma K, Li Y, Yuan H, Zhu J, Duan W, Ou J, Huang Y, Wu L, Pan X, Zhang H, Du J, Li Y
Nat Commun 2021 Jun 7;12(1):3401. doi: 10.1038/s41467-021-23787-5. PMID: 34099729Free PMC Article
Acute type A aortic dissection - a review.
Gudbjartsson T, Ahlsson A, Geirsson A, Gunn J, Hjortdal V, Jeppsson A, Mennander A, Zindovic I, Olsson C
Scand Cardiovasc J 2020 Feb;54(1):1-13. Epub 2019 Sep 23 doi: 10.1080/14017431.2019.1660401. PMID: 31542960
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932
Predicting long-term outcomes of acute aortic dissection: a focus on gender.
Divchev D, Najjar T, Tillwich F, Rehders T, Palisch H, Nienaber CA
Expert Rev Cardiovasc Ther 2015 Mar;13(3):325-31. Epub 2015 Jan 21 doi: 10.1586/14779072.2015.1004313. PMID: 25608580

Clinical prediction guides

OPG/TRAIL ratio as a predictive biomarker of mortality in patients with type A acute aortic dissection.
Lu J, Li P, Ma K, Li Y, Yuan H, Zhu J, Duan W, Ou J, Huang Y, Wu L, Pan X, Zhang H, Du J, Li Y
Nat Commun 2021 Jun 7;12(1):3401. doi: 10.1038/s41467-021-23787-5. PMID: 34099729Free PMC Article
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results.
Markus HS, Levi C, King A, Madigan J, Norris J; Cervical Artery Dissection in Stroke Study (CADISS) Investigators
JAMA Neurol 2019 Jun 1;76(6):657-664. doi: 10.1001/jamaneurol.2019.0072. PMID: 30801621Free PMC Article
VI2TA2 S2C2ORE: a new score system for in hospital mortality in acute aortic dissections.
Orrico M, Ronchey S, Praquin B, Setacci C, Lachat M, Mangialardi N
J Cardiovasc Surg (Torino) 2019 Aug;60(4):496-500. Epub 2016 Apr 8 doi: 10.23736/S0021-9509.16.09172-2. PMID: 27145124
Oral Fluoroquinolone and the Risk of Aortic Dissection.
Lee CC, Lee MG, Hsieh R, Porta L, Lee WC, Lee SH, Chang SS
J Am Coll Cardiol 2018 Sep 18;72(12):1369-1378. doi: 10.1016/j.jacc.2018.06.067. PMID: 30213330
Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research.
Evangelista A, Isselbacher EM, Bossone E, Gleason TG, Eusanio MD, Sechtem U, Ehrlich MP, Trimarchi S, Braverman AC, Myrmel T, Harris KM, Hutchinson S, O'Gara P, Suzuki T, Nienaber CA, Eagle KA; IRAD Investigators
Circulation 2018 Apr 24;137(17):1846-1860. doi: 10.1161/CIRCULATIONAHA.117.031264. PMID: 29685932

Recent systematic reviews

Antithrombotic Treatment for Cervical Artery Dissection: A Systematic Review and Individual Patient Data Meta-Analysis.
Kaufmann JE, Harshfield EL, Gensicke H, Wegener S, Michel P, Kägi G, Nedeltchev K, Kellert L, Rosenbaum S, Nolte CH, Christensen H, Arnold M, Lyrer P, Levi C, Bath PM, Engelter ST, Traenka C, Markus HS; CADISS and TREAT-CAD Investigators
JAMA Neurol 2024 Jun 1;81(6):630-637. doi: 10.1001/jamaneurol.2024.1141. PMID: 38739383Free PMC Article
Blood Pressure, Hypertension, and the Risk of Aortic Dissection Incidence and Mortality: Results From the J-SCH Study, the UK Biobank Study, and a Meta-Analysis of Cohort Studies.
Hibino M, Otaki Y, Kobeissi E, Pan H, Hibino H, Taddese H, Majeed A, Verma S, Konta T, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Kasahara M, Shibagaki Y, Iseki K, Moriyama T, Kondo M, Asahi K, Watanabe T, Watanabe T, Watanabe M, Aune D
Circulation 2022 Mar;145(9):633-644. Epub 2021 Nov 8 doi: 10.1161/CIRCULATIONAHA.121.056546. PMID: 34743557
Aneurysmal degeneration of type B aortic dissections after thoracic endovascular aortic repair: A systematic review.
Famularo M, Meyermann K, Lombardi JV
J Vasc Surg 2017 Sep;66(3):924-930. Epub 2017 Jul 21 doi: 10.1016/j.jvs.2017.06.067. PMID: 28736120
Acute Aortic Dissection and Intramural Hematoma: A Systematic Review.
Mussa FF, Horton JD, Moridzadeh R, Nicholson J, Trimarchi S, Eagle KA
JAMA 2016 Aug 16;316(7):754-63. doi: 10.1001/jama.2016.10026. PMID: 27533160
The genetics of cervical artery dissection: a systematic review.
Debette S, Markus HS
Stroke 2009 Jun;40(6):e459-66. Epub 2009 Apr 23 doi: 10.1161/STROKEAHA.108.534669. PMID: 19390073

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On
    • Significant Arterial Dissection
      Significant Arterial Dissection
      MedGen
    • Sialic Acid Storage Disease
      Sialic Acid Storage Disease
      Autosomal recessive neurodegenerative disorders caused by lysosomal membrane transport defects that result in accumulation of free sialic acid (N-ACETYLNEURAMINIC ACID) within...<br/>Year introduced: 2002
      MeSH
    • Glycogen Storage Disease Type II
      Glycogen Storage Disease Type II
      An autosomal recessively inherited glycogen storage disease caused by GLUCAN 1,4-ALPHA-GLUCOSIDASE deficiency. Large amounts of GLYCOGEN accumulate in the LYSOSOMES of skeleta...<br/>Year introduced: 1989(1975)
      MeSH

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...